Amino acid dipepetide frequency for Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba caterpillar fungus) (Hirsutella sinensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.14AlaAla: 11.14 ± 0.105	1.244AlaCys: 1.244 ± 0.023	5.183AlaAsp: 5.183 ± 0.067	5.579AlaGlu: 5.579 ± 0.056	3.123AlaPhe: 3.123 ± 0.038	6.599AlaGly: 6.599 ± 0.065	2.131AlaHis: 2.131 ± 0.027	3.866AlaIle: 3.866 ± 0.039	4.487AlaLys: 4.487 ± 0.048	8.59AlaLeu: 8.59 ± 0.065	2.385AlaMet: 2.385 ± 0.028	2.993AlaAsn: 2.993 ± 0.034	5.524AlaPro: 5.524 ± 0.064	3.813AlaGln: 3.813 ± 0.052	6.263AlaArg: 6.263 ± 0.053	8.092AlaSer: 8.092 ± 0.058	5.32AlaThr: 5.32 ± 0.05	6.149AlaVal: 6.149 ± 0.056	1.258AlaTrp: 1.258 ± 0.023	2.049AlaTyr: 2.049 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.062CysAla: 1.062 ± 0.02	0.259CysCys: 0.259 ± 0.011	0.705CysAsp: 0.705 ± 0.017	0.643CysGlu: 0.643 ± 0.014	0.557CysPhe: 0.557 ± 0.015	1.022CysGly: 1.022 ± 0.023	0.412CysHis: 0.412 ± 0.013	0.635CysIle: 0.635 ± 0.013	0.558CysLys: 0.558 ± 0.014	1.365CysLeu: 1.365 ± 0.021	0.286CysMet: 0.286 ± 0.009	0.442CysAsn: 0.442 ± 0.013	0.799CysPro: 0.799 ± 0.022	0.499CysGln: 0.499 ± 0.013	0.937CysArg: 0.937 ± 0.019	0.94CysSer: 0.94 ± 0.021	0.672CysThr: 0.672 ± 0.016	0.889CysVal: 0.889 ± 0.018	0.199CysTrp: 0.199 ± 0.009	0.338CysTyr: 0.338 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.026AspAla: 6.026 ± 0.066	0.735AspCys: 0.735 ± 0.017	5.35AspAsp: 5.35 ± 0.074	4.921AspGlu: 4.921 ± 0.055	2.318AspPhe: 2.318 ± 0.027	4.973AspGly: 4.973 ± 0.056	1.283AspHis: 1.283 ± 0.022	2.616AspIle: 2.616 ± 0.029	2.807AspLys: 2.807 ± 0.048	4.941AspLeu: 4.941 ± 0.043	1.578AspMet: 1.578 ± 0.026	1.754AspAsn: 1.754 ± 0.022	3.119AspPro: 3.119 ± 0.035	1.952AspGln: 1.952 ± 0.028	3.221AspArg: 3.221 ± 0.037	4.185AspSer: 4.185 ± 0.046	2.647AspThr: 2.647 ± 0.032	4.129AspVal: 4.129 ± 0.039	0.911AspTrp: 0.911 ± 0.017	1.48AspTyr: 1.48 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.224GluAla: 6.224 ± 0.055	0.676GluCys: 0.676 ± 0.015	3.885GluAsp: 3.885 ± 0.052	4.514GluGlu: 4.514 ± 0.068	1.794GluPhe: 1.794 ± 0.025	3.616GluGly: 3.616 ± 0.049	1.463GluHis: 1.463 ± 0.026	2.36GluIle: 2.36 ± 0.027	3.107GluLys: 3.107 ± 0.043	5.287GluLeu: 5.287 ± 0.042	1.524GluMet: 1.524 ± 0.022	1.851GluAsn: 1.851 ± 0.028	3.024GluPro: 3.024 ± 0.037	2.465GluGln: 2.465 ± 0.033	4.17GluArg: 4.17 ± 0.043	4.193GluSer: 4.193 ± 0.043	3.362GluThr: 3.362 ± 0.033	3.307GluVal: 3.307 ± 0.036	0.837GluTrp: 0.837 ± 0.017	1.478GluTyr: 1.478 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.139PheAla: 3.139 ± 0.033	0.566PheCys: 0.566 ± 0.016	2.357PheAsp: 2.357 ± 0.027	2.028PheGlu: 2.028 ± 0.027	1.513PhePhe: 1.513 ± 0.023	2.716PheGly: 2.716 ± 0.036	0.909PheHis: 0.909 ± 0.018	1.481PheIle: 1.481 ± 0.024	1.436PheLys: 1.436 ± 0.023	3.361PheLeu: 3.361 ± 0.042	0.769PheMet: 0.769 ± 0.015	1.279PheAsn: 1.279 ± 0.023	1.847PhePro: 1.847 ± 0.025	1.322PheGln: 1.322 ± 0.023	2.081PheArg: 2.081 ± 0.027	2.673PheSer: 2.673 ± 0.029	1.841PheThr: 1.841 ± 0.025	2.451PheVal: 2.451 ± 0.029	0.583PheTrp: 0.583 ± 0.016	0.957PheTyr: 0.957 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.161GlyAla: 6.161 ± 0.063	0.929GlyCys: 0.929 ± 0.019	4.169GlyAsp: 4.169 ± 0.043	3.918GlyGlu: 3.918 ± 0.039	2.761GlyPhe: 2.761 ± 0.036	6.347GlyGly: 6.347 ± 0.078	2.034GlyHis: 2.034 ± 0.031	3.201GlyIle: 3.201 ± 0.035	3.588GlyLys: 3.588 ± 0.049	6.402GlyLeu: 6.402 ± 0.054	1.603GlyMet: 1.603 ± 0.024	2.526GlyAsn: 2.526 ± 0.034	3.991GlyPro: 3.991 ± 0.047	2.925GlyGln: 2.925 ± 0.032	5.035GlyArg: 5.035 ± 0.048	5.774GlySer: 5.774 ± 0.059	3.857GlyThr: 3.857 ± 0.052	4.38GlyVal: 4.38 ± 0.04	1.122GlyTrp: 1.122 ± 0.021	1.879GlyTyr: 1.879 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.083HisAla: 2.083 ± 0.028	0.365HisCys: 0.365 ± 0.013	1.611HisAsp: 1.611 ± 0.026	1.397HisGlu: 1.397 ± 0.022	0.892HisPhe: 0.892 ± 0.015	2.132HisGly: 2.132 ± 0.026	0.971HisHis: 0.971 ± 0.024	1.025HisIle: 1.025 ± 0.018	0.93HisLys: 0.93 ± 0.02	2.388HisLeu: 2.388 ± 0.033	0.582HisMet: 0.582 ± 0.013	0.723HisAsn: 0.723 ± 0.015	1.592HisPro: 1.592 ± 0.03	1.106HisGln: 1.106 ± 0.024	1.742HisArg: 1.742 ± 0.027	1.691HisSer: 1.691 ± 0.026	1.105HisThr: 1.105 ± 0.022	1.855HisVal: 1.855 ± 0.027	0.354HisTrp: 0.354 ± 0.01	0.618HisTyr: 0.618 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.536IleAla: 3.536 ± 0.041	0.658IleCys: 0.658 ± 0.016	2.495IleAsp: 2.495 ± 0.026	2.33IleGlu: 2.33 ± 0.03	1.626IlePhe: 1.626 ± 0.024	2.706IleGly: 2.706 ± 0.027	1.05IleHis: 1.05 ± 0.017	1.868IleIle: 1.868 ± 0.027	2.057IleLys: 2.057 ± 0.026	3.824IleLeu: 3.824 ± 0.041	0.938IleMet: 0.938 ± 0.019	1.448IleAsn: 1.448 ± 0.023	2.367IlePro: 2.367 ± 0.027	1.551IleGln: 1.551 ± 0.023	2.669IleArg: 2.669 ± 0.03	2.957IleSer: 2.957 ± 0.033	2.155IleThr: 2.155 ± 0.055	2.869IleVal: 2.869 ± 0.028	0.601IleTrp: 0.601 ± 0.016	1.078IleTyr: 1.078 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.577LysAla: 4.577 ± 0.052	0.53LysCys: 0.53 ± 0.016	2.726LysAsp: 2.726 ± 0.042	2.862LysGlu: 2.862 ± 0.048	1.366LysPhe: 1.366 ± 0.024	3.003LysGly: 3.003 ± 0.037	1.149LysHis: 1.149 ± 0.021	1.835LysIle: 1.835 ± 0.025	3.023LysLys: 3.023 ± 0.061	4.065LysLeu: 4.065 ± 0.039	1.124LysMet: 1.124 ± 0.022	1.464LysAsn: 1.464 ± 0.031	2.83LysPro: 2.83 ± 0.04	1.95LysGln: 1.95 ± 0.042	3.577LysArg: 3.577 ± 0.043	3.251LysSer: 3.251 ± 0.037	2.806LysThr: 2.806 ± 0.038	2.711LysVal: 2.711 ± 0.034	0.608LysTrp: 0.608 ± 0.017	1.163LysTyr: 1.163 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.938LeuAla: 8.938 ± 0.062	1.309LeuCys: 1.309 ± 0.025	5.758LeuAsp: 5.758 ± 0.05	5.414LeuGlu: 5.414 ± 0.054	3.183LeuPhe: 3.183 ± 0.037	6.489LeuGly: 6.489 ± 0.053	2.255LeuHis: 2.255 ± 0.032	3.294LeuIle: 3.294 ± 0.034	3.905LeuLys: 3.905 ± 0.043	8.579LeuLeu: 8.579 ± 0.077	1.839LeuMet: 1.839 ± 0.026	2.716LeuAsn: 2.716 ± 0.03	5.398LeuPro: 5.398 ± 0.051	3.7LeuGln: 3.7 ± 0.046	6.334LeuArg: 6.334 ± 0.057	6.991LeuSer: 6.991 ± 0.055	4.553LeuThr: 4.553 ± 0.045	6.215LeuVal: 6.215 ± 0.056	1.208LeuTrp: 1.208 ± 0.027	2.2LeuTyr: 2.2 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.744MetAla: 2.744 ± 0.027	0.274MetCys: 0.274 ± 0.009	1.428MetAsp: 1.428 ± 0.02	1.36MetGlu: 1.36 ± 0.021	0.738MetPhe: 0.738 ± 0.016	1.622MetGly: 1.622 ± 0.023	0.503MetHis: 0.503 ± 0.012	0.855MetIle: 0.855 ± 0.018	0.973MetLys: 0.973 ± 0.021	2.012MetLeu: 2.012 ± 0.03	0.641MetMet: 0.641 ± 0.016	0.679MetAsn: 0.679 ± 0.016	1.456MetPro: 1.456 ± 0.024	0.897MetGln: 0.897 ± 0.019	1.482MetArg: 1.482 ± 0.023	1.919MetSer: 1.919 ± 0.025	1.42MetThr: 1.42 ± 0.025	1.405MetVal: 1.405 ± 0.023	0.279MetTrp: 0.279 ± 0.009	0.494MetTyr: 0.494 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.931AsnAla: 2.931 ± 0.032	0.419AsnCys: 0.419 ± 0.01	1.809AsnAsp: 1.809 ± 0.021	1.721AsnGlu: 1.721 ± 0.026	1.156AsnPhe: 1.156 ± 0.019	2.657AsnGly: 2.657 ± 0.036	0.789AsnHis: 0.789 ± 0.015	1.554AsnIle: 1.554 ± 0.024	1.547AsnLys: 1.547 ± 0.025	2.89AsnLeu: 2.89 ± 0.039	0.849AsnMet: 0.849 ± 0.018	1.148AsnAsn: 1.148 ± 0.03	2.081AsnPro: 2.081 ± 0.027	1.147AsnGln: 1.147 ± 0.026	1.889AsnArg: 1.889 ± 0.029	2.228AsnSer: 2.228 ± 0.031	1.632AsnThr: 1.632 ± 0.021	2.176AsnVal: 2.176 ± 0.029	0.478AsnTrp: 0.478 ± 0.013	0.824AsnTyr: 0.824 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.924ProAla: 5.924 ± 0.067	0.676ProCys: 0.676 ± 0.017	3.582ProAsp: 3.582 ± 0.042	3.648ProGlu: 3.648 ± 0.04	1.998ProPhe: 1.998 ± 0.028	4.604ProGly: 4.604 ± 0.057	1.368ProHis: 1.368 ± 0.027	1.986ProIle: 1.986 ± 0.024	2.54ProLys: 2.54 ± 0.031	4.888ProLeu: 4.888 ± 0.049	1.201ProMet: 1.201 ± 0.02	1.859ProAsn: 1.859 ± 0.03	5.414ProPro: 5.414 ± 0.084	2.41ProGln: 2.41 ± 0.033	4.212ProArg: 4.212 ± 0.052	5.828ProSer: 5.828 ± 0.058	3.549ProThr: 3.549 ± 0.041	3.688ProVal: 3.688 ± 0.046	0.797ProTrp: 0.797 ± 0.016	1.313ProTyr: 1.313 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.908GlnAla: 3.908 ± 0.055	0.451GlnCys: 0.451 ± 0.012	2.342GlnAsp: 2.342 ± 0.031	2.292GlnGlu: 2.292 ± 0.034	1.153GlnPhe: 1.153 ± 0.018	2.859GlnGly: 2.859 ± 0.05	1.132GlnHis: 1.132 ± 0.026	1.535GlnIle: 1.535 ± 0.021	1.745GlnLys: 1.745 ± 0.029	3.562GlnLeu: 3.562 ± 0.041	0.937GlnMet: 0.937 ± 0.018	1.237GlnAsn: 1.237 ± 0.027	2.594GlnPro: 2.594 ± 0.043	2.651GlnGln: 2.651 ± 0.099	2.929GlnArg: 2.929 ± 0.04	2.963GlnSer: 2.963 ± 0.036	2.164GlnThr: 2.164 ± 0.036	2.369GlnVal: 2.369 ± 0.03	0.563GlnTrp: 0.563 ± 0.014	0.984GlnTyr: 0.984 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	5.864ArgAla: 5.864 ± 0.054	0.91ArgCys: 0.91 ± 0.02	4.048ArgAsp: 4.048 ± 0.051	3.969ArgGlu: 3.969 ± 0.04	2.359ArgPhe: 2.359 ± 0.034	4.643ArgGly: 4.643 ± 0.045	2.005ArgHis: 2.005 ± 0.029	2.72ArgIle: 2.72 ± 0.031	3.382ArgLys: 3.382 ± 0.041	6.459ArgLeu: 6.459 ± 0.048	1.441ArgMet: 1.441 ± 0.02	2.234ArgAsn: 2.234 ± 0.028	4.276ArgPro: 4.276 ± 0.054	3.091ArgGln: 3.091 ± 0.032	6.273ArgArg: 6.273 ± 0.071	4.906ArgSer: 4.906 ± 0.046	3.247ArgThr: 3.247 ± 0.034	3.829ArgVal: 3.829 ± 0.041	1.011ArgTrp: 1.011 ± 0.019	1.644ArgTyr: 1.644 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.936SerAla: 6.936 ± 0.056	0.953SerCys: 0.953 ± 0.02	4.18SerAsp: 4.18 ± 0.045	3.711SerGlu: 3.711 ± 0.041	2.826SerPhe: 2.826 ± 0.033	5.596SerGly: 5.596 ± 0.055	1.952SerHis: 1.952 ± 0.025	3.265SerIle: 3.265 ± 0.032	3.515SerLys: 3.515 ± 0.045	7.184SerLeu: 7.184 ± 0.058	1.778SerMet: 1.778 ± 0.026	2.463SerAsn: 2.463 ± 0.033	5.6SerPro: 5.6 ± 0.068	3.078SerGln: 3.078 ± 0.037	5.51SerArg: 5.51 ± 0.054	7.884SerSer: 7.884 ± 0.099	4.78SerThr: 4.78 ± 0.05	4.499SerVal: 4.499 ± 0.043	1.082SerTrp: 1.082 ± 0.019	1.72SerTyr: 1.72 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.261ThrAla: 5.261 ± 0.051	0.759ThrCys: 0.759 ± 0.016	2.671ThrAsp: 2.671 ± 0.031	2.691ThrGlu: 2.691 ± 0.03	1.931ThrPhe: 1.931 ± 0.026	3.954ThrGly: 3.954 ± 0.039	1.204ThrHis: 1.204 ± 0.026	2.452ThrIle: 2.452 ± 0.056	2.374ThrLys: 2.374 ± 0.031	4.941ThrLeu: 4.941 ± 0.051	1.287ThrMet: 1.287 ± 0.026	1.653ThrAsn: 1.653 ± 0.022	3.953ThrPro: 3.953 ± 0.051	1.919ThrGln: 1.919 ± 0.046	3.444ThrArg: 3.444 ± 0.043	4.546ThrSer: 4.546 ± 0.046	3.538ThrThr: 3.538 ± 0.057	3.535ThrVal: 3.535 ± 0.042	0.803ThrTrp: 0.803 ± 0.017	1.33ThrTyr: 1.33 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	6.082ValAla: 6.082 ± 0.049	0.896ValCys: 0.896 ± 0.019	4.139ValAsp: 4.139 ± 0.037	3.987ValGlu: 3.987 ± 0.038	2.498ValPhe: 2.498 ± 0.032	4.332ValGly: 4.332 ± 0.049	1.485ValHis: 1.485 ± 0.023	2.531ValIle: 2.531 ± 0.031	2.939ValLys: 2.939 ± 0.033	5.831ValLeu: 5.831 ± 0.053	1.445ValMet: 1.445 ± 0.02	2.047ValAsn: 2.047 ± 0.025	3.707ValPro: 3.707 ± 0.039	2.397ValGln: 2.397 ± 0.03	3.918ValArg: 3.918 ± 0.04	4.703ValSer: 4.703 ± 0.044	3.396ValThr: 3.396 ± 0.035	4.775ValVal: 4.775 ± 0.05	0.857ValTrp: 0.857 ± 0.018	1.634ValTyr: 1.634 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.223TrpAla: 1.223 ± 0.026	0.202TrpCys: 0.202 ± 0.008	0.931TrpAsp: 0.931 ± 0.019	0.815TrpGlu: 0.815 ± 0.018	0.49TrpPhe: 0.49 ± 0.013	0.883TrpGly: 0.883 ± 0.018	0.381TrpHis: 0.381 ± 0.011	0.646TrpIle: 0.646 ± 0.015	0.692TrpLys: 0.692 ± 0.017	1.358TrpLeu: 1.358 ± 0.026	0.352TrpMet: 0.352 ± 0.01	0.566TrpAsn: 0.566 ± 0.014	0.663TrpPro: 0.663 ± 0.016	0.573TrpGln: 0.573 ± 0.014	1.042TrpArg: 1.042 ± 0.02	1.032TrpSer: 1.032 ± 0.02	0.899TrpThr: 0.899 ± 0.017	0.814TrpVal: 0.814 ± 0.017	0.276TrpTrp: 0.276 ± 0.01	0.376TrpTyr: 0.376 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.026TyrAla: 2.026 ± 0.034	0.407TyrCys: 0.407 ± 0.013	1.578TyrAsp: 1.578 ± 0.022	1.336TyrGlu: 1.336 ± 0.021	1.026TyrPhe: 1.026 ± 0.018	1.849TyrGly: 1.849 ± 0.026	0.687TyrHis: 0.687 ± 0.016	1.062TyrIle: 1.062 ± 0.021	1.015TyrLys: 1.015 ± 0.023	2.353TyrLeu: 2.353 ± 0.034	0.623TyrMet: 0.623 ± 0.014	0.843TyrAsn: 0.843 ± 0.019	1.25TyrPro: 1.25 ± 0.021	0.925TyrGln: 0.925 ± 0.02	1.581TyrArg: 1.581 ± 0.023	1.756TyrSer: 1.756 ± 0.025	1.302TyrThr: 1.302 ± 0.022	1.555TyrVal: 1.555 ± 0.023	0.387TyrTrp: 0.387 ± 0.011	0.752TyrTyr: 0.752 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6968 proteins (3101960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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