Amino acid dipepetide frequency for Secundilactobacillus mixtipabuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.551AlaAla: 7.551 ± 0.139	0.384AlaCys: 0.384 ± 0.025	5.439AlaAsp: 5.439 ± 0.096	4.452AlaGlu: 4.452 ± 0.099	3.367AlaPhe: 3.367 ± 0.086	6.296AlaGly: 6.296 ± 0.099	1.745AlaHis: 1.745 ± 0.058	5.954AlaIle: 5.954 ± 0.117	5.684AlaLys: 5.684 ± 0.086	7.57AlaLeu: 7.57 ± 0.142	2.272AlaMet: 2.272 ± 0.064	3.903AlaAsn: 3.903 ± 0.078	2.544AlaPro: 2.544 ± 0.071	3.7AlaGln: 3.7 ± 0.075	2.88AlaArg: 2.88 ± 0.069	4.7AlaSer: 4.7 ± 0.094	5.583AlaThr: 5.583 ± 0.121	6.192AlaVal: 6.192 ± 0.112	0.663AlaTrp: 0.663 ± 0.029	2.745AlaTyr: 2.745 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.332CysAla: 0.332 ± 0.024	0.041CysCys: 0.041 ± 0.007	0.251CysAsp: 0.251 ± 0.019	0.211CysGlu: 0.211 ± 0.016	0.198CysPhe: 0.198 ± 0.016	0.48CysGly: 0.48 ± 0.031	0.159CysHis: 0.159 ± 0.015	0.228CysIle: 0.228 ± 0.019	0.14CysLys: 0.14 ± 0.014	0.513CysLeu: 0.513 ± 0.03	0.117CysMet: 0.117 ± 0.012	0.139CysAsn: 0.139 ± 0.012	0.223CysPro: 0.223 ± 0.021	0.197CysGln: 0.197 ± 0.018	0.167CysArg: 0.167 ± 0.016	0.26CysSer: 0.26 ± 0.02	0.24CysThr: 0.24 ± 0.017	0.31CysVal: 0.31 ± 0.022	0.042CysTrp: 0.042 ± 0.008	0.191CysTyr: 0.191 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.684AspAla: 4.684 ± 0.097	0.25AspCys: 0.25 ± 0.02	3.855AspAsp: 3.855 ± 0.103	3.91AspGlu: 3.91 ± 0.098	2.47AspPhe: 2.47 ± 0.07	4.206AspGly: 4.206 ± 0.295	1.627AspHis: 1.627 ± 0.052	3.498AspIle: 3.498 ± 0.069	3.313AspLys: 3.313 ± 0.088	5.417AspLeu: 5.417 ± 0.087	1.465AspMet: 1.465 ± 0.043	2.613AspAsn: 2.613 ± 0.079	2.614AspPro: 2.614 ± 0.066	3.467AspGln: 3.467 ± 0.074	2.405AspArg: 2.405 ± 0.064	3.172AspSer: 3.172 ± 0.073	3.244AspThr: 3.244 ± 0.102	3.932AspVal: 3.932 ± 0.088	0.742AspTrp: 0.742 ± 0.036	2.51AspTyr: 2.51 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.467GluAla: 4.467 ± 0.094	0.174GluCys: 0.174 ± 0.017	2.789GluAsp: 2.789 ± 0.075	2.77GluGlu: 2.77 ± 0.083	1.84GluPhe: 1.84 ± 0.058	2.713GluGly: 2.713 ± 0.063	1.217GluHis: 1.217 ± 0.041	3.467GluIle: 3.467 ± 0.081	3.593GluLys: 3.593 ± 0.093	5.312GluLeu: 5.312 ± 0.123	1.711GluMet: 1.711 ± 0.061	2.746GluAsn: 2.746 ± 0.062	1.903GluPro: 1.903 ± 0.054	2.672GluGln: 2.672 ± 0.074	2.457GluArg: 2.457 ± 0.071	2.635GluSer: 2.635 ± 0.069	3.429GluThr: 3.429 ± 0.078	3.529GluVal: 3.529 ± 0.073	0.541GluTrp: 0.541 ± 0.032	1.448GluTyr: 1.448 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.11PheAla: 3.11 ± 0.075	0.264PheCys: 0.264 ± 0.022	2.899PheAsp: 2.899 ± 0.073	2.173PheGlu: 2.173 ± 0.061	1.753PhePhe: 1.753 ± 0.064	3.202PheGly: 3.202 ± 0.079	0.812PheHis: 0.812 ± 0.032	2.648PheIle: 2.648 ± 0.077	2.582PheLys: 2.582 ± 0.064	3.549PheLeu: 3.549 ± 0.095	1.034PheMet: 1.034 ± 0.044	2.125PheAsn: 2.125 ± 0.057	1.439PhePro: 1.439 ± 0.05	1.377PheGln: 1.377 ± 0.049	1.356PheArg: 1.356 ± 0.052	2.804PheSer: 2.804 ± 0.069	2.517PheThr: 2.517 ± 0.083	2.919PheVal: 2.919 ± 0.076	0.542PheTrp: 0.542 ± 0.03	1.544PheTyr: 1.544 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	5.132GlyAla: 5.132 ± 0.094	0.367GlyCys: 0.367 ± 0.025	3.903GlyAsp: 3.903 ± 0.113	3.557GlyGlu: 3.557 ± 0.1	3.095GlyPhe: 3.095 ± 0.073	4.606GlyGly: 4.606 ± 0.106	1.717GlyHis: 1.717 ± 0.057	5.403GlyIle: 5.403 ± 0.108	4.32GlyLys: 4.32 ± 0.115	6.716GlyLeu: 6.716 ± 0.112	1.96GlyMet: 1.96 ± 0.059	3.01GlyAsn: 3.01 ± 0.098	1.687GlyPro: 1.687 ± 0.052	3.128GlyGln: 3.128 ± 0.089	2.62GlyArg: 2.62 ± 0.061	4.183GlySer: 4.183 ± 0.12	4.82GlyThr: 4.82 ± 0.182	5.142GlyVal: 5.142 ± 0.087	0.804GlyTrp: 0.804 ± 0.038	2.819GlyTyr: 2.819 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	1.544HisAla: 1.544 ± 0.05	0.11HisCys: 0.11 ± 0.013	1.443HisAsp: 1.443 ± 0.044	1.242HisGlu: 1.242 ± 0.048	1.16HisPhe: 1.16 ± 0.04	1.601HisGly: 1.601 ± 0.056	0.802HisHis: 0.802 ± 0.039	1.294HisIle: 1.294 ± 0.046	0.927HisLys: 0.927 ± 0.036	2.373HisLeu: 2.373 ± 0.05	0.525HisMet: 0.525 ± 0.027	0.896HisAsn: 0.896 ± 0.034	1.107HisPro: 1.107 ± 0.039	1.329HisGln: 1.329 ± 0.054	1.075HisArg: 1.075 ± 0.039	1.19HisSer: 1.19 ± 0.038	1.18HisThr: 1.18 ± 0.046	1.594HisVal: 1.594 ± 0.043	0.309HisTrp: 0.309 ± 0.018	1.103HisTyr: 1.103 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.889IleAla: 5.889 ± 0.123	0.402IleCys: 0.402 ± 0.023	4.279IleAsp: 4.279 ± 0.075	3.453IleGlu: 3.453 ± 0.079	2.655IlePhe: 2.655 ± 0.07	5.215IleGly: 5.215 ± 0.095	1.323IleHis: 1.323 ± 0.046	4.523IleIle: 4.523 ± 0.104	4.028IleLys: 4.028 ± 0.074	5.897IleLeu: 5.897 ± 0.127	1.67IleMet: 1.67 ± 0.053	3.339IleAsn: 3.339 ± 0.08	2.787IlePro: 2.787 ± 0.065	2.512IleGln: 2.512 ± 0.06	2.536IleArg: 2.536 ± 0.066	4.457IleSer: 4.457 ± 0.086	4.442IleThr: 4.442 ± 0.098	4.918IleVal: 4.918 ± 0.098	0.589IleTrp: 0.589 ± 0.029	2.01IleTyr: 2.01 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.208LysAla: 5.208 ± 0.097	0.167LysCys: 0.167 ± 0.017	3.214LysAsp: 3.214 ± 0.147	3.148LysGlu: 3.148 ± 0.074	1.805LysPhe: 1.805 ± 0.05	3.366LysGly: 3.366 ± 0.074	1.276LysHis: 1.276 ± 0.045	3.768LysIle: 3.768 ± 0.082	4.101LysLys: 4.101 ± 0.083	5.702LysLeu: 5.702 ± 0.097	2.075LysMet: 2.075 ± 0.057	2.963LysAsn: 2.963 ± 0.063	2.583LysPro: 2.583 ± 0.07	3.724LysGln: 3.724 ± 0.087	3.2LysArg: 3.2 ± 0.073	3.27LysSer: 3.27 ± 0.081	4.271LysThr: 4.271 ± 0.086	4.321LysVal: 4.321 ± 0.082	0.607LysTrp: 0.607 ± 0.03	2.013LysTyr: 2.013 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	8.725LeuAla: 8.725 ± 0.152	0.461LeuCys: 0.461 ± 0.026	5.115LeuAsp: 5.115 ± 0.099	4.009LeuGlu: 4.009 ± 0.09	3.99LeuPhe: 3.99 ± 0.097	6.626LeuGly: 6.626 ± 0.106	1.84LeuHis: 1.84 ± 0.056	6.826LeuIle: 6.826 ± 0.133	6.409LeuLys: 6.409 ± 0.114	8.836LeuLeu: 8.836 ± 0.175	2.73LeuMet: 2.73 ± 0.072	4.772LeuAsn: 4.772 ± 0.088	4.247LeuPro: 4.247 ± 0.09	3.553LeuGln: 3.553 ± 0.086	3.541LeuArg: 3.541 ± 0.078	6.754LeuSer: 6.754 ± 0.105	7.104LeuThr: 7.104 ± 0.102	6.663LeuVal: 6.663 ± 0.126	0.797LeuTrp: 0.797 ± 0.035	2.633LeuTyr: 2.633 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.689MetAla: 2.689 ± 0.071	0.11MetCys: 0.11 ± 0.013	1.332MetAsp: 1.332 ± 0.047	0.915MetGlu: 0.915 ± 0.038	0.934MetPhe: 0.934 ± 0.041	1.801MetGly: 1.801 ± 0.059	0.451MetHis: 0.451 ± 0.026	1.978MetIle: 1.978 ± 0.064	1.908MetLys: 1.908 ± 0.046	2.321MetLeu: 2.321 ± 0.068	0.863MetMet: 0.863 ± 0.038	1.413MetAsn: 1.413 ± 0.042	1.163MetPro: 1.163 ± 0.043	1.115MetGln: 1.115 ± 0.04	1.055MetArg: 1.055 ± 0.039	1.701MetSer: 1.701 ± 0.05	2.298MetThr: 2.298 ± 0.061	1.887MetVal: 1.887 ± 0.056	0.205MetTrp: 0.205 ± 0.018	0.67MetTyr: 0.67 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.742AsnAla: 3.742 ± 0.083	0.23AsnCys: 0.23 ± 0.02	2.762AsnAsp: 2.762 ± 0.076	2.517AsnGlu: 2.517 ± 0.067	1.8AsnPhe: 1.8 ± 0.055	3.943AsnGly: 3.943 ± 0.148	1.297AsnHis: 1.297 ± 0.048	2.627AsnIle: 2.627 ± 0.071	2.381AsnLys: 2.381 ± 0.06	4.131AsnLeu: 4.131 ± 0.067	1.134AsnMet: 1.134 ± 0.041	2.418AsnAsn: 2.418 ± 0.07	2.2AsnPro: 2.2 ± 0.07	3.075AsnGln: 3.075 ± 0.069	2.234AsnArg: 2.234 ± 0.061	2.61AsnSer: 2.61 ± 0.078	2.541AsnThr: 2.541 ± 0.081	3.346AsnVal: 3.346 ± 0.072	0.594AsnTrp: 0.594 ± 0.031	1.731AsnTyr: 1.731 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	3.387ProAla: 3.387 ± 0.076	0.103ProCys: 0.103 ± 0.011	2.786ProAsp: 2.786 ± 0.105	2.883ProGlu: 2.883 ± 0.075	1.644ProPhe: 1.644 ± 0.046	2.519ProGly: 2.519 ± 0.085	0.774ProHis: 0.774 ± 0.035	2.56ProIle: 2.56 ± 0.063	2.45ProLys: 2.45 ± 0.065	3.254ProLeu: 3.254 ± 0.067	0.934ProMet: 0.934 ± 0.036	1.92ProAsn: 1.92 ± 0.065	0.631ProPro: 0.631 ± 0.03	1.707ProGln: 1.707 ± 0.054	1.193ProArg: 1.193 ± 0.038	2.27ProSer: 2.27 ± 0.054	2.767ProThr: 2.767 ± 0.09	3.228ProVal: 3.228 ± 0.074	0.343ProTrp: 0.343 ± 0.024	1.246ProTyr: 1.246 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	4.28GlnAla: 4.28 ± 0.086	0.149GlnCys: 0.149 ± 0.015	1.998GlnAsp: 1.998 ± 0.059	2.019GlnGlu: 2.019 ± 0.06	2.01GlnPhe: 2.01 ± 0.058	2.373GlnGly: 2.373 ± 0.057	1.121GlnHis: 1.121 ± 0.039	3.246GlnIle: 3.246 ± 0.071	2.897GlnLys: 2.897 ± 0.065	5.755GlnLeu: 5.755 ± 0.109	1.235GlnMet: 1.235 ± 0.043	2.215GlnAsn: 2.215 ± 0.05	2.086GlnPro: 2.086 ± 0.082	3.01GlnGln: 3.01 ± 0.099	2.294GlnArg: 2.294 ± 0.074	2.867GlnSer: 2.867 ± 0.071	3.186GlnThr: 3.186 ± 0.082	3.561GlnVal: 3.561 ± 0.075	0.452GlnTrp: 0.452 ± 0.027	1.608GlnTyr: 1.608 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.79ArgAla: 2.79 ± 0.065	0.146ArgCys: 0.146 ± 0.014	2.162ArgAsp: 2.162 ± 0.067	2.315ArgGlu: 2.315 ± 0.064	1.887ArgPhe: 1.887 ± 0.055	2.324ArgGly: 2.324 ± 0.06	1.12ArgHis: 1.12 ± 0.043	2.793ArgIle: 2.793 ± 0.072	2.304ArgLys: 2.304 ± 0.063	4.411ArgLeu: 4.411 ± 0.096	1.122ArgMet: 1.122 ± 0.046	1.729ArgAsn: 1.729 ± 0.053	1.485ArgPro: 1.485 ± 0.048	2.523ArgGln: 2.523 ± 0.075	2.078ArgArg: 2.078 ± 0.062	2.017ArgSer: 2.017 ± 0.055	2.131ArgThr: 2.131 ± 0.057	2.881ArgVal: 2.881 ± 0.082	0.413ArgTrp: 0.413 ± 0.024	1.746ArgTyr: 1.746 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.889SerAla: 4.889 ± 0.088	0.236SerCys: 0.236 ± 0.019	3.654SerAsp: 3.654 ± 0.068	3.178SerGlu: 3.178 ± 0.069	2.621SerPhe: 2.621 ± 0.077	4.639SerGly: 4.639 ± 0.089	1.448SerHis: 1.448 ± 0.047	3.664SerIle: 3.664 ± 0.085	3.574SerLys: 3.574 ± 0.071	5.887SerLeu: 5.887 ± 0.096	1.513SerMet: 1.513 ± 0.042	2.7SerAsn: 2.7 ± 0.07	1.913SerPro: 1.913 ± 0.06	2.898SerGln: 2.898 ± 0.073	2.429SerArg: 2.429 ± 0.064	3.738SerSer: 3.738 ± 0.083	3.755SerThr: 3.755 ± 0.106	4.304SerVal: 4.304 ± 0.088	0.608SerTrp: 0.608 ± 0.032	2.191SerTyr: 2.191 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.616ThrAla: 5.616 ± 0.112	0.256ThrCys: 0.256 ± 0.023	4.431ThrAsp: 4.431 ± 0.138	3.074ThrGlu: 3.074 ± 0.077	2.56ThrPhe: 2.56 ± 0.064	5.024ThrGly: 5.024 ± 0.12	1.395ThrHis: 1.395 ± 0.041	4.727ThrIle: 4.727 ± 0.129	3.599ThrLys: 3.599 ± 0.079	6.041ThrLeu: 6.041 ± 0.093	1.519ThrMet: 1.519 ± 0.049	3.096ThrAsn: 3.096 ± 0.101	3.255ThrPro: 3.255 ± 0.143	2.78ThrGln: 2.78 ± 0.076	2.03ThrArg: 2.03 ± 0.059	3.966ThrSer: 3.966 ± 0.097	4.852ThrThr: 4.852 ± 0.211	5.508ThrVal: 5.508 ± 0.15	0.635ThrTrp: 0.635 ± 0.037	2.252ThrTyr: 2.252 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	6.416ValAla: 6.416 ± 0.098	0.378ValCys: 0.378 ± 0.026	4.448ValAsp: 4.448 ± 0.088	3.492ValGlu: 3.492 ± 0.075	2.687ValPhe: 2.687 ± 0.067	5.017ValGly: 5.017 ± 0.081	1.336ValHis: 1.336 ± 0.043	5.262ValIle: 5.262 ± 0.09	4.585ValLys: 4.585 ± 0.082	6.737ValLeu: 6.737 ± 0.117	1.933ValMet: 1.933 ± 0.056	3.416ValAsn: 3.416 ± 0.072	3.017ValPro: 3.017 ± 0.078	2.692ValGln: 2.692 ± 0.065	2.586ValArg: 2.586 ± 0.061	4.73ValSer: 4.73 ± 0.077	5.598ValThr: 5.598 ± 0.141	5.559ValVal: 5.559 ± 0.097	0.659ValTrp: 0.659 ± 0.029	2.255ValTyr: 2.255 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.652TrpAla: 0.652 ± 0.027	0.051TrpCys: 0.051 ± 0.007	0.479TrpAsp: 0.479 ± 0.031	0.382TrpGlu: 0.382 ± 0.022	0.51TrpPhe: 0.51 ± 0.026	0.652TrpGly: 0.652 ± 0.03	0.343TrpHis: 0.343 ± 0.024	0.628TrpIle: 0.628 ± 0.037	0.379TrpLys: 0.379 ± 0.026	1.492TrpLeu: 1.492 ± 0.054	0.26TrpMet: 0.26 ± 0.023	0.445TrpAsn: 0.445 ± 0.026	0.315TrpPro: 0.315 ± 0.019	0.708TrpGln: 0.708 ± 0.036	0.479TrpArg: 0.479 ± 0.025	0.583TrpSer: 0.583 ± 0.026	0.532TrpThr: 0.532 ± 0.029	0.693TrpVal: 0.693 ± 0.035	0.163TrpTrp: 0.163 ± 0.016	0.374TrpTyr: 0.374 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.522TyrAla: 2.522 ± 0.057	0.163TyrCys: 0.163 ± 0.016	2.155TyrAsp: 2.155 ± 0.062	1.715TyrGlu: 1.715 ± 0.055	1.663TyrPhe: 1.663 ± 0.053	2.388TyrGly: 2.388 ± 0.057	1.003TyrHis: 1.003 ± 0.04	1.832TyrIle: 1.832 ± 0.046	1.608TyrLys: 1.608 ± 0.058	3.716TyrLeu: 3.716 ± 0.078	0.736TyrMet: 0.736 ± 0.031	1.453TyrAsn: 1.453 ± 0.044	1.396TyrPro: 1.396 ± 0.05	2.197TyrGln: 2.197 ± 0.06	1.763TyrArg: 1.763 ± 0.057	1.93TyrSer: 1.93 ± 0.061	2.123TyrThr: 2.123 ± 0.098	2.315TyrVal: 2.315 ± 0.059	0.412TyrTrp: 0.412 ± 0.021	1.43TyrTyr: 1.43 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2292 proteins (711849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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