Amino acid dipepetide frequency for Prevotella sp. CAG:279

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.264AlaAla: 8.264 ± 0.14	1.069AlaCys: 1.069 ± 0.04	6.062AlaAsp: 6.062 ± 0.103	5.412AlaGlu: 5.412 ± 0.11	3.723AlaPhe: 3.723 ± 0.082	5.844AlaGly: 5.844 ± 0.104	1.277AlaHis: 1.277 ± 0.046	5.246AlaIle: 5.246 ± 0.085	4.671AlaLys: 4.671 ± 0.095	7.544AlaLeu: 7.544 ± 0.122	2.45AlaMet: 2.45 ± 0.066	3.424AlaAsn: 3.424 ± 0.066	2.598AlaPro: 2.598 ± 0.068	2.703AlaGln: 2.703 ± 0.078	3.608AlaArg: 3.608 ± 0.075	4.96AlaSer: 4.96 ± 0.089	4.84AlaThr: 4.84 ± 0.092	6.713AlaVal: 6.713 ± 0.11	0.792AlaTrp: 0.792 ± 0.031	2.958AlaTyr: 2.958 ± 0.073	0.003AlaXaa: 0.003 ± 0.002
Cys	0.983CysAla: 0.983 ± 0.039	0.245CysCys: 0.245 ± 0.022	0.84CysAsp: 0.84 ± 0.037	0.706CysGlu: 0.706 ± 0.033	0.517CysPhe: 0.517 ± 0.029	1.229CysGly: 1.229 ± 0.046	0.35CysHis: 0.35 ± 0.023	0.788CysIle: 0.788 ± 0.033	0.572CysLys: 0.572 ± 0.033	1.094CysLeu: 1.094 ± 0.038	0.282CysMet: 0.282 ± 0.019	0.612CysAsn: 0.612 ± 0.03	0.581CysPro: 0.581 ± 0.033	0.405CysGln: 0.405 ± 0.027	0.87CysArg: 0.87 ± 0.037	0.85CysSer: 0.85 ± 0.04	0.625CysThr: 0.625 ± 0.029	0.953CysVal: 0.953 ± 0.038	0.147CysTrp: 0.147 ± 0.015	0.581CysTyr: 0.581 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	5.112AspAla: 5.112 ± 0.105	0.852AspCys: 0.852 ± 0.041	3.481AspAsp: 3.481 ± 0.079	3.791AspGlu: 3.791 ± 0.086	3.166AspPhe: 3.166 ± 0.073	5.068AspGly: 5.068 ± 0.094	0.866AspHis: 0.866 ± 0.034	4.346AspIle: 4.346 ± 0.087	4.11AspLys: 4.11 ± 0.068	4.493AspLeu: 4.493 ± 0.084	1.656AspMet: 1.656 ± 0.051	3.468AspAsn: 3.468 ± 0.071	1.813AspPro: 1.813 ± 0.048	1.132AspGln: 1.132 ± 0.043	2.838AspArg: 2.838 ± 0.069	3.67AspSer: 3.67 ± 0.08	2.835AspThr: 2.835 ± 0.061	4.4AspVal: 4.4 ± 0.088	0.756AspTrp: 0.756 ± 0.034	2.968AspTyr: 2.968 ± 0.075	0.0AspXaa: 0.0 ± 0.0
Glu	5.043GluAla: 5.043 ± 0.103	0.703GluCys: 0.703 ± 0.034	2.719GluAsp: 2.719 ± 0.068	4.039GluGlu: 4.039 ± 0.101	2.44GluPhe: 2.44 ± 0.063	3.875GluGly: 3.875 ± 0.073	1.234GluHis: 1.234 ± 0.04	4.372GluIle: 4.372 ± 0.088	4.473GluLys: 4.473 ± 0.093	5.11GluLeu: 5.11 ± 0.079	2.054GluMet: 2.054 ± 0.055	3.102GluAsn: 3.102 ± 0.071	1.771GluPro: 1.771 ± 0.055	2.271GluGln: 2.271 ± 0.061	3.266GluArg: 3.266 ± 0.088	3.296GluSer: 3.296 ± 0.067	3.272GluThr: 3.272 ± 0.07	3.842GluVal: 3.842 ± 0.074	0.753GluTrp: 0.753 ± 0.031	2.5GluTyr: 2.5 ± 0.062	0.001GluXaa: 0.001 ± 0.001
Phe	3.584PheAla: 3.584 ± 0.075	0.701PheCys: 0.701 ± 0.032	3.072PheAsp: 3.072 ± 0.062	2.438PheGlu: 2.438 ± 0.063	2.119PhePhe: 2.119 ± 0.062	3.457PheGly: 3.457 ± 0.075	0.809PheHis: 0.809 ± 0.033	2.587PheIle: 2.587 ± 0.068	2.378PheLys: 2.378 ± 0.059	3.536PheLeu: 3.536 ± 0.077	1.118PheMet: 1.118 ± 0.042	2.343PheAsn: 2.343 ± 0.064	1.645PhePro: 1.645 ± 0.052	1.081PheGln: 1.081 ± 0.038	2.084PheArg: 2.084 ± 0.052	3.414PheSer: 3.414 ± 0.087	2.547PheThr: 2.547 ± 0.061	3.431PheVal: 3.431 ± 0.071	0.496PheTrp: 0.496 ± 0.03	1.74PheTyr: 1.74 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.147GlyAla: 5.147 ± 0.123	1.195GlyCys: 1.195 ± 0.045	4.024GlyAsp: 4.024 ± 0.076	4.169GlyGlu: 4.169 ± 0.086	3.209GlyPhe: 3.209 ± 0.067	5.18GlyGly: 5.18 ± 0.109	1.289GlyHis: 1.289 ± 0.042	5.154GlyIle: 5.154 ± 0.099	5.251GlyLys: 5.251 ± 0.091	5.677GlyLeu: 5.677 ± 0.095	2.106GlyMet: 2.106 ± 0.057	3.685GlyAsn: 3.685 ± 0.085	1.194GlyPro: 1.194 ± 0.043	1.922GlyGln: 1.922 ± 0.046	3.166GlyArg: 3.166 ± 0.064	4.283GlySer: 4.283 ± 0.089	4.125GlyThr: 4.125 ± 0.084	5.522GlyVal: 5.522 ± 0.097	0.88GlyTrp: 0.88 ± 0.04	3.227GlyTyr: 3.227 ± 0.069	0.001GlyXaa: 0.001 ± 0.001
His	1.19HisAla: 1.19 ± 0.043	0.324HisCys: 0.324 ± 0.023	1.045HisAsp: 1.045 ± 0.042	0.878HisGlu: 0.878 ± 0.038	0.974HisPhe: 0.974 ± 0.042	1.235HisGly: 1.235 ± 0.048	0.498HisHis: 0.498 ± 0.033	1.386HisIle: 1.386 ± 0.046	1.043HisLys: 1.043 ± 0.044	1.62HisLeu: 1.62 ± 0.047	0.364HisMet: 0.364 ± 0.02	0.974HisAsn: 0.974 ± 0.041	0.928HisPro: 0.928 ± 0.041	0.534HisGln: 0.534 ± 0.029	1.042HisArg: 1.042 ± 0.039	1.224HisSer: 1.224 ± 0.043	1.043HisThr: 1.043 ± 0.037	0.971HisVal: 0.971 ± 0.038	0.226HisTrp: 0.226 ± 0.019	0.733HisTyr: 0.733 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.01IleAla: 6.01 ± 0.103	0.915IleCys: 0.915 ± 0.036	4.671IleAsp: 4.671 ± 0.089	4.119IleGlu: 4.119 ± 0.084	2.666IlePhe: 2.666 ± 0.071	4.668IleGly: 4.668 ± 0.098	1.133IleHis: 1.133 ± 0.048	3.919IleIle: 3.919 ± 0.099	3.667IleLys: 3.667 ± 0.079	4.907IleLeu: 4.907 ± 0.097	1.351IleMet: 1.351 ± 0.044	3.175IleAsn: 3.175 ± 0.071	2.779IlePro: 2.779 ± 0.061	1.528IleGln: 1.528 ± 0.052	2.901IleArg: 2.901 ± 0.065	4.272IleSer: 4.272 ± 0.085	3.592IleThr: 3.592 ± 0.075	5.136IleVal: 5.136 ± 0.092	0.565IleTrp: 0.565 ± 0.03	2.38IleTyr: 2.38 ± 0.059	0.001IleXaa: 0.001 ± 0.002
Lys	5.015LysAla: 5.015 ± 0.1	0.584LysCys: 0.584 ± 0.033	3.454LysAsp: 3.454 ± 0.079	4.406LysGlu: 4.406 ± 0.106	2.57LysPhe: 2.57 ± 0.061	3.967LysGly: 3.967 ± 0.077	1.156LysHis: 1.156 ± 0.044	4.091LysIle: 4.091 ± 0.085	4.62LysLys: 4.62 ± 0.101	4.696LysLeu: 4.696 ± 0.079	2.177LysMet: 2.177 ± 0.052	3.041LysAsn: 3.041 ± 0.071	2.161LysPro: 2.161 ± 0.048	2.122LysGln: 2.122 ± 0.055	3.071LysArg: 3.071 ± 0.079	3.681LysSer: 3.681 ± 0.085	3.541LysThr: 3.541 ± 0.07	4.181LysVal: 4.181 ± 0.085	0.685LysTrp: 0.685 ± 0.03	2.569LysTyr: 2.569 ± 0.066	0.001LysXaa: 0.001 ± 0.002
Leu	7.069LeuAla: 7.069 ± 0.12	1.222LeuCys: 1.222 ± 0.048	4.895LeuAsp: 4.895 ± 0.078	4.339LeuGlu: 4.339 ± 0.086	3.651LeuPhe: 3.651 ± 0.073	5.563LeuGly: 5.563 ± 0.105	1.664LeuHis: 1.664 ± 0.053	4.735LeuIle: 4.735 ± 0.08	5.402LeuLys: 5.402 ± 0.084	8.01LeuLeu: 8.01 ± 0.139	2.415LeuMet: 2.415 ± 0.071	4.064LeuAsn: 4.064 ± 0.082	3.878LeuPro: 3.878 ± 0.078	2.705LeuGln: 2.705 ± 0.068	4.731LeuArg: 4.731 ± 0.078	6.574LeuSer: 6.574 ± 0.109	5.383LeuThr: 5.383 ± 0.086	5.404LeuVal: 5.404 ± 0.107	0.952LeuTrp: 0.952 ± 0.043	2.925LeuTyr: 2.925 ± 0.072	0.003LeuXaa: 0.003 ± 0.002
Met	2.61MetAla: 2.61 ± 0.067	0.312MetCys: 0.312 ± 0.022	1.36MetAsp: 1.36 ± 0.043	1.672MetGlu: 1.672 ± 0.051	1.084MetPhe: 1.084 ± 0.04	1.697MetGly: 1.697 ± 0.05	0.489MetHis: 0.489 ± 0.023	1.554MetIle: 1.554 ± 0.048	2.12MetLys: 2.12 ± 0.053	2.931MetLeu: 2.931 ± 0.074	0.871MetMet: 0.871 ± 0.041	1.298MetAsn: 1.298 ± 0.039	1.344MetPro: 1.344 ± 0.042	0.987MetGln: 0.987 ± 0.034	1.695MetArg: 1.695 ± 0.052	1.703MetSer: 1.703 ± 0.056	1.654MetThr: 1.654 ± 0.05	1.747MetVal: 1.747 ± 0.05	0.248MetTrp: 0.248 ± 0.017	0.672MetTyr: 0.672 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	4.241AsnAla: 4.241 ± 0.081	0.63AsnCys: 0.63 ± 0.036	2.725AsnAsp: 2.725 ± 0.072	2.608AsnGlu: 2.608 ± 0.069	2.102AsnPhe: 2.102 ± 0.06	3.856AsnGly: 3.856 ± 0.079	0.894AsnHis: 0.894 ± 0.041	3.283AsnIle: 3.283 ± 0.064	2.687AsnLys: 2.687 ± 0.059	3.98AsnLeu: 3.98 ± 0.08	1.236AsnMet: 1.236 ± 0.041	2.371AsnAsn: 2.371 ± 0.069	2.469AsnPro: 2.469 ± 0.067	1.31AsnGln: 1.31 ± 0.039	2.391AsnArg: 2.391 ± 0.063	2.732AsnSer: 2.732 ± 0.065	2.429AsnThr: 2.429 ± 0.068	3.753AsnVal: 3.753 ± 0.087	0.537AsnTrp: 0.537 ± 0.027	2.113AsnTyr: 2.113 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	3.117ProAla: 3.117 ± 0.073	0.382ProCys: 0.382 ± 0.023	2.657ProAsp: 2.657 ± 0.064	3.063ProGlu: 3.063 ± 0.068	1.637ProPhe: 1.637 ± 0.044	2.36ProGly: 2.36 ± 0.062	0.68ProHis: 0.68 ± 0.031	2.078ProIle: 2.078 ± 0.056	1.85ProLys: 1.85 ± 0.048	3.034ProLeu: 3.034 ± 0.064	1.001ProMet: 1.001 ± 0.034	1.579ProAsn: 1.579 ± 0.052	0.751ProPro: 0.751 ± 0.035	1.27ProGln: 1.27 ± 0.042	1.403ProArg: 1.403 ± 0.046	2.384ProSer: 2.384 ± 0.059	2.146ProThr: 2.146 ± 0.056	2.941ProVal: 2.941 ± 0.067	0.416ProTrp: 0.416 ± 0.027	1.566ProTyr: 1.566 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.263GlnAla: 2.263 ± 0.071	0.345GlnCys: 0.345 ± 0.024	1.184GlnAsp: 1.184 ± 0.044	1.719GlnGlu: 1.719 ± 0.058	1.339GlnPhe: 1.339 ± 0.045	1.733GlnGly: 1.733 ± 0.051	0.534GlnHis: 0.534 ± 0.021	2.086GlnIle: 2.086 ± 0.049	2.156GlnLys: 2.156 ± 0.061	3.025GlnLeu: 3.025 ± 0.07	1.08GlnMet: 1.08 ± 0.043	1.391GlnAsn: 1.391 ± 0.04	1.18GlnPro: 1.18 ± 0.048	1.422GlnGln: 1.422 ± 0.068	1.819GlnArg: 1.819 ± 0.06	1.813GlnSer: 1.813 ± 0.053	1.809GlnThr: 1.809 ± 0.051	1.86GlnVal: 1.86 ± 0.061	0.405GlnTrp: 0.405 ± 0.026	1.173GlnTyr: 1.173 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.133ArgAla: 3.133 ± 0.07	0.634ArgCys: 0.634 ± 0.032	2.528ArgAsp: 2.528 ± 0.06	2.894ArgGlu: 2.894 ± 0.07	2.378ArgPhe: 2.378 ± 0.062	2.842ArgGly: 2.842 ± 0.069	1.21ArgHis: 1.21 ± 0.045	3.677ArgIle: 3.677 ± 0.073	3.041ArgLys: 3.041 ± 0.069	4.95ArgLeu: 4.95 ± 0.087	1.63ArgMet: 1.63 ± 0.053	2.512ArgAsn: 2.512 ± 0.06	1.789ArgPro: 1.789 ± 0.047	2.198ArgGln: 2.198 ± 0.062	3.319ArgArg: 3.319 ± 0.086	2.618ArgSer: 2.618 ± 0.073	2.504ArgThr: 2.504 ± 0.062	2.99ArgVal: 2.99 ± 0.075	0.632ArgTrp: 0.632 ± 0.032	2.198ArgTyr: 2.198 ± 0.06	0.001ArgXaa: 0.001 ± 0.001
Ser	5.222SerAla: 5.222 ± 0.101	0.788SerCys: 0.788 ± 0.037	3.853SerAsp: 3.853 ± 0.081	3.438SerGlu: 3.438 ± 0.067	2.999SerPhe: 2.999 ± 0.07	4.838SerGly: 4.838 ± 0.088	1.242SerHis: 1.242 ± 0.045	4.066SerIle: 4.066 ± 0.075	3.338SerLys: 3.338 ± 0.073	5.904SerLeu: 5.904 ± 0.1	1.597SerMet: 1.597 ± 0.049	2.755SerAsn: 2.755 ± 0.068	2.316SerPro: 2.316 ± 0.059	1.957SerGln: 1.957 ± 0.06	3.151SerArg: 3.151 ± 0.062	3.847SerSer: 3.847 ± 0.09	3.567SerThr: 3.567 ± 0.074	4.967SerVal: 4.967 ± 0.098	0.684SerTrp: 0.684 ± 0.033	2.471SerTyr: 2.471 ± 0.066	0.003SerXaa: 0.003 ± 0.002
Thr	4.989ThrAla: 4.989 ± 0.103	0.547ThrCys: 0.547 ± 0.031	3.798ThrAsp: 3.798 ± 0.075	3.099ThrGlu: 3.099 ± 0.079	2.625ThrPhe: 2.625 ± 0.063	4.136ThrGly: 4.136 ± 0.084	0.891ThrHis: 0.891 ± 0.038	3.85ThrIle: 3.85 ± 0.084	2.846ThrLys: 2.846 ± 0.061	5.174ThrLeu: 5.174 ± 0.087	1.413ThrMet: 1.413 ± 0.043	2.232ThrAsn: 2.232 ± 0.067	2.653ThrPro: 2.653 ± 0.065	1.506ThrGln: 1.506 ± 0.049	2.177ThrArg: 2.177 ± 0.063	3.532ThrSer: 3.532 ± 0.074	3.431ThrThr: 3.431 ± 0.068	4.778ThrVal: 4.778 ± 0.103	0.544ThrTrp: 0.544 ± 0.025	2.28ThrTyr: 2.28 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	7.126ValAla: 7.126 ± 0.109	1.08ValCys: 1.08 ± 0.04	5.055ValAsp: 5.055 ± 0.098	4.645ValGlu: 4.645 ± 0.093	2.973ValPhe: 2.973 ± 0.066	5.112ValGly: 5.112 ± 0.103	1.0ValHis: 1.0 ± 0.036	4.139ValIle: 4.139 ± 0.088	4.532ValLys: 4.532 ± 0.095	5.607ValLeu: 5.607 ± 0.103	1.843ValMet: 1.843 ± 0.057	3.458ValAsn: 3.458 ± 0.066	2.625ValPro: 2.625 ± 0.068	1.666ValGln: 1.666 ± 0.05	3.436ValArg: 3.436 ± 0.064	4.741ValSer: 4.741 ± 0.089	4.159ValThr: 4.159 ± 0.088	6.262ValVal: 6.262 ± 0.12	0.742ValTrp: 0.742 ± 0.032	2.913ValTyr: 2.913 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.035	0.176TrpCys: 0.176 ± 0.018	0.627TrpAsp: 0.627 ± 0.033	0.586TrpGlu: 0.586 ± 0.03	0.524TrpPhe: 0.524 ± 0.031	0.806TrpGly: 0.806 ± 0.035	0.264TrpHis: 0.264 ± 0.02	0.689TrpIle: 0.689 ± 0.031	0.681TrpLys: 0.681 ± 0.035	1.115TrpLeu: 1.115 ± 0.035	0.381TrpMet: 0.381 ± 0.022	0.586TrpAsn: 0.586 ± 0.033	0.235TrpPro: 0.235 ± 0.02	0.493TrpGln: 0.493 ± 0.027	0.623TrpArg: 0.623 ± 0.029	0.633TrpSer: 0.633 ± 0.031	0.723TrpThr: 0.723 ± 0.035	0.594TrpVal: 0.594 ± 0.031	0.148TrpTrp: 0.148 ± 0.016	0.416TrpTyr: 0.416 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.295TyrAla: 3.295 ± 0.074	0.523TyrCys: 0.523 ± 0.029	2.769TyrAsp: 2.769 ± 0.058	2.115TyrGlu: 2.115 ± 0.055	1.882TyrPhe: 1.882 ± 0.06	2.938TyrGly: 2.938 ± 0.071	0.754TyrHis: 0.754 ± 0.036	2.308TyrIle: 2.308 ± 0.059	2.347TyrLys: 2.347 ± 0.066	3.178TyrLeu: 3.178 ± 0.07	1.022TyrMet: 1.022 ± 0.038	2.275TyrAsn: 2.275 ± 0.067	1.603TyrPro: 1.603 ± 0.043	1.124TyrGln: 1.124 ± 0.04	2.086TyrArg: 2.086 ± 0.06	2.774TyrSer: 2.774 ± 0.07	2.274TyrThr: 2.274 ± 0.061	2.67TyrVal: 2.67 ± 0.062	0.443TyrTrp: 0.443 ± 0.026	1.891TyrTyr: 1.891 ± 0.053	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.03XaaXaa: 0.03 ± 0.009

Statistics based on 2076 proteins (709329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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