Amino acid dipepetide frequency for Bacillus nealsonii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.638AlaAla: 5.638 ± 0.084	0.65AlaCys: 0.65 ± 0.024	3.178AlaAsp: 3.178 ± 0.053	4.533AlaGlu: 4.533 ± 0.068	3.244AlaPhe: 3.244 ± 0.057	4.859AlaGly: 4.859 ± 0.072	1.15AlaHis: 1.15 ± 0.034	6.162AlaIle: 6.162 ± 0.068	5.178AlaLys: 5.178 ± 0.073	6.805AlaLeu: 6.805 ± 0.081	1.875AlaMet: 1.875 ± 0.042	3.063AlaAsn: 3.063 ± 0.05	1.824AlaPro: 1.824 ± 0.044	2.023AlaGln: 2.023 ± 0.041	2.123AlaArg: 2.123 ± 0.044	4.185AlaSer: 4.185 ± 0.066	3.4AlaThr: 3.4 ± 0.052	5.102AlaVal: 5.102 ± 0.069	0.575AlaTrp: 0.575 ± 0.022	2.34AlaTyr: 2.34 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.445CysAla: 0.445 ± 0.019	0.108CysCys: 0.108 ± 0.01	0.351CysAsp: 0.351 ± 0.017	0.464CysGlu: 0.464 ± 0.019	0.372CysPhe: 0.372 ± 0.016	0.66CysGly: 0.66 ± 0.025	0.191CysHis: 0.191 ± 0.012	0.61CysIle: 0.61 ± 0.023	0.443CysLys: 0.443 ± 0.019	0.815CysLeu: 0.815 ± 0.029	0.224CysMet: 0.224 ± 0.013	0.326CysAsn: 0.326 ± 0.016	0.332CysPro: 0.332 ± 0.017	0.24CysGln: 0.24 ± 0.014	0.272CysArg: 0.272 ± 0.016	0.559CysSer: 0.559 ± 0.022	0.418CysThr: 0.418 ± 0.02	0.407CysVal: 0.407 ± 0.019	0.073CysTrp: 0.073 ± 0.008	0.298CysTyr: 0.298 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.116AspAla: 3.116 ± 0.052	0.377AspCys: 0.377 ± 0.018	2.044AspAsp: 2.044 ± 0.049	3.658AspGlu: 3.658 ± 0.063	2.45AspPhe: 2.45 ± 0.048	3.047AspGly: 3.047 ± 0.057	0.96AspHis: 0.96 ± 0.028	4.351AspIle: 4.351 ± 0.059	3.473AspLys: 3.473 ± 0.054	4.794AspLeu: 4.794 ± 0.065	1.262AspMet: 1.262 ± 0.029	1.999AspAsn: 1.999 ± 0.043	1.647AspPro: 1.647 ± 0.038	1.695AspGln: 1.695 ± 0.039	1.857AspArg: 1.857 ± 0.04	2.729AspSer: 2.729 ± 0.053	2.387AspThr: 2.387 ± 0.049	3.18AspVal: 3.18 ± 0.053	0.601AspTrp: 0.601 ± 0.025	2.27AspTyr: 2.27 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.908GluAla: 4.908 ± 0.064	0.391GluCys: 0.391 ± 0.018	3.567GluAsp: 3.567 ± 0.056	7.376GluGlu: 7.376 ± 0.099	2.583GluPhe: 2.583 ± 0.049	3.976GluGly: 3.976 ± 0.065	1.355GluHis: 1.355 ± 0.036	5.944GluIle: 5.944 ± 0.075	7.607GluLys: 7.607 ± 0.088	7.07GluLeu: 7.07 ± 0.087	2.248GluMet: 2.248 ± 0.041	4.1GluAsn: 4.1 ± 0.063	1.666GluPro: 1.666 ± 0.038	3.142GluGln: 3.142 ± 0.064	2.822GluArg: 2.822 ± 0.053	3.441GluSer: 3.441 ± 0.055	3.751GluThr: 3.751 ± 0.06	4.803GluVal: 4.803 ± 0.071	0.763GluTrp: 0.763 ± 0.023	2.438GluTyr: 2.438 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.133PheAla: 3.133 ± 0.06	0.429PheCys: 0.429 ± 0.018	2.272PheAsp: 2.272 ± 0.042	2.574PheGlu: 2.574 ± 0.045	2.633PhePhe: 2.633 ± 0.057	3.209PheGly: 3.209 ± 0.063	1.088PheHis: 1.088 ± 0.032	4.38PheIle: 4.38 ± 0.077	2.525PheLys: 2.525 ± 0.044	4.79PheLeu: 4.79 ± 0.089	1.155PheMet: 1.155 ± 0.031	1.931PheAsn: 1.931 ± 0.039	1.766PhePro: 1.766 ± 0.039	1.778PheGln: 1.778 ± 0.04	1.459PheArg: 1.459 ± 0.035	3.421PheSer: 3.421 ± 0.058	2.575PheThr: 2.575 ± 0.049	2.956PheVal: 2.956 ± 0.054	0.456PheTrp: 0.456 ± 0.022	1.92PheTyr: 1.92 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.487GlyAla: 4.487 ± 0.071	0.629GlyCys: 0.629 ± 0.024	2.887GlyAsp: 2.887 ± 0.056	4.359GlyGlu: 4.359 ± 0.071	3.417GlyPhe: 3.417 ± 0.058	4.478GlyGly: 4.478 ± 0.079	1.171GlyHis: 1.171 ± 0.035	6.433GlyIle: 6.433 ± 0.069	5.297GlyLys: 5.297 ± 0.072	6.246GlyLeu: 6.246 ± 0.086	2.0GlyMet: 2.0 ± 0.037	2.843GlyAsn: 2.843 ± 0.05	1.54GlyPro: 1.54 ± 0.036	1.91GlyGln: 1.91 ± 0.04	2.266GlyArg: 2.266 ± 0.043	3.874GlySer: 3.874 ± 0.067	3.775GlyThr: 3.775 ± 0.056	4.644GlyVal: 4.644 ± 0.063	0.748GlyTrp: 0.748 ± 0.028	2.718GlyTyr: 2.718 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.2HisAla: 1.2 ± 0.031	0.217HisCys: 0.217 ± 0.014	0.868HisAsp: 0.868 ± 0.027	1.162HisGlu: 1.162 ± 0.03	1.052HisPhe: 1.052 ± 0.028	1.221HisGly: 1.221 ± 0.037	0.651HisHis: 0.651 ± 0.026	1.637HisIle: 1.637 ± 0.038	1.095HisLys: 1.095 ± 0.032	2.049HisLeu: 2.049 ± 0.047	0.457HisMet: 0.457 ± 0.017	0.8HisAsn: 0.8 ± 0.023	1.013HisPro: 1.013 ± 0.027	0.824HisGln: 0.824 ± 0.029	0.72HisArg: 0.72 ± 0.026	1.215HisSer: 1.215 ± 0.031	1.057HisThr: 1.057 ± 0.033	1.261HisVal: 1.261 ± 0.029	0.202HisTrp: 0.202 ± 0.011	0.937HisTyr: 0.937 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.443IleAla: 6.443 ± 0.079	0.809IleCys: 0.809 ± 0.029	4.253IleAsp: 4.253 ± 0.056	5.836IleGlu: 5.836 ± 0.074	3.744IlePhe: 3.744 ± 0.066	6.397IleGly: 6.397 ± 0.076	1.749IleHis: 1.749 ± 0.035	7.419IleIle: 7.419 ± 0.09	5.946IleLys: 5.946 ± 0.063	7.901IleLeu: 7.901 ± 0.089	2.049IleMet: 2.049 ± 0.042	3.982IleAsn: 3.982 ± 0.061	3.486IlePro: 3.486 ± 0.053	3.15IleGln: 3.15 ± 0.05	2.975IleArg: 2.975 ± 0.059	5.803IleSer: 5.803 ± 0.088	4.883IleThr: 4.883 ± 0.067	5.79IleVal: 5.79 ± 0.072	0.706IleTrp: 0.706 ± 0.025	2.885IleTyr: 2.885 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.727LysAla: 4.727 ± 0.07	0.353LysCys: 0.353 ± 0.015	4.172LysAsp: 4.172 ± 0.066	8.415LysGlu: 8.415 ± 0.105	2.104LysPhe: 2.104 ± 0.039	4.899LysGly: 4.899 ± 0.071	1.329LysHis: 1.329 ± 0.033	5.809LysIle: 5.809 ± 0.079	7.71LysLys: 7.71 ± 0.088	6.403LysLeu: 6.403 ± 0.084	2.51LysMet: 2.51 ± 0.048	4.336LysAsn: 4.336 ± 0.066	2.111LysPro: 2.111 ± 0.039	3.483LysGln: 3.483 ± 0.062	3.251LysArg: 3.251 ± 0.052	3.961LysSer: 3.961 ± 0.056	4.094LysThr: 4.094 ± 0.067	4.86LysVal: 4.86 ± 0.069	0.886LysTrp: 0.886 ± 0.026	2.552LysTyr: 2.552 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	7.344LeuAla: 7.344 ± 0.087	0.693LeuCys: 0.693 ± 0.023	4.728LeuAsp: 4.728 ± 0.07	6.758LeuGlu: 6.758 ± 0.093	5.06LeuPhe: 5.06 ± 0.081	6.106LeuGly: 6.106 ± 0.08	1.896LeuHis: 1.896 ± 0.042	7.575LeuIle: 7.575 ± 0.083	7.19LeuLys: 7.19 ± 0.068	10.69LeuLeu: 10.69 ± 0.132	2.422LeuMet: 2.422 ± 0.046	4.495LeuAsn: 4.495 ± 0.062	3.762LeuPro: 3.762 ± 0.062	3.79LeuGln: 3.79 ± 0.059	3.094LeuArg: 3.094 ± 0.049	6.826LeuSer: 6.826 ± 0.081	5.579LeuThr: 5.579 ± 0.071	6.031LeuVal: 6.031 ± 0.07	0.777LeuTrp: 0.777 ± 0.028	3.273LeuTyr: 3.273 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.899MetAla: 1.899 ± 0.04	0.156MetCys: 0.156 ± 0.011	1.482MetAsp: 1.482 ± 0.031	2.19MetGlu: 2.19 ± 0.044	1.025MetPhe: 1.025 ± 0.033	1.711MetGly: 1.711 ± 0.04	0.469MetHis: 0.469 ± 0.019	2.27MetIle: 2.27 ± 0.046	2.469MetLys: 2.469 ± 0.044	2.566MetLeu: 2.566 ± 0.052	0.834MetMet: 0.834 ± 0.029	1.533MetAsn: 1.533 ± 0.035	1.028MetPro: 1.028 ± 0.031	1.01MetGln: 1.01 ± 0.032	0.911MetArg: 0.911 ± 0.028	1.559MetSer: 1.559 ± 0.037	1.447MetThr: 1.447 ± 0.031	1.688MetVal: 1.688 ± 0.036	0.172MetTrp: 0.172 ± 0.013	0.757MetTyr: 0.757 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.808AsnAla: 2.808 ± 0.049	0.342AsnCys: 0.342 ± 0.015	2.172AsnAsp: 2.172 ± 0.043	3.497AsnGlu: 3.497 ± 0.059	1.821AsnPhe: 1.821 ± 0.04	3.5AsnGly: 3.5 ± 0.061	1.072AsnHis: 1.072 ± 0.03	4.26AsnIle: 4.26 ± 0.061	3.925AsnLys: 3.925 ± 0.068	4.131AsnLeu: 4.131 ± 0.055	1.3AsnMet: 1.3 ± 0.033	2.498AsnAsn: 2.498 ± 0.05	2.153AsnPro: 2.153 ± 0.049	1.988AsnGln: 1.988 ± 0.038	2.024AsnArg: 2.024 ± 0.039	2.838AsnSer: 2.838 ± 0.058	2.427AsnThr: 2.427 ± 0.043	2.899AsnVal: 2.899 ± 0.049	0.597AsnTrp: 0.597 ± 0.02	1.801AsnTyr: 1.801 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.082ProAla: 2.082 ± 0.047	0.198ProCys: 0.198 ± 0.013	1.691ProAsp: 1.691 ± 0.042	2.463ProGlu: 2.463 ± 0.046	1.988ProPhe: 1.988 ± 0.039	1.89ProGly: 1.89 ± 0.04	0.777ProHis: 0.777 ± 0.024	3.017ProIle: 3.017 ± 0.052	2.26ProLys: 2.26 ± 0.044	3.446ProLeu: 3.446 ± 0.056	0.746ProMet: 0.746 ± 0.022	1.7ProAsn: 1.7 ± 0.036	0.857ProPro: 0.857 ± 0.029	0.955ProGln: 0.955 ± 0.028	0.896ProArg: 0.896 ± 0.031	2.196ProSer: 2.196 ± 0.049	1.912ProThr: 1.912 ± 0.039	2.482ProVal: 2.482 ± 0.043	0.353ProTrp: 0.353 ± 0.014	1.384ProTyr: 1.384 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.482GlnAla: 2.482 ± 0.047	0.21GlnCys: 0.21 ± 0.012	1.516GlnAsp: 1.516 ± 0.029	2.831GlnGlu: 2.831 ± 0.054	1.542GlnPhe: 1.542 ± 0.033	2.027GlnGly: 2.027 ± 0.045	0.732GlnHis: 0.732 ± 0.023	2.76GlnIle: 2.76 ± 0.041	3.373GlnLys: 3.373 ± 0.048	3.948GlnLeu: 3.948 ± 0.063	1.069GlnMet: 1.069 ± 0.029	1.845GlnAsn: 1.845 ± 0.041	1.017GlnPro: 1.017 ± 0.027	1.741GlnGln: 1.741 ± 0.046	1.251GlnArg: 1.251 ± 0.032	2.095GlnSer: 2.095 ± 0.044	2.174GlnThr: 2.174 ± 0.045	2.118GlnVal: 2.118 ± 0.042	0.372GlnTrp: 0.372 ± 0.017	1.416GlnTyr: 1.416 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.075ArgAla: 2.075 ± 0.042	0.242ArgCys: 0.242 ± 0.015	1.665ArgAsp: 1.665 ± 0.037	2.719ArgGlu: 2.719 ± 0.058	1.716ArgPhe: 1.716 ± 0.034	2.041ArgGly: 2.041 ± 0.047	0.629ArgHis: 0.629 ± 0.02	2.913ArgIle: 2.913 ± 0.048	3.107ArgLys: 3.107 ± 0.051	3.55ArgLeu: 3.55 ± 0.058	1.1ArgMet: 1.1 ± 0.028	1.8ArgAsn: 1.8 ± 0.037	1.067ArgPro: 1.067 ± 0.029	1.262ArgGln: 1.262 ± 0.033	1.437ArgArg: 1.437 ± 0.042	1.864ArgSer: 1.864 ± 0.043	1.859ArgThr: 1.859 ± 0.039	2.158ArgVal: 2.158 ± 0.046	0.343ArgTrp: 0.343 ± 0.015	1.385ArgTyr: 1.385 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.896SerAla: 3.896 ± 0.062	0.464SerCys: 0.464 ± 0.018	2.745SerAsp: 2.745 ± 0.045	3.696SerGlu: 3.696 ± 0.06	3.527SerPhe: 3.527 ± 0.056	4.174SerGly: 4.174 ± 0.054	1.128SerHis: 1.128 ± 0.028	6.214SerIle: 6.214 ± 0.077	4.292SerLys: 4.292 ± 0.065	6.445SerLeu: 6.445 ± 0.082	1.665SerMet: 1.665 ± 0.036	2.877SerAsn: 2.877 ± 0.055	2.054SerPro: 2.054 ± 0.043	1.964SerGln: 1.964 ± 0.04	1.941SerArg: 1.941 ± 0.037	4.586SerSer: 4.586 ± 0.077	3.329SerThr: 3.329 ± 0.06	4.013SerVal: 4.013 ± 0.063	0.636SerTrp: 0.636 ± 0.025	2.482SerTyr: 2.482 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.896ThrAla: 3.896 ± 0.053	0.357ThrCys: 0.357 ± 0.018	2.564ThrAsp: 2.564 ± 0.043	3.521ThrGlu: 3.521 ± 0.054	2.641ThrPhe: 2.641 ± 0.053	3.974ThrGly: 3.974 ± 0.056	0.91ThrHis: 0.91 ± 0.03	5.139ThrIle: 5.139 ± 0.063	3.94ThrLys: 3.94 ± 0.063	5.064ThrLeu: 5.064 ± 0.062	1.266ThrMet: 1.266 ± 0.031	2.691ThrAsn: 2.691 ± 0.051	2.046ThrPro: 2.046 ± 0.038	1.395ThrGln: 1.395 ± 0.039	1.674ThrArg: 1.674 ± 0.045	3.459ThrSer: 3.459 ± 0.058	2.968ThrThr: 2.968 ± 0.058	4.052ThrVal: 4.052 ± 0.058	0.501ThrTrp: 0.501 ± 0.023	1.886ThrTyr: 1.886 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.673ValAla: 4.673 ± 0.066	0.603ValCys: 0.603 ± 0.023	3.38ValAsp: 3.38 ± 0.056	4.695ValGlu: 4.695 ± 0.073	3.079ValPhe: 3.079 ± 0.055	4.404ValGly: 4.404 ± 0.068	1.28ValHis: 1.28 ± 0.035	5.526ValIle: 5.526 ± 0.078	4.795ValLys: 4.795 ± 0.065	6.588ValLeu: 6.588 ± 0.074	1.708ValMet: 1.708 ± 0.035	2.993ValAsn: 2.993 ± 0.048	2.327ValPro: 2.327 ± 0.046	2.205ValGln: 2.205 ± 0.049	2.162ValArg: 2.162 ± 0.043	4.461ValSer: 4.461 ± 0.065	3.493ValThr: 3.493 ± 0.054	4.562ValVal: 4.562 ± 0.07	0.573ValTrp: 0.573 ± 0.023	2.228ValTyr: 2.228 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.517TrpAla: 0.517 ± 0.02	0.062TrpCys: 0.062 ± 0.007	0.506TrpAsp: 0.506 ± 0.02	0.68TrpGlu: 0.68 ± 0.025	0.472TrpPhe: 0.472 ± 0.023	0.668TrpGly: 0.668 ± 0.023	0.231TrpHis: 0.231 ± 0.015	0.881TrpIle: 0.881 ± 0.029	0.838TrpLys: 0.838 ± 0.028	1.009TrpLeu: 1.009 ± 0.032	0.327TrpMet: 0.327 ± 0.019	0.613TrpAsn: 0.613 ± 0.022	0.201TrpPro: 0.201 ± 0.014	0.379TrpGln: 0.379 ± 0.02	0.355TrpArg: 0.355 ± 0.018	0.63TrpSer: 0.63 ± 0.024	0.485TrpThr: 0.485 ± 0.021	0.534TrpVal: 0.534 ± 0.024	0.123TrpTrp: 0.123 ± 0.01	0.356TrpTyr: 0.356 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.136TyrAla: 2.136 ± 0.042	0.322TyrCys: 0.322 ± 0.015	1.855TyrAsp: 1.855 ± 0.044	2.525TyrGlu: 2.525 ± 0.051	1.978TyrPhe: 1.978 ± 0.045	2.481TyrGly: 2.481 ± 0.053	0.867TyrHis: 0.867 ± 0.028	2.906TyrIle: 2.906 ± 0.051	2.502TyrLys: 2.502 ± 0.051	3.78TyrLeu: 3.78 ± 0.061	0.957TyrMet: 0.957 ± 0.031	1.629TyrAsn: 1.629 ± 0.036	1.398TyrPro: 1.398 ± 0.037	1.585TyrGln: 1.585 ± 0.035	1.444TyrArg: 1.444 ± 0.037	2.427TyrSer: 2.427 ± 0.047	1.933TyrThr: 1.933 ± 0.038	2.195TyrVal: 2.195 ± 0.046	0.408TyrTrp: 0.408 ± 0.02	1.585TyrTyr: 1.585 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4253 proteins (1240416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---