Amino acid dipepetide frequency for Desulfosporosinus sp. Sb-LF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.245AlaAla: 6.245 ± 0.098	0.894AlaCys: 0.894 ± 0.035	3.453AlaAsp: 3.453 ± 0.06	4.876AlaGlu: 4.876 ± 0.075	2.963AlaPhe: 2.963 ± 0.057	6.059AlaGly: 6.059 ± 0.086	1.468AlaHis: 1.468 ± 0.037	5.656AlaIle: 5.656 ± 0.078	4.771AlaLys: 4.771 ± 0.075	8.702AlaLeu: 8.702 ± 0.115	2.178AlaMet: 2.178 ± 0.046	2.908AlaAsn: 2.908 ± 0.059	2.378AlaPro: 2.378 ± 0.049	3.17AlaGln: 3.17 ± 0.064	3.555AlaArg: 3.555 ± 0.06	4.297AlaSer: 4.297 ± 0.071	4.048AlaThr: 4.048 ± 0.079	5.744AlaVal: 5.744 ± 0.077	0.769AlaTrp: 0.769 ± 0.028	2.252AlaTyr: 2.252 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.728CysAla: 0.728 ± 0.028	0.211CysCys: 0.211 ± 0.016	0.505CysAsp: 0.505 ± 0.023	0.577CysGlu: 0.577 ± 0.024	0.424CysPhe: 0.424 ± 0.017	1.106CysGly: 1.106 ± 0.033	0.345CysHis: 0.345 ± 0.024	0.675CysIle: 0.675 ± 0.026	0.542CysLys: 0.542 ± 0.023	1.071CysLeu: 1.071 ± 0.028	0.262CysMet: 0.262 ± 0.017	0.4CysAsn: 0.4 ± 0.023	0.629CysPro: 0.629 ± 0.027	0.446CysGln: 0.446 ± 0.021	0.541CysArg: 0.541 ± 0.022	0.753CysSer: 0.753 ± 0.027	0.578CysThr: 0.578 ± 0.02	0.684CysVal: 0.684 ± 0.03	0.114CysTrp: 0.114 ± 0.011	0.35CysTyr: 0.35 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.364AspAla: 3.364 ± 0.05	0.55AspCys: 0.55 ± 0.023	2.047AspAsp: 2.047 ± 0.046	3.373AspGlu: 3.373 ± 0.059	2.303AspPhe: 2.303 ± 0.043	3.286AspGly: 3.286 ± 0.06	0.959AspHis: 0.959 ± 0.026	3.882AspIle: 3.882 ± 0.066	2.868AspLys: 2.868 ± 0.06	5.504AspLeu: 5.504 ± 0.071	1.257AspMet: 1.257 ± 0.036	1.732AspAsn: 1.732 ± 0.036	2.205AspPro: 2.205 ± 0.053	1.832AspGln: 1.832 ± 0.043	2.421AspArg: 2.421 ± 0.046	2.623AspSer: 2.623 ± 0.045	2.354AspThr: 2.354 ± 0.044	3.568AspVal: 3.568 ± 0.058	0.606AspTrp: 0.606 ± 0.022	1.918AspTyr: 1.918 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.011GluAla: 5.011 ± 0.074	0.61GluCys: 0.61 ± 0.022	3.181GluAsp: 3.181 ± 0.057	5.328GluGlu: 5.328 ± 0.076	2.503GluPhe: 2.503 ± 0.05	4.38GluGly: 4.38 ± 0.068	1.305GluHis: 1.305 ± 0.036	5.329GluIle: 5.329 ± 0.073	4.721GluLys: 4.721 ± 0.068	6.9GluLeu: 6.9 ± 0.089	1.985GluMet: 1.985 ± 0.036	2.845GluAsn: 2.845 ± 0.05	1.864GluPro: 1.864 ± 0.037	2.81GluGln: 2.81 ± 0.052	3.765GluArg: 3.765 ± 0.075	3.315GluSer: 3.315 ± 0.05	3.36GluThr: 3.36 ± 0.057	4.998GluVal: 4.998 ± 0.067	0.694GluTrp: 0.694 ± 0.025	1.874GluTyr: 1.874 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.056PheAla: 3.056 ± 0.054	0.514PheCys: 0.514 ± 0.021	2.045PheAsp: 2.045 ± 0.046	2.338PheGlu: 2.338 ± 0.05	1.781PhePhe: 1.781 ± 0.047	3.227PheGly: 3.227 ± 0.052	0.775PheHis: 0.775 ± 0.027	2.887PheIle: 2.887 ± 0.055	2.082PheLys: 2.082 ± 0.042	4.294PheLeu: 4.294 ± 0.077	1.024PheMet: 1.024 ± 0.034	1.682PheAsn: 1.682 ± 0.041	1.659PhePro: 1.659 ± 0.04	1.347PheGln: 1.347 ± 0.034	1.766PheArg: 1.766 ± 0.039	2.987PheSer: 2.987 ± 0.053	2.196PheThr: 2.196 ± 0.049	2.854PheVal: 2.854 ± 0.054	0.5PheTrp: 0.5 ± 0.023	1.364PheTyr: 1.364 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.366GlyAla: 5.366 ± 0.075	1.069GlyCys: 1.069 ± 0.031	3.27GlyAsp: 3.27 ± 0.053	4.519GlyGlu: 4.519 ± 0.067	3.375GlyPhe: 3.375 ± 0.063	5.641GlyGly: 5.641 ± 0.103	1.428GlyHis: 1.428 ± 0.038	6.379GlyIle: 6.379 ± 0.089	5.048GlyLys: 5.048 ± 0.065	7.89GlyLeu: 7.89 ± 0.092	2.333GlyMet: 2.333 ± 0.055	2.882GlyAsn: 2.882 ± 0.054	2.01GlyPro: 2.01 ± 0.052	2.775GlyGln: 2.775 ± 0.056	3.328GlyArg: 3.328 ± 0.057	4.35GlySer: 4.35 ± 0.085	4.481GlyThr: 4.481 ± 0.086	5.929GlyVal: 5.929 ± 0.087	0.873GlyTrp: 0.873 ± 0.033	2.751GlyTyr: 2.751 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.276HisAla: 1.276 ± 0.037	0.282HisCys: 0.282 ± 0.017	0.904HisAsp: 0.904 ± 0.029	1.174HisGlu: 1.174 ± 0.032	0.896HisPhe: 0.896 ± 0.03	1.414HisGly: 1.414 ± 0.033	0.511HisHis: 0.511 ± 0.023	1.268HisIle: 1.268 ± 0.036	0.963HisLys: 0.963 ± 0.03	2.05HisLeu: 2.05 ± 0.046	0.485HisMet: 0.485 ± 0.02	0.714HisAsn: 0.714 ± 0.026	1.118HisPro: 1.118 ± 0.029	0.739HisGln: 0.739 ± 0.026	0.959HisArg: 0.959 ± 0.028	1.203HisSer: 1.203 ± 0.033	1.006HisThr: 1.006 ± 0.029	1.272HisVal: 1.272 ± 0.038	0.272HisTrp: 0.272 ± 0.015	0.705HisTyr: 0.705 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.098IleAla: 6.098 ± 0.081	0.767IleCys: 0.767 ± 0.025	3.657IleAsp: 3.657 ± 0.063	4.82IleGlu: 4.82 ± 0.069	2.786IlePhe: 2.786 ± 0.055	5.631IleGly: 5.631 ± 0.081	1.398IleHis: 1.398 ± 0.03	5.23IleIle: 5.23 ± 0.086	4.032IleLys: 4.032 ± 0.062	7.658IleLeu: 7.658 ± 0.107	1.816IleMet: 1.816 ± 0.043	3.113IleAsn: 3.113 ± 0.054	3.48IlePro: 3.48 ± 0.059	2.658IleGln: 2.658 ± 0.049	3.467IleArg: 3.467 ± 0.061	4.99IleSer: 4.99 ± 0.077	4.112IleThr: 4.112 ± 0.062	5.216IleVal: 5.216 ± 0.07	0.67IleTrp: 0.67 ± 0.028	2.136IleTyr: 2.136 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.743LysAla: 4.743 ± 0.078	0.473LysCys: 0.473 ± 0.023	3.262LysAsp: 3.262 ± 0.052	4.69LysGlu: 4.69 ± 0.067	1.907LysPhe: 1.907 ± 0.036	4.169LysGly: 4.169 ± 0.053	1.055LysHis: 1.055 ± 0.031	4.331LysIle: 4.331 ± 0.065	3.763LysLys: 3.763 ± 0.067	5.512LysLeu: 5.512 ± 0.073	1.759LysMet: 1.759 ± 0.041	2.629LysAsn: 2.629 ± 0.052	2.244LysPro: 2.244 ± 0.046	2.196LysGln: 2.196 ± 0.045	2.883LysArg: 2.883 ± 0.053	3.33LysSer: 3.33 ± 0.053	3.524LysThr: 3.524 ± 0.051	4.712LysVal: 4.712 ± 0.069	0.545LysTrp: 0.545 ± 0.021	1.77LysTyr: 1.77 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.893LeuAla: 8.893 ± 0.1	1.036LeuCys: 1.036 ± 0.034	5.311LeuAsp: 5.311 ± 0.074	7.059LeuGlu: 7.059 ± 0.109	4.043LeuPhe: 4.043 ± 0.078	8.131LeuGly: 8.131 ± 0.09	1.852LeuHis: 1.852 ± 0.045	7.053LeuIle: 7.053 ± 0.098	6.485LeuLys: 6.485 ± 0.075	10.239LeuLeu: 10.239 ± 0.12	2.684LeuMet: 2.684 ± 0.055	4.446LeuAsn: 4.446 ± 0.065	4.31LeuPro: 4.31 ± 0.07	3.546LeuGln: 3.546 ± 0.06	5.003LeuArg: 5.003 ± 0.075	6.99LeuSer: 6.99 ± 0.074	6.131LeuThr: 6.131 ± 0.066	7.215LeuVal: 7.215 ± 0.086	1.067LeuTrp: 1.067 ± 0.033	2.643LeuTyr: 2.643 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.36MetAla: 2.36 ± 0.049	0.221MetCys: 0.221 ± 0.015	1.514MetAsp: 1.514 ± 0.041	1.764MetGlu: 1.764 ± 0.042	0.931MetPhe: 0.931 ± 0.031	2.215MetGly: 2.215 ± 0.043	0.451MetHis: 0.451 ± 0.021	1.877MetIle: 1.877 ± 0.037	1.717MetLys: 1.717 ± 0.04	2.487MetLeu: 2.487 ± 0.045	0.759MetMet: 0.759 ± 0.033	1.291MetAsn: 1.291 ± 0.036	1.076MetPro: 1.076 ± 0.034	0.895MetGln: 0.895 ± 0.028	1.295MetArg: 1.295 ± 0.033	1.736MetSer: 1.736 ± 0.041	1.547MetThr: 1.547 ± 0.035	1.988MetVal: 1.988 ± 0.044	0.163MetTrp: 0.163 ± 0.012	0.596MetTyr: 0.596 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.909AsnAla: 2.909 ± 0.05	0.487AsnCys: 0.487 ± 0.024	1.861AsnAsp: 1.861 ± 0.041	2.394AsnGlu: 2.394 ± 0.049	1.623AsnPhe: 1.623 ± 0.037	2.917AsnGly: 2.917 ± 0.058	0.847AsnHis: 0.847 ± 0.029	2.949AsnIle: 2.949 ± 0.05	2.33AsnLys: 2.33 ± 0.047	4.366AsnLeu: 4.366 ± 0.069	1.041AsnMet: 1.041 ± 0.033	1.751AsnAsn: 1.751 ± 0.049	2.294AsnPro: 2.294 ± 0.044	1.641AsnGln: 1.641 ± 0.04	1.908AsnArg: 1.908 ± 0.042	2.559AsnSer: 2.559 ± 0.047	2.131AsnThr: 2.131 ± 0.042	2.982AsnVal: 2.982 ± 0.057	0.453AsnTrp: 0.453 ± 0.022	1.512AsnTyr: 1.512 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.566ProAla: 2.566 ± 0.055	0.39ProCys: 0.39 ± 0.022	2.091ProAsp: 2.091 ± 0.049	3.21ProGlu: 3.21 ± 0.06	1.735ProPhe: 1.735 ± 0.043	2.929ProGly: 2.929 ± 0.057	0.755ProHis: 0.755 ± 0.028	2.876ProIle: 2.876 ± 0.048	2.143ProLys: 2.143 ± 0.048	4.026ProLeu: 4.026 ± 0.063	0.941ProMet: 0.941 ± 0.028	1.703ProAsn: 1.703 ± 0.034	1.269ProPro: 1.269 ± 0.038	1.536ProGln: 1.536 ± 0.043	1.568ProArg: 1.568 ± 0.046	2.439ProSer: 2.439 ± 0.043	2.321ProThr: 2.321 ± 0.054	3.074ProVal: 3.074 ± 0.05	0.518ProTrp: 0.518 ± 0.024	1.237ProTyr: 1.237 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.26GlnAla: 3.26 ± 0.055	0.343GlnCys: 0.343 ± 0.018	1.794GlnAsp: 1.794 ± 0.038	2.81GlnGlu: 2.81 ± 0.054	1.351GlnPhe: 1.351 ± 0.039	3.0GlnGly: 3.0 ± 0.072	0.68GlnHis: 0.68 ± 0.024	2.791GlnIle: 2.791 ± 0.048	2.404GlnLys: 2.404 ± 0.051	3.609GlnLeu: 3.609 ± 0.058	1.06GlnMet: 1.06 ± 0.028	1.514GlnAsn: 1.514 ± 0.037	1.242GlnPro: 1.242 ± 0.038	1.569GlnGln: 1.569 ± 0.053	1.944GlnArg: 1.944 ± 0.045	2.155GlnSer: 2.155 ± 0.051	2.159GlnThr: 2.159 ± 0.043	2.801GlnVal: 2.801 ± 0.053	0.432GlnTrp: 0.432 ± 0.018	1.042GlnTyr: 1.042 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.182ArgAla: 3.182 ± 0.057	0.526ArgCys: 0.526 ± 0.023	2.259ArgAsp: 2.259 ± 0.046	3.637ArgGlu: 3.637 ± 0.06	2.036ArgPhe: 2.036 ± 0.046	3.029ArgGly: 3.029 ± 0.054	0.944ArgHis: 0.944 ± 0.029	3.614ArgIle: 3.614 ± 0.067	2.998ArgLys: 2.998 ± 0.057	5.161ArgLeu: 5.161 ± 0.078	1.36ArgMet: 1.36 ± 0.033	1.889ArgAsn: 1.889 ± 0.044	1.686ArgPro: 1.686 ± 0.048	2.033ArgGln: 2.033 ± 0.045	2.482ArgArg: 2.482 ± 0.051	2.545ArgSer: 2.545 ± 0.049	2.307ArgThr: 2.307 ± 0.041	3.491ArgVal: 3.491 ± 0.055	0.554ArgTrp: 0.554 ± 0.021	1.632ArgTyr: 1.632 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.272SerAla: 4.272 ± 0.072	0.681SerCys: 0.681 ± 0.026	2.807SerAsp: 2.807 ± 0.049	3.678SerGlu: 3.678 ± 0.071	2.629SerPhe: 2.629 ± 0.051	5.134SerGly: 5.134 ± 0.074	1.136SerHis: 1.136 ± 0.031	4.544SerIle: 4.544 ± 0.077	3.455SerLys: 3.455 ± 0.054	6.584SerLeu: 6.584 ± 0.078	1.68SerMet: 1.68 ± 0.036	2.421SerAsn: 2.421 ± 0.049	2.526SerPro: 2.526 ± 0.05	2.373SerGln: 2.373 ± 0.052	2.818SerArg: 2.818 ± 0.052	4.311SerSer: 4.311 ± 0.075	3.342SerThr: 3.342 ± 0.062	4.441SerVal: 4.441 ± 0.062	0.718SerTrp: 0.718 ± 0.029	1.904SerTyr: 1.904 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.151ThrAla: 4.151 ± 0.086	0.561ThrCys: 0.561 ± 0.022	2.634ThrAsp: 2.634 ± 0.053	3.199ThrGlu: 3.199 ± 0.063	2.273ThrPhe: 2.273 ± 0.045	4.716ThrGly: 4.716 ± 0.069	1.111ThrHis: 1.111 ± 0.029	4.115ThrIle: 4.115 ± 0.075	2.928ThrLys: 2.928 ± 0.05	5.975ThrLeu: 5.975 ± 0.075	1.402ThrMet: 1.402 ± 0.035	2.13ThrAsn: 2.13 ± 0.047	2.644ThrPro: 2.644 ± 0.051	2.011ThrGln: 2.011 ± 0.042	2.17ThrArg: 2.17 ± 0.04	3.399ThrSer: 3.399 ± 0.066	3.331ThrThr: 3.331 ± 0.082	4.226ThrVal: 4.226 ± 0.073	0.598ThrTrp: 0.598 ± 0.027	1.671ThrTyr: 1.671 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.826ValAla: 5.826 ± 0.084	0.818ValCys: 0.818 ± 0.027	3.882ValAsp: 3.882 ± 0.058	4.799ValGlu: 4.799 ± 0.081	2.932ValPhe: 2.932 ± 0.053	5.391ValGly: 5.391 ± 0.076	1.318ValHis: 1.318 ± 0.038	5.621ValIle: 5.621 ± 0.075	4.023ValLys: 4.023 ± 0.064	7.686ValLeu: 7.686 ± 0.09	1.903ValMet: 1.903 ± 0.04	3.123ValAsn: 3.123 ± 0.053	2.875ValPro: 2.875 ± 0.051	2.616ValGln: 2.616 ± 0.049	3.337ValArg: 3.337 ± 0.054	4.873ValSer: 4.873 ± 0.068	4.163ValThr: 4.163 ± 0.075	5.703ValVal: 5.703 ± 0.082	0.732ValTrp: 0.732 ± 0.029	2.096ValTyr: 2.096 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.793TrpAla: 0.793 ± 0.029	0.098TrpCys: 0.098 ± 0.009	0.562TrpAsp: 0.562 ± 0.023	0.683TrpGlu: 0.683 ± 0.028	0.413TrpPhe: 0.413 ± 0.022	0.874TrpGly: 0.874 ± 0.036	0.198TrpHis: 0.198 ± 0.013	0.717TrpIle: 0.717 ± 0.03	0.629TrpLys: 0.629 ± 0.024	1.14TrpLeu: 1.14 ± 0.037	0.3TrpMet: 0.3 ± 0.016	0.516TrpAsn: 0.516 ± 0.021	0.38TrpPro: 0.38 ± 0.019	0.535TrpGln: 0.535 ± 0.023	0.548TrpArg: 0.548 ± 0.022	0.63TrpSer: 0.63 ± 0.026	0.518TrpThr: 0.518 ± 0.023	0.801TrpVal: 0.801 ± 0.03	0.134TrpTrp: 0.134 ± 0.01	0.296TrpTyr: 0.296 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.043	0.413TyrCys: 0.413 ± 0.021	1.614TyrAsp: 1.614 ± 0.039	1.852TyrGlu: 1.852 ± 0.039	1.476TyrPhe: 1.476 ± 0.048	2.447TyrGly: 2.447 ± 0.051	0.676TyrHis: 0.676 ± 0.022	1.942TyrIle: 1.942 ± 0.045	1.591TyrLys: 1.591 ± 0.038	3.281TyrLeu: 3.281 ± 0.058	0.65TyrMet: 0.65 ± 0.024	1.265TyrAsn: 1.265 ± 0.034	1.439TyrPro: 1.439 ± 0.039	1.231TyrGln: 1.231 ± 0.039	1.609TyrArg: 1.609 ± 0.041	1.969TyrSer: 1.969 ± 0.042	1.634TyrThr: 1.634 ± 0.043	2.022TyrVal: 2.022 ± 0.042	0.351TyrTrp: 0.351 ± 0.018	1.174TyrTyr: 1.174 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3743 proteins (1146958 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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