Amino acid dipepetide frequency for Sphingobacterium sp. IITKGP-BTPF85

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.797AlaAla: 4.797 ± 0.076	0.603AlaCys: 0.603 ± 0.021	3.642AlaAsp: 3.642 ± 0.056	3.742AlaGlu: 3.742 ± 0.055	3.163AlaPhe: 3.163 ± 0.049	4.56AlaGly: 4.56 ± 0.057	1.271AlaHis: 1.271 ± 0.031	5.647AlaIle: 5.647 ± 0.069	4.568AlaLys: 4.568 ± 0.062	6.581AlaLeu: 6.581 ± 0.073	1.611AlaMet: 1.611 ± 0.036	3.487AlaAsn: 3.487 ± 0.048	1.935AlaPro: 1.935 ± 0.038	2.732AlaGln: 2.732 ± 0.046	2.178AlaArg: 2.178 ± 0.041	4.485AlaSer: 4.485 ± 0.061	3.893AlaThr: 3.893 ± 0.058	4.562AlaVal: 4.562 ± 0.063	0.711AlaTrp: 0.711 ± 0.018	2.816AlaTyr: 2.816 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.02	0.143CysCys: 0.143 ± 0.011	0.364CysAsp: 0.364 ± 0.017	0.354CysGlu: 0.354 ± 0.017	0.41CysPhe: 0.41 ± 0.018	0.551CysGly: 0.551 ± 0.021	0.209CysHis: 0.209 ± 0.013	0.633CysIle: 0.633 ± 0.021	0.448CysLys: 0.448 ± 0.016	0.763CysLeu: 0.763 ± 0.025	0.204CysMet: 0.204 ± 0.011	0.361CysAsn: 0.361 ± 0.016	0.28CysPro: 0.28 ± 0.018	0.29CysGln: 0.29 ± 0.017	0.306CysArg: 0.306 ± 0.014	0.521CysSer: 0.521 ± 0.018	0.446CysThr: 0.446 ± 0.02	0.408CysVal: 0.408 ± 0.015	0.082CysTrp: 0.082 ± 0.008	0.341CysTyr: 0.341 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.558AspAla: 3.558 ± 0.057	0.361AspCys: 0.361 ± 0.016	2.524AspAsp: 2.524 ± 0.048	3.395AspGlu: 3.395 ± 0.057	3.236AspPhe: 3.236 ± 0.046	3.563AspGly: 3.563 ± 0.05	1.215AspHis: 1.215 ± 0.03	4.198AspIle: 4.198 ± 0.062	4.012AspLys: 4.012 ± 0.048	5.475AspLeu: 5.475 ± 0.064	1.206AspMet: 1.206 ± 0.032	2.789AspAsn: 2.789 ± 0.044	1.972AspPro: 1.972 ± 0.039	2.286AspGln: 2.286 ± 0.038	2.318AspArg: 2.318 ± 0.043	2.918AspSer: 2.918 ± 0.049	2.34AspThr: 2.34 ± 0.038	3.291AspVal: 3.291 ± 0.052	0.846AspTrp: 0.846 ± 0.025	2.658AspTyr: 2.658 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	3.913GluAla: 3.913 ± 0.056	0.314GluCys: 0.314 ± 0.016	3.024GluAsp: 3.024 ± 0.048	4.175GluGlu: 4.175 ± 0.06	2.439GluPhe: 2.439 ± 0.039	3.3GluGly: 3.3 ± 0.042	1.179GluHis: 1.179 ± 0.03	4.926GluIle: 4.926 ± 0.057	5.116GluLys: 5.116 ± 0.066	5.896GluLeu: 5.896 ± 0.076	1.479GluMet: 1.479 ± 0.033	3.971GluAsn: 3.971 ± 0.055	1.507GluPro: 1.507 ± 0.03	2.714GluGln: 2.714 ± 0.046	2.549GluArg: 2.549 ± 0.047	3.314GluSer: 3.314 ± 0.049	2.969GluThr: 2.969 ± 0.048	3.905GluVal: 3.905 ± 0.056	0.655GluTrp: 0.655 ± 0.02	2.115GluTyr: 2.115 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.121PheAla: 3.121 ± 0.046	0.433PheCys: 0.433 ± 0.018	3.031PheAsp: 3.031 ± 0.045	3.067PheGlu: 3.067 ± 0.049	2.486PhePhe: 2.486 ± 0.052	3.387PheGly: 3.387 ± 0.054	0.91PheHis: 0.91 ± 0.025	3.752PheIle: 3.752 ± 0.06	3.433PheLys: 3.433 ± 0.048	4.535PheLeu: 4.535 ± 0.065	1.247PheMet: 1.247 ± 0.026	3.042PheAsn: 3.042 ± 0.051	1.746PhePro: 1.746 ± 0.034	1.725PheGln: 1.725 ± 0.035	1.788PheArg: 1.788 ± 0.034	3.76PheSer: 3.76 ± 0.053	2.783PheThr: 2.783 ± 0.048	2.933PheVal: 2.933 ± 0.05	0.612PheTrp: 0.612 ± 0.024	2.119PheTyr: 2.119 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.201GlyAla: 4.201 ± 0.064	0.51GlyCys: 0.51 ± 0.02	3.132GlyAsp: 3.132 ± 0.047	3.251GlyGlu: 3.251 ± 0.046	3.424GlyPhe: 3.424 ± 0.048	4.29GlyGly: 4.29 ± 0.071	1.167GlyHis: 1.167 ± 0.034	5.384GlyIle: 5.384 ± 0.062	5.063GlyLys: 5.063 ± 0.066	6.089GlyLeu: 6.089 ± 0.07	1.653GlyMet: 1.653 ± 0.032	3.636GlyAsn: 3.636 ± 0.054	1.354GlyPro: 1.354 ± 0.031	2.291GlyGln: 2.291 ± 0.036	2.379GlyArg: 2.379 ± 0.05	4.084GlySer: 4.084 ± 0.067	3.793GlyThr: 3.793 ± 0.054	4.099GlyVal: 4.099 ± 0.069	0.856GlyTrp: 0.856 ± 0.023	3.079GlyTyr: 3.079 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.228HisAla: 1.228 ± 0.03	0.189HisCys: 0.189 ± 0.012	0.99HisAsp: 0.99 ± 0.031	1.079HisGlu: 1.079 ± 0.028	1.137HisPhe: 1.137 ± 0.029	1.087HisGly: 1.087 ± 0.027	0.548HisHis: 0.548 ± 0.025	1.641HisIle: 1.641 ± 0.034	1.042HisLys: 1.042 ± 0.028	1.967HisLeu: 1.967 ± 0.04	0.464HisMet: 0.464 ± 0.016	0.962HisAsn: 0.962 ± 0.026	0.886HisPro: 0.886 ± 0.025	0.862HisGln: 0.862 ± 0.023	0.792HisArg: 0.792 ± 0.024	1.056HisSer: 1.056 ± 0.029	0.985HisThr: 0.985 ± 0.028	1.106HisVal: 1.106 ± 0.03	0.261HisTrp: 0.261 ± 0.015	0.979HisTyr: 0.979 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.036IleAla: 6.036 ± 0.07	0.741IleCys: 0.741 ± 0.026	4.546IleAsp: 4.546 ± 0.049	4.707IleGlu: 4.707 ± 0.062	3.625IlePhe: 3.625 ± 0.057	5.201IleGly: 5.201 ± 0.072	1.496IleHis: 1.496 ± 0.035	5.756IleIle: 5.756 ± 0.085	5.555IleLys: 5.555 ± 0.072	7.279IleLeu: 7.279 ± 0.077	1.66IleMet: 1.66 ± 0.033	4.488IleAsn: 4.488 ± 0.057	3.307IlePro: 3.307 ± 0.051	2.843IleGln: 2.843 ± 0.044	3.065IleArg: 3.065 ± 0.045	5.511IleSer: 5.511 ± 0.066	4.415IleThr: 4.415 ± 0.054	4.627IleVal: 4.627 ± 0.061	0.86IleTrp: 0.86 ± 0.025	2.911IleTyr: 2.911 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.604LysAla: 4.604 ± 0.059	0.332LysCys: 0.332 ± 0.015	4.321LysAsp: 4.321 ± 0.058	5.255LysGlu: 5.255 ± 0.067	2.825LysPhe: 2.825 ± 0.044	4.497LysGly: 4.497 ± 0.057	1.379LysHis: 1.379 ± 0.033	5.763LysIle: 5.763 ± 0.076	5.833LysLys: 5.833 ± 0.069	6.545LysLeu: 6.545 ± 0.067	2.169LysMet: 2.169 ± 0.042	4.942LysAsn: 4.942 ± 0.049	2.406LysPro: 2.406 ± 0.041	2.896LysGln: 2.896 ± 0.048	2.887LysArg: 2.887 ± 0.041	4.603LysSer: 4.603 ± 0.061	4.103LysThr: 4.103 ± 0.056	4.234LysVal: 4.234 ± 0.063	0.864LysTrp: 0.864 ± 0.026	3.026LysTyr: 3.026 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.513LeuAla: 6.513 ± 0.071	0.771LeuCys: 0.771 ± 0.026	5.134LeuAsp: 5.134 ± 0.056	5.518LeuGlu: 5.518 ± 0.069	4.96LeuPhe: 4.96 ± 0.063	5.752LeuGly: 5.752 ± 0.075	1.775LeuHis: 1.775 ± 0.039	7.238LeuIle: 7.238 ± 0.081	7.546LeuLys: 7.546 ± 0.086	9.828LeuLeu: 9.828 ± 0.1	2.389LeuMet: 2.389 ± 0.045	5.616LeuAsn: 5.616 ± 0.069	3.943LeuPro: 3.943 ± 0.058	3.729LeuGln: 3.729 ± 0.055	3.668LeuArg: 3.668 ± 0.057	7.186LeuSer: 7.186 ± 0.068	5.367LeuThr: 5.367 ± 0.068	5.364LeuVal: 5.364 ± 0.061	0.949LeuTrp: 0.949 ± 0.024	3.587LeuTyr: 3.587 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.652MetAla: 1.652 ± 0.033	0.157MetCys: 0.157 ± 0.011	1.341MetAsp: 1.341 ± 0.038	1.528MetGlu: 1.528 ± 0.037	0.871MetPhe: 0.871 ± 0.024	1.536MetGly: 1.536 ± 0.033	0.426MetHis: 0.426 ± 0.018	1.879MetIle: 1.879 ± 0.035	2.114MetLys: 2.114 ± 0.04	2.312MetLeu: 2.312 ± 0.04	0.7MetMet: 0.7 ± 0.022	1.474MetAsn: 1.474 ± 0.033	0.977MetPro: 0.977 ± 0.025	1.006MetGln: 1.006 ± 0.027	0.98MetArg: 0.98 ± 0.024	1.542MetSer: 1.542 ± 0.03	1.31MetThr: 1.31 ± 0.031	1.445MetVal: 1.445 ± 0.03	0.226MetTrp: 0.226 ± 0.012	0.724MetTyr: 0.724 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.673AsnAla: 3.673 ± 0.054	0.388AsnCys: 0.388 ± 0.018	2.841AsnAsp: 2.841 ± 0.047	3.192AsnGlu: 3.192 ± 0.046	2.963AsnPhe: 2.963 ± 0.048	3.82AsnGly: 3.82 ± 0.057	1.076AsnHis: 1.076 ± 0.025	4.553AsnIle: 4.553 ± 0.059	4.324AsnLys: 4.324 ± 0.056	5.39AsnLeu: 5.39 ± 0.059	1.412AsnMet: 1.412 ± 0.032	3.628AsnAsn: 3.628 ± 0.061	2.62AsnPro: 2.62 ± 0.045	2.346AsnGln: 2.346 ± 0.041	2.458AsnArg: 2.458 ± 0.044	3.697AsnSer: 3.697 ± 0.061	3.272AsnThr: 3.272 ± 0.059	3.061AsnVal: 3.061 ± 0.051	0.847AsnTrp: 0.847 ± 0.024	2.718AsnTyr: 2.718 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.384ProAla: 2.384 ± 0.046	0.193ProCys: 0.193 ± 0.011	2.096ProAsp: 2.096 ± 0.039	2.541ProGlu: 2.541 ± 0.042	1.905ProPhe: 1.905 ± 0.037	2.037ProGly: 2.037 ± 0.037	0.682ProHis: 0.682 ± 0.024	2.841ProIle: 2.841 ± 0.046	2.353ProLys: 2.353 ± 0.038	3.262ProLeu: 3.262 ± 0.05	0.76ProMet: 0.76 ± 0.023	2.069ProAsn: 2.069 ± 0.039	0.797ProPro: 0.797 ± 0.027	1.306ProGln: 1.306 ± 0.031	1.003ProArg: 1.003 ± 0.024	2.204ProSer: 2.204 ± 0.041	1.973ProThr: 1.973 ± 0.035	2.444ProVal: 2.444 ± 0.038	0.395ProTrp: 0.395 ± 0.018	1.491ProTyr: 1.491 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.545GlnAla: 2.545 ± 0.042	0.193GlnCys: 0.193 ± 0.011	2.057GlnAsp: 2.057 ± 0.035	2.444GlnGlu: 2.444 ± 0.047	1.822GlnPhe: 1.822 ± 0.031	2.055GlnGly: 2.055 ± 0.038	0.901GlnHis: 0.901 ± 0.027	3.056GlnIle: 3.056 ± 0.052	2.839GlnLys: 2.839 ± 0.041	4.094GlnLeu: 4.094 ± 0.049	0.94GlnMet: 0.94 ± 0.027	2.257GlnAsn: 2.257 ± 0.046	1.163GlnPro: 1.163 ± 0.025	1.998GlnGln: 1.998 ± 0.041	1.49GlnArg: 1.49 ± 0.031	2.413GlnSer: 2.413 ± 0.036	1.97GlnThr: 1.97 ± 0.039	2.568GlnVal: 2.568 ± 0.042	0.445GlnTrp: 0.445 ± 0.018	1.799GlnTyr: 1.799 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.323ArgAla: 2.323 ± 0.044	0.239ArgCys: 0.239 ± 0.013	2.062ArgAsp: 2.062 ± 0.035	2.174ArgGlu: 2.174 ± 0.039	1.981ArgPhe: 1.981 ± 0.037	2.026ArgGly: 2.026 ± 0.035	0.658ArgHis: 0.658 ± 0.023	3.238ArgIle: 3.238 ± 0.05	2.965ArgLys: 2.965 ± 0.052	3.685ArgLeu: 3.685 ± 0.054	1.066ArgMet: 1.066 ± 0.025	2.339ArgAsn: 2.339 ± 0.042	1.238ArgPro: 1.238 ± 0.032	1.384ArgGln: 1.384 ± 0.034	1.448ArgArg: 1.448 ± 0.033	2.395ArgSer: 2.395 ± 0.042	2.095ArgThr: 2.095 ± 0.045	2.28ArgVal: 2.28 ± 0.04	0.535ArgTrp: 0.535 ± 0.021	1.888ArgTyr: 1.888 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.073SerAla: 4.073 ± 0.06	0.674SerCys: 0.674 ± 0.022	3.385SerAsp: 3.385 ± 0.042	3.515SerGlu: 3.515 ± 0.047	3.85SerPhe: 3.85 ± 0.056	4.553SerGly: 4.553 ± 0.065	1.157SerHis: 1.157 ± 0.029	5.348SerIle: 5.348 ± 0.062	4.644SerLys: 4.644 ± 0.057	6.459SerLeu: 6.459 ± 0.067	1.467SerMet: 1.467 ± 0.034	3.617SerAsn: 3.617 ± 0.06	2.192SerPro: 2.192 ± 0.041	2.256SerGln: 2.256 ± 0.037	2.399SerArg: 2.399 ± 0.04	4.49SerSer: 4.49 ± 0.069	3.794SerThr: 3.794 ± 0.057	3.873SerVal: 3.873 ± 0.054	0.816SerTrp: 0.816 ± 0.028	3.033SerTyr: 3.033 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.181ThrAla: 4.181 ± 0.053	0.373ThrCys: 0.373 ± 0.017	3.19ThrAsp: 3.19 ± 0.046	3.03ThrGlu: 3.03 ± 0.047	2.777ThrPhe: 2.777 ± 0.045	4.057ThrGly: 4.057 ± 0.053	0.996ThrHis: 0.996 ± 0.027	4.467ThrIle: 4.467 ± 0.054	3.554ThrLys: 3.554 ± 0.048	5.341ThrLeu: 5.341 ± 0.067	1.059ThrMet: 1.059 ± 0.024	2.846ThrAsn: 2.846 ± 0.05	2.141ThrPro: 2.141 ± 0.033	1.785ThrGln: 1.785 ± 0.037	1.706ThrArg: 1.706 ± 0.033	3.481ThrSer: 3.481 ± 0.052	3.077ThrThr: 3.077 ± 0.05	3.753ThrVal: 3.753 ± 0.059	0.631ThrTrp: 0.631 ± 0.021	2.373ThrTyr: 2.373 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.213ValAla: 4.213 ± 0.07	0.481ValCys: 0.481 ± 0.019	3.478ValAsp: 3.478 ± 0.051	3.529ValGlu: 3.529 ± 0.058	3.056ValPhe: 3.056 ± 0.047	3.752ValGly: 3.752 ± 0.052	1.081ValHis: 1.081 ± 0.03	4.594ValIle: 4.594 ± 0.06	4.319ValLys: 4.319 ± 0.06	6.055ValLeu: 6.055 ± 0.069	1.413ValMet: 1.413 ± 0.033	3.55ValAsn: 3.55 ± 0.052	2.244ValPro: 2.244 ± 0.042	2.232ValGln: 2.232 ± 0.042	2.254ValArg: 2.254 ± 0.038	4.343ValSer: 4.343 ± 0.052	3.237ValThr: 3.237 ± 0.048	3.945ValVal: 3.945 ± 0.065	0.648ValTrp: 0.648 ± 0.02	2.359ValTyr: 2.359 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.674TrpAla: 0.674 ± 0.022	0.109TrpCys: 0.109 ± 0.009	0.645TrpAsp: 0.645 ± 0.024	0.714TrpGlu: 0.714 ± 0.022	0.503TrpPhe: 0.503 ± 0.019	0.832TrpGly: 0.832 ± 0.023	0.262TrpHis: 0.262 ± 0.014	0.865TrpIle: 0.865 ± 0.023	0.983TrpLys: 0.983 ± 0.028	1.112TrpLeu: 1.112 ± 0.026	0.388TrpMet: 0.388 ± 0.016	0.787TrpAsn: 0.787 ± 0.023	0.308TrpPro: 0.308 ± 0.016	0.491TrpGln: 0.491 ± 0.017	0.497TrpArg: 0.497 ± 0.018	0.789TrpSer: 0.789 ± 0.024	0.659TrpThr: 0.659 ± 0.021	0.628TrpVal: 0.628 ± 0.02	0.174TrpTrp: 0.174 ± 0.011	0.525TrpTyr: 0.525 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.833TyrAla: 2.833 ± 0.047	0.369TyrCys: 0.369 ± 0.016	2.359TyrAsp: 2.359 ± 0.047	2.251TyrGlu: 2.251 ± 0.039	2.48TyrPhe: 2.48 ± 0.045	2.881TyrGly: 2.881 ± 0.045	0.869TyrHis: 0.869 ± 0.025	2.849TyrIle: 2.849 ± 0.044	2.773TyrLys: 2.773 ± 0.04	4.166TyrLeu: 4.166 ± 0.056	0.914TyrMet: 0.914 ± 0.028	2.418TyrAsn: 2.418 ± 0.048	1.722TyrPro: 1.722 ± 0.037	1.877TyrGln: 1.877 ± 0.035	1.854TyrArg: 1.854 ± 0.039	2.804TyrSer: 2.804 ± 0.042	2.336TyrThr: 2.336 ± 0.041	2.258TyrVal: 2.258 ± 0.036	0.531TyrTrp: 0.531 ± 0.019	2.008TyrTyr: 2.008 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6019 proteins (1462207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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