Amino acid dipepetide frequency for Hubei tombus-like virus 20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.962AlaAla: 3.962 ± 1.456
1.698AlaCys: 1.698 ± 0.946
2.264AlaAsp: 2.264 ± 0.645
3.962AlaGlu: 3.962 ± 1.224
2.264AlaPhe: 2.264 ± 0.784
6.225AlaGly: 6.225 ± 1.356
3.396AlaHis: 3.396 ± 1.507
5.093AlaIle: 5.093 ± 0.948
9.055AlaLys: 9.055 ± 2.28
7.923AlaLeu: 7.923 ± 1.377
2.264AlaMet: 2.264 ± 0.239
3.396AlaAsn: 3.396 ± 0.969
4.527AlaPro: 4.527 ± 0.78
2.264AlaGln: 2.264 ± 1.383
2.83AlaArg: 2.83 ± 1.464
6.791AlaSer: 6.791 ± 1.699
5.659AlaThr: 5.659 ± 0.617
1.698AlaVal: 1.698 ± 0.589
1.132AlaTrp: 1.132 ± 0.593
1.132AlaTyr: 1.132 ± 0.671
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.498
0.0CysCys: 0.0 ± 0.0
1.132CysAsp: 1.132 ± 0.81
0.566CysGlu: 0.566 ± 0.497
0.566CysPhe: 0.566 ± 0.497
2.264CysGly: 2.264 ± 0.821
0.566CysHis: 0.566 ± 0.62
0.0CysIle: 0.0 ± 0.0
1.698CysLys: 1.698 ± 0.946
1.698CysLeu: 1.698 ± 0.89
0.0CysMet: 0.0 ± 0.0
0.566CysAsn: 0.566 ± 0.405
0.566CysPro: 0.566 ± 0.405
1.132CysGln: 1.132 ± 0.997
1.132CysArg: 1.132 ± 0.997
1.698CysSer: 1.698 ± 1.006
1.132CysThr: 1.132 ± 0.691
2.264CysVal: 2.264 ± 1.342
0.0CysTrp: 0.0 ± 0.0
1.132CysTyr: 1.132 ± 0.568
0.0CysXaa: 0.0 ± 0.0
Asp
2.264AspAla: 2.264 ± 0.645
1.698AspCys: 1.698 ± 0.734
3.962AspAsp: 3.962 ± 1.382
2.83AspGlu: 2.83 ± 1.713
1.698AspPhe: 1.698 ± 0.589
5.093AspGly: 5.093 ± 1.452
1.132AspHis: 1.132 ± 0.997
0.566AspIle: 0.566 ± 0.405
2.83AspLys: 2.83 ± 1.001
6.225AspLeu: 6.225 ± 1.751
0.0AspMet: 0.0 ± 0.0
2.264AspAsn: 2.264 ± 0.958
2.83AspPro: 2.83 ± 1.172
3.396AspGln: 3.396 ± 1.387
1.698AspArg: 1.698 ± 0.977
2.264AspSer: 2.264 ± 1.993
2.264AspThr: 2.264 ± 0.738
2.83AspVal: 2.83 ± 0.944
1.698AspTrp: 1.698 ± 1.032
1.132AspTyr: 1.132 ± 0.671
0.0AspXaa: 0.0 ± 0.0
Glu
2.83GluAla: 2.83 ± 0.823
1.698GluCys: 1.698 ± 1.491
2.264GluAsp: 2.264 ± 0.915
1.132GluGlu: 1.132 ± 1.24
3.962GluPhe: 3.962 ± 1.804
4.527GluGly: 4.527 ± 1.28
1.698GluHis: 1.698 ± 0.89
4.527GluIle: 4.527 ± 1.265
2.83GluLys: 2.83 ± 0.514
3.396GluLeu: 3.396 ± 0.917
2.264GluMet: 2.264 ± 0.645
0.566GluAsn: 0.566 ± 0.498
1.132GluPro: 1.132 ± 0.479
2.264GluGln: 2.264 ± 1.135
3.396GluArg: 3.396 ± 1.673
3.396GluSer: 3.396 ± 2.065
2.83GluThr: 2.83 ± 0.738
1.698GluVal: 1.698 ± 0.589
1.132GluTrp: 1.132 ± 0.81
1.698GluTyr: 1.698 ± 0.609
0.0GluXaa: 0.0 ± 0.0
Phe
2.264PheAla: 2.264 ± 0.239
1.132PheCys: 1.132 ± 0.997
1.698PheAsp: 1.698 ± 0.89
3.396PheGlu: 3.396 ± 0.896
0.0PhePhe: 0.0 ± 0.0
0.566PheGly: 0.566 ± 0.498
1.132PheHis: 1.132 ± 0.81
0.566PheIle: 0.566 ± 0.498
2.83PheLys: 2.83 ± 0.888
2.83PheLeu: 2.83 ± 1.597
0.0PheMet: 0.0 ± 0.0
1.698PheAsn: 1.698 ± 1.215
3.396PhePro: 3.396 ± 0.896
1.698PheGln: 1.698 ± 1.215
2.83PheArg: 2.83 ± 0.944
1.132PheSer: 1.132 ± 0.81
1.698PheThr: 1.698 ± 0.89
3.396PheVal: 3.396 ± 2.013
1.132PheTrp: 1.132 ± 0.81
1.132PheTyr: 1.132 ± 0.568
0.0PheXaa: 0.0 ± 0.0
Gly
2.83GlyAla: 2.83 ± 2.026
0.566GlyCys: 0.566 ± 0.498
2.83GlyAsp: 2.83 ± 1.221
4.527GlyGlu: 4.527 ± 1.02
1.698GlyPhe: 1.698 ± 0.485
7.923GlyGly: 7.923 ± 1.011
0.0GlyHis: 0.0 ± 0.0
2.83GlyIle: 2.83 ± 0.738
5.093GlyLys: 5.093 ± 0.606
3.962GlyLeu: 3.962 ± 1.63
2.83GlyMet: 2.83 ± 1.904
5.093GlyAsn: 5.093 ± 1.683
5.659GlyPro: 5.659 ± 2.219
0.566GlyGln: 0.566 ± 0.62
6.791GlyArg: 6.791 ± 2.4
5.659GlySer: 5.659 ± 1.642
5.093GlyThr: 5.093 ± 2.614
2.83GlyVal: 2.83 ± 1.349
2.264GlyTrp: 2.264 ± 1.09
3.396GlyTyr: 3.396 ± 1.151
0.0GlyXaa: 0.0 ± 0.0
His
1.698HisAla: 1.698 ± 0.485
0.566HisCys: 0.566 ± 0.405
0.566HisAsp: 0.566 ± 0.62
0.566HisGlu: 0.566 ± 0.498
0.0HisPhe: 0.0 ± 0.0
1.132HisGly: 1.132 ± 0.997
0.0HisHis: 0.0 ± 0.0
0.566HisIle: 0.566 ± 0.62
0.566HisLys: 0.566 ± 0.497
2.264HisLeu: 2.264 ± 1.342
0.566HisMet: 0.566 ± 0.442
0.566HisAsn: 0.566 ± 0.498
1.132HisPro: 1.132 ± 0.691
0.0HisGln: 0.0 ± 0.0
1.132HisArg: 1.132 ± 0.568
2.264HisSer: 2.264 ± 0.771
1.132HisThr: 1.132 ± 0.479
1.698HisVal: 1.698 ± 1.215
0.0HisTrp: 0.0 ± 0.0
2.264HisTyr: 2.264 ± 0.59
0.0HisXaa: 0.0 ± 0.0
Ile
2.264IleAla: 2.264 ± 1.085
0.0IleCys: 0.0 ± 0.0
3.396IleAsp: 3.396 ± 1.468
3.396IleGlu: 3.396 ± 1.113
1.132IlePhe: 1.132 ± 0.997
2.83IleGly: 2.83 ± 0.789
0.566IleHis: 0.566 ± 0.62
3.396IleIle: 3.396 ± 0.644
4.527IleLys: 4.527 ± 1.184
5.659IleLeu: 5.659 ± 1.043
1.698IleMet: 1.698 ± 0.539
2.83IleAsn: 2.83 ± 0.978
3.396IlePro: 3.396 ± 0.896
1.698IleGln: 1.698 ± 1.192
1.698IleArg: 1.698 ± 0.734
2.264IleSer: 2.264 ± 0.771
5.659IleThr: 5.659 ± 1.75
3.396IleVal: 3.396 ± 1.248
0.566IleTrp: 0.566 ± 0.62
0.566IleTyr: 0.566 ± 0.405
0.0IleXaa: 0.0 ± 0.0
Lys
3.962LysAla: 3.962 ± 1.106
1.132LysCys: 1.132 ± 0.691
3.396LysAsp: 3.396 ± 1.297
4.527LysGlu: 4.527 ± 2.28
3.396LysPhe: 3.396 ± 0.983
5.659LysGly: 5.659 ± 1.245
0.0LysHis: 0.0 ± 0.0
1.132LysIle: 1.132 ± 0.997
2.83LysLys: 2.83 ± 0.887
4.527LysLeu: 4.527 ± 1.557
2.264LysMet: 2.264 ± 0.897
1.132LysAsn: 1.132 ± 0.671
5.093LysPro: 5.093 ± 2.564
2.83LysGln: 2.83 ± 1.929
4.527LysArg: 4.527 ± 1.804
3.396LysSer: 3.396 ± 1.522
4.527LysThr: 4.527 ± 1.058
5.093LysVal: 5.093 ± 1.811
2.264LysTrp: 2.264 ± 0.239
1.698LysTyr: 1.698 ± 1.495
0.0LysXaa: 0.0 ± 0.0
Leu
6.791LeuAla: 6.791 ± 0.922
1.132LeuCys: 1.132 ± 0.479
2.83LeuAsp: 2.83 ± 1.001
3.396LeuGlu: 3.396 ± 0.538
3.962LeuPhe: 3.962 ± 1.808
2.264LeuGly: 2.264 ± 1.073
1.132LeuHis: 1.132 ± 0.671
3.962LeuIle: 3.962 ± 1.758
6.791LeuLys: 6.791 ± 2.659
4.527LeuLeu: 4.527 ± 0.824
4.527LeuMet: 4.527 ± 1.161
2.83LeuAsn: 2.83 ± 1.339
5.659LeuPro: 5.659 ± 1.1
5.093LeuGln: 5.093 ± 0.992
5.093LeuArg: 5.093 ± 1.889
6.791LeuSer: 6.791 ± 0.32
5.659LeuThr: 5.659 ± 1.101
2.264LeuVal: 2.264 ± 0.239
0.0LeuTrp: 0.0 ± 0.0
3.962LeuTyr: 3.962 ± 0.581
0.0LeuXaa: 0.0 ± 0.0
Met
2.83MetAla: 2.83 ± 1.219
1.132MetCys: 1.132 ± 0.997
1.132MetAsp: 1.132 ± 0.671
0.566MetGlu: 0.566 ± 0.498
0.0MetPhe: 0.0 ± 0.0
2.264MetGly: 2.264 ± 1.36
0.566MetHis: 0.566 ± 0.498
0.566MetIle: 0.566 ± 0.405
0.0MetLys: 0.0 ± 0.0
1.132MetLeu: 1.132 ± 0.671
1.132MetMet: 1.132 ± 0.559
1.132MetAsn: 1.132 ± 0.568
1.132MetPro: 1.132 ± 0.997
0.566MetGln: 0.566 ± 0.62
2.264MetArg: 2.264 ± 0.784
2.264MetSer: 2.264 ± 0.59
0.566MetThr: 0.566 ± 0.497
2.83MetVal: 2.83 ± 0.268
0.566MetTrp: 0.566 ± 0.498
1.132MetTyr: 1.132 ± 0.593
0.0MetXaa: 0.0 ± 0.0
Asn
2.264AsnAla: 2.264 ± 0.784
0.566AsnCys: 0.566 ± 0.498
2.264AsnAsp: 2.264 ± 0.645
2.264AsnGlu: 2.264 ± 1.004
0.566AsnPhe: 0.566 ± 0.498
5.659AsnGly: 5.659 ± 1.245
0.0AsnHis: 0.0 ± 0.0
3.962AsnIle: 3.962 ± 1.804
3.396AsnLys: 3.396 ± 1.485
2.264AsnLeu: 2.264 ± 0.958
0.0AsnMet: 0.0 ± 0.0
2.83AsnAsn: 2.83 ± 0.978
3.396AsnPro: 3.396 ± 1.35
2.264AsnGln: 2.264 ± 1.397
1.132AsnArg: 1.132 ± 0.568
2.264AsnSer: 2.264 ± 0.645
2.83AsnThr: 2.83 ± 0.738
1.698AsnVal: 1.698 ± 0.89
1.132AsnTrp: 1.132 ± 0.559
1.132AsnTyr: 1.132 ± 0.479
0.0AsnXaa: 0.0 ± 0.0
Pro
5.659ProAla: 5.659 ± 2.709
0.0ProCys: 0.0 ± 0.0
3.962ProAsp: 3.962 ± 0.581
2.83ProGlu: 2.83 ± 0.962
3.396ProPhe: 3.396 ± 1.437
3.962ProGly: 3.962 ± 1.042
1.132ProHis: 1.132 ± 0.559
3.962ProIle: 3.962 ± 0.832
2.83ProLys: 2.83 ± 1.219
3.396ProLeu: 3.396 ± 1.108
1.698ProMet: 1.698 ± 0.485
3.396ProAsn: 3.396 ± 1.891
4.527ProPro: 4.527 ± 1.633
3.962ProGln: 3.962 ± 1.722
3.962ProArg: 3.962 ± 0.801
2.83ProSer: 2.83 ± 1.575
6.791ProThr: 6.791 ± 1.186
5.093ProVal: 5.093 ± 1.249
0.0ProTrp: 0.0 ± 0.0
3.962ProTyr: 3.962 ± 0.731
0.0ProXaa: 0.0 ± 0.0
Gln
3.396GlnAla: 3.396 ± 1.167
1.132GlnCys: 1.132 ± 0.671
0.0GlnAsp: 0.0 ± 0.0
0.566GlnGlu: 0.566 ± 0.405
1.132GlnPhe: 1.132 ± 0.81
2.83GlnGly: 2.83 ± 0.268
1.132GlnHis: 1.132 ± 0.568
1.698GlnIle: 1.698 ± 1.032
1.132GlnLys: 1.132 ± 0.671
5.093GlnLeu: 5.093 ± 1.845
0.566GlnMet: 0.566 ± 0.498
0.0GlnAsn: 0.0 ± 0.0
1.698GlnPro: 1.698 ± 0.943
2.264GlnGln: 2.264 ± 0.239
4.527GlnArg: 4.527 ± 1.557
2.83GlnSer: 2.83 ± 1.349
3.396GlnThr: 3.396 ± 1.108
3.396GlnVal: 3.396 ± 1.108
0.566GlnTrp: 0.566 ± 0.405
1.132GlnTyr: 1.132 ± 0.568
0.0GlnXaa: 0.0 ± 0.0
Arg
9.621ArgAla: 9.621 ± 1.484
0.566ArgCys: 0.566 ± 0.497
3.962ArgAsp: 3.962 ± 1.462
4.527ArgGlu: 4.527 ± 1.542
1.698ArgPhe: 1.698 ± 1.144
2.83ArgGly: 2.83 ± 0.823
2.264ArgHis: 2.264 ± 1.439
1.698ArgIle: 1.698 ± 0.734
3.396ArgLys: 3.396 ± 1.438
3.962ArgLeu: 3.962 ± 0.968
1.698ArgMet: 1.698 ± 1.006
0.0ArgAsn: 0.0 ± 0.0
5.659ArgPro: 5.659 ± 1.467
1.698ArgGln: 1.698 ± 0.485
4.527ArgArg: 4.527 ± 0.78
4.527ArgSer: 4.527 ± 2.186
3.396ArgThr: 3.396 ± 1.285
5.659ArgVal: 5.659 ± 1.775
1.698ArgTrp: 1.698 ± 0.805
1.698ArgTyr: 1.698 ± 0.734
0.0ArgXaa: 0.0 ± 0.0
Ser
5.659SerAla: 5.659 ± 2.083
1.698SerCys: 1.698 ± 0.485
2.264SerAsp: 2.264 ± 0.915
1.698SerGlu: 1.698 ± 0.589
4.527SerPhe: 4.527 ± 1.179
6.225SerGly: 6.225 ± 1.607
0.566SerHis: 0.566 ± 0.497
4.527SerIle: 4.527 ± 1.766
4.527SerLys: 4.527 ± 2.152
4.527SerLeu: 4.527 ± 1.31
0.566SerMet: 0.566 ± 0.405
3.962SerAsn: 3.962 ± 1.466
3.962SerPro: 3.962 ± 0.749
1.132SerGln: 1.132 ± 0.593
6.791SerArg: 6.791 ± 2.13
6.791SerSer: 6.791 ± 1.884
1.698SerThr: 1.698 ± 0.841
1.132SerVal: 1.132 ± 0.997
2.83SerTrp: 2.83 ± 1.513
2.83SerTyr: 2.83 ± 0.789
0.0SerXaa: 0.0 ± 0.0
Thr
6.791ThrAla: 6.791 ± 1.807
1.132ThrCys: 1.132 ± 0.671
3.962ThrAsp: 3.962 ± 0.506
5.093ThrGlu: 5.093 ± 1.308
1.698ThrPhe: 1.698 ± 1.215
1.698ThrGly: 1.698 ± 0.943
1.132ThrHis: 1.132 ± 0.479
2.83ThrIle: 2.83 ± 0.888
1.698ThrLys: 1.698 ± 1.491
4.527ThrLeu: 4.527 ± 1.911
0.566ThrMet: 0.566 ± 0.552
3.396ThrAsn: 3.396 ± 0.309
7.357ThrPro: 7.357 ± 2.508
2.83ThrGln: 2.83 ± 0.789
6.225ThrArg: 6.225 ± 1.246
3.396ThrSer: 3.396 ± 1.61
3.962ThrThr: 3.962 ± 1.273
2.83ThrVal: 2.83 ± 1.65
1.132ThrTrp: 1.132 ± 0.81
2.264ThrTyr: 2.264 ± 1.118
0.0ThrXaa: 0.0 ± 0.0
Val
7.357ValAla: 7.357 ± 1.625
1.698ValCys: 1.698 ± 0.609
4.527ValAsp: 4.527 ± 1.542
1.132ValGlu: 1.132 ± 0.593
1.132ValPhe: 1.132 ± 0.593
3.962ValGly: 3.962 ± 1.042
0.566ValHis: 0.566 ± 0.405
3.962ValIle: 3.962 ± 1.808
4.527ValLys: 4.527 ± 1.486
3.396ValLeu: 3.396 ± 0.309
0.0ValMet: 0.0 ± 0.0
3.962ValAsn: 3.962 ± 1.71
4.527ValPro: 4.527 ± 1.161
1.698ValGln: 1.698 ± 0.841
1.698ValArg: 1.698 ± 1.144
5.093ValSer: 5.093 ± 1.154
2.83ValThr: 2.83 ± 1.035
7.357ValVal: 7.357 ± 1.285
0.0ValTrp: 0.0 ± 0.0
2.264ValTyr: 2.264 ± 1.09
0.0ValXaa: 0.0 ± 0.0
Trp
1.698TrpAla: 1.698 ± 0.589
1.132TrpCys: 1.132 ± 0.479
1.698TrpAsp: 1.698 ± 0.841
0.566TrpGlu: 0.566 ± 0.62
0.0TrpPhe: 0.0 ± 0.0
1.132TrpGly: 1.132 ± 0.81
0.566TrpHis: 0.566 ± 0.405
2.83TrpIle: 2.83 ± 1.035
0.566TrpLys: 0.566 ± 0.497
1.698TrpLeu: 1.698 ± 0.485
0.0TrpMet: 0.0 ± 0.0
1.132TrpAsn: 1.132 ± 0.691
0.566TrpPro: 0.566 ± 0.497
0.0TrpGln: 0.0 ± 0.0
1.132TrpArg: 1.132 ± 0.559
0.566TrpSer: 0.566 ± 0.405
0.0TrpThr: 0.0 ± 0.0
2.264TrpVal: 2.264 ± 0.239
1.698TrpTrp: 1.698 ± 0.805
1.132TrpTyr: 1.132 ± 0.671
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.83TyrAla: 2.83 ± 0.962
0.0TyrCys: 0.0 ± 0.0
0.566TyrAsp: 0.566 ± 0.62
1.698TyrGlu: 1.698 ± 0.943
1.698TyrPhe: 1.698 ± 0.609
3.396TyrGly: 3.396 ± 0.99
1.132TyrHis: 1.132 ± 0.568
2.264TyrIle: 2.264 ± 1.36
2.264TyrLys: 2.264 ± 1.401
5.659TyrLeu: 5.659 ± 1.309
0.566TyrMet: 0.566 ± 0.498
1.132TyrAsn: 1.132 ± 0.479
1.132TyrPro: 1.132 ± 0.593
1.132TyrGln: 1.132 ± 0.479
1.698TyrArg: 1.698 ± 0.946
1.698TyrSer: 1.698 ± 0.805
3.962TyrThr: 3.962 ± 0.801
2.264TyrVal: 2.264 ± 1.186
0.566TyrTrp: 0.566 ± 0.498
0.566TyrTyr: 0.566 ± 0.405
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski