Amino acid dipepetide frequency for Marinibacterium profundimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.668AlaAla: 16.668 ± 0.161	1.144AlaCys: 1.144 ± 0.027	6.997AlaAsp: 6.997 ± 0.071	8.718AlaGlu: 8.718 ± 0.091	4.354AlaPhe: 4.354 ± 0.057	10.802AlaGly: 10.802 ± 0.11	2.342AlaHis: 2.342 ± 0.036	5.668AlaIle: 5.668 ± 0.054	3.165AlaLys: 3.165 ± 0.056	13.933AlaLeu: 13.933 ± 0.13	3.929AlaMet: 3.929 ± 0.042	2.424AlaAsn: 2.424 ± 0.042	6.173AlaPro: 6.173 ± 0.077	4.25AlaGln: 4.25 ± 0.055	9.377AlaArg: 9.377 ± 0.103	5.52AlaSer: 5.52 ± 0.068	5.996AlaThr: 5.996 ± 0.077	8.422AlaVal: 8.422 ± 0.085	1.612AlaTrp: 1.612 ± 0.037	2.564AlaTyr: 2.564 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.026	0.118CysCys: 0.118 ± 0.009	0.626CysAsp: 0.626 ± 0.022	0.419CysGlu: 0.419 ± 0.018	0.33CysPhe: 0.33 ± 0.013	0.928CysGly: 0.928 ± 0.026	0.279CysHis: 0.279 ± 0.013	0.401CysIle: 0.401 ± 0.015	0.195CysLys: 0.195 ± 0.011	0.874CysLeu: 0.874 ± 0.021	0.183CysMet: 0.183 ± 0.01	0.201CysAsn: 0.201 ± 0.012	0.501CysPro: 0.501 ± 0.021	0.23CysGln: 0.23 ± 0.012	0.601CysArg: 0.601 ± 0.021	0.456CysSer: 0.456 ± 0.018	0.424CysThr: 0.424 ± 0.017	0.592CysVal: 0.592 ± 0.02	0.133CysTrp: 0.133 ± 0.009	0.209CysTyr: 0.209 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.157AspAla: 7.157 ± 0.085	0.522AspCys: 0.522 ± 0.018	3.461AspAsp: 3.461 ± 0.056	3.569AspGlu: 3.569 ± 0.054	2.389AspPhe: 2.389 ± 0.041	5.902AspGly: 5.902 ± 0.074	1.429AspHis: 1.429 ± 0.033	3.165AspIle: 3.165 ± 0.043	1.498AspLys: 1.498 ± 0.034	6.581AspLeu: 6.581 ± 0.065	1.696AspMet: 1.696 ± 0.031	1.235AspAsn: 1.235 ± 0.03	4.156AspPro: 4.156 ± 0.055	1.847AspGln: 1.847 ± 0.032	4.939AspArg: 4.939 ± 0.063	2.254AspSer: 2.254 ± 0.044	3.127AspThr: 3.127 ± 0.049	4.234AspVal: 4.234 ± 0.058	1.226AspTrp: 1.226 ± 0.029	1.61AspTyr: 1.61 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.624GluAla: 8.624 ± 0.095	0.347GluCys: 0.347 ± 0.014	3.714GluAsp: 3.714 ± 0.056	3.797GluGlu: 3.797 ± 0.053	1.804GluPhe: 1.804 ± 0.034	4.934GluGly: 4.934 ± 0.063	1.067GluHis: 1.067 ± 0.028	3.79GluIle: 3.79 ± 0.056	1.972GluLys: 1.972 ± 0.041	5.397GluLeu: 5.397 ± 0.064	1.935GluMet: 1.935 ± 0.035	1.572GluAsn: 1.572 ± 0.034	2.739GluPro: 2.739 ± 0.041	1.882GluGln: 1.882 ± 0.036	4.277GluArg: 4.277 ± 0.056	2.135GluSer: 2.135 ± 0.034	4.105GluThr: 4.105 ± 0.054	4.363GluVal: 4.363 ± 0.052	0.686GluTrp: 0.686 ± 0.023	1.038GluTyr: 1.038 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.4PheAla: 4.4 ± 0.06	0.417PheCys: 0.417 ± 0.015	2.886PheAsp: 2.886 ± 0.048	2.18PheGlu: 2.18 ± 0.038	1.425PhePhe: 1.425 ± 0.035	3.699PheGly: 3.699 ± 0.057	0.747PheHis: 0.747 ± 0.023	1.607PheIle: 1.607 ± 0.033	0.781PheLys: 0.781 ± 0.022	3.393PheLeu: 3.393 ± 0.058	0.842PheMet: 0.842 ± 0.024	0.971PheAsn: 0.971 ± 0.025	1.609PhePro: 1.609 ± 0.032	0.977PheGln: 0.977 ± 0.027	2.297PheArg: 2.297 ± 0.041	2.051PheSer: 2.051 ± 0.037	2.061PheThr: 2.061 ± 0.033	2.685PheVal: 2.685 ± 0.048	0.572PheTrp: 0.572 ± 0.019	0.923PheTyr: 0.923 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.301GlyAla: 10.301 ± 0.111	0.868GlyCys: 0.868 ± 0.025	4.856GlyAsp: 4.856 ± 0.068	4.843GlyGlu: 4.843 ± 0.063	3.647GlyPhe: 3.647 ± 0.047	7.843GlyGly: 7.843 ± 0.178	1.998GlyHis: 1.998 ± 0.036	4.589GlyIle: 4.589 ± 0.062	2.768GlyLys: 2.768 ± 0.053	9.62GlyLeu: 9.62 ± 0.091	2.7GlyMet: 2.7 ± 0.044	2.006GlyAsn: 2.006 ± 0.052	4.188GlyPro: 4.188 ± 0.054	3.278GlyGln: 3.278 ± 0.049	6.139GlyArg: 6.139 ± 0.067	4.371GlySer: 4.371 ± 0.063	5.029GlyThr: 5.029 ± 0.065	6.441GlyVal: 6.441 ± 0.073	1.583GlyTrp: 1.583 ± 0.031	2.379GlyTyr: 2.379 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.333HisAla: 2.333 ± 0.035	0.229HisCys: 0.229 ± 0.012	1.36HisAsp: 1.36 ± 0.027	1.054HisGlu: 1.054 ± 0.025	0.794HisPhe: 0.794 ± 0.021	2.029HisGly: 2.029 ± 0.04	0.551HisHis: 0.551 ± 0.019	0.866HisIle: 0.866 ± 0.026	0.453HisLys: 0.453 ± 0.017	2.048HisLeu: 2.048 ± 0.03	0.579HisMet: 0.579 ± 0.021	0.435HisAsn: 0.435 ± 0.017	1.403HisPro: 1.403 ± 0.033	0.536HisGln: 0.536 ± 0.02	1.377HisArg: 1.377 ± 0.032	0.82HisSer: 0.82 ± 0.026	0.794HisThr: 0.794 ± 0.023	1.619HisVal: 1.619 ± 0.032	0.358HisTrp: 0.358 ± 0.015	0.539HisTyr: 0.539 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.766IleAla: 6.766 ± 0.074	0.607IleCys: 0.607 ± 0.02	3.481IleAsp: 3.481 ± 0.051	3.41IleGlu: 3.41 ± 0.047	1.844IlePhe: 1.844 ± 0.039	4.886IleGly: 4.886 ± 0.058	0.961IleHis: 0.961 ± 0.025	2.07IleIle: 2.07 ± 0.043	1.097IleLys: 1.097 ± 0.032	4.79IleLeu: 4.79 ± 0.061	1.059IleMet: 1.059 ± 0.025	1.234IleAsn: 1.234 ± 0.029	2.365IlePro: 2.365 ± 0.044	1.138IleGln: 1.138 ± 0.026	3.325IleArg: 3.325 ± 0.047	2.779IleSer: 2.779 ± 0.041	2.848IleThr: 2.848 ± 0.049	3.836IleVal: 3.836 ± 0.054	0.721IleTrp: 0.721 ± 0.02	1.161IleTyr: 1.161 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.49LysAla: 3.49 ± 0.054	0.164LysCys: 0.164 ± 0.01	1.533LysAsp: 1.533 ± 0.033	1.334LysGlu: 1.334 ± 0.034	0.738LysPhe: 0.738 ± 0.023	2.495LysGly: 2.495 ± 0.042	0.507LysHis: 0.507 ± 0.017	1.429LysIle: 1.429 ± 0.033	0.919LysLys: 0.919 ± 0.033	2.622LysLeu: 2.622 ± 0.046	0.763LysMet: 0.763 ± 0.024	0.615LysAsn: 0.615 ± 0.02	1.622LysPro: 1.622 ± 0.032	0.713LysGln: 0.713 ± 0.018	1.901LysArg: 1.901 ± 0.036	1.573LysSer: 1.573 ± 0.031	1.711LysThr: 1.711 ± 0.037	2.14LysVal: 2.14 ± 0.038	0.311LysTrp: 0.311 ± 0.015	0.53LysTyr: 0.53 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.108LeuAla: 13.108 ± 0.127	0.958LeuCys: 0.958 ± 0.027	6.573LeuAsp: 6.573 ± 0.068	5.451LeuGlu: 5.451 ± 0.062	3.423LeuPhe: 3.423 ± 0.051	8.678LeuGly: 8.678 ± 0.092	1.837LeuHis: 1.837 ± 0.035	4.987LeuIle: 4.987 ± 0.065	2.936LeuLys: 2.936 ± 0.05	9.065LeuLeu: 9.065 ± 0.118	2.738LeuMet: 2.738 ± 0.048	2.553LeuAsn: 2.553 ± 0.041	5.735LeuPro: 5.735 ± 0.066	2.796LeuGln: 2.796 ± 0.048	7.161LeuArg: 7.161 ± 0.073	6.504LeuSer: 6.504 ± 0.07	6.028LeuThr: 6.028 ± 0.064	7.15LeuVal: 7.15 ± 0.072	1.262LeuTrp: 1.262 ± 0.03	2.022LeuTyr: 2.022 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.601MetAla: 3.601 ± 0.042	0.192MetCys: 0.192 ± 0.011	1.516MetAsp: 1.516 ± 0.032	1.47MetGlu: 1.47 ± 0.029	0.785MetPhe: 0.785 ± 0.023	2.333MetGly: 2.333 ± 0.036	0.474MetHis: 0.474 ± 0.018	1.58MetIle: 1.58 ± 0.03	0.972MetLys: 0.972 ± 0.024	2.636MetLeu: 2.636 ± 0.04	0.8MetMet: 0.8 ± 0.024	0.766MetAsn: 0.766 ± 0.023	1.575MetPro: 1.575 ± 0.034	0.947MetGln: 0.947 ± 0.025	1.993MetArg: 1.993 ± 0.034	1.832MetSer: 1.832 ± 0.036	2.209MetThr: 2.209 ± 0.037	1.941MetVal: 1.941 ± 0.04	0.247MetTrp: 0.247 ± 0.012	0.368MetTyr: 0.368 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.897AsnAla: 2.897 ± 0.04	0.242AsnCys: 0.242 ± 0.013	1.296AsnAsp: 1.296 ± 0.03	1.131AsnGlu: 1.131 ± 0.026	0.891AsnPhe: 0.891 ± 0.023	2.212AsnGly: 2.212 ± 0.048	0.46AsnHis: 0.46 ± 0.017	1.281AsnIle: 1.281 ± 0.029	0.523AsnLys: 0.523 ± 0.019	2.3AsnLeu: 2.3 ± 0.045	0.662AsnMet: 0.662 ± 0.02	0.581AsnAsn: 0.581 ± 0.022	1.741AsnPro: 1.741 ± 0.035	0.637AsnGln: 0.637 ± 0.02	1.628AsnArg: 1.628 ± 0.034	1.049AsnSer: 1.049 ± 0.031	1.223AsnThr: 1.223 ± 0.032	1.722AsnVal: 1.722 ± 0.036	0.407AsnTrp: 0.407 ± 0.017	0.638AsnTyr: 0.638 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.037ProAla: 6.037 ± 0.074	0.364ProCys: 0.364 ± 0.017	4.296ProAsp: 4.296 ± 0.049	4.55ProGlu: 4.55 ± 0.056	1.956ProPhe: 1.956 ± 0.032	5.238ProGly: 5.238 ± 0.066	1.065ProHis: 1.065 ± 0.027	2.2ProIle: 2.2 ± 0.033	1.434ProLys: 1.434 ± 0.033	4.791ProLeu: 4.791 ± 0.057	1.395ProMet: 1.395 ± 0.029	1.249ProAsn: 1.249 ± 0.03	2.603ProPro: 2.603 ± 0.05	1.681ProGln: 1.681 ± 0.032	3.074ProArg: 3.074 ± 0.046	2.575ProSer: 2.575 ± 0.035	2.374ProThr: 2.374 ± 0.036	4.534ProVal: 4.534 ± 0.054	0.759ProTrp: 0.759 ± 0.024	1.187ProTyr: 1.187 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.086GlnAla: 4.086 ± 0.047	0.197GlnCys: 0.197 ± 0.011	1.631GlnAsp: 1.631 ± 0.032	1.612GlnGlu: 1.612 ± 0.033	0.979GlnPhe: 0.979 ± 0.026	2.574GlnGly: 2.574 ± 0.045	0.529GlnHis: 0.529 ± 0.019	1.826GlnIle: 1.826 ± 0.035	0.908GlnLys: 0.908 ± 0.023	2.85GlnLeu: 2.85 ± 0.046	1.027GlnMet: 1.027 ± 0.027	0.757GlnAsn: 0.757 ± 0.022	1.599GlnPro: 1.599 ± 0.032	1.015GlnGln: 1.015 ± 0.032	2.106GlnArg: 2.106 ± 0.038	1.729GlnSer: 1.729 ± 0.043	1.652GlnThr: 1.652 ± 0.029	2.46GlnVal: 2.46 ± 0.043	0.387GlnTrp: 0.387 ± 0.015	0.56GlnTyr: 0.56 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.662ArgAla: 8.662 ± 0.083	0.497ArgCys: 0.497 ± 0.019	4.546ArgAsp: 4.546 ± 0.057	3.962ArgGlu: 3.962 ± 0.05	2.765ArgPhe: 2.765 ± 0.04	4.867ArgGly: 4.867 ± 0.06	1.602ArgHis: 1.602 ± 0.034	3.989ArgIle: 3.989 ± 0.054	2.143ArgLys: 2.143 ± 0.04	7.687ArgLeu: 7.687 ± 0.089	2.04ArgMet: 2.04 ± 0.04	1.688ArgAsn: 1.688 ± 0.032	3.618ArgPro: 3.618 ± 0.05	2.354ArgGln: 2.354 ± 0.039	5.247ArgArg: 5.247 ± 0.077	3.294ArgSer: 3.294 ± 0.048	3.145ArgThr: 3.145 ± 0.045	4.821ArgVal: 4.821 ± 0.058	0.96ArgTrp: 0.96 ± 0.028	1.582ArgTyr: 1.582 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.641SerAla: 5.641 ± 0.07	0.408SerCys: 0.408 ± 0.017	3.361SerAsp: 3.361 ± 0.052	2.841SerGlu: 2.841 ± 0.043	2.107SerPhe: 2.107 ± 0.042	5.52SerGly: 5.52 ± 0.085	1.056SerHis: 1.056 ± 0.027	2.357SerIle: 2.357 ± 0.043	1.225SerLys: 1.225 ± 0.03	4.86SerLeu: 4.86 ± 0.061	1.42SerMet: 1.42 ± 0.032	1.198SerAsn: 1.198 ± 0.029	2.547SerPro: 2.547 ± 0.038	1.485SerGln: 1.485 ± 0.032	3.294SerArg: 3.294 ± 0.043	2.525SerSer: 2.525 ± 0.052	2.488SerThr: 2.488 ± 0.044	3.891SerVal: 3.891 ± 0.06	0.763SerTrp: 0.763 ± 0.02	1.318SerTyr: 1.318 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.327ThrAla: 6.327 ± 0.069	0.499ThrCys: 0.499 ± 0.02	3.248ThrAsp: 3.248 ± 0.057	3.286ThrGlu: 3.286 ± 0.04	2.001ThrPhe: 2.001 ± 0.04	5.878ThrGly: 5.878 ± 0.075	1.102ThrHis: 1.102 ± 0.026	2.758ThrIle: 2.758 ± 0.046	1.204ThrLys: 1.204 ± 0.032	6.013ThrLeu: 6.013 ± 0.066	1.331ThrMet: 1.331 ± 0.032	1.2ThrAsn: 1.2 ± 0.029	3.447ThrPro: 3.447 ± 0.055	1.464ThrGln: 1.464 ± 0.034	3.723ThrArg: 3.723 ± 0.054	2.598ThrSer: 2.598 ± 0.045	2.918ThrThr: 2.918 ± 0.046	4.199ThrVal: 4.199 ± 0.056	0.772ThrTrp: 0.772 ± 0.022	1.27ThrTyr: 1.27 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.829ValAla: 8.829 ± 0.083	0.633ValCys: 0.633 ± 0.017	4.155ValAsp: 4.155 ± 0.058	4.584ValGlu: 4.584 ± 0.063	2.82ValPhe: 2.82 ± 0.055	5.436ValGly: 5.436 ± 0.07	1.331ValHis: 1.331 ± 0.031	4.146ValIle: 4.146 ± 0.05	1.944ValLys: 1.944 ± 0.039	7.55ValLeu: 7.55 ± 0.075	2.21ValMet: 2.21 ± 0.041	1.853ValAsn: 1.853 ± 0.035	3.853ValPro: 3.853 ± 0.047	2.041ValGln: 2.041 ± 0.039	4.337ValArg: 4.337 ± 0.05	4.288ValSer: 4.288 ± 0.057	5.052ValThr: 5.052 ± 0.066	5.658ValVal: 5.658 ± 0.075	0.94ValTrp: 0.94 ± 0.028	1.52ValTyr: 1.52 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.466TrpAla: 1.466 ± 0.036	0.137TrpCys: 0.137 ± 0.01	0.786TrpAsp: 0.786 ± 0.023	0.683TrpGlu: 0.683 ± 0.021	0.584TrpPhe: 0.584 ± 0.02	1.037TrpGly: 1.037 ± 0.025	0.343TrpHis: 0.343 ± 0.015	0.743TrpIle: 0.743 ± 0.021	0.454TrpLys: 0.454 ± 0.019	1.658TrpLeu: 1.658 ± 0.033	0.427TrpMet: 0.427 ± 0.018	0.416TrpAsn: 0.416 ± 0.017	0.743TrpPro: 0.743 ± 0.022	0.581TrpGln: 0.581 ± 0.02	1.114TrpArg: 1.114 ± 0.029	0.832TrpSer: 0.832 ± 0.023	0.899TrpThr: 0.899 ± 0.024	0.881TrpVal: 0.881 ± 0.024	0.237TrpTrp: 0.237 ± 0.012	0.275TrpTyr: 0.275 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.571TyrAla: 2.571 ± 0.039	0.25TyrCys: 0.25 ± 0.014	1.678TyrAsp: 1.678 ± 0.032	1.285TyrGlu: 1.285 ± 0.029	0.886TyrPhe: 0.886 ± 0.024	2.156TyrGly: 2.156 ± 0.041	0.497TyrHis: 0.497 ± 0.016	0.925TyrIle: 0.925 ± 0.024	0.517TyrLys: 0.517 ± 0.019	2.295TyrLeu: 2.295 ± 0.041	0.501TyrMet: 0.501 ± 0.019	0.566TyrAsn: 0.566 ± 0.022	1.144TyrPro: 1.144 ± 0.03	0.636TyrGln: 0.636 ± 0.022	1.56TyrArg: 1.56 ± 0.033	1.119TyrSer: 1.119 ± 0.028	1.158TyrThr: 1.158 ± 0.026	1.591TyrVal: 1.591 ± 0.03	0.359TyrTrp: 0.359 ± 0.018	0.587TyrTyr: 0.587 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5086 proteins (1621870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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