human papillomavirus 163

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 20

Average proteome isoelectric point is 6.07

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MYX6|K4MYX6_9PAPI Regulatory protein E2 OS=human papillomavirus 163 OX=1315262 GN=E2 PE=3 SV=1
MM1 pKa = 7.88RR2 pKa = 11.84GNAPNIQDD10 pKa = 3.16IEE12 pKa = 4.56LNLEE16 pKa = 4.09EE17 pKa = 5.32LVLPINVLSEE27 pKa = 4.14EE28 pKa = 4.64VIVSSDD34 pKa = 3.63DD35 pKa = 3.59EE36 pKa = 4.31EE37 pKa = 4.79QEE39 pKa = 3.94EE40 pKa = 4.84EE41 pKa = 4.24EE42 pKa = 4.26FVAYY46 pKa = 10.43RR47 pKa = 11.84IDD49 pKa = 3.93TCCHH53 pKa = 5.07SCRR56 pKa = 11.84ASVRR60 pKa = 11.84FTVFAKK66 pKa = 9.98TFAIRR71 pKa = 11.84LLEE74 pKa = 3.87QLILDD79 pKa = 4.48EE80 pKa = 5.62GLSLCCPSCARR91 pKa = 11.84NRR93 pKa = 11.84GRR95 pKa = 11.84NGRR98 pKa = 11.84RR99 pKa = 3.09

Molecular weight: 11.26 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MYX6|K4MYX6_9PAPI Regulatory protein E2 OS=human papillomavirus 163 OX=1315262 GN=E2 PE=3 SV=1
MM1 pKa = 8.34AMEE4 pKa = 4.65SLTDD8 pKa = 3.98RR9 pKa = 11.84FDD11 pKa = 3.95ALQEE15 pKa = 4.61LILKK19 pKa = 9.93HH20 pKa = 6.32IEE22 pKa = 3.92SDD24 pKa = 3.74STSLQSHH31 pKa = 5.16ITYY34 pKa = 8.85WGYY37 pKa = 10.2VRR39 pKa = 11.84KK40 pKa = 9.81EE41 pKa = 3.7NALMHH46 pKa = 6.2VARR49 pKa = 11.84QQGLTRR55 pKa = 11.84LGLQPLPALPVTEE68 pKa = 4.7YY69 pKa = 10.67NAKK72 pKa = 9.54QAITIQLTLQSLLRR86 pKa = 11.84SQYY89 pKa = 11.21GNEE92 pKa = 3.77PWTLTEE98 pKa = 4.67VSAEE102 pKa = 4.48LINTPPQNLLKK113 pKa = 10.34KK114 pKa = 10.28DD115 pKa = 3.72GFSVEE120 pKa = 3.77VWFDD124 pKa = 3.25NDD126 pKa = 3.08KK127 pKa = 11.13NNAMVYY133 pKa = 8.43TNWNDD138 pKa = 2.96MYY140 pKa = 11.26YY141 pKa = 10.69QDD143 pKa = 5.61AQEE146 pKa = 4.25TWHH149 pKa = 6.63KK150 pKa = 10.43VHH152 pKa = 7.14GSVDD156 pKa = 3.58YY157 pKa = 11.27NGLYY161 pKa = 8.8FTDD164 pKa = 3.91HH165 pKa = 6.19NGEE168 pKa = 3.88RR169 pKa = 11.84AYY171 pKa = 9.7FTLFDD176 pKa = 3.96TDD178 pKa = 4.61AIRR181 pKa = 11.84YY182 pKa = 6.27STTGLWTVHH191 pKa = 5.74YY192 pKa = 8.81KK193 pKa = 10.1SHH195 pKa = 6.57VISSSVVSSTTRR207 pKa = 11.84DD208 pKa = 3.15SSTTPEE214 pKa = 4.3DD215 pKa = 3.7SVDD218 pKa = 3.83RR219 pKa = 11.84PSTSYY224 pKa = 11.61ASTSKK229 pKa = 9.13TRR231 pKa = 11.84QQEE234 pKa = 4.11SPARR238 pKa = 11.84RR239 pKa = 11.84RR240 pKa = 11.84LQKK243 pKa = 10.53SGEE246 pKa = 4.22SPKK249 pKa = 10.38PSSTTSPEE257 pKa = 3.79TRR259 pKa = 11.84SIPLRR264 pKa = 11.84RR265 pKa = 11.84RR266 pKa = 11.84RR267 pKa = 11.84GEE269 pKa = 4.06GEE271 pKa = 3.99SAEE274 pKa = 4.41GPGGEE279 pKa = 4.41TPTKK283 pKa = 9.59RR284 pKa = 11.84RR285 pKa = 11.84RR286 pKa = 11.84GGRR289 pKa = 11.84EE290 pKa = 3.53LGFVPSPEE298 pKa = 4.3EE299 pKa = 3.45VGSRR303 pKa = 11.84HH304 pKa = 5.23RR305 pKa = 11.84TPEE308 pKa = 3.83TTGLSRR314 pKa = 11.84LGQLQADD321 pKa = 3.63AWDD324 pKa = 3.92PPIILVRR331 pKa = 11.84GLPNTLKK338 pKa = 9.98CWRR341 pKa = 11.84YY342 pKa = 10.14RR343 pKa = 11.84KK344 pKa = 9.08FQNANKK350 pKa = 9.14CFWKK354 pKa = 10.41ISTVFNWVGDD364 pKa = 3.89CDD366 pKa = 3.83KK367 pKa = 11.1SSRR370 pKa = 11.84GRR372 pKa = 11.84LIIAFKK378 pKa = 10.52SDD380 pKa = 2.95KK381 pKa = 10.32QRR383 pKa = 11.84EE384 pKa = 4.5CFVKK388 pKa = 10.15QHH390 pKa = 6.63LFPKK394 pKa = 10.0GSSYY398 pKa = 11.01TYY400 pKa = 10.71GHH402 pKa = 7.22LNGLL406 pKa = 4.02

Molecular weight: 46.18 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2277

99

607

379.5

42.76

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.621 ± 0.271

2.459 ± 1.039

6.28 ± 0.416

6.017 ± 0.597

4.787 ± 0.437

6.061 ± 0.764

2.108 ± 0.189

5.402 ± 0.572

5.094 ± 1.057

8.608 ± 0.624

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.581 ± 0.218

4.348 ± 0.327

5.621 ± 0.943

4.48 ± 0.351

5.621 ± 0.993

7.422 ± 0.795

6.807 ± 0.771

6.895 ± 0.627

1.361 ± 0.359

3.426 ± 0.383
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski