Amino acid dipepetide frequency for Streptomyces sp. CB02056

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.511AlaAla: 24.511 ± 0.189	1.043AlaCys: 1.043 ± 0.021	8.938AlaAsp: 8.938 ± 0.086	9.675AlaGlu: 9.675 ± 0.105	3.6AlaPhe: 3.6 ± 0.043	14.375AlaGly: 14.375 ± 0.1	2.871AlaHis: 2.871 ± 0.045	3.159AlaIle: 3.159 ± 0.043	2.609AlaLys: 2.609 ± 0.047	15.736AlaLeu: 15.736 ± 0.131	2.407AlaMet: 2.407 ± 0.036	2.006AlaAsn: 2.006 ± 0.032	8.089AlaPro: 8.089 ± 0.093	3.697AlaGln: 3.697 ± 0.043	10.593AlaArg: 10.593 ± 0.087	5.35AlaSer: 5.35 ± 0.057	7.303AlaThr: 7.303 ± 0.056	13.28AlaVal: 13.28 ± 0.106	1.929AlaTrp: 1.929 ± 0.028	2.62AlaTyr: 2.62 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.059CysAla: 1.059 ± 0.022	0.09CysCys: 0.09 ± 0.008	0.454CysAsp: 0.454 ± 0.015	0.372CysGlu: 0.372 ± 0.012	0.214CysPhe: 0.214 ± 0.009	0.944CysGly: 0.944 ± 0.023	0.198CysHis: 0.198 ± 0.01	0.147CysIle: 0.147 ± 0.008	0.09CysLys: 0.09 ± 0.006	0.806CysLeu: 0.806 ± 0.02	0.113CysMet: 0.113 ± 0.007	0.131CysAsn: 0.131 ± 0.009	0.511CysPro: 0.511 ± 0.018	0.168CysGln: 0.168 ± 0.008	0.613CysArg: 0.613 ± 0.018	0.421CysSer: 0.421 ± 0.013	0.487CysThr: 0.487 ± 0.017	0.574CysVal: 0.574 ± 0.018	0.125CysTrp: 0.125 ± 0.007	0.156CysTyr: 0.156 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.378AspAla: 7.378 ± 0.064	0.446AspCys: 0.446 ± 0.016	2.999AspAsp: 2.999 ± 0.045	3.565AspGlu: 3.565 ± 0.051	1.61AspPhe: 1.61 ± 0.027	6.748AspGly: 6.748 ± 0.061	1.483AspHis: 1.483 ± 0.027	1.488AspIle: 1.488 ± 0.028	0.975AspLys: 0.975 ± 0.027	6.701AspLeu: 6.701 ± 0.066	0.596AspMet: 0.596 ± 0.016	0.879AspAsn: 0.879 ± 0.024	4.805AspPro: 4.805 ± 0.058	1.643AspGln: 1.643 ± 0.028	5.195AspArg: 5.195 ± 0.051	2.298AspSer: 2.298 ± 0.031	3.104AspThr: 3.104 ± 0.038	4.252AspVal: 4.252 ± 0.049	1.049AspTrp: 1.049 ± 0.023	1.127AspTyr: 1.127 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.638GluAla: 7.638 ± 0.087	0.343GluCys: 0.343 ± 0.013	2.789GluAsp: 2.789 ± 0.036	3.441GluGlu: 3.441 ± 0.05	1.48GluPhe: 1.48 ± 0.026	4.003GluGly: 4.003 ± 0.043	1.567GluHis: 1.567 ± 0.028	1.923GluIle: 1.923 ± 0.031	1.124GluLys: 1.124 ± 0.027	7.45GluLeu: 7.45 ± 0.086	0.681GluMet: 0.681 ± 0.021	0.857GluAsn: 0.857 ± 0.021	3.444GluPro: 3.444 ± 0.044	2.397GluGln: 2.397 ± 0.037	5.632GluArg: 5.632 ± 0.066	2.288GluSer: 2.288 ± 0.035	2.535GluThr: 2.535 ± 0.032	4.549GluVal: 4.549 ± 0.058	0.704GluTrp: 0.704 ± 0.019	1.061GluTyr: 1.061 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.725PheAla: 3.725 ± 0.046	0.259PheCys: 0.259 ± 0.011	2.001PheAsp: 2.001 ± 0.035	1.431PheGlu: 1.431 ± 0.023	0.804PhePhe: 0.804 ± 0.021	3.005PheGly: 3.005 ± 0.036	0.632PheHis: 0.632 ± 0.014	0.641PheIle: 0.641 ± 0.017	0.418PheLys: 0.418 ± 0.015	2.555PheLeu: 2.555 ± 0.042	0.339PheMet: 0.339 ± 0.011	0.555PheAsn: 0.555 ± 0.016	1.428PhePro: 1.428 ± 0.024	0.679PheGln: 0.679 ± 0.017	1.805PheArg: 1.805 ± 0.026	1.333PheSer: 1.333 ± 0.026	1.979PheThr: 1.979 ± 0.028	2.062PheVal: 2.062 ± 0.032	0.404PheTrp: 0.404 ± 0.015	0.541PheTyr: 0.541 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.79GlyAla: 11.79 ± 0.096	0.853GlyCys: 0.853 ± 0.018	4.886GlyAsp: 4.886 ± 0.044	5.145GlyGlu: 5.145 ± 0.047	2.882GlyPhe: 2.882 ± 0.039	9.306GlyGly: 9.306 ± 0.087	2.38GlyHis: 2.38 ± 0.036	3.217GlyIle: 3.217 ± 0.038	2.079GlyLys: 2.079 ± 0.039	10.359GlyLeu: 10.359 ± 0.08	1.835GlyMet: 1.835 ± 0.031	1.71GlyAsn: 1.71 ± 0.031	5.947GlyPro: 5.947 ± 0.066	2.797GlyGln: 2.797 ± 0.036	8.335GlyArg: 8.335 ± 0.069	5.342GlySer: 5.342 ± 0.059	6.488GlyThr: 6.488 ± 0.056	7.496GlyVal: 7.496 ± 0.066	1.835GlyTrp: 1.835 ± 0.029	2.44GlyTyr: 2.44 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.634HisAla: 2.634 ± 0.035	0.222HisCys: 0.222 ± 0.011	1.239HisAsp: 1.239 ± 0.024	1.114HisGlu: 1.114 ± 0.024	0.619HisPhe: 0.619 ± 0.018	2.505HisGly: 2.505 ± 0.035	0.72HisHis: 0.72 ± 0.023	0.546HisIle: 0.546 ± 0.017	0.294HisLys: 0.294 ± 0.01	2.679HisLeu: 2.679 ± 0.039	0.275HisMet: 0.275 ± 0.012	0.364HisAsn: 0.364 ± 0.013	1.925HisPro: 1.925 ± 0.033	0.678HisGln: 0.678 ± 0.017	2.23HisArg: 2.23 ± 0.035	0.98HisSer: 0.98 ± 0.023	1.224HisThr: 1.224 ± 0.023	1.538HisVal: 1.538 ± 0.028	0.415HisTrp: 0.415 ± 0.013	0.49HisTyr: 0.49 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.56IleAla: 4.56 ± 0.052	0.262IleCys: 0.262 ± 0.01	1.967IleAsp: 1.967 ± 0.03	1.782IleGlu: 1.782 ± 0.028	0.548IlePhe: 0.548 ± 0.016	3.474IleGly: 3.474 ± 0.042	0.533IleHis: 0.533 ± 0.016	0.692IleIle: 0.692 ± 0.019	0.578IleLys: 0.578 ± 0.017	2.042IleLeu: 2.042 ± 0.032	0.37IleMet: 0.37 ± 0.014	0.606IleAsn: 0.606 ± 0.017	1.576IlePro: 1.576 ± 0.026	0.625IleGln: 0.625 ± 0.017	2.072IleArg: 2.072 ± 0.031	1.444IleSer: 1.444 ± 0.025	2.025IleThr: 2.025 ± 0.035	2.299IleVal: 2.299 ± 0.034	0.334IleTrp: 0.334 ± 0.013	0.422IleTyr: 0.422 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.6LysAla: 2.6 ± 0.047	0.09LysCys: 0.09 ± 0.007	1.098LysAsp: 1.098 ± 0.024	0.938LysGlu: 0.938 ± 0.023	0.38LysPhe: 0.38 ± 0.013	1.533LysGly: 1.533 ± 0.03	0.39LysHis: 0.39 ± 0.012	0.659LysIle: 0.659 ± 0.021	0.543LysLys: 0.543 ± 0.023	1.79LysLeu: 1.79 ± 0.032	0.296LysMet: 0.296 ± 0.013	0.399LysAsn: 0.399 ± 0.018	1.23LysPro: 1.23 ± 0.03	0.623LysGln: 0.623 ± 0.018	1.197LysArg: 1.197 ± 0.026	0.947LysSer: 0.947 ± 0.025	1.041LysThr: 1.041 ± 0.025	1.65LysVal: 1.65 ± 0.03	0.201LysTrp: 0.201 ± 0.01	0.381LysTyr: 0.381 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	17.488LeuAla: 17.488 ± 0.128	0.828LeuCys: 0.828 ± 0.022	7.258LeuAsp: 7.258 ± 0.067	4.627LeuGlu: 4.627 ± 0.046	2.629LeuPhe: 2.629 ± 0.038	10.016LeuGly: 10.016 ± 0.078	2.401LeuHis: 2.401 ± 0.035	2.941LeuIle: 2.941 ± 0.044	1.759LeuLys: 1.759 ± 0.036	12.405LeuLeu: 12.405 ± 0.115	1.482LeuMet: 1.482 ± 0.027	1.712LeuAsn: 1.712 ± 0.029	7.317LeuPro: 7.317 ± 0.078	2.151LeuGln: 2.151 ± 0.032	9.186LeuArg: 9.186 ± 0.082	5.176LeuSer: 5.176 ± 0.048	7.023LeuThr: 7.023 ± 0.064	9.306LeuVal: 9.306 ± 0.072	1.363LeuTrp: 1.363 ± 0.026	1.799LeuTyr: 1.799 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.081MetAla: 2.081 ± 0.029	0.115MetCys: 0.115 ± 0.007	0.798MetAsp: 0.798 ± 0.018	0.615MetGlu: 0.615 ± 0.018	0.405MetPhe: 0.405 ± 0.014	1.146MetGly: 1.146 ± 0.026	0.307MetHis: 0.307 ± 0.012	0.569MetIle: 0.569 ± 0.015	0.319MetLys: 0.319 ± 0.011	1.569MetLeu: 1.569 ± 0.028	0.25MetMet: 0.25 ± 0.011	0.363MetAsn: 0.363 ± 0.012	1.013MetPro: 1.013 ± 0.021	0.368MetGln: 0.368 ± 0.014	1.251MetArg: 1.251 ± 0.023	1.082MetSer: 1.082 ± 0.019	1.386MetThr: 1.386 ± 0.025	1.229MetVal: 1.229 ± 0.023	0.167MetTrp: 0.167 ± 0.008	0.287MetTyr: 0.287 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.141AsnAla: 2.141 ± 0.042	0.151AsnCys: 0.151 ± 0.008	0.888AsnAsp: 0.888 ± 0.018	0.738AsnGlu: 0.738 ± 0.02	0.444AsnPhe: 0.444 ± 0.015	1.947AsnGly: 1.947 ± 0.037	0.374AsnHis: 0.374 ± 0.015	0.554AsnIle: 0.554 ± 0.017	0.326AsnLys: 0.326 ± 0.015	1.691AsnLeu: 1.691 ± 0.033	0.246AsnMet: 0.246 ± 0.01	0.393AsnAsn: 0.393 ± 0.016	1.399AsnPro: 1.399 ± 0.029	0.533AsnGln: 0.533 ± 0.014	1.236AsnArg: 1.236 ± 0.02	0.907AsnSer: 0.907 ± 0.023	1.1AsnThr: 1.1 ± 0.028	1.248AsnVal: 1.248 ± 0.025	0.265AsnTrp: 0.265 ± 0.011	0.394AsnTyr: 0.394 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.311ProAla: 10.311 ± 0.103	0.343ProCys: 0.343 ± 0.012	4.709ProAsp: 4.709 ± 0.049	4.517ProGlu: 4.517 ± 0.056	1.549ProPhe: 1.549 ± 0.027	7.518ProGly: 7.518 ± 0.07	1.294ProHis: 1.294 ± 0.025	1.296ProIle: 1.296 ± 0.022	1.058ProLys: 1.058 ± 0.028	5.727ProLeu: 5.727 ± 0.069	0.9ProMet: 0.9 ± 0.02	1.011ProAsn: 1.011 ± 0.023	3.525ProPro: 3.525 ± 0.059	1.78ProGln: 1.78 ± 0.033	3.995ProArg: 3.995 ± 0.045	3.092ProSer: 3.092 ± 0.04	3.54ProThr: 3.54 ± 0.048	6.002ProVal: 6.002 ± 0.054	0.927ProTrp: 0.927 ± 0.018	1.376ProTyr: 1.376 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.033GlnAla: 4.033 ± 0.048	0.181GlnCys: 0.181 ± 0.008	1.412GlnAsp: 1.412 ± 0.026	1.37GlnGlu: 1.37 ± 0.027	0.631GlnPhe: 0.631 ± 0.015	2.244GlnGly: 2.244 ± 0.034	0.641GlnHis: 0.641 ± 0.015	0.925GlnIle: 0.925 ± 0.022	0.501GlnLys: 0.501 ± 0.016	3.244GlnLeu: 3.244 ± 0.038	0.374GlnMet: 0.374 ± 0.014	0.482GlnAsn: 0.482 ± 0.016	1.815GlnPro: 1.815 ± 0.035	1.294GlnGln: 1.294 ± 0.035	2.392GlnArg: 2.392 ± 0.036	1.254GlnSer: 1.254 ± 0.024	1.206GlnThr: 1.206 ± 0.025	2.404GlnVal: 2.404 ± 0.032	0.464GlnTrp: 0.464 ± 0.013	0.581GlnTyr: 0.581 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.379ArgAla: 10.379 ± 0.081	0.562ArgCys: 0.562 ± 0.017	4.011ArgAsp: 4.011 ± 0.046	4.823ArgGlu: 4.823 ± 0.06	2.299ArgPhe: 2.299 ± 0.027	5.652ArgGly: 5.652 ± 0.057	2.165ArgHis: 2.165 ± 0.033	3.251ArgIle: 3.251 ± 0.04	1.344ArgLys: 1.344 ± 0.028	9.563ArgLeu: 9.563 ± 0.082	1.666ArgMet: 1.666 ± 0.028	1.264ArgAsn: 1.264 ± 0.025	5.588ArgPro: 5.588 ± 0.068	2.314ArgGln: 2.314 ± 0.033	7.881ArgArg: 7.881 ± 0.078	3.944ArgSer: 3.944 ± 0.043	5.496ArgThr: 5.496 ± 0.046	5.701ArgVal: 5.701 ± 0.049	1.384ArgTrp: 1.384 ± 0.026	1.869ArgTyr: 1.869 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.533SerAla: 6.533 ± 0.069	0.435SerCys: 0.435 ± 0.016	2.332SerAsp: 2.332 ± 0.037	2.079SerGlu: 2.079 ± 0.031	1.456SerPhe: 1.456 ± 0.023	5.737SerGly: 5.737 ± 0.059	0.917SerHis: 0.917 ± 0.019	1.34SerIle: 1.34 ± 0.025	0.852SerLys: 0.852 ± 0.023	4.521SerLeu: 4.521 ± 0.046	0.947SerMet: 0.947 ± 0.021	0.824SerAsn: 0.824 ± 0.022	3.043SerPro: 3.043 ± 0.04	1.099SerGln: 1.099 ± 0.025	3.326SerArg: 3.326 ± 0.037	2.546SerSer: 2.546 ± 0.048	3.03SerThr: 3.03 ± 0.041	4.029SerVal: 4.029 ± 0.041	0.911SerTrp: 0.911 ± 0.02	1.173SerTyr: 1.173 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.662ThrAla: 9.662 ± 0.076	0.408ThrCys: 0.408 ± 0.016	3.522ThrAsp: 3.522 ± 0.042	3.099ThrGlu: 3.099 ± 0.036	1.497ThrPhe: 1.497 ± 0.029	7.133ThrGly: 7.133 ± 0.068	1.066ThrHis: 1.066 ± 0.02	1.49ThrIle: 1.49 ± 0.028	0.94ThrLys: 0.94 ± 0.024	5.562ThrLeu: 5.562 ± 0.045	0.823ThrMet: 0.823 ± 0.019	0.987ThrAsn: 0.987 ± 0.028	4.249ThrPro: 4.249 ± 0.057	1.127ThrGln: 1.127 ± 0.025	3.777ThrArg: 3.777 ± 0.04	2.798ThrSer: 2.798 ± 0.043	3.89ThrThr: 3.89 ± 0.06	6.466ThrVal: 6.466 ± 0.06	0.849ThrTrp: 0.849 ± 0.022	1.153ThrTyr: 1.153 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.026ValAla: 11.026 ± 0.081	0.712ValCys: 0.712 ± 0.019	4.994ValAsp: 4.994 ± 0.052	4.779ValGlu: 4.779 ± 0.052	2.441ValPhe: 2.441 ± 0.035	6.558ValGly: 6.558 ± 0.057	1.979ValHis: 1.979 ± 0.029	2.456ValIle: 2.456 ± 0.036	1.546ValLys: 1.546 ± 0.027	10.36ValLeu: 10.36 ± 0.078	1.238ValMet: 1.238 ± 0.024	1.648ValAsn: 1.648 ± 0.03	5.571ValPro: 5.571 ± 0.055	2.116ValGln: 2.116 ± 0.032	7.126ValArg: 7.126 ± 0.062	4.078ValSer: 4.078 ± 0.045	5.407ValThr: 5.407 ± 0.065	7.954ValVal: 7.954 ± 0.081	1.062ValTrp: 1.062 ± 0.022	1.503ValTyr: 1.503 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.7TrpAla: 1.7 ± 0.027	0.147TrpCys: 0.147 ± 0.008	0.76TrpAsp: 0.76 ± 0.02	0.75TrpGlu: 0.75 ± 0.02	0.481TrpPhe: 0.481 ± 0.015	1.025TrpGly: 1.025 ± 0.023	0.381TrpHis: 0.381 ± 0.013	0.513TrpIle: 0.513 ± 0.016	0.312TrpLys: 0.312 ± 0.011	1.829TrpLeu: 1.829 ± 0.033	0.272TrpMet: 0.272 ± 0.01	0.389TrpAsn: 0.389 ± 0.015	0.826TrpPro: 0.826 ± 0.018	0.671TrpGln: 0.671 ± 0.017	1.337TrpArg: 1.337 ± 0.022	0.963TrpSer: 0.963 ± 0.023	1.062TrpThr: 1.062 ± 0.022	0.988TrpVal: 0.988 ± 0.022	0.334TrpTrp: 0.334 ± 0.013	0.36TrpTyr: 0.36 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.544TyrAla: 2.544 ± 0.033	0.182TyrCys: 0.182 ± 0.01	1.29TyrAsp: 1.29 ± 0.028	1.048TyrGlu: 1.048 ± 0.023	0.623TyrPhe: 0.623 ± 0.017	2.251TyrGly: 2.251 ± 0.033	0.389TyrHis: 0.389 ± 0.013	0.402TyrIle: 0.402 ± 0.014	0.317TyrLys: 0.317 ± 0.013	2.279TyrLeu: 2.279 ± 0.034	0.209TyrMet: 0.209 ± 0.01	0.399TyrAsn: 0.399 ± 0.017	1.168TyrPro: 1.168 ± 0.025	0.691TyrGln: 0.691 ± 0.016	1.977TyrArg: 1.977 ± 0.028	0.887TyrSer: 0.887 ± 0.021	1.174TyrThr: 1.174 ± 0.025	1.524TyrVal: 1.524 ± 0.03	0.379TyrTrp: 0.379 ± 0.014	0.434TyrTyr: 0.434 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.004

Statistics based on 7266 proteins (2401140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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