Amino acid dipepetide frequency for Dokdonia pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.933AlaAla: 3.933 ± 0.073	0.564AlaCys: 0.564 ± 0.018	3.212AlaAsp: 3.212 ± 0.086	3.272AlaGlu: 3.272 ± 0.051	3.636AlaPhe: 3.636 ± 0.054	3.954AlaGly: 3.954 ± 0.065	1.203AlaHis: 1.203 ± 0.025	5.939AlaIle: 5.939 ± 0.069	4.124AlaLys: 4.124 ± 0.07	6.323AlaLeu: 6.323 ± 0.076	1.457AlaMet: 1.457 ± 0.033	3.249AlaAsn: 3.249 ± 0.055	2.022AlaPro: 2.022 ± 0.035	2.768AlaGln: 2.768 ± 0.04	2.029AlaArg: 2.029 ± 0.04	4.513AlaSer: 4.513 ± 0.051	4.405AlaThr: 4.405 ± 0.071	3.833AlaVal: 3.833 ± 0.054	0.61AlaTrp: 0.61 ± 0.021	2.624AlaTyr: 2.624 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.463CysAla: 0.463 ± 0.018	0.127CysCys: 0.127 ± 0.01	0.489CysAsp: 0.489 ± 0.023	0.434CysGlu: 0.434 ± 0.018	0.4CysPhe: 0.4 ± 0.018	0.572CysGly: 0.572 ± 0.019	0.172CysHis: 0.172 ± 0.011	0.697CysIle: 0.697 ± 0.019	0.449CysLys: 0.449 ± 0.016	0.65CysLeu: 0.65 ± 0.023	0.181CysMet: 0.181 ± 0.012	0.408CysAsn: 0.408 ± 0.015	0.326CysPro: 0.326 ± 0.016	0.226CysGln: 0.226 ± 0.013	0.185CysArg: 0.185 ± 0.011	0.572CysSer: 0.572 ± 0.022	0.495CysThr: 0.495 ± 0.021	0.457CysVal: 0.457 ± 0.018	0.063CysTrp: 0.063 ± 0.006	0.311CysTyr: 0.311 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.229AspAla: 4.229 ± 0.063	0.467AspCys: 0.467 ± 0.022	3.454AspAsp: 3.454 ± 0.074	3.513AspGlu: 3.513 ± 0.052	3.629AspPhe: 3.629 ± 0.055	4.478AspGly: 4.478 ± 0.159	1.113AspHis: 1.113 ± 0.029	5.134AspIle: 5.134 ± 0.063	3.338AspLys: 3.338 ± 0.051	5.112AspLeu: 5.112 ± 0.066	1.103AspMet: 1.103 ± 0.028	3.106AspAsn: 3.106 ± 0.056	2.224AspPro: 2.224 ± 0.066	2.076AspGln: 2.076 ± 0.038	2.112AspArg: 2.112 ± 0.036	3.265AspSer: 3.265 ± 0.05	3.927AspThr: 3.927 ± 0.058	3.769AspVal: 3.769 ± 0.067	0.76AspTrp: 0.76 ± 0.022	2.763AspTyr: 2.763 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.413GluAla: 4.413 ± 0.06	0.353GluCys: 0.353 ± 0.015	3.851GluAsp: 3.851 ± 0.054	5.086GluGlu: 5.086 ± 0.075	2.644GluPhe: 2.644 ± 0.046	3.986GluGly: 3.986 ± 0.055	1.168GluHis: 1.168 ± 0.028	5.385GluIle: 5.385 ± 0.059	5.197GluLys: 5.197 ± 0.072	5.769GluLeu: 5.769 ± 0.066	1.455GluMet: 1.455 ± 0.031	4.415GluAsn: 4.415 ± 0.059	1.462GluPro: 1.462 ± 0.029	2.333GluGln: 2.333 ± 0.045	2.538GluArg: 2.538 ± 0.044	3.439GluSer: 3.439 ± 0.054	3.908GluThr: 3.908 ± 0.051	4.459GluVal: 4.459 ± 0.057	0.597GluTrp: 0.597 ± 0.02	2.459GluTyr: 2.459 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.973PheAla: 2.973 ± 0.046	0.431PheCys: 0.431 ± 0.016	3.372PheAsp: 3.372 ± 0.055	3.359PheGlu: 3.359 ± 0.046	2.754PhePhe: 2.754 ± 0.052	3.27PheGly: 3.27 ± 0.05	0.765PheHis: 0.765 ± 0.02	3.976PheIle: 3.976 ± 0.067	3.37PheLys: 3.37 ± 0.055	4.644PheLeu: 4.644 ± 0.062	1.054PheMet: 1.054 ± 0.025	2.98PheAsn: 2.98 ± 0.052	1.712PhePro: 1.712 ± 0.033	1.599PheGln: 1.599 ± 0.036	1.661PheArg: 1.661 ± 0.039	3.815PheSer: 3.815 ± 0.055	3.378PheThr: 3.378 ± 0.056	2.878PheVal: 2.878 ± 0.048	0.598PheTrp: 0.598 ± 0.021	2.189PheTyr: 2.189 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.265GlyAla: 4.265 ± 0.108	0.59GlyCys: 0.59 ± 0.025	3.939GlyAsp: 3.939 ± 0.075	3.592GlyGlu: 3.592 ± 0.052	3.453GlyPhe: 3.453 ± 0.056	4.56GlyGly: 4.56 ± 0.082	1.082GlyHis: 1.082 ± 0.028	5.497GlyIle: 5.497 ± 0.07	4.139GlyLys: 4.139 ± 0.068	5.405GlyLeu: 5.405 ± 0.068	1.527GlyMet: 1.527 ± 0.038	3.909GlyAsn: 3.909 ± 0.07	1.589GlyPro: 1.589 ± 0.176	2.008GlyGln: 2.008 ± 0.039	2.114GlyArg: 2.114 ± 0.037	3.848GlySer: 3.848 ± 0.06	4.441GlyThr: 4.441 ± 0.092	4.433GlyVal: 4.433 ± 0.067	0.75GlyTrp: 0.75 ± 0.023	2.787GlyTyr: 2.787 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.98HisAla: 0.98 ± 0.027	0.181HisCys: 0.181 ± 0.012	0.83HisAsp: 0.83 ± 0.024	0.908HisGlu: 0.908 ± 0.025	1.124HisPhe: 1.124 ± 0.03	0.982HisGly: 0.982 ± 0.03	0.535HisHis: 0.535 ± 0.021	1.714HisIle: 1.714 ± 0.038	1.312HisLys: 1.312 ± 0.035	1.899HisLeu: 1.899 ± 0.034	0.361HisMet: 0.361 ± 0.013	0.914HisAsn: 0.914 ± 0.024	0.902HisPro: 0.902 ± 0.025	0.8HisGln: 0.8 ± 0.024	0.711HisArg: 0.711 ± 0.024	1.054HisSer: 1.054 ± 0.025	1.259HisThr: 1.259 ± 0.028	0.924HisVal: 0.924 ± 0.024	0.258HisTrp: 0.258 ± 0.013	0.896HisTyr: 0.896 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.063IleAla: 6.063 ± 0.061	0.651IleCys: 0.651 ± 0.02	5.46IleAsp: 5.46 ± 0.066	5.522IleGlu: 5.522 ± 0.072	3.422IlePhe: 3.422 ± 0.051	5.177IleGly: 5.177 ± 0.07	1.563IleHis: 1.563 ± 0.033	6.262IleIle: 6.262 ± 0.075	5.411IleLys: 5.411 ± 0.074	7.014IleLeu: 7.014 ± 0.086	1.235IleMet: 1.235 ± 0.027	4.537IleAsn: 4.537 ± 0.062	3.464IlePro: 3.464 ± 0.045	3.105IleGln: 3.105 ± 0.042	2.615IleArg: 2.615 ± 0.037	5.774IleSer: 5.774 ± 0.067	5.853IleThr: 5.853 ± 0.064	4.91IleVal: 4.91 ± 0.067	0.726IleTrp: 0.726 ± 0.021	2.916IleTyr: 2.916 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.73LysAla: 4.73 ± 0.07	0.302LysCys: 0.302 ± 0.016	4.186LysAsp: 4.186 ± 0.055	6.292LysGlu: 6.292 ± 0.091	2.253LysPhe: 2.253 ± 0.042	4.142LysGly: 4.142 ± 0.058	1.326LysHis: 1.326 ± 0.03	5.175LysIle: 5.175 ± 0.07	6.468LysLys: 6.468 ± 0.084	5.548LysLeu: 5.548 ± 0.072	1.708LysMet: 1.708 ± 0.031	4.496LysAsn: 4.496 ± 0.067	1.988LysPro: 1.988 ± 0.04	2.572LysGln: 2.572 ± 0.049	2.936LysArg: 2.936 ± 0.049	3.885LysSer: 3.885 ± 0.061	4.42LysThr: 4.42 ± 0.065	4.012LysVal: 4.012 ± 0.051	0.679LysTrp: 0.679 ± 0.023	2.685LysTyr: 2.685 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	5.376LeuAla: 5.376 ± 0.058	0.784LeuCys: 0.784 ± 0.024	5.439LeuAsp: 5.439 ± 0.063	6.227LeuGlu: 6.227 ± 0.074	4.978LeuPhe: 4.978 ± 0.068	5.596LeuGly: 5.596 ± 0.069	1.668LeuHis: 1.668 ± 0.037	6.912LeuIle: 6.912 ± 0.084	6.836LeuLys: 6.836 ± 0.095	8.869LeuLeu: 8.869 ± 0.116	1.86LeuMet: 1.86 ± 0.035	4.872LeuAsn: 4.872 ± 0.061	3.429LeuPro: 3.429 ± 0.053	3.525LeuGln: 3.525 ± 0.047	3.261LeuArg: 3.261 ± 0.052	6.748LeuSer: 6.748 ± 0.062	5.199LeuThr: 5.199 ± 0.067	5.009LeuVal: 5.009 ± 0.058	0.873LeuTrp: 0.873 ± 0.024	3.394LeuTyr: 3.394 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.361MetAla: 1.361 ± 0.033	0.131MetCys: 0.131 ± 0.008	1.066MetAsp: 1.066 ± 0.027	1.201MetGlu: 1.201 ± 0.026	0.714MetPhe: 0.714 ± 0.034	1.299MetGly: 1.299 ± 0.034	0.422MetHis: 0.422 ± 0.017	1.609MetIle: 1.609 ± 0.032	1.963MetLys: 1.963 ± 0.038	1.758MetLeu: 1.758 ± 0.033	0.549MetMet: 0.549 ± 0.02	1.23MetAsn: 1.23 ± 0.027	0.775MetPro: 0.775 ± 0.023	0.767MetGln: 0.767 ± 0.019	0.895MetArg: 0.895 ± 0.023	1.397MetSer: 1.397 ± 0.032	1.224MetThr: 1.224 ± 0.027	1.168MetVal: 1.168 ± 0.024	0.169MetTrp: 0.169 ± 0.012	0.772MetTyr: 0.772 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.844AsnAla: 3.844 ± 0.053	0.448AsnCys: 0.448 ± 0.016	3.603AsnAsp: 3.603 ± 0.069	3.451AsnGlu: 3.451 ± 0.052	2.729AsnPhe: 2.729 ± 0.054	4.278AsnGly: 4.278 ± 0.081	1.06AsnHis: 1.06 ± 0.028	4.27AsnIle: 4.27 ± 0.058	3.537AsnLys: 3.537 ± 0.056	4.774AsnLeu: 4.774 ± 0.066	1.071AsnMet: 1.071 ± 0.028	3.633AsnAsn: 3.633 ± 0.075	2.771AsnPro: 2.771 ± 0.045	2.125AsnGln: 2.125 ± 0.036	2.125AsnArg: 2.125 ± 0.037	3.565AsnSer: 3.565 ± 0.048	4.321AsnThr: 4.321 ± 0.059	3.251AsnVal: 3.251 ± 0.057	0.71AsnTrp: 0.71 ± 0.025	2.589AsnTyr: 2.589 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	1.922ProAla: 1.922 ± 0.05	0.218ProCys: 0.218 ± 0.017	2.402ProAsp: 2.402 ± 0.047	2.835ProGlu: 2.835 ± 0.043	1.956ProPhe: 1.956 ± 0.034	1.826ProGly: 1.826 ± 0.038	0.622ProHis: 0.622 ± 0.019	2.902ProIle: 2.902 ± 0.041	2.322ProLys: 2.322 ± 0.041	3.056ProLeu: 3.056 ± 0.044	0.67ProMet: 0.67 ± 0.023	2.245ProAsn: 2.245 ± 0.045	0.979ProPro: 0.979 ± 0.03	1.23ProGln: 1.23 ± 0.104	0.919ProArg: 0.919 ± 0.024	2.416ProSer: 2.416 ± 0.044	2.289ProThr: 2.289 ± 0.043	2.307ProVal: 2.307 ± 0.041	0.344ProTrp: 0.344 ± 0.018	1.432ProTyr: 1.432 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.168GlnAla: 2.168 ± 0.035	0.201GlnCys: 0.201 ± 0.011	2.048GlnAsp: 2.048 ± 0.034	2.898GlnGlu: 2.898 ± 0.042	1.703GlnPhe: 1.703 ± 0.034	2.242GlnGly: 2.242 ± 0.119	0.66GlnHis: 0.66 ± 0.02	2.676GlnIle: 2.676 ± 0.046	2.929GlnLys: 2.929 ± 0.049	3.809GlnLeu: 3.809 ± 0.055	0.8GlnMet: 0.8 ± 0.025	2.157GlnAsn: 2.157 ± 0.04	1.201GlnPro: 1.201 ± 0.026	1.569GlnGln: 1.569 ± 0.032	1.331GlnArg: 1.331 ± 0.028	2.114GlnSer: 2.114 ± 0.038	2.101GlnThr: 2.101 ± 0.043	2.12GlnVal: 2.12 ± 0.036	0.389GlnTrp: 0.389 ± 0.016	1.43GlnTyr: 1.43 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.05ArgAla: 2.05 ± 0.038	0.204ArgCys: 0.204 ± 0.012	1.993ArgAsp: 1.993 ± 0.038	2.175ArgGlu: 2.175 ± 0.036	2.067ArgPhe: 2.067 ± 0.034	1.969ArgGly: 1.969 ± 0.038	0.606ArgHis: 0.606 ± 0.02	3.117ArgIle: 3.117 ± 0.046	2.748ArgLys: 2.748 ± 0.043	3.337ArgLeu: 3.337 ± 0.051	0.853ArgMet: 0.853 ± 0.023	2.121ArgAsn: 2.121 ± 0.038	1.1ArgPro: 1.1 ± 0.028	1.093ArgGln: 1.093 ± 0.028	1.381ArgArg: 1.381 ± 0.04	2.076ArgSer: 2.076 ± 0.041	1.991ArgThr: 1.991 ± 0.037	2.155ArgVal: 2.155 ± 0.034	0.417ArgTrp: 0.417 ± 0.015	1.636ArgTyr: 1.636 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	3.556SerAla: 3.556 ± 0.055	0.683SerCys: 0.683 ± 0.022	3.782SerAsp: 3.782 ± 0.061	3.932SerGlu: 3.932 ± 0.054	3.845SerPhe: 3.845 ± 0.055	4.457SerGly: 4.457 ± 0.078	1.131SerHis: 1.131 ± 0.032	5.598SerIle: 5.598 ± 0.063	4.627SerLys: 4.627 ± 0.071	6.109SerLeu: 6.109 ± 0.069	1.26SerMet: 1.26 ± 0.029	3.858SerAsn: 3.858 ± 0.055	2.076SerPro: 2.076 ± 0.037	2.447SerGln: 2.447 ± 0.039	2.236SerArg: 2.236 ± 0.038	4.289SerSer: 4.289 ± 0.065	3.744SerThr: 3.744 ± 0.063	3.796SerVal: 3.796 ± 0.05	0.682SerTrp: 0.682 ± 0.021	2.968SerTyr: 2.968 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.192ThrAla: 4.192 ± 0.065	0.389ThrCys: 0.389 ± 0.016	3.758ThrAsp: 3.758 ± 0.074	3.578ThrGlu: 3.578 ± 0.044	3.306ThrPhe: 3.306 ± 0.06	4.177ThrGly: 4.177 ± 0.071	1.294ThrHis: 1.294 ± 0.029	5.949ThrIle: 5.949 ± 0.08	3.744ThrLys: 3.744 ± 0.054	6.307ThrLeu: 6.307 ± 0.068	1.065ThrMet: 1.065 ± 0.027	3.586ThrAsn: 3.586 ± 0.064	2.955ThrPro: 2.955 ± 0.048	2.319ThrGln: 2.319 ± 0.039	1.884ThrArg: 1.884 ± 0.037	4.662ThrSer: 4.662 ± 0.06	4.688ThrThr: 4.688 ± 0.077	4.218ThrVal: 4.218 ± 0.083	0.634ThrTrp: 0.634 ± 0.023	2.89ThrTyr: 2.89 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.081ValAla: 4.081 ± 0.059	0.522ValCys: 0.522 ± 0.016	3.518ValAsp: 3.518 ± 0.057	3.437ValGlu: 3.437 ± 0.048	3.344ValPhe: 3.344 ± 0.052	3.73ValGly: 3.73 ± 0.065	1.048ValHis: 1.048 ± 0.028	4.946ValIle: 4.946 ± 0.056	3.649ValLys: 3.649 ± 0.056	5.767ValLeu: 5.767 ± 0.064	1.236ValMet: 1.236 ± 0.028	3.248ValAsn: 3.248 ± 0.05	2.16ValPro: 2.16 ± 0.037	2.012ValGln: 2.012 ± 0.035	1.99ValArg: 1.99 ± 0.036	4.554ValSer: 4.554 ± 0.059	4.332ValThr: 4.332 ± 0.09	4.04ValVal: 4.04 ± 0.061	0.585ValTrp: 0.585 ± 0.02	2.448ValTyr: 2.448 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.54TrpAla: 0.54 ± 0.02	0.103TrpCys: 0.103 ± 0.008	0.635TrpAsp: 0.635 ± 0.019	0.703TrpGlu: 0.703 ± 0.023	0.532TrpPhe: 0.532 ± 0.018	0.686TrpGly: 0.686 ± 0.022	0.223TrpHis: 0.223 ± 0.012	0.807TrpIle: 0.807 ± 0.026	0.748TrpLys: 0.748 ± 0.023	0.975TrpLeu: 0.975 ± 0.025	0.294TrpMet: 0.294 ± 0.014	0.699TrpAsn: 0.699 ± 0.023	0.221TrpPro: 0.221 ± 0.012	0.398TrpGln: 0.398 ± 0.017	0.424TrpArg: 0.424 ± 0.016	0.677TrpSer: 0.677 ± 0.021	0.579TrpThr: 0.579 ± 0.023	0.605TrpVal: 0.605 ± 0.019	0.159TrpTrp: 0.159 ± 0.011	0.462TrpTyr: 0.462 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.036	0.328TyrCys: 0.328 ± 0.012	2.535TyrAsp: 2.535 ± 0.046	2.502TyrGlu: 2.502 ± 0.038	2.289TyrPhe: 2.289 ± 0.044	2.543TyrGly: 2.543 ± 0.045	0.879TyrHis: 0.879 ± 0.021	3.117TyrIle: 3.117 ± 0.047	2.892TyrLys: 2.892 ± 0.048	3.729TyrLeu: 3.729 ± 0.051	0.732TyrMet: 0.732 ± 0.021	2.492TyrAsn: 2.492 ± 0.045	1.536TyrPro: 1.536 ± 0.037	1.575TyrGln: 1.575 ± 0.03	1.744TyrArg: 1.744 ± 0.033	2.416TyrSer: 2.416 ± 0.041	3.043TyrThr: 3.043 ± 0.057	2.305TyrVal: 2.305 ± 0.043	0.469TyrTrp: 0.469 ± 0.017	1.981TyrTyr: 1.981 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4883 proteins (1653407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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