Amino acid dipepetide frequency for Hubei picorna-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.538AlaAla: 6.538 ± 2.227
0.385AlaCys: 0.385 ± 0.205
1.538AlaAsp: 1.538 ± 0.186
2.308AlaGlu: 2.308 ± 0.597
3.077AlaPhe: 3.077 ± 0.372
3.077AlaGly: 3.077 ± 1.534
1.154AlaHis: 1.154 ± 0.655
4.231AlaIle: 4.231 ± 1.624
2.692AlaLys: 2.692 ± 0.167
4.615AlaLeu: 4.615 ± 0.077
0.769AlaMet: 0.769 ± 0.411
3.846AlaAsn: 3.846 ± 3.029
6.538AlaPro: 6.538 ± 0.956
1.923AlaGln: 1.923 ± 1.027
1.154AlaArg: 1.154 ± 0.019
7.308AlaSer: 7.308 ± 1.816
3.846AlaThr: 3.846 ± 2.394
4.231AlaVal: 4.231 ± 2.188
0.769AlaTrp: 0.769 ± 0.86
3.462AlaTyr: 3.462 ± 0.578
0.0AlaXaa: 0.0 ± 0.0
Cys
0.385CysAla: 0.385 ± 0.43
0.385CysCys: 0.385 ± 0.43
1.154CysAsp: 1.154 ± 0.616
3.846CysGlu: 3.846 ± 2.054
0.769CysPhe: 0.769 ± 0.411
1.538CysGly: 1.538 ± 0.822
0.0CysHis: 0.0 ± 0.0
1.923CysIle: 1.923 ± 1.027
1.154CysLys: 1.154 ± 0.616
0.769CysLeu: 0.769 ± 0.225
0.769CysMet: 0.769 ± 0.411
0.385CysAsn: 0.385 ± 0.43
1.538CysPro: 1.538 ± 0.449
0.385CysGln: 0.385 ± 0.205
0.769CysArg: 0.769 ± 0.411
0.0CysSer: 0.0 ± 0.0
0.385CysThr: 0.385 ± 0.43
1.154CysVal: 1.154 ± 0.616
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.077AspAla: 3.077 ± 1.008
1.154AspCys: 1.154 ± 0.616
3.077AspAsp: 3.077 ± 0.263
4.615AspGlu: 4.615 ± 0.712
2.692AspPhe: 2.692 ± 0.167
2.692AspGly: 2.692 ± 0.167
1.154AspHis: 1.154 ± 0.019
5.385AspIle: 5.385 ± 0.301
3.462AspLys: 3.462 ± 1.213
3.462AspLeu: 3.462 ± 1.213
1.538AspMet: 1.538 ± 0.449
2.308AspAsn: 2.308 ± 1.232
3.462AspPro: 3.462 ± 1.964
0.769AspGln: 0.769 ± 0.225
3.077AspArg: 3.077 ± 1.008
2.308AspSer: 2.308 ± 1.232
3.077AspThr: 3.077 ± 2.804
2.308AspVal: 2.308 ± 1.309
1.538AspTrp: 1.538 ± 0.186
1.538AspTyr: 1.538 ± 0.822
0.0AspXaa: 0.0 ± 0.0
Glu
5.385GluAla: 5.385 ± 1.605
1.538GluCys: 1.538 ± 0.449
1.923GluAsp: 1.923 ± 0.244
5.0GluGlu: 5.0 ± 2.035
2.308GluPhe: 2.308 ± 0.597
1.154GluGly: 1.154 ± 0.019
1.923GluHis: 1.923 ± 0.392
3.077GluIle: 3.077 ± 0.372
2.308GluLys: 2.308 ± 1.232
5.0GluLeu: 5.0 ± 0.129
2.308GluMet: 2.308 ± 0.597
1.923GluAsn: 1.923 ± 1.027
3.846GluPro: 3.846 ± 0.488
1.154GluGln: 1.154 ± 0.616
2.308GluArg: 2.308 ± 1.232
2.692GluSer: 2.692 ± 0.802
3.462GluThr: 3.462 ± 0.578
3.077GluVal: 3.077 ± 0.263
0.385GluTrp: 0.385 ± 0.205
2.692GluTyr: 2.692 ± 0.802
0.0GluXaa: 0.0 ± 0.0
Phe
1.538PheAla: 1.538 ± 0.449
0.0PheCys: 0.0 ± 0.0
4.231PheAsp: 4.231 ± 2.259
1.538PheGlu: 1.538 ± 0.186
3.462PhePhe: 3.462 ± 0.578
5.385PheGly: 5.385 ± 0.937
0.769PheHis: 0.769 ± 0.411
2.308PheIle: 2.308 ± 1.232
1.538PheLys: 1.538 ± 0.186
3.462PheLeu: 3.462 ± 0.578
0.0PheMet: 0.0 ± 0.0
2.308PheAsn: 2.308 ± 1.309
1.923PhePro: 1.923 ± 1.027
1.923PheGln: 1.923 ± 0.244
1.923PheArg: 1.923 ± 0.244
2.692PheSer: 2.692 ± 1.438
6.923PheThr: 6.923 ± 1.386
3.077PheVal: 3.077 ± 0.372
0.385PheTrp: 0.385 ± 0.205
1.538PheTyr: 1.538 ± 0.449
0.0PheXaa: 0.0 ± 0.0
Gly
3.462GlyAla: 3.462 ± 0.058
0.385GlyCys: 0.385 ± 0.205
5.0GlyAsp: 5.0 ± 1.399
3.077GlyGlu: 3.077 ± 0.263
5.0GlyPhe: 5.0 ± 0.129
3.462GlyGly: 3.462 ± 0.578
0.385GlyHis: 0.385 ± 0.205
3.462GlyIle: 3.462 ± 1.328
1.923GlyLys: 1.923 ± 0.392
4.615GlyLeu: 4.615 ± 0.559
0.769GlyMet: 0.769 ± 0.225
1.538GlyAsn: 1.538 ± 0.186
1.923GlyPro: 1.923 ± 0.244
1.538GlyGln: 1.538 ± 0.186
2.308GlyArg: 2.308 ± 0.597
3.462GlySer: 3.462 ± 1.328
6.923GlyThr: 6.923 ± 3.292
3.846GlyVal: 3.846 ± 0.148
0.769GlyTrp: 0.769 ± 0.225
1.538GlyTyr: 1.538 ± 0.449
0.0GlyXaa: 0.0 ± 0.0
His
1.154HisAla: 1.154 ± 0.019
0.385HisCys: 0.385 ± 0.205
0.0HisAsp: 0.0 ± 0.0
0.385HisGlu: 0.385 ± 0.205
0.769HisPhe: 0.769 ± 0.411
2.308HisGly: 2.308 ± 0.597
1.154HisHis: 1.154 ± 0.616
1.538HisIle: 1.538 ± 0.186
0.769HisLys: 0.769 ± 0.225
1.538HisLeu: 1.538 ± 0.186
0.0HisMet: 0.0 ± 0.0
1.154HisAsn: 1.154 ± 0.616
0.385HisPro: 0.385 ± 0.205
0.385HisGln: 0.385 ± 0.43
0.385HisArg: 0.385 ± 0.43
0.0HisSer: 0.0 ± 0.0
2.692HisThr: 2.692 ± 0.802
0.769HisVal: 0.769 ± 0.225
0.0HisTrp: 0.0 ± 0.0
1.154HisTyr: 1.154 ± 0.616
0.0HisXaa: 0.0 ± 0.0
Ile
3.462IleAla: 3.462 ± 0.058
1.538IleCys: 1.538 ± 0.822
3.077IleAsp: 3.077 ± 1.008
3.462IleGlu: 3.462 ± 1.849
3.462IlePhe: 3.462 ± 1.213
5.0IleGly: 5.0 ± 0.507
1.154IleHis: 1.154 ± 0.616
3.077IleIle: 3.077 ± 1.008
2.308IleLys: 2.308 ± 0.038
2.308IleLeu: 2.308 ± 1.232
1.538IleMet: 1.538 ± 0.186
5.0IleAsn: 5.0 ± 1.142
3.077IlePro: 3.077 ± 2.169
2.308IleGln: 2.308 ± 0.038
2.692IleArg: 2.692 ± 0.468
3.077IleSer: 3.077 ± 0.263
4.231IleThr: 4.231 ± 0.353
3.077IleVal: 3.077 ± 0.263
1.538IleTrp: 1.538 ± 0.449
2.692IleTyr: 2.692 ± 0.802
0.0IleXaa: 0.0 ± 0.0
Lys
1.923LysAla: 1.923 ± 0.392
2.692LysCys: 2.692 ± 1.438
3.077LysAsp: 3.077 ± 1.643
3.846LysGlu: 3.846 ± 1.419
3.846LysPhe: 3.846 ± 1.419
3.462LysGly: 3.462 ± 1.213
0.769LysHis: 0.769 ± 0.411
3.462LysIle: 3.462 ± 0.693
4.231LysLys: 4.231 ± 0.989
5.0LysLeu: 5.0 ± 0.507
1.538LysMet: 1.538 ± 0.822
3.462LysAsn: 3.462 ± 0.578
1.923LysPro: 1.923 ± 0.392
0.769LysGln: 0.769 ± 0.411
2.308LysArg: 2.308 ± 1.232
6.923LysSer: 6.923 ± 0.52
3.846LysThr: 3.846 ± 1.419
4.231LysVal: 4.231 ± 0.282
0.769LysTrp: 0.769 ± 0.411
1.538LysTyr: 1.538 ± 0.186
0.0LysXaa: 0.0 ± 0.0
Leu
7.308LeuAla: 7.308 ± 1.361
1.154LeuCys: 1.154 ± 0.616
5.769LeuAsp: 5.769 ± 2.002
5.0LeuGlu: 5.0 ± 0.764
2.308LeuPhe: 2.308 ± 0.597
3.846LeuGly: 3.846 ± 1.123
1.538LeuHis: 1.538 ± 0.186
2.308LeuIle: 2.308 ± 0.038
5.385LeuLys: 5.385 ± 0.969
5.0LeuLeu: 5.0 ± 0.764
2.308LeuMet: 2.308 ± 1.309
5.769LeuAsn: 5.769 ± 1.175
5.385LeuPro: 5.385 ± 0.969
3.077LeuGln: 3.077 ± 0.263
5.0LeuArg: 5.0 ± 0.129
6.538LeuSer: 6.538 ± 1.591
7.308LeuThr: 7.308 ± 0.726
5.769LeuVal: 5.769 ± 0.539
0.769LeuTrp: 0.769 ± 0.411
2.692LeuTyr: 2.692 ± 0.167
0.0LeuXaa: 0.0 ± 0.0
Met
2.692MetAla: 2.692 ± 1.104
0.385MetCys: 0.385 ± 0.205
0.769MetAsp: 0.769 ± 0.225
1.154MetGlu: 1.154 ± 0.019
0.385MetPhe: 0.385 ± 0.43
2.692MetGly: 2.692 ± 0.468
0.385MetHis: 0.385 ± 0.43
0.769MetIle: 0.769 ± 0.411
1.538MetLys: 1.538 ± 0.822
1.923MetLeu: 1.923 ± 1.027
0.385MetMet: 0.385 ± 0.205
1.154MetAsn: 1.154 ± 0.019
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
2.692MetArg: 2.692 ± 0.167
1.923MetSer: 1.923 ± 0.392
2.692MetThr: 2.692 ± 1.438
2.308MetVal: 2.308 ± 0.597
0.385MetTrp: 0.385 ± 0.205
1.154MetTyr: 1.154 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.692AsnAla: 2.692 ± 0.468
0.769AsnCys: 0.769 ± 0.411
0.769AsnAsp: 0.769 ± 0.225
0.769AsnGlu: 0.769 ± 0.225
2.692AsnPhe: 2.692 ± 1.739
2.308AsnGly: 2.308 ± 1.309
0.769AsnHis: 0.769 ± 0.411
5.385AsnIle: 5.385 ± 0.334
5.0AsnLys: 5.0 ± 1.399
4.615AsnLeu: 4.615 ± 1.829
1.154AsnMet: 1.154 ± 0.616
4.615AsnAsn: 4.615 ± 0.712
2.308AsnPro: 2.308 ± 0.674
1.538AsnGln: 1.538 ± 0.186
1.154AsnArg: 1.154 ± 1.29
3.846AsnSer: 3.846 ± 1.123
6.154AsnThr: 6.154 ± 1.161
5.385AsnVal: 5.385 ± 0.334
0.385AsnTrp: 0.385 ± 0.43
2.308AsnTyr: 2.308 ± 1.309
0.0AsnXaa: 0.0 ± 0.0
Pro
1.538ProAla: 1.538 ± 1.085
0.769ProCys: 0.769 ± 0.411
2.692ProAsp: 2.692 ± 1.438
1.154ProGlu: 1.154 ± 0.616
3.462ProPhe: 3.462 ± 0.693
1.923ProGly: 1.923 ± 0.244
0.385ProHis: 0.385 ± 0.205
1.538ProIle: 1.538 ± 0.186
2.308ProLys: 2.308 ± 0.038
5.769ProLeu: 5.769 ± 0.731
1.154ProMet: 1.154 ± 0.235
3.077ProAsn: 3.077 ± 1.534
1.154ProPro: 1.154 ± 0.019
2.308ProGln: 2.308 ± 0.038
1.154ProArg: 1.154 ± 0.019
4.615ProSer: 4.615 ± 0.559
4.615ProThr: 4.615 ± 1.983
2.692ProVal: 2.692 ± 0.468
1.538ProTrp: 1.538 ± 0.822
3.846ProTyr: 3.846 ± 2.394
0.0ProXaa: 0.0 ± 0.0
Gln
1.538GlnAla: 1.538 ± 0.822
1.154GlnCys: 1.154 ± 0.655
1.923GlnAsp: 1.923 ± 0.244
2.692GlnGlu: 2.692 ± 0.802
0.769GlnPhe: 0.769 ± 0.225
1.923GlnGly: 1.923 ± 1.027
0.0GlnHis: 0.0 ± 0.0
1.538GlnIle: 1.538 ± 1.085
1.923GlnLys: 1.923 ± 0.392
1.923GlnLeu: 1.923 ± 0.392
1.154GlnMet: 1.154 ± 0.019
1.923GlnAsn: 1.923 ± 0.392
0.385GlnPro: 0.385 ± 0.205
1.923GlnGln: 1.923 ± 0.244
1.154GlnArg: 1.154 ± 0.019
4.231GlnSer: 4.231 ± 1.553
1.154GlnThr: 1.154 ± 0.019
1.923GlnVal: 1.923 ± 0.392
1.154GlnTrp: 1.154 ± 0.019
1.154GlnTyr: 1.154 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
3.462ArgAla: 3.462 ± 1.328
1.154ArgCys: 1.154 ± 0.616
1.538ArgAsp: 1.538 ± 0.186
2.308ArgGlu: 2.308 ± 0.597
1.923ArgPhe: 1.923 ± 0.392
2.308ArgGly: 2.308 ± 1.945
0.385ArgHis: 0.385 ± 0.205
3.462ArgIle: 3.462 ± 1.213
4.231ArgLys: 4.231 ± 0.989
5.385ArgLeu: 5.385 ± 1.605
1.154ArgMet: 1.154 ± 0.616
1.154ArgAsn: 1.154 ± 0.616
1.538ArgPro: 1.538 ± 0.186
2.692ArgGln: 2.692 ± 0.167
2.308ArgArg: 2.308 ± 0.038
1.923ArgSer: 1.923 ± 0.244
3.077ArgThr: 3.077 ± 1.008
3.462ArgVal: 3.462 ± 1.328
0.0ArgTrp: 0.0 ± 0.0
3.462ArgTyr: 3.462 ± 0.578
0.0ArgXaa: 0.0 ± 0.0
Ser
4.615SerAla: 4.615 ± 2.618
0.385SerCys: 0.385 ± 0.205
3.846SerAsp: 3.846 ± 1.123
5.385SerGlu: 5.385 ± 0.301
4.231SerPhe: 4.231 ± 0.353
2.692SerGly: 2.692 ± 0.167
2.308SerHis: 2.308 ± 1.232
3.846SerIle: 3.846 ± 1.123
6.154SerLys: 6.154 ± 1.38
8.462SerLeu: 8.462 ± 0.071
1.538SerMet: 1.538 ± 0.822
5.385SerAsn: 5.385 ± 1.572
1.538SerPro: 1.538 ± 0.186
1.154SerGln: 1.154 ± 0.019
3.077SerArg: 3.077 ± 0.263
4.231SerSer: 4.231 ± 0.353
6.154SerThr: 6.154 ± 3.703
5.0SerVal: 5.0 ± 0.129
0.385SerTrp: 0.385 ± 0.205
3.077SerTyr: 3.077 ± 0.263
0.0SerXaa: 0.0 ± 0.0
Thr
5.0ThrAla: 5.0 ± 3.048
0.769ThrCys: 0.769 ± 0.225
6.154ThrAsp: 6.154 ± 3.067
3.077ThrGlu: 3.077 ± 0.372
1.154ThrPhe: 1.154 ± 0.019
4.231ThrGly: 4.231 ± 1.624
1.154ThrHis: 1.154 ± 0.616
5.769ThrIle: 5.769 ± 0.096
5.385ThrLys: 5.385 ± 0.969
7.308ThrLeu: 7.308 ± 2.451
3.077ThrMet: 3.077 ± 0.208
2.692ThrAsn: 2.692 ± 1.104
5.0ThrPro: 5.0 ± 0.129
3.077ThrGln: 3.077 ± 1.534
3.846ThrArg: 3.846 ± 0.783
8.462ThrSer: 8.462 ± 3.106
8.077ThrThr: 8.077 ± 3.311
7.308ThrVal: 7.308 ± 1.18
1.154ThrTrp: 1.154 ± 1.29
2.308ThrTyr: 2.308 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.769ValAla: 5.769 ± 2.637
1.154ValCys: 1.154 ± 0.019
4.231ValAsp: 4.231 ± 0.282
2.692ValGlu: 2.692 ± 0.167
1.923ValPhe: 1.923 ± 0.244
3.077ValGly: 3.077 ± 0.263
0.385ValHis: 0.385 ± 0.205
3.077ValIle: 3.077 ± 0.372
4.231ValLys: 4.231 ± 1.624
5.0ValLeu: 5.0 ± 1.142
1.154ValMet: 1.154 ± 0.019
3.462ValAsn: 3.462 ± 0.058
4.615ValPro: 4.615 ± 0.712
3.077ValGln: 3.077 ± 1.008
5.0ValArg: 5.0 ± 0.129
4.231ValSer: 4.231 ± 0.282
5.385ValThr: 5.385 ± 1.572
4.615ValVal: 4.615 ± 0.077
1.154ValTrp: 1.154 ± 0.616
4.615ValTyr: 4.615 ± 1.348
0.0ValXaa: 0.0 ± 0.0
Trp
0.385TrpAla: 0.385 ± 0.205
0.769TrpCys: 0.769 ± 0.411
0.385TrpAsp: 0.385 ± 0.205
0.385TrpGlu: 0.385 ± 0.205
0.0TrpPhe: 0.0 ± 0.0
0.385TrpGly: 0.385 ± 0.43
0.0TrpHis: 0.0 ± 0.0
0.769TrpIle: 0.769 ± 0.411
0.769TrpLys: 0.769 ± 0.411
1.538TrpLeu: 1.538 ± 1.085
0.385TrpMet: 0.385 ± 0.205
1.923TrpAsn: 1.923 ± 0.392
0.385TrpPro: 0.385 ± 0.43
0.385TrpGln: 0.385 ± 0.43
1.923TrpArg: 1.923 ± 0.392
2.308TrpSer: 2.308 ± 0.038
0.385TrpThr: 0.385 ± 0.43
0.385TrpVal: 0.385 ± 0.205
0.0TrpTrp: 0.0 ± 0.0
0.769TrpTyr: 0.769 ± 0.411
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.538TyrAla: 1.538 ± 0.449
0.385TyrCys: 0.385 ± 0.205
1.538TyrAsp: 1.538 ± 0.449
0.769TyrGlu: 0.769 ± 0.411
2.692TyrPhe: 2.692 ± 0.167
1.923TyrGly: 1.923 ± 0.244
1.154TyrHis: 1.154 ± 1.29
1.154TyrIle: 1.154 ± 0.019
2.308TyrLys: 2.308 ± 0.038
6.538TyrLeu: 6.538 ± 0.321
2.308TyrMet: 2.308 ± 0.038
1.538TyrAsn: 1.538 ± 0.449
0.769TyrPro: 0.769 ± 0.225
1.154TyrGln: 1.154 ± 0.019
2.692TyrArg: 2.692 ± 0.802
2.692TyrSer: 2.692 ± 0.167
5.0TyrThr: 5.0 ± 0.129
4.231TyrVal: 4.231 ± 0.282
1.154TyrTrp: 1.154 ± 0.616
2.692TyrTyr: 2.692 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski