Amino acid dipepetide frequency for Lacisediminihabitans profunda

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.907AlaAla: 18.907 ± 0.167	0.648AlaCys: 0.648 ± 0.023	7.006AlaAsp: 7.006 ± 0.076	7.273AlaGlu: 7.273 ± 0.102	3.88AlaPhe: 3.88 ± 0.064	11.767AlaGly: 11.767 ± 0.117	2.308AlaHis: 2.308 ± 0.047	6.738AlaIle: 6.738 ± 0.085	3.077AlaLys: 3.077 ± 0.07	13.541AlaLeu: 13.541 ± 0.119	2.578AlaMet: 2.578 ± 0.048	2.863AlaAsn: 2.863 ± 0.055	5.699AlaPro: 5.699 ± 0.093	3.445AlaGln: 3.445 ± 0.067	8.652AlaArg: 8.652 ± 0.103	7.766AlaSer: 7.766 ± 0.09	7.597AlaThr: 7.597 ± 0.092	11.045AlaVal: 11.045 ± 0.107	1.784AlaTrp: 1.784 ± 0.04	2.283AlaTyr: 2.283 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.611CysAla: 0.611 ± 0.024	0.062CysCys: 0.062 ± 0.008	0.332CysAsp: 0.332 ± 0.017	0.269CysGlu: 0.269 ± 0.014	0.151CysPhe: 0.151 ± 0.011	0.548CysGly: 0.548 ± 0.02	0.109CysHis: 0.109 ± 0.01	0.222CysIle: 0.222 ± 0.015	0.076CysLys: 0.076 ± 0.008	0.477CysLeu: 0.477 ± 0.021	0.079CysMet: 0.079 ± 0.008	0.115CysAsn: 0.115 ± 0.01	0.296CysPro: 0.296 ± 0.015	0.117CysGln: 0.117 ± 0.011	0.317CysArg: 0.317 ± 0.016	0.401CysSer: 0.401 ± 0.019	0.321CysThr: 0.321 ± 0.018	0.452CysVal: 0.452 ± 0.019	0.09CysTrp: 0.09 ± 0.009	0.097CysTyr: 0.097 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.299AspAla: 7.299 ± 0.096	0.27AspCys: 0.27 ± 0.014	3.483AspAsp: 3.483 ± 0.07	3.616AspGlu: 3.616 ± 0.057	1.923AspPhe: 1.923 ± 0.041	5.354AspGly: 5.354 ± 0.074	1.206AspHis: 1.206 ± 0.037	2.485AspIle: 2.485 ± 0.047	1.129AspLys: 1.129 ± 0.036	6.021AspLeu: 6.021 ± 0.081	0.74AspMet: 0.74 ± 0.023	1.153AspAsn: 1.153 ± 0.032	3.657AspPro: 3.657 ± 0.06	1.552AspGln: 1.552 ± 0.032	4.135AspArg: 4.135 ± 0.078	3.179AspSer: 3.179 ± 0.05	2.712AspThr: 2.712 ± 0.051	4.812AspVal: 4.812 ± 0.072	0.997AspTrp: 0.997 ± 0.029	1.332AspTyr: 1.332 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.46GluAla: 6.46 ± 0.095	0.239GluCys: 0.239 ± 0.017	2.236GluAsp: 2.236 ± 0.05	2.571GluGlu: 2.571 ± 0.056	1.853GluPhe: 1.853 ± 0.043	3.429GluGly: 3.429 ± 0.061	1.396GluHis: 1.396 ± 0.033	2.791GluIle: 2.791 ± 0.054	1.426GluLys: 1.426 ± 0.04	6.488GluLeu: 6.488 ± 0.089	0.924GluMet: 0.924 ± 0.028	1.227GluAsn: 1.227 ± 0.034	2.773GluPro: 2.773 ± 0.05	1.975GluGln: 1.975 ± 0.045	4.598GluArg: 4.598 ± 0.084	3.199GluSer: 3.199 ± 0.054	2.841GluThr: 2.841 ± 0.055	4.2GluVal: 4.2 ± 0.068	0.849GluTrp: 0.849 ± 0.028	1.088GluTyr: 1.088 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.491PheAla: 4.491 ± 0.066	0.208PheCys: 0.208 ± 0.013	2.44PheAsp: 2.44 ± 0.043	1.853PheGlu: 1.853 ± 0.042	1.227PhePhe: 1.227 ± 0.035	3.672PheGly: 3.672 ± 0.058	0.552PheHis: 0.552 ± 0.02	1.407PheIle: 1.407 ± 0.038	0.572PheLys: 0.572 ± 0.023	3.026PheLeu: 3.026 ± 0.06	0.478PheMet: 0.478 ± 0.02	0.81PheAsn: 0.81 ± 0.029	1.504PhePro: 1.504 ± 0.04	0.776PheGln: 0.776 ± 0.025	1.807PheArg: 1.807 ± 0.038	2.184PheSer: 2.184 ± 0.048	2.16PheThr: 2.16 ± 0.043	3.045PheVal: 3.045 ± 0.049	0.517PheTrp: 0.517 ± 0.021	0.78PheTyr: 0.78 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.124GlyAla: 10.124 ± 0.117	0.578GlyCys: 0.578 ± 0.025	4.589GlyAsp: 4.589 ± 0.072	4.399GlyGlu: 4.399 ± 0.067	3.387GlyPhe: 3.387 ± 0.067	7.498GlyGly: 7.498 ± 0.107	1.933GlyHis: 1.933 ± 0.043	5.255GlyIle: 5.255 ± 0.059	2.427GlyLys: 2.427 ± 0.055	9.125GlyLeu: 9.125 ± 0.101	1.86GlyMet: 1.86 ± 0.042	1.972GlyAsn: 1.972 ± 0.044	3.722GlyPro: 3.722 ± 0.052	2.579GlyGln: 2.579 ± 0.051	6.097GlyArg: 6.097 ± 0.071	6.044GlySer: 6.044 ± 0.081	5.564GlyThr: 5.564 ± 0.083	7.821GlyVal: 7.821 ± 0.09	1.643GlyTrp: 1.643 ± 0.043	2.239GlyTyr: 2.239 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.116HisAla: 2.116 ± 0.048	0.112HisCys: 0.112 ± 0.009	1.277HisAsp: 1.277 ± 0.032	1.068HisGlu: 1.068 ± 0.03	0.628HisPhe: 0.628 ± 0.023	2.0HisGly: 2.0 ± 0.046	0.521HisHis: 0.521 ± 0.022	0.802HisIle: 0.802 ± 0.027	0.303HisLys: 0.303 ± 0.016	2.098HisLeu: 2.098 ± 0.048	0.296HisMet: 0.296 ± 0.016	0.443HisAsn: 0.443 ± 0.021	1.493HisPro: 1.493 ± 0.037	0.542HisGln: 0.542 ± 0.02	1.514HisArg: 1.514 ± 0.038	1.18HisSer: 1.18 ± 0.033	0.97HisThr: 0.97 ± 0.03	1.523HisVal: 1.523 ± 0.036	0.292HisTrp: 0.292 ± 0.017	0.479HisTyr: 0.479 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.265IleAla: 7.265 ± 0.089	0.267IleCys: 0.267 ± 0.014	3.609IleAsp: 3.609 ± 0.058	2.909IleGlu: 2.909 ± 0.053	1.449IlePhe: 1.449 ± 0.039	5.013IleGly: 5.013 ± 0.077	0.828IleHis: 0.828 ± 0.026	2.126IleIle: 2.126 ± 0.048	0.953IleLys: 0.953 ± 0.032	4.217IleLeu: 4.217 ± 0.072	0.69IleMet: 0.69 ± 0.025	1.128IleAsn: 1.128 ± 0.031	2.631IlePro: 2.631 ± 0.054	1.073IleGln: 1.073 ± 0.028	2.981IleArg: 2.981 ± 0.052	2.874IleSer: 2.874 ± 0.058	3.151IleThr: 3.151 ± 0.052	5.137IleVal: 5.137 ± 0.071	0.541IleTrp: 0.541 ± 0.023	0.923IleTyr: 0.923 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.754LysAla: 2.754 ± 0.067	0.076LysCys: 0.076 ± 0.007	1.274LysAsp: 1.274 ± 0.038	0.964LysGlu: 0.964 ± 0.031	0.698LysPhe: 0.698 ± 0.022	1.762LysGly: 1.762 ± 0.051	0.471LysHis: 0.471 ± 0.022	1.153LysIle: 1.153 ± 0.032	0.908LysLys: 0.908 ± 0.04	2.172LysLeu: 2.172 ± 0.045	0.452LysMet: 0.452 ± 0.018	0.746LysAsn: 0.746 ± 0.031	1.348LysPro: 1.348 ± 0.035	0.735LysGln: 0.735 ± 0.025	1.601LysArg: 1.601 ± 0.047	1.556LysSer: 1.556 ± 0.042	1.596LysThr: 1.596 ± 0.047	1.792LysVal: 1.792 ± 0.046	0.305LysTrp: 0.305 ± 0.016	0.562LysTyr: 0.562 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.895LeuAla: 14.895 ± 0.135	0.552LeuCys: 0.552 ± 0.022	6.513LeuAsp: 6.513 ± 0.088	5.362LeuGlu: 5.362 ± 0.088	3.162LeuPhe: 3.162 ± 0.06	9.621LeuGly: 9.621 ± 0.101	1.869LeuHis: 1.869 ± 0.043	4.792LeuIle: 4.792 ± 0.076	2.069LeuLys: 2.069 ± 0.051	10.318LeuLeu: 10.318 ± 0.131	1.558LeuMet: 1.558 ± 0.037	2.131LeuAsn: 2.131 ± 0.045	5.603LeuPro: 5.603 ± 0.06	2.486LeuGln: 2.486 ± 0.042	7.097LeuArg: 7.097 ± 0.096	6.499LeuSer: 6.499 ± 0.08	6.089LeuThr: 6.089 ± 0.069	9.574LeuVal: 9.574 ± 0.1	1.265LeuTrp: 1.265 ± 0.036	1.887LeuTyr: 1.887 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.142MetAla: 2.142 ± 0.042	0.089MetCys: 0.089 ± 0.008	0.793MetAsp: 0.793 ± 0.029	0.625MetGlu: 0.625 ± 0.028	0.518MetPhe: 0.518 ± 0.021	1.18MetGly: 1.18 ± 0.031	0.306MetHis: 0.306 ± 0.016	0.9MetIle: 0.9 ± 0.028	0.468MetLys: 0.468 ± 0.022	1.854MetLeu: 1.854 ± 0.038	0.3MetMet: 0.3 ± 0.018	0.517MetAsn: 0.517 ± 0.019	1.033MetPro: 1.033 ± 0.027	0.494MetGln: 0.494 ± 0.019	1.266MetArg: 1.266 ± 0.031	1.404MetSer: 1.404 ± 0.035	1.682MetThr: 1.682 ± 0.04	1.355MetVal: 1.355 ± 0.033	0.183MetTrp: 0.183 ± 0.013	0.273MetTyr: 0.273 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.761AsnAla: 2.761 ± 0.047	0.149AsnCys: 0.149 ± 0.011	1.263AsnAsp: 1.263 ± 0.039	1.113AsnGlu: 1.113 ± 0.032	0.82AsnPhe: 0.82 ± 0.027	2.262AsnGly: 2.262 ± 0.053	0.453AsnHis: 0.453 ± 0.021	1.028AsnIle: 1.028 ± 0.03	0.528AsnLys: 0.528 ± 0.024	2.236AsnLeu: 2.236 ± 0.045	0.381AsnMet: 0.381 ± 0.02	0.625AsnAsn: 0.625 ± 0.024	1.771AsnPro: 1.771 ± 0.038	0.66AsnGln: 0.66 ± 0.022	1.482AsnArg: 1.482 ± 0.037	1.406AsnSer: 1.406 ± 0.038	1.341AsnThr: 1.341 ± 0.034	1.902AsnVal: 1.902 ± 0.039	0.368AsnTrp: 0.368 ± 0.019	0.607AsnTyr: 0.607 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.674ProAla: 6.674 ± 0.088	0.178ProCys: 0.178 ± 0.013	3.403ProAsp: 3.403 ± 0.053	3.259ProGlu: 3.259 ± 0.059	1.75ProPhe: 1.75 ± 0.039	5.004ProGly: 5.004 ± 0.072	1.056ProHis: 1.056 ± 0.029	2.393ProIle: 2.393 ± 0.049	1.193ProLys: 1.193 ± 0.039	4.898ProLeu: 4.898 ± 0.061	0.921ProMet: 0.921 ± 0.027	1.258ProAsn: 1.258 ± 0.033	2.235ProPro: 2.235 ± 0.049	1.488ProGln: 1.488 ± 0.037	3.347ProArg: 3.347 ± 0.063	3.397ProSer: 3.397 ± 0.059	3.538ProThr: 3.538 ± 0.058	4.815ProVal: 4.815 ± 0.069	0.803ProTrp: 0.803 ± 0.027	1.034ProTyr: 1.034 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.264GlnAla: 3.264 ± 0.056	0.131GlnCys: 0.131 ± 0.01	1.181GlnAsp: 1.181 ± 0.037	1.164GlnGlu: 1.164 ± 0.036	1.031GlnPhe: 1.031 ± 0.025	1.91GlnGly: 1.91 ± 0.041	0.576GlnHis: 0.576 ± 0.021	1.406GlnIle: 1.406 ± 0.04	0.793GlnLys: 0.793 ± 0.026	3.305GlnLeu: 3.305 ± 0.057	0.502GlnMet: 0.502 ± 0.024	0.756GlnAsn: 0.756 ± 0.026	1.499GlnPro: 1.499 ± 0.039	1.096GlnGln: 1.096 ± 0.037	2.154GlnArg: 2.154 ± 0.05	1.716GlnSer: 1.716 ± 0.038	1.556GlnThr: 1.556 ± 0.037	2.374GlnVal: 2.374 ± 0.047	0.461GlnTrp: 0.461 ± 0.018	0.641GlnTyr: 0.641 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.149ArgAla: 8.149 ± 0.093	0.303ArgCys: 0.303 ± 0.015	3.782ArgAsp: 3.782 ± 0.059	4.003ArgGlu: 4.003 ± 0.073	2.44ArgPhe: 2.44 ± 0.046	5.234ArgGly: 5.234 ± 0.069	1.494ArgHis: 1.494 ± 0.039	3.501ArgIle: 3.501 ± 0.054	1.478ArgLys: 1.478 ± 0.036	7.528ArgLeu: 7.528 ± 0.089	1.514ArgMet: 1.514 ± 0.035	1.464ArgAsn: 1.464 ± 0.038	3.621ArgPro: 3.621 ± 0.068	2.147ArgGln: 2.147 ± 0.045	5.911ArgArg: 5.911 ± 0.094	4.439ArgSer: 4.439 ± 0.067	3.818ArgThr: 3.818 ± 0.058	5.949ArgVal: 5.949 ± 0.086	1.083ArgTrp: 1.083 ± 0.034	1.589ArgTyr: 1.589 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.874SerAla: 7.874 ± 0.094	0.312SerCys: 0.312 ± 0.017	3.235SerAsp: 3.235 ± 0.052	2.861SerGlu: 2.861 ± 0.054	2.182SerPhe: 2.182 ± 0.048	6.265SerGly: 6.265 ± 0.082	1.203SerHis: 1.203 ± 0.037	3.22SerIle: 3.22 ± 0.05	1.462SerLys: 1.462 ± 0.043	6.266SerLeu: 6.266 ± 0.079	1.183SerMet: 1.183 ± 0.029	1.462SerAsn: 1.462 ± 0.037	3.429SerPro: 3.429 ± 0.054	1.655SerGln: 1.655 ± 0.038	4.353SerArg: 4.353 ± 0.057	4.168SerSer: 4.168 ± 0.079	4.254SerThr: 4.254 ± 0.068	5.404SerVal: 5.404 ± 0.063	0.966SerTrp: 0.966 ± 0.033	1.357SerTyr: 1.357 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.7ThrAla: 7.7 ± 0.1	0.246ThrCys: 0.246 ± 0.013	3.316ThrAsp: 3.316 ± 0.049	3.041ThrGlu: 3.041 ± 0.056	1.985ThrPhe: 1.985 ± 0.042	5.788ThrGly: 5.788 ± 0.071	1.049ThrHis: 1.049 ± 0.032	3.309ThrIle: 3.309 ± 0.054	1.388ThrLys: 1.388 ± 0.035	6.138ThrLeu: 6.138 ± 0.072	1.013ThrMet: 1.013 ± 0.032	1.406ThrAsn: 1.406 ± 0.04	3.893ThrPro: 3.893 ± 0.066	1.405ThrGln: 1.405 ± 0.038	3.707ThrArg: 3.707 ± 0.06	3.754ThrSer: 3.754 ± 0.066	3.911ThrThr: 3.911 ± 0.073	6.057ThrVal: 6.057 ± 0.072	0.856ThrTrp: 0.856 ± 0.026	1.11ThrTyr: 1.11 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	11.527ValAla: 11.527 ± 0.113	0.502ValCys: 0.502 ± 0.022	5.324ValAsp: 5.324 ± 0.067	4.569ValGlu: 4.569 ± 0.076	3.03ValPhe: 3.03 ± 0.055	7.488ValGly: 7.488 ± 0.082	1.661ValHis: 1.661 ± 0.04	4.726ValIle: 4.726 ± 0.07	1.889ValLys: 1.889 ± 0.052	9.333ValLeu: 9.333 ± 0.13	1.335ValMet: 1.335 ± 0.029	2.067ValAsn: 2.067 ± 0.045	4.568ValPro: 4.568 ± 0.056	2.067ValGln: 2.067 ± 0.041	5.605ValArg: 5.605 ± 0.077	5.649ValSer: 5.649 ± 0.064	5.913ValThr: 5.913 ± 0.073	8.643ValVal: 8.643 ± 0.105	1.109ValTrp: 1.109 ± 0.033	1.571ValTyr: 1.571 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.573TrpAla: 1.573 ± 0.038	0.092TrpCys: 0.092 ± 0.009	0.72TrpAsp: 0.72 ± 0.027	0.599TrpGlu: 0.599 ± 0.024	0.553TrpPhe: 0.553 ± 0.02	1.042TrpGly: 1.042 ± 0.033	0.335TrpHis: 0.335 ± 0.016	0.761TrpIle: 0.761 ± 0.029	0.37TrpLys: 0.37 ± 0.017	1.819TrpLeu: 1.819 ± 0.042	0.322TrpMet: 0.322 ± 0.016	0.468TrpAsn: 0.468 ± 0.018	0.772TrpPro: 0.772 ± 0.027	0.612TrpGln: 0.612 ± 0.023	1.155TrpArg: 1.155 ± 0.034	0.976TrpSer: 0.976 ± 0.029	0.918TrpThr: 0.918 ± 0.028	1.074TrpVal: 1.074 ± 0.033	0.335TrpTrp: 0.335 ± 0.018	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.269TyrAla: 2.269 ± 0.044	0.125TyrCys: 0.125 ± 0.01	1.279TyrAsp: 1.279 ± 0.037	1.045TyrGlu: 1.045 ± 0.035	0.841TyrPhe: 0.841 ± 0.028	2.02TyrGly: 2.02 ± 0.039	0.332TyrHis: 0.332 ± 0.018	0.75TyrIle: 0.75 ± 0.027	0.42TyrLys: 0.42 ± 0.021	2.482TyrLeu: 2.482 ± 0.049	0.254TyrMet: 0.254 ± 0.014	0.542TyrAsn: 0.542 ± 0.023	1.099TyrPro: 1.099 ± 0.032	0.613TyrGln: 0.613 ± 0.024	1.667TyrArg: 1.667 ± 0.04	1.321TyrSer: 1.321 ± 0.032	1.141TyrThr: 1.141 ± 0.033	1.603TyrVal: 1.603 ± 0.036	0.35TyrTrp: 0.35 ± 0.017	0.476TyrTyr: 0.476 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3747 proteins (1191165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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