Amino acid dipepetide frequency for Synergistes sp. 3_1_syn1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.323AlaAla: 14.323 ± 0.214	1.398AlaCys: 1.398 ± 0.046	5.235AlaAsp: 5.235 ± 0.083	7.506AlaGlu: 7.506 ± 0.116	3.825AlaPhe: 3.825 ± 0.064	8.966AlaGly: 8.966 ± 0.119	1.513AlaHis: 1.513 ± 0.041	5.377AlaIle: 5.377 ± 0.084	5.319AlaLys: 5.319 ± 0.093	10.338AlaLeu: 10.338 ± 0.118	3.007AlaMet: 3.007 ± 0.065	2.655AlaAsn: 2.655 ± 0.061	3.623AlaPro: 3.623 ± 0.068	2.627AlaGln: 2.627 ± 0.057	5.147AlaArg: 5.147 ± 0.083	5.366AlaSer: 5.366 ± 0.085	3.487AlaThr: 3.487 ± 0.073	8.231AlaVal: 8.231 ± 0.099	0.943AlaTrp: 0.943 ± 0.035	2.535AlaTyr: 2.535 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.675CysAla: 1.675 ± 0.048	0.29CysCys: 0.29 ± 0.02	0.781CysAsp: 0.781 ± 0.028	0.93CysGlu: 0.93 ± 0.035	0.647CysPhe: 0.647 ± 0.029	1.906CysGly: 1.906 ± 0.056	0.276CysHis: 0.276 ± 0.015	0.785CysIle: 0.785 ± 0.032	0.525CysLys: 0.525 ± 0.025	1.288CysLeu: 1.288 ± 0.041	0.366CysMet: 0.366 ± 0.018	0.397CysAsn: 0.397 ± 0.024	0.729CysPro: 0.729 ± 0.029	0.284CysGln: 0.284 ± 0.017	1.093CysArg: 1.093 ± 0.045	0.901CysSer: 0.901 ± 0.037	0.754CysThr: 0.754 ± 0.032	1.029CysVal: 1.029 ± 0.037	0.19CysTrp: 0.19 ± 0.014	0.461CysTyr: 0.461 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.631AspAla: 4.631 ± 0.076	0.722AspCys: 0.722 ± 0.029	2.716AspAsp: 2.716 ± 0.065	3.973AspGlu: 3.973 ± 0.079	2.527AspPhe: 2.527 ± 0.058	4.88AspGly: 4.88 ± 0.093	0.796AspHis: 0.796 ± 0.031	4.14AspIle: 4.14 ± 0.063	2.963AspLys: 2.963 ± 0.065	4.21AspLeu: 4.21 ± 0.065	1.67AspMet: 1.67 ± 0.045	1.717AspAsn: 1.717 ± 0.042	2.306AspPro: 2.306 ± 0.047	0.822AspGln: 0.822 ± 0.03	2.779AspArg: 2.779 ± 0.062	2.604AspSer: 2.604 ± 0.059	2.417AspThr: 2.417 ± 0.066	3.608AspVal: 3.608 ± 0.073	0.565AspTrp: 0.565 ± 0.027	1.931AspTyr: 1.931 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.938GluAla: 6.938 ± 0.095	0.835GluCys: 0.835 ± 0.033	3.23GluAsp: 3.23 ± 0.061	5.651GluGlu: 5.651 ± 0.091	2.19GluPhe: 2.19 ± 0.056	4.899GluGly: 4.899 ± 0.076	1.138GluHis: 1.138 ± 0.034	4.815GluIle: 4.815 ± 0.072	4.952GluLys: 4.952 ± 0.079	6.845GluLeu: 6.845 ± 0.101	2.221GluMet: 2.221 ± 0.049	2.932GluAsn: 2.932 ± 0.057	2.217GluPro: 2.217 ± 0.055	1.738GluGln: 1.738 ± 0.045	4.709GluArg: 4.709 ± 0.086	3.369GluSer: 3.369 ± 0.061	3.347GluThr: 3.347 ± 0.068	3.929GluVal: 3.929 ± 0.062	0.705GluTrp: 0.705 ± 0.028	2.168GluTyr: 2.168 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	4.131PheAla: 4.131 ± 0.066	0.723PheCys: 0.723 ± 0.03	2.303PheAsp: 2.303 ± 0.048	2.301PheGlu: 2.301 ± 0.059	1.989PhePhe: 1.989 ± 0.055	3.433PheGly: 3.433 ± 0.062	0.639PheHis: 0.639 ± 0.025	2.896PheIle: 2.896 ± 0.053	1.869PheLys: 1.869 ± 0.041	3.647PheLeu: 3.647 ± 0.07	1.19PheMet: 1.19 ± 0.039	1.289PheAsn: 1.289 ± 0.041	1.689PhePro: 1.689 ± 0.042	0.846PheGln: 0.846 ± 0.029	2.085PheArg: 2.085 ± 0.051	3.055PheSer: 3.055 ± 0.058	2.289PheThr: 2.289 ± 0.057	2.891PheVal: 2.891 ± 0.06	0.505PheTrp: 0.505 ± 0.022	1.382PheTyr: 1.382 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	8.292GlyAla: 8.292 ± 0.111	1.569GlyCys: 1.569 ± 0.044	4.123GlyAsp: 4.123 ± 0.079	5.558GlyGlu: 5.558 ± 0.083	3.419GlyPhe: 3.419 ± 0.061	7.653GlyGly: 7.653 ± 0.123	1.442GlyHis: 1.442 ± 0.041	5.746GlyIle: 5.746 ± 0.079	4.706GlyLys: 4.706 ± 0.075	7.634GlyLeu: 7.634 ± 0.093	2.595GlyMet: 2.595 ± 0.059	2.4GlyAsn: 2.4 ± 0.057	2.13GlyPro: 2.13 ± 0.051	1.847GlyGln: 1.847 ± 0.043	4.902GlyArg: 4.902 ± 0.087	4.665GlySer: 4.665 ± 0.075	4.523GlyThr: 4.523 ± 0.089	6.232GlyVal: 6.232 ± 0.095	1.023GlyTrp: 1.023 ± 0.036	2.831GlyTyr: 2.831 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.335HisAla: 1.335 ± 0.036	0.281HisCys: 0.281 ± 0.016	0.824HisAsp: 0.824 ± 0.029	0.985HisGlu: 0.985 ± 0.036	0.686HisPhe: 0.686 ± 0.03	1.419HisGly: 1.419 ± 0.039	0.341HisHis: 0.341 ± 0.02	1.152HisIle: 1.152 ± 0.033	0.763HisLys: 0.763 ± 0.029	1.465HisLeu: 1.465 ± 0.044	0.447HisMet: 0.447 ± 0.024	0.597HisAsn: 0.597 ± 0.024	1.003HisPro: 1.003 ± 0.03	0.316HisGln: 0.316 ± 0.018	0.878HisArg: 0.878 ± 0.033	0.917HisSer: 0.917 ± 0.034	0.875HisThr: 0.875 ± 0.03	1.005HisVal: 1.005 ± 0.03	0.179HisTrp: 0.179 ± 0.015	0.57HisTyr: 0.57 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.45IleAla: 6.45 ± 0.097	1.116IleCys: 1.116 ± 0.041	3.659IleAsp: 3.659 ± 0.064	4.194IleGlu: 4.194 ± 0.083	2.916IlePhe: 2.916 ± 0.058	5.028IleGly: 5.028 ± 0.089	0.979IleHis: 0.979 ± 0.034	4.095IleIle: 4.095 ± 0.077	3.71IleLys: 3.71 ± 0.073	5.675IleLeu: 5.675 ± 0.08	1.778IleMet: 1.778 ± 0.046	2.265IleAsn: 2.265 ± 0.051	3.22IlePro: 3.22 ± 0.071	1.377IleGln: 1.377 ± 0.037	3.303IleArg: 3.303 ± 0.061	4.426IleSer: 4.426 ± 0.069	3.693IleThr: 3.693 ± 0.088	4.414IleVal: 4.414 ± 0.076	0.621IleTrp: 0.621 ± 0.03	2.056IleTyr: 2.056 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.762LysAla: 4.762 ± 0.083	0.66LysCys: 0.66 ± 0.032	3.148LysAsp: 3.148 ± 0.068	4.563LysGlu: 4.563 ± 0.086	1.966LysPhe: 1.966 ± 0.05	3.916LysGly: 3.916 ± 0.075	0.777LysHis: 0.777 ± 0.03	4.013LysIle: 4.013 ± 0.07	4.239LysLys: 4.239 ± 0.072	4.892LysLeu: 4.892 ± 0.072	1.839LysMet: 1.839 ± 0.045	2.595LysAsn: 2.595 ± 0.058	1.804LysPro: 1.804 ± 0.049	1.318LysGln: 1.318 ± 0.043	3.26LysArg: 3.26 ± 0.065	2.92LysSer: 2.92 ± 0.059	2.883LysThr: 2.883 ± 0.055	3.385LysVal: 3.385 ± 0.069	0.615LysTrp: 0.615 ± 0.028	2.082LysTyr: 2.082 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	9.893LeuAla: 9.893 ± 0.124	1.68LeuCys: 1.68 ± 0.048	4.837LeuAsp: 4.837 ± 0.083	5.723LeuGlu: 5.723 ± 0.08	4.17LeuPhe: 4.17 ± 0.072	7.127LeuGly: 7.127 ± 0.109	1.475LeuHis: 1.475 ± 0.043	5.606LeuIle: 5.606 ± 0.086	5.134LeuLys: 5.134 ± 0.078	9.283LeuLeu: 9.283 ± 0.155	2.702LeuMet: 2.702 ± 0.052	3.001LeuAsn: 3.001 ± 0.066	4.778LeuPro: 4.778 ± 0.071	1.97LeuGln: 1.97 ± 0.052	5.7LeuArg: 5.7 ± 0.096	6.834LeuSer: 6.834 ± 0.091	5.112LeuThr: 5.112 ± 0.068	5.796LeuVal: 5.796 ± 0.087	1.098LeuTrp: 1.098 ± 0.038	2.786LeuTyr: 2.786 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	3.035MetAla: 3.035 ± 0.055	0.308MetCys: 0.308 ± 0.017	1.511MetAsp: 1.511 ± 0.041	2.046MetGlu: 2.046 ± 0.042	0.854MetPhe: 0.854 ± 0.033	2.297MetGly: 2.297 ± 0.056	0.419MetHis: 0.419 ± 0.025	1.875MetIle: 1.875 ± 0.045	2.061MetLys: 2.061 ± 0.05	2.934MetLeu: 2.934 ± 0.059	0.861MetMet: 0.861 ± 0.03	1.174MetAsn: 1.174 ± 0.041	1.482MetPro: 1.482 ± 0.038	0.748MetGln: 0.748 ± 0.028	1.838MetArg: 1.838 ± 0.045	1.706MetSer: 1.706 ± 0.049	1.764MetThr: 1.764 ± 0.045	1.752MetVal: 1.752 ± 0.045	0.239MetTrp: 0.239 ± 0.017	0.613MetTyr: 0.613 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.885AsnAla: 2.885 ± 0.054	0.564AsnCys: 0.564 ± 0.028	1.761AsnAsp: 1.761 ± 0.05	1.943AsnGlu: 1.943 ± 0.049	1.427AsnPhe: 1.427 ± 0.041	3.058AsnGly: 3.058 ± 0.063	0.522AsnHis: 0.522 ± 0.022	2.833AsnIle: 2.833 ± 0.054	1.717AsnLys: 1.717 ± 0.05	2.939AsnLeu: 2.939 ± 0.061	1.068AsnMet: 1.068 ± 0.033	1.267AsnAsn: 1.267 ± 0.043	1.735AsnPro: 1.735 ± 0.047	0.674AsnGln: 0.674 ± 0.03	1.731AsnArg: 1.731 ± 0.049	1.946AsnSer: 1.946 ± 0.054	1.625AsnThr: 1.625 ± 0.048	2.348AsnVal: 2.348 ± 0.053	0.384AsnTrp: 0.384 ± 0.019	1.171AsnTyr: 1.171 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.287ProAla: 4.287 ± 0.076	0.587ProCys: 0.587 ± 0.027	2.428ProAsp: 2.428 ± 0.052	3.739ProGlu: 3.739 ± 0.071	1.785ProPhe: 1.785 ± 0.043	3.343ProGly: 3.343 ± 0.068	0.765ProHis: 0.765 ± 0.031	2.139ProIle: 2.139 ± 0.046	1.956ProLys: 1.956 ± 0.05	4.218ProLeu: 4.218 ± 0.064	1.025ProMet: 1.025 ± 0.037	1.212ProAsn: 1.212 ± 0.033	1.457ProPro: 1.457 ± 0.043	1.327ProGln: 1.327 ± 0.039	2.059ProArg: 2.059 ± 0.052	2.169ProSer: 2.169 ± 0.042	1.859ProThr: 1.859 ± 0.049	3.523ProVal: 3.523 ± 0.058	0.53ProTrp: 0.53 ± 0.025	1.379ProTyr: 1.379 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.187GlnAla: 2.187 ± 0.046	0.3GlnCys: 0.3 ± 0.018	1.078GlnAsp: 1.078 ± 0.036	1.554GlnGlu: 1.554 ± 0.043	0.847GlnPhe: 0.847 ± 0.032	1.651GlnGly: 1.651 ± 0.04	0.376GlnHis: 0.376 ± 0.021	1.744GlnIle: 1.744 ± 0.042	1.539GlnLys: 1.539 ± 0.044	2.157GlnLeu: 2.157 ± 0.048	0.793GlnMet: 0.793 ± 0.031	0.99GlnAsn: 0.99 ± 0.036	0.906GlnPro: 0.906 ± 0.033	0.774GlnGln: 0.774 ± 0.032	1.546GlnArg: 1.546 ± 0.044	1.349GlnSer: 1.349 ± 0.037	1.173GlnThr: 1.173 ± 0.041	1.457GlnVal: 1.457 ± 0.04	0.287GlnTrp: 0.287 ± 0.017	0.782GlnTyr: 0.782 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.312ArgAla: 5.312 ± 0.095	0.922ArgCys: 0.922 ± 0.037	2.946ArgAsp: 2.946 ± 0.062	4.719ArgGlu: 4.719 ± 0.096	2.246ArgPhe: 2.246 ± 0.048	4.67ArgGly: 4.67 ± 0.079	1.025ArgHis: 1.025 ± 0.034	3.679ArgIle: 3.679 ± 0.062	2.877ArgLys: 2.877 ± 0.059	5.617ArgLeu: 5.617 ± 0.098	1.737ArgMet: 1.737 ± 0.043	1.813ArgAsn: 1.813 ± 0.043	2.181ArgPro: 2.181 ± 0.053	1.6ArgGln: 1.6 ± 0.041	4.19ArgArg: 4.19 ± 0.083	2.982ArgSer: 2.982 ± 0.065	2.461ArgThr: 2.461 ± 0.046	3.687ArgVal: 3.687 ± 0.066	0.715ArgTrp: 0.715 ± 0.03	1.98ArgTyr: 1.98 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.968SerAla: 5.968 ± 0.093	0.915SerCys: 0.915 ± 0.033	2.821SerAsp: 2.821 ± 0.059	3.391SerGlu: 3.391 ± 0.066	2.899SerPhe: 2.899 ± 0.059	5.776SerGly: 5.776 ± 0.101	1.009SerHis: 1.009 ± 0.032	3.365SerIle: 3.365 ± 0.061	2.561SerLys: 2.561 ± 0.049	6.044SerLeu: 6.044 ± 0.081	1.626SerMet: 1.626 ± 0.042	1.655SerAsn: 1.655 ± 0.038	2.716SerPro: 2.716 ± 0.06	1.352SerGln: 1.352 ± 0.042	3.195SerArg: 3.195 ± 0.065	3.588SerSer: 3.588 ± 0.074	2.559SerThr: 2.559 ± 0.061	4.629SerVal: 4.629 ± 0.071	0.778SerTrp: 0.778 ± 0.029	1.934SerTyr: 1.934 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.512ThrAla: 5.512 ± 0.095	0.545ThrCys: 0.545 ± 0.024	2.645ThrAsp: 2.645 ± 0.086	3.24ThrGlu: 3.24 ± 0.055	1.946ThrPhe: 1.946 ± 0.049	4.618ThrGly: 4.618 ± 0.091	0.777ThrHis: 0.777 ± 0.028	3.064ThrIle: 3.064 ± 0.077	2.481ThrLys: 2.481 ± 0.057	4.97ThrLeu: 4.97 ± 0.08	1.311ThrMet: 1.311 ± 0.037	1.498ThrAsn: 1.498 ± 0.046	2.825ThrPro: 2.825 ± 0.056	1.191ThrGln: 1.191 ± 0.035	2.285ThrArg: 2.285 ± 0.048	2.528ThrSer: 2.528 ± 0.057	2.453ThrThr: 2.453 ± 0.07	4.022ThrVal: 4.022 ± 0.081	0.508ThrTrp: 0.508 ± 0.024	1.336ThrTyr: 1.336 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.195ValAla: 6.195 ± 0.1	1.19ValCys: 1.19 ± 0.042	3.45ValAsp: 3.45 ± 0.072	4.137ValGlu: 4.137 ± 0.073	2.913ValPhe: 2.913 ± 0.056	4.922ValGly: 4.922 ± 0.082	0.986ValHis: 0.986 ± 0.028	4.99ValIle: 4.99 ± 0.085	4.027ValLys: 4.027 ± 0.074	6.414ValLeu: 6.414 ± 0.09	2.122ValMet: 2.122 ± 0.049	2.442ValAsn: 2.442 ± 0.053	3.211ValPro: 3.211 ± 0.06	1.518ValGln: 1.518 ± 0.041	3.958ValArg: 3.958 ± 0.069	4.824ValSer: 4.824 ± 0.069	4.351ValThr: 4.351 ± 0.106	5.247ValVal: 5.247 ± 0.091	0.718ValTrp: 0.718 ± 0.03	2.069ValTyr: 2.069 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.825TrpAla: 0.825 ± 0.028	0.171TrpCys: 0.171 ± 0.014	0.557TrpAsp: 0.557 ± 0.025	0.728TrpGlu: 0.728 ± 0.028	0.481TrpPhe: 0.481 ± 0.023	0.943TrpGly: 0.943 ± 0.031	0.247TrpHis: 0.247 ± 0.017	0.613TrpIle: 0.613 ± 0.023	0.684TrpLys: 0.684 ± 0.026	1.191TrpLeu: 1.191 ± 0.038	0.326TrpMet: 0.326 ± 0.023	0.496TrpAsn: 0.496 ± 0.025	0.395TrpPro: 0.395 ± 0.02	0.378TrpGln: 0.378 ± 0.023	0.767TrpArg: 0.767 ± 0.033	0.671TrpSer: 0.671 ± 0.027	0.54TrpThr: 0.54 ± 0.024	0.606TrpVal: 0.606 ± 0.026	0.172TrpTrp: 0.172 ± 0.013	0.359TrpTyr: 0.359 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.783TyrAla: 2.783 ± 0.064	0.532TyrCys: 0.532 ± 0.027	1.924TyrAsp: 1.924 ± 0.051	1.948TyrGlu: 1.948 ± 0.047	1.419TyrPhe: 1.419 ± 0.036	2.784TyrGly: 2.784 ± 0.056	0.536TyrHis: 0.536 ± 0.026	2.049TyrIle: 2.049 ± 0.049	1.554TyrLys: 1.554 ± 0.045	2.944TyrLeu: 2.944 ± 0.062	0.829TyrMet: 0.829 ± 0.028	1.203TyrAsn: 1.203 ± 0.042	1.381TyrPro: 1.381 ± 0.042	0.783TyrGln: 0.783 ± 0.029	1.936TyrArg: 1.936 ± 0.05	1.96TyrSer: 1.96 ± 0.051	1.591TyrThr: 1.591 ± 0.053	1.895TyrVal: 1.895 ± 0.042	0.375TyrTrp: 0.375 ± 0.018	1.129TyrTyr: 1.129 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2957 proteins (957959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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