Amino acid dipepetide frequency for Microviridae sp. ctOsc38

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.277AlaAla: 17.277 ± 5.521
1.382AlaCys: 1.382 ± 1.276
9.675AlaAsp: 9.675 ± 1.876
8.293AlaGlu: 8.293 ± 3.424
2.764AlaPhe: 2.764 ± 1.255
9.675AlaGly: 9.675 ± 1.546
2.764AlaHis: 2.764 ± 1.059
2.073AlaIle: 2.073 ± 1.241
4.147AlaLys: 4.147 ± 3.057
9.675AlaLeu: 9.675 ± 1.614
2.764AlaMet: 2.764 ± 1.572
3.455AlaAsn: 3.455 ± 1.1
2.764AlaPro: 2.764 ± 1.766
4.838AlaGln: 4.838 ± 1.436
7.602AlaArg: 7.602 ± 3.092
7.602AlaSer: 7.602 ± 1.931
8.984AlaThr: 8.984 ± 3.018
7.602AlaVal: 7.602 ± 1.504
0.0AlaTrp: 0.0 ± 0.0
3.455AlaTyr: 3.455 ± 1.1
0.0AlaXaa: 0.0 ± 0.0
Cys
1.382CysAla: 1.382 ± 0.883
0.691CysCys: 0.691 ± 0.638
0.691CysAsp: 0.691 ± 0.638
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.073CysGly: 2.073 ± 1.915
0.691CysHis: 0.691 ± 0.638
0.691CysIle: 0.691 ± 0.638
0.0CysLys: 0.0 ± 0.0
2.764CysLeu: 2.764 ± 0.902
0.0CysMet: 0.0 ± 0.0
0.691CysAsn: 0.691 ± 0.939
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.293AspAla: 8.293 ± 3.354
0.0AspCys: 0.0 ± 0.0
2.764AspAsp: 2.764 ± 0.731
4.147AspGlu: 4.147 ± 0.958
3.455AspPhe: 3.455 ± 2.126
4.147AspGly: 4.147 ± 1.741
1.382AspHis: 1.382 ± 0.883
0.691AspIle: 0.691 ± 0.681
0.691AspLys: 0.691 ± 0.509
3.455AspLeu: 3.455 ± 1.103
1.382AspMet: 1.382 ± 1.3
1.382AspAsn: 1.382 ± 0.661
6.22AspPro: 6.22 ± 2.382
1.382AspGln: 1.382 ± 0.58
2.764AspArg: 2.764 ± 1.155
4.147AspSer: 4.147 ± 1.594
2.073AspThr: 2.073 ± 1.415
2.764AspVal: 2.764 ± 1.714
2.764AspTrp: 2.764 ± 1.924
2.764AspTyr: 2.764 ± 1.732
0.0AspXaa: 0.0 ± 0.0
Glu
8.984GluAla: 8.984 ± 3.771
0.691GluCys: 0.691 ± 0.939
2.073GluAsp: 2.073 ± 0.853
2.764GluGlu: 2.764 ± 1.874
4.147GluPhe: 4.147 ± 1.71
4.838GluGly: 4.838 ± 3.257
1.382GluHis: 1.382 ± 1.018
2.764GluIle: 2.764 ± 1.323
4.838GluLys: 4.838 ± 1.795
3.455GluLeu: 3.455 ± 2.597
0.0GluMet: 0.0 ± 0.0
2.764GluAsn: 2.764 ± 1.644
1.382GluPro: 1.382 ± 0.883
2.764GluGln: 2.764 ± 1.766
4.838GluArg: 4.838 ± 0.951
2.764GluSer: 2.764 ± 1.874
0.691GluThr: 0.691 ± 1.25
2.764GluVal: 2.764 ± 1.415
1.382GluTrp: 1.382 ± 1.234
3.455GluTyr: 3.455 ± 1.068
0.0GluXaa: 0.0 ± 0.0
Phe
6.22PheAla: 6.22 ± 3.341
0.0PheCys: 0.0 ± 0.0
3.455PheAsp: 3.455 ± 0.977
2.764PheGlu: 2.764 ± 1.874
2.073PhePhe: 2.073 ± 1.527
6.22PheGly: 6.22 ± 0.911
0.691PheHis: 0.691 ± 0.638
0.691PheIle: 0.691 ± 0.509
0.691PheLys: 0.691 ± 0.509
3.455PheLeu: 3.455 ± 1.117
2.764PheMet: 2.764 ± 1.21
2.764PheAsn: 2.764 ± 0.731
0.0PhePro: 0.0 ± 0.0
1.382PheGln: 1.382 ± 1.018
5.529PheArg: 5.529 ± 1.557
0.691PheSer: 0.691 ± 0.509
2.764PheThr: 2.764 ± 1.85
2.073PheVal: 2.073 ± 0.964
0.0PheTrp: 0.0 ± 0.0
0.691PheTyr: 0.691 ± 0.509
0.0PheXaa: 0.0 ± 0.0
Gly
10.366GlyAla: 10.366 ± 4.18
0.691GlyCys: 0.691 ± 0.638
5.529GlyAsp: 5.529 ± 1.463
4.147GlyGlu: 4.147 ± 1.332
2.764GlyPhe: 2.764 ± 0.722
17.277GlyGly: 17.277 ± 8.561
1.382GlyHis: 1.382 ± 0.58
4.838GlyIle: 4.838 ± 1.733
4.838GlyLys: 4.838 ± 2.197
3.455GlyLeu: 3.455 ± 1.222
1.382GlyMet: 1.382 ± 0.562
2.073GlyAsn: 2.073 ± 1.093
3.455GlyPro: 3.455 ± 0.567
2.073GlyGln: 2.073 ± 0.845
6.911GlyArg: 6.911 ± 3.139
5.529GlySer: 5.529 ± 2.096
7.602GlyThr: 7.602 ± 2.995
4.147GlyVal: 4.147 ± 1.507
0.0GlyTrp: 0.0 ± 0.0
4.838GlyTyr: 4.838 ± 2.815
0.0GlyXaa: 0.0 ± 0.0
His
2.764HisAla: 2.764 ± 1.221
1.382HisCys: 1.382 ± 0.58
1.382HisAsp: 1.382 ± 0.58
2.073HisGlu: 2.073 ± 1.501
1.382HisPhe: 1.382 ± 1.018
0.0HisGly: 0.0 ± 0.0
0.691HisHis: 0.691 ± 0.509
0.691HisIle: 0.691 ± 0.509
0.691HisLys: 0.691 ± 0.681
0.691HisLeu: 0.691 ± 0.509
0.0HisMet: 0.0 ± 0.0
2.073HisAsn: 2.073 ± 1.527
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.073HisArg: 2.073 ± 1.401
1.382HisSer: 1.382 ± 1.276
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.691HisTrp: 0.691 ± 0.509
2.073HisTyr: 2.073 ± 1.915
0.0HisXaa: 0.0 ± 0.0
Ile
1.382IleAla: 1.382 ± 0.58
0.0IleCys: 0.0 ± 0.0
1.382IleAsp: 1.382 ± 0.661
0.691IleGlu: 0.691 ± 0.509
2.073IlePhe: 2.073 ± 0.886
4.838IleGly: 4.838 ± 1.475
0.691IleHis: 0.691 ± 0.638
0.691IleIle: 0.691 ± 0.509
0.0IleLys: 0.0 ± 0.0
0.691IleLeu: 0.691 ± 0.638
0.691IleMet: 0.691 ± 0.939
1.382IleAsn: 1.382 ± 0.661
5.529IlePro: 5.529 ± 1.463
1.382IleGln: 1.382 ± 0.661
3.455IleArg: 3.455 ± 1.117
1.382IleSer: 1.382 ± 1.361
1.382IleThr: 1.382 ± 1.018
1.382IleVal: 1.382 ± 1.018
0.0IleTrp: 0.0 ± 0.0
0.691IleTyr: 0.691 ± 1.25
0.0IleXaa: 0.0 ± 0.0
Lys
6.911LysAla: 6.911 ± 3.431
0.691LysCys: 0.691 ± 0.638
3.455LysAsp: 3.455 ± 1.113
3.455LysGlu: 3.455 ± 1.834
2.073LysPhe: 2.073 ± 0.61
2.764LysGly: 2.764 ± 1.155
0.691LysHis: 0.691 ± 0.638
0.691LysIle: 0.691 ± 0.638
4.838LysLys: 4.838 ± 2.539
2.073LysLeu: 2.073 ± 0.845
1.382LysMet: 1.382 ± 1.05
0.0LysAsn: 0.0 ± 0.0
0.691LysPro: 0.691 ± 0.509
0.691LysGln: 0.691 ± 0.681
5.529LysArg: 5.529 ± 3.995
0.691LysSer: 0.691 ± 0.509
4.147LysThr: 4.147 ± 0.869
1.382LysVal: 1.382 ± 1.077
1.382LysTrp: 1.382 ± 0.853
0.691LysTyr: 0.691 ± 1.25
0.0LysXaa: 0.0 ± 0.0
Leu
4.838LeuAla: 4.838 ± 1.902
0.0LeuCys: 0.0 ± 0.0
4.147LeuAsp: 4.147 ± 1.209
4.147LeuGlu: 4.147 ± 1.22
2.764LeuPhe: 2.764 ± 1.427
6.911LeuGly: 6.911 ± 2.028
2.073LeuHis: 2.073 ± 1.109
2.073LeuIle: 2.073 ± 1.093
4.147LeuLys: 4.147 ± 2.342
4.147LeuLeu: 4.147 ± 1.143
0.691LeuMet: 0.691 ± 1.602
4.147LeuAsn: 4.147 ± 0.8
6.911LeuPro: 6.911 ± 1.271
3.455LeuGln: 3.455 ± 1.192
6.22LeuArg: 6.22 ± 1.83
2.073LeuSer: 2.073 ± 0.964
3.455LeuThr: 3.455 ± 1.651
6.22LeuVal: 6.22 ± 2.196
1.382LeuTrp: 1.382 ± 0.58
2.073LeuTyr: 2.073 ± 0.886
0.0LeuXaa: 0.0 ± 0.0
Met
3.455MetAla: 3.455 ± 1.113
0.691MetCys: 0.691 ± 0.939
1.382MetAsp: 1.382 ± 0.661
1.382MetGlu: 1.382 ± 1.878
0.0MetPhe: 0.0 ± 0.0
3.455MetGly: 3.455 ± 1.192
0.0MetHis: 0.0 ± 0.0
0.691MetIle: 0.691 ± 0.939
1.382MetLys: 1.382 ± 0.853
2.073MetLeu: 2.073 ± 0.61
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.382MetPro: 1.382 ± 0.661
0.691MetGln: 0.691 ± 0.681
2.073MetArg: 2.073 ± 3.243
2.073MetSer: 2.073 ± 1.401
0.691MetThr: 0.691 ± 0.509
2.073MetVal: 2.073 ± 1.235
0.691MetTrp: 0.691 ± 0.509
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.838AsnAla: 4.838 ± 2.311
0.0AsnCys: 0.0 ± 0.0
1.382AsnAsp: 1.382 ± 1.58
2.073AsnGlu: 2.073 ± 1.448
2.073AsnPhe: 2.073 ± 0.886
2.073AsnGly: 2.073 ± 1.59
0.0AsnHis: 0.0 ± 0.0
2.073AsnIle: 2.073 ± 1.344
0.691AsnLys: 0.691 ± 0.509
5.529AsnLeu: 5.529 ± 2.559
0.0AsnMet: 0.0 ± 0.0
2.073AsnAsn: 2.073 ± 0.886
2.073AsnPro: 2.073 ± 1.344
0.691AsnGln: 0.691 ± 0.939
3.455AsnArg: 3.455 ± 1.869
3.455AsnSer: 3.455 ± 1.573
1.382AsnThr: 1.382 ± 0.661
1.382AsnVal: 1.382 ± 1.077
0.691AsnTrp: 0.691 ± 0.509
1.382AsnTyr: 1.382 ± 1.018
0.0AsnXaa: 0.0 ± 0.0
Pro
4.147ProAla: 4.147 ± 1.849
0.0ProCys: 0.0 ± 0.0
2.073ProAsp: 2.073 ± 0.964
4.838ProGlu: 4.838 ± 2.408
2.073ProPhe: 2.073 ± 0.61
5.529ProGly: 5.529 ± 1.652
0.691ProHis: 0.691 ± 0.638
2.764ProIle: 2.764 ± 1.393
1.382ProLys: 1.382 ± 1.58
4.147ProLeu: 4.147 ± 1.47
1.382ProMet: 1.382 ± 0.661
1.382ProAsn: 1.382 ± 0.661
3.455ProPro: 3.455 ± 1.615
5.529ProGln: 5.529 ± 2.876
3.455ProArg: 3.455 ± 1.651
4.147ProSer: 4.147 ± 1.332
2.764ProThr: 2.764 ± 2.036
4.838ProVal: 4.838 ± 2.045
0.691ProTrp: 0.691 ± 0.509
0.691ProTyr: 0.691 ± 0.509
0.0ProXaa: 0.0 ± 0.0
Gln
4.838GlnAla: 4.838 ± 1.732
0.0GlnCys: 0.0 ± 0.0
2.764GlnAsp: 2.764 ± 1.227
2.073GlnGlu: 2.073 ± 1.75
3.455GlnPhe: 3.455 ± 1.222
2.073GlnGly: 2.073 ± 0.964
0.691GlnHis: 0.691 ± 0.509
0.691GlnIle: 0.691 ± 0.509
3.455GlnLys: 3.455 ± 1.103
2.073GlnLeu: 2.073 ± 1.5
2.073GlnMet: 2.073 ± 1.332
1.382GlnAsn: 1.382 ± 0.883
0.0GlnPro: 0.0 ± 0.0
1.382GlnGln: 1.382 ± 0.58
3.455GlnArg: 3.455 ± 1.113
0.0GlnSer: 0.0 ± 0.0
2.764GlnThr: 2.764 ± 1.323
2.073GlnVal: 2.073 ± 1.113
0.0GlnTrp: 0.0 ± 0.0
2.073GlnTyr: 2.073 ± 0.845
0.0GlnXaa: 0.0 ± 0.0
Arg
5.529ArgAla: 5.529 ± 0.78
1.382ArgCys: 1.382 ± 1.276
3.455ArgAsp: 3.455 ± 1.615
4.147ArgGlu: 4.147 ± 2.162
2.764ArgPhe: 2.764 ± 2.667
8.984ArgGly: 8.984 ± 2.663
0.691ArgHis: 0.691 ± 0.509
1.382ArgIle: 1.382 ± 0.58
4.838ArgLys: 4.838 ± 2.539
8.984ArgLeu: 8.984 ± 3.329
4.838ArgMet: 4.838 ± 1.355
0.691ArgAsn: 0.691 ± 1.601
4.838ArgPro: 4.838 ± 2.214
2.764ArgGln: 2.764 ± 0.731
8.984ArgArg: 8.984 ± 8.77
6.911ArgSer: 6.911 ± 1.98
4.147ArgThr: 4.147 ± 2.55
2.073ArgVal: 2.073 ± 3.124
1.382ArgTrp: 1.382 ± 0.58
4.147ArgTyr: 4.147 ± 2.218
0.0ArgXaa: 0.0 ± 0.0
Ser
9.675SerAla: 9.675 ± 2.302
0.691SerCys: 0.691 ± 0.509
0.691SerAsp: 0.691 ± 0.509
3.455SerGlu: 3.455 ± 2.412
0.691SerPhe: 0.691 ± 0.509
3.455SerGly: 3.455 ± 1.117
2.073SerHis: 2.073 ± 1.527
1.382SerIle: 1.382 ± 1.018
2.073SerLys: 2.073 ± 2.645
4.838SerLeu: 4.838 ± 1.475
0.691SerMet: 0.691 ± 0.509
2.073SerAsn: 2.073 ± 1.241
2.764SerPro: 2.764 ± 0.731
1.382SerGln: 1.382 ± 1.018
5.529SerArg: 5.529 ± 2.233
2.764SerSer: 2.764 ± 1.393
4.838SerThr: 4.838 ± 2.033
4.838SerVal: 4.838 ± 2.194
0.691SerTrp: 0.691 ± 0.638
1.382SerTyr: 1.382 ± 1.018
0.0SerXaa: 0.0 ± 0.0
Thr
8.293ThrAla: 8.293 ± 3.835
0.0ThrCys: 0.0 ± 0.0
3.455ThrAsp: 3.455 ± 2.546
1.382ThrGlu: 1.382 ± 1.018
4.147ThrPhe: 4.147 ± 1.143
4.147ThrGly: 4.147 ± 2.001
0.0ThrHis: 0.0 ± 0.0
0.691ThrIle: 0.691 ± 0.509
1.382ThrLys: 1.382 ± 1.05
6.22ThrLeu: 6.22 ± 1.52
1.382ThrMet: 1.382 ± 0.853
2.073ThrAsn: 2.073 ± 2.042
4.838ThrPro: 4.838 ± 2.843
0.0ThrGln: 0.0 ± 0.0
4.147ThrArg: 4.147 ± 2.165
4.147ThrSer: 4.147 ± 3.055
3.455ThrThr: 3.455 ± 2.373
4.147ThrVal: 4.147 ± 1.12
0.691ThrTrp: 0.691 ± 0.509
0.691ThrTyr: 0.691 ± 0.638
0.0ThrXaa: 0.0 ± 0.0
Val
3.455ValAla: 3.455 ± 1.795
1.382ValCys: 1.382 ± 0.883
4.147ValAsp: 4.147 ± 1.631
3.455ValGlu: 3.455 ± 1.311
2.764ValPhe: 2.764 ± 1.161
0.691ValGly: 0.691 ± 0.681
1.382ValHis: 1.382 ± 1.551
2.073ValIle: 2.073 ± 0.886
2.764ValLys: 2.764 ± 1.221
1.382ValLeu: 1.382 ± 1.018
2.073ValMet: 2.073 ± 1.688
2.073ValAsn: 2.073 ± 1.59
6.911ValPro: 6.911 ± 3.52
2.073ValGln: 2.073 ± 1.75
4.838ValArg: 4.838 ± 3.291
4.147ValSer: 4.147 ± 1.772
2.764ValThr: 2.764 ± 1.323
4.147ValVal: 4.147 ± 1.234
1.382ValTrp: 1.382 ± 0.58
2.073ValTyr: 2.073 ± 0.886
0.0ValXaa: 0.0 ± 0.0
Trp
2.073TrpAla: 2.073 ± 0.61
0.0TrpCys: 0.0 ± 0.0
1.382TrpAsp: 1.382 ± 1.234
0.691TrpGlu: 0.691 ± 0.638
0.691TrpPhe: 0.691 ± 0.509
0.0TrpGly: 0.0 ± 0.0
0.691TrpHis: 0.691 ± 0.509
0.691TrpIle: 0.691 ± 0.638
0.0TrpLys: 0.0 ± 0.0
0.691TrpLeu: 0.691 ± 0.681
0.0TrpMet: 0.0 ± 0.0
2.073TrpAsn: 2.073 ± 0.886
2.073TrpPro: 2.073 ± 0.886
1.382TrpGln: 1.382 ± 0.58
0.691TrpArg: 0.691 ± 0.638
1.382TrpSer: 1.382 ± 0.58
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.073TyrAla: 2.073 ± 1.109
0.0TyrCys: 0.0 ± 0.0
1.382TyrAsp: 1.382 ± 1.276
2.764TyrGlu: 2.764 ± 1.714
2.764TyrPhe: 2.764 ± 1.323
4.147TyrGly: 4.147 ± 2.337
1.382TyrHis: 1.382 ± 1.077
1.382TyrIle: 1.382 ± 0.58
1.382TyrLys: 1.382 ± 1.234
2.764TyrLeu: 2.764 ± 0.731
0.0TyrMet: 0.0 ± 0.0
2.764TyrAsn: 2.764 ± 1.393
0.691TyrPro: 0.691 ± 1.25
3.455TyrGln: 3.455 ± 1.1
1.382TyrArg: 1.382 ± 1.018
0.691TyrSer: 0.691 ± 1.25
1.382TyrThr: 1.382 ± 1.018
2.073TyrVal: 2.073 ± 1.109
0.691TyrTrp: 0.691 ± 0.509
1.382TyrTyr: 1.382 ± 1.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski