Amino acid dipepetide frequency for Macrococcus caseolyticus (strain JCSC5402)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.606AlaAla: 4.606 ± 0.101	0.546AlaCys: 0.546 ± 0.028	3.19AlaAsp: 3.19 ± 0.082	4.023AlaGlu: 4.023 ± 0.084	2.998AlaPhe: 2.998 ± 0.078	4.481AlaGly: 4.481 ± 0.097	1.61AlaHis: 1.61 ± 0.059	5.654AlaIle: 5.654 ± 0.105	4.301AlaLys: 4.301 ± 0.093	7.123AlaLeu: 7.123 ± 0.126	2.13AlaMet: 2.13 ± 0.072	2.41AlaAsn: 2.41 ± 0.07	1.99AlaPro: 1.99 ± 0.062	2.657AlaGln: 2.657 ± 0.07	2.52AlaArg: 2.52 ± 0.063	3.711AlaSer: 3.711 ± 0.072	3.545AlaThr: 3.545 ± 0.086	4.788AlaVal: 4.788 ± 0.09	0.425AlaTrp: 0.425 ± 0.027	2.406AlaTyr: 2.406 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.423CysAla: 0.423 ± 0.027	0.086CysCys: 0.086 ± 0.012	0.387CysAsp: 0.387 ± 0.027	0.387CysGlu: 0.387 ± 0.03	0.269CysPhe: 0.269 ± 0.02	0.624CysGly: 0.624 ± 0.033	0.199CysHis: 0.199 ± 0.017	0.591CysIle: 0.591 ± 0.03	0.356CysLys: 0.356 ± 0.019	0.582CysLeu: 0.582 ± 0.029	0.145CysMet: 0.145 ± 0.015	0.331CysAsn: 0.331 ± 0.022	0.313CysPro: 0.313 ± 0.022	0.176CysGln: 0.176 ± 0.017	0.247CysArg: 0.247 ± 0.021	0.381CysSer: 0.381 ± 0.026	0.415CysThr: 0.415 ± 0.026	0.42CysVal: 0.42 ± 0.027	0.042CysTrp: 0.042 ± 0.008	0.241CysTyr: 0.241 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.173AspAla: 4.173 ± 0.084	0.392AspCys: 0.392 ± 0.028	3.226AspAsp: 3.226 ± 0.086	4.987AspGlu: 4.987 ± 0.097	2.671AspPhe: 2.671 ± 0.065	3.442AspGly: 3.442 ± 0.079	1.176AspHis: 1.176 ± 0.043	5.479AspIle: 5.479 ± 0.095	4.654AspLys: 4.654 ± 0.088	4.696AspLeu: 4.696 ± 0.087	1.563AspMet: 1.563 ± 0.043	2.951AspAsn: 2.951 ± 0.087	1.487AspPro: 1.487 ± 0.062	1.556AspGln: 1.556 ± 0.048	2.056AspArg: 2.056 ± 0.061	2.602AspSer: 2.602 ± 0.069	3.134AspThr: 3.134 ± 0.069	4.122AspVal: 4.122 ± 0.089	0.431AspTrp: 0.431 ± 0.026	2.76AspTyr: 2.76 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	5.143GluAla: 5.143 ± 0.117	0.317GluCys: 0.317 ± 0.025	4.093GluAsp: 4.093 ± 0.074	5.513GluGlu: 5.513 ± 0.109	2.382GluPhe: 2.382 ± 0.063	3.828GluGly: 3.828 ± 0.076	1.862GluHis: 1.862 ± 0.056	6.062GluIle: 6.062 ± 0.112	5.538GluLys: 5.538 ± 0.105	6.325GluLeu: 6.325 ± 0.112	2.322GluMet: 2.322 ± 0.061	3.386GluAsn: 3.386 ± 0.082	1.58GluPro: 1.58 ± 0.044	3.231GluGln: 3.231 ± 0.082	3.612GluArg: 3.612 ± 0.078	3.704GluSer: 3.704 ± 0.073	4.041GluThr: 4.041 ± 0.093	5.222GluVal: 5.222 ± 0.108	0.565GluTrp: 0.565 ± 0.031	2.601GluTyr: 2.601 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.526PheAla: 2.526 ± 0.068	0.292PheCys: 0.292 ± 0.021	2.814PheAsp: 2.814 ± 0.065	3.117PheGlu: 3.117 ± 0.065	2.108PhePhe: 2.108 ± 0.077	3.155PheGly: 3.155 ± 0.076	0.915PheHis: 0.915 ± 0.038	4.374PheIle: 4.374 ± 0.101	3.302PheLys: 3.302 ± 0.078	3.803PheLeu: 3.803 ± 0.097	1.305PheMet: 1.305 ± 0.047	2.837PheAsn: 2.837 ± 0.075	1.274PhePro: 1.274 ± 0.044	1.258PheGln: 1.258 ± 0.043	1.358PheArg: 1.358 ± 0.048	2.784PheSer: 2.784 ± 0.077	2.571PheThr: 2.571 ± 0.066	2.979PheVal: 2.979 ± 0.077	0.319PheTrp: 0.319 ± 0.022	1.7PheTyr: 1.7 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.368GlyAla: 4.368 ± 0.107	0.502GlyCys: 0.502 ± 0.031	3.197GlyAsp: 3.197 ± 0.08	3.875GlyGlu: 3.875 ± 0.082	2.985GlyPhe: 2.985 ± 0.086	4.285GlyGly: 4.285 ± 0.114	1.514GlyHis: 1.514 ± 0.051	5.734GlyIle: 5.734 ± 0.102	4.562GlyLys: 4.562 ± 0.092	5.787GlyLeu: 5.787 ± 0.12	1.918GlyMet: 1.918 ± 0.055	2.714GlyAsn: 2.714 ± 0.071	1.529GlyPro: 1.529 ± 0.061	2.092GlyGln: 2.092 ± 0.053	2.453GlyArg: 2.453 ± 0.062	3.357GlySer: 3.357 ± 0.075	3.827GlyThr: 3.827 ± 0.089	4.572GlyVal: 4.572 ± 0.096	0.543GlyTrp: 0.543 ± 0.034	2.907GlyTyr: 2.907 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.515HisAla: 1.515 ± 0.055	0.157HisCys: 0.157 ± 0.015	1.361HisAsp: 1.361 ± 0.046	1.664HisGlu: 1.664 ± 0.057	1.181HisPhe: 1.181 ± 0.044	1.428HisGly: 1.428 ± 0.053	0.846HisHis: 0.846 ± 0.039	2.137HisIle: 2.137 ± 0.058	1.341HisLys: 1.341 ± 0.053	2.26HisLeu: 2.26 ± 0.059	0.649HisMet: 0.649 ± 0.032	1.173HisAsn: 1.173 ± 0.044	1.145HisPro: 1.145 ± 0.045	0.868HisGln: 0.868 ± 0.036	0.873HisArg: 0.873 ± 0.038	1.178HisSer: 1.178 ± 0.045	1.262HisThr: 1.262 ± 0.052	1.542HisVal: 1.542 ± 0.056	0.137HisTrp: 0.137 ± 0.014	1.188HisTyr: 1.188 ± 0.049	0.0HisXaa: 0.0 ± 0.0
Ile	6.07IleAla: 6.07 ± 0.103	0.681IleCys: 0.681 ± 0.035	5.664IleAsp: 5.664 ± 0.095	6.763IleGlu: 6.763 ± 0.12	3.547IlePhe: 3.547 ± 0.098	5.928IleGly: 5.928 ± 0.113	1.94IleHis: 1.94 ± 0.063	7.395IleIle: 7.395 ± 0.156	6.124IleLys: 6.124 ± 0.102	6.907IleLeu: 6.907 ± 0.138	2.232IleMet: 2.232 ± 0.071	4.562IleAsn: 4.562 ± 0.093	3.131IlePro: 3.131 ± 0.065	2.931IleGln: 2.931 ± 0.07	2.868IleArg: 2.868 ± 0.065	5.063IleSer: 5.063 ± 0.09	4.936IleThr: 4.936 ± 0.082	5.699IleVal: 5.699 ± 0.101	0.526IleTrp: 0.526 ± 0.03	3.063IleTyr: 3.063 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.836LysAla: 4.836 ± 0.081	0.344LysCys: 0.344 ± 0.027	4.755LysAsp: 4.755 ± 0.093	6.16LysGlu: 6.16 ± 0.118	2.725LysPhe: 2.725 ± 0.069	4.228LysGly: 4.228 ± 0.087	1.825LysHis: 1.825 ± 0.055	5.034LysIle: 5.034 ± 0.097	5.857LysLys: 5.857 ± 0.12	6.441LysLeu: 6.441 ± 0.114	2.318LysMet: 2.318 ± 0.059	3.68LysAsn: 3.68 ± 0.085	2.13LysPro: 2.13 ± 0.057	3.212LysGln: 3.212 ± 0.073	3.383LysArg: 3.383 ± 0.081	4.268LysSer: 4.268 ± 0.092	3.925LysThr: 3.925 ± 0.087	5.213LysVal: 5.213 ± 0.108	0.557LysTrp: 0.557 ± 0.022	2.879LysTyr: 2.879 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	5.687LeuAla: 5.687 ± 0.1	0.649LeuCys: 0.649 ± 0.032	5.073LeuAsp: 5.073 ± 0.11	6.034LeuGlu: 6.034 ± 0.115	4.513LeuPhe: 4.513 ± 0.109	5.502LeuGly: 5.502 ± 0.124	1.825LeuHis: 1.825 ± 0.055	7.709LeuIle: 7.709 ± 0.139	7.236LeuLys: 7.236 ± 0.12	8.933LeuLeu: 8.933 ± 0.164	2.847LeuMet: 2.847 ± 0.062	5.387LeuAsn: 5.387 ± 0.102	3.416LeuPro: 3.416 ± 0.072	3.029LeuGln: 3.029 ± 0.07	3.06LeuArg: 3.06 ± 0.071	6.703LeuSer: 6.703 ± 0.114	5.339LeuThr: 5.339 ± 0.093	5.472LeuVal: 5.472 ± 0.104	0.582LeuTrp: 0.582 ± 0.031	3.281LeuTyr: 3.281 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.804MetAla: 1.804 ± 0.051	0.16MetCys: 0.16 ± 0.016	1.593MetAsp: 1.593 ± 0.051	1.66MetGlu: 1.66 ± 0.051	1.198MetPhe: 1.198 ± 0.04	1.594MetGly: 1.594 ± 0.053	0.753MetHis: 0.753 ± 0.036	2.68MetIle: 2.68 ± 0.062	2.663MetLys: 2.663 ± 0.075	2.865MetLeu: 2.865 ± 0.074	1.083MetMet: 1.083 ± 0.044	2.019MetAsn: 2.019 ± 0.058	1.041MetPro: 1.041 ± 0.038	1.042MetGln: 1.042 ± 0.046	1.199MetArg: 1.199 ± 0.036	1.857MetSer: 1.857 ± 0.062	1.935MetThr: 1.935 ± 0.059	1.528MetVal: 1.528 ± 0.046	0.194MetTrp: 0.194 ± 0.017	0.972MetTyr: 0.972 ± 0.043	0.0MetXaa: 0.0 ± 0.0
Asn	3.046AsnAla: 3.046 ± 0.068	0.31AsnCys: 0.31 ± 0.024	3.15AsnAsp: 3.15 ± 0.077	3.795AsnGlu: 3.795 ± 0.083	2.07AsnPhe: 2.07 ± 0.061	3.259AsnGly: 3.259 ± 0.073	1.322AsnHis: 1.322 ± 0.046	4.513AsnIle: 4.513 ± 0.086	4.206AsnLys: 4.206 ± 0.094	4.167AsnLeu: 4.167 ± 0.088	1.44AsnMet: 1.44 ± 0.052	2.882AsnAsn: 2.882 ± 0.084	1.943AsnPro: 1.943 ± 0.052	1.999AsnGln: 1.999 ± 0.059	2.014AsnArg: 2.014 ± 0.056	2.33AsnSer: 2.33 ± 0.081	2.691AsnThr: 2.691 ± 0.081	3.376AsnVal: 3.376 ± 0.075	0.378AsnTrp: 0.378 ± 0.025	2.038AsnTyr: 2.038 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.938ProAla: 1.938 ± 0.058	0.168ProCys: 0.168 ± 0.019	1.885ProAsp: 1.885 ± 0.064	2.805ProGlu: 2.805 ± 0.074	1.752ProPhe: 1.752 ± 0.059	2.105ProGly: 2.105 ± 0.068	0.781ProHis: 0.781 ± 0.036	2.48ProIle: 2.48 ± 0.061	2.162ProLys: 2.162 ± 0.058	2.957ProLeu: 2.957 ± 0.076	0.866ProMet: 0.866 ± 0.035	1.51ProAsn: 1.51 ± 0.055	0.728ProPro: 0.728 ± 0.038	0.848ProGln: 0.848 ± 0.033	0.898ProArg: 0.898 ± 0.038	1.882ProSer: 1.882 ± 0.06	1.699ProThr: 1.699 ± 0.06	2.764ProVal: 2.764 ± 0.081	0.264ProTrp: 0.264 ± 0.02	1.361ProTyr: 1.361 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	2.324GlnAla: 2.324 ± 0.069	0.185GlnCys: 0.185 ± 0.017	1.831GlnAsp: 1.831 ± 0.05	2.312GlnGlu: 2.312 ± 0.06	1.739GlnPhe: 1.739 ± 0.051	1.87GlnGly: 1.87 ± 0.052	0.932GlnHis: 0.932 ± 0.044	2.826GlnIle: 2.826 ± 0.074	2.564GlnLys: 2.564 ± 0.068	3.906GlnLeu: 3.906 ± 0.084	1.276GlnMet: 1.276 ± 0.041	1.629GlnAsn: 1.629 ± 0.055	1.111GlnPro: 1.111 ± 0.047	1.61GlnGln: 1.61 ± 0.063	1.336GlnArg: 1.336 ± 0.046	2.417GlnSer: 2.417 ± 0.064	1.871GlnThr: 1.871 ± 0.064	2.212GlnVal: 2.212 ± 0.063	0.257GlnTrp: 0.257 ± 0.019	1.622GlnTyr: 1.622 ± 0.053	0.0GlnXaa: 0.0 ± 0.0
Arg	2.377ArgAla: 2.377 ± 0.071	0.227ArgCys: 0.227 ± 0.019	2.119ArgAsp: 2.119 ± 0.059	2.64ArgGlu: 2.64 ± 0.07	1.767ArgPhe: 1.767 ± 0.051	2.189ArgGly: 2.189 ± 0.064	0.921ArgHis: 0.921 ± 0.043	3.256ArgIle: 3.256 ± 0.084	2.914ArgLys: 2.914 ± 0.073	3.663ArgLeu: 3.663 ± 0.079	1.332ArgMet: 1.332 ± 0.046	2.055ArgAsn: 2.055 ± 0.057	1.139ArgPro: 1.139 ± 0.042	1.467ArgGln: 1.467 ± 0.044	1.75ArgArg: 1.75 ± 0.054	1.972ArgSer: 1.972 ± 0.055	2.131ArgThr: 2.131 ± 0.061	2.453ArgVal: 2.453 ± 0.075	0.285ArgTrp: 0.285 ± 0.022	1.57ArgTyr: 1.57 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.432SerAla: 3.432 ± 0.08	0.386SerCys: 0.386 ± 0.028	3.254SerAsp: 3.254 ± 0.07	4.1SerGlu: 4.1 ± 0.083	2.876SerPhe: 2.876 ± 0.061	3.998SerGly: 3.998 ± 0.094	1.347SerHis: 1.347 ± 0.05	5.045SerIle: 5.045 ± 0.096	4.055SerLys: 4.055 ± 0.085	5.499SerLeu: 5.499 ± 0.097	1.599SerMet: 1.599 ± 0.05	2.917SerAsn: 2.917 ± 0.067	1.654SerPro: 1.654 ± 0.055	1.865SerGln: 1.865 ± 0.055	2.34SerArg: 2.34 ± 0.063	3.366SerSer: 3.366 ± 0.083	3.103SerThr: 3.103 ± 0.084	3.917SerVal: 3.917 ± 0.069	0.428SerTrp: 0.428 ± 0.028	2.467SerTyr: 2.467 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	3.589ThrAla: 3.589 ± 0.095	0.308ThrCys: 0.308 ± 0.023	3.178ThrAsp: 3.178 ± 0.081	3.764ThrGlu: 3.764 ± 0.099	2.746ThrPhe: 2.746 ± 0.066	4.021ThrGly: 4.021 ± 0.092	1.49ThrHis: 1.49 ± 0.05	4.769ThrIle: 4.769 ± 0.091	3.604ThrLys: 3.604 ± 0.073	5.734ThrLeu: 5.734 ± 0.086	1.464ThrMet: 1.464 ± 0.05	2.489ThrAsn: 2.489 ± 0.057	2.347ThrPro: 2.347 ± 0.067	1.801ThrGln: 1.801 ± 0.06	1.871ThrArg: 1.871 ± 0.052	3.218ThrSer: 3.218 ± 0.069	3.301ThrThr: 3.301 ± 0.105	4.231ThrVal: 4.231 ± 0.094	0.439ThrTrp: 0.439 ± 0.025	2.285ThrTyr: 2.285 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.334ValAla: 4.334 ± 0.087	0.544ValCys: 0.544 ± 0.032	3.861ValAsp: 3.861 ± 0.073	4.536ValGlu: 4.536 ± 0.085	2.792ValPhe: 2.792 ± 0.07	4.023ValGly: 4.023 ± 0.089	1.412ValHis: 1.412 ± 0.042	6.214ValIle: 6.214 ± 0.104	5.029ValLys: 5.029 ± 0.094	6.172ValLeu: 6.172 ± 0.118	2.069ValMet: 2.069 ± 0.058	3.444ValAsn: 3.444 ± 0.075	2.369ValPro: 2.369 ± 0.062	2.315ValGln: 2.315 ± 0.058	2.466ValArg: 2.466 ± 0.061	4.242ValSer: 4.242 ± 0.081	4.435ValThr: 4.435 ± 0.101	4.772ValVal: 4.772 ± 0.1	0.439ValTrp: 0.439 ± 0.028	2.425ValTyr: 2.425 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.417TrpAla: 0.417 ± 0.025	0.07TrpCys: 0.07 ± 0.012	0.359TrpAsp: 0.359 ± 0.026	0.362TrpGlu: 0.362 ± 0.024	0.394TrpPhe: 0.394 ± 0.027	0.401TrpGly: 0.401 ± 0.025	0.182TrpHis: 0.182 ± 0.017	0.734TrpIle: 0.734 ± 0.037	0.474TrpLys: 0.474 ± 0.029	0.82TrpLeu: 0.82 ± 0.04	0.257TrpMet: 0.257 ± 0.02	0.434TrpAsn: 0.434 ± 0.027	0.208TrpPro: 0.208 ± 0.019	0.286TrpGln: 0.286 ± 0.025	0.264TrpArg: 0.264 ± 0.021	0.411TrpSer: 0.411 ± 0.025	0.355TrpThr: 0.355 ± 0.022	0.406TrpVal: 0.406 ± 0.029	0.081TrpTrp: 0.081 ± 0.012	0.291TrpTyr: 0.291 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.506TyrAla: 2.506 ± 0.064	0.291TyrCys: 0.291 ± 0.022	2.57TyrAsp: 2.57 ± 0.072	2.828TyrGlu: 2.828 ± 0.063	2.084TyrPhe: 2.084 ± 0.058	2.36TyrGly: 2.36 ± 0.063	1.053TyrHis: 1.053 ± 0.045	3.344TyrIle: 3.344 ± 0.083	2.826TyrLys: 2.826 ± 0.068	3.634TyrLeu: 3.634 ± 0.087	1.027TyrMet: 1.027 ± 0.043	2.119TyrAsn: 2.119 ± 0.064	1.319TyrPro: 1.319 ± 0.05	1.587TyrGln: 1.587 ± 0.052	1.655TyrArg: 1.655 ± 0.057	2.198TyrSer: 2.198 ± 0.06	2.134TyrThr: 2.134 ± 0.059	2.206TyrVal: 2.206 ± 0.059	0.317TyrTrp: 0.317 ± 0.023	1.766TyrTyr: 1.766 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2059 proteins (642868 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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