Amino acid dipepetide frequency for Anaerotruncus sp. CAG:390

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.632AlaAla: 13.632 ± 0.232	1.408AlaCys: 1.408 ± 0.054	6.755AlaAsp: 6.755 ± 0.099	7.458AlaGlu: 7.458 ± 0.119	3.56AlaPhe: 3.56 ± 0.085	7.756AlaGly: 7.756 ± 0.117	1.765AlaHis: 1.765 ± 0.052	4.71AlaIle: 4.71 ± 0.088	4.359AlaLys: 4.359 ± 0.087	9.072AlaLeu: 9.072 ± 0.113	2.384AlaMet: 2.384 ± 0.074	2.393AlaAsn: 2.393 ± 0.061	3.364AlaPro: 3.364 ± 0.088	1.981AlaGln: 1.981 ± 0.061	4.985AlaArg: 4.985 ± 0.089	5.23AlaSer: 5.23 ± 0.09	3.733AlaThr: 3.733 ± 0.086	9.147AlaVal: 9.147 ± 0.144	0.685AlaTrp: 0.685 ± 0.038	3.079AlaTyr: 3.079 ± 0.072	0.006AlaXaa: 0.006 ± 0.003
Cys	1.711CysAla: 1.711 ± 0.052	0.383CysCys: 0.383 ± 0.028	1.295CysAsp: 1.295 ± 0.045	1.092CysGlu: 1.092 ± 0.045	0.768CysPhe: 0.768 ± 0.034	2.265CysGly: 2.265 ± 0.066	0.324CysHis: 0.324 ± 0.022	0.982CysIle: 0.982 ± 0.041	0.569CysLys: 0.569 ± 0.032	1.228CysLeu: 1.228 ± 0.04	0.343CysMet: 0.343 ± 0.024	0.486CysAsn: 0.486 ± 0.026	0.775CysPro: 0.775 ± 0.038	0.227CysGln: 0.227 ± 0.02	1.463CysArg: 1.463 ± 0.055	1.0CysSer: 1.0 ± 0.048	0.888CysThr: 0.888 ± 0.038	1.199CysVal: 1.199 ± 0.044	0.117CysTrp: 0.117 ± 0.013	0.527CysTyr: 0.527 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	6.094AspAla: 6.094 ± 0.106	0.98AspCys: 0.98 ± 0.037	3.798AspAsp: 3.798 ± 0.081	4.55AspGlu: 4.55 ± 0.087	2.613AspPhe: 2.613 ± 0.066	6.385AspGly: 6.385 ± 0.129	0.915AspHis: 0.915 ± 0.043	4.658AspIle: 4.658 ± 0.08	3.026AspLys: 3.026 ± 0.07	4.405AspLeu: 4.405 ± 0.085	1.696AspMet: 1.696 ± 0.045	2.026AspAsn: 2.026 ± 0.056	2.43AspPro: 2.43 ± 0.058	0.753AspGln: 0.753 ± 0.039	3.713AspArg: 3.713 ± 0.08	3.461AspSer: 3.461 ± 0.061	3.412AspThr: 3.412 ± 0.068	4.037AspVal: 4.037 ± 0.078	0.569AspTrp: 0.569 ± 0.036	2.495AspTyr: 2.495 ± 0.065	0.001AspXaa: 0.001 ± 0.001
Glu	5.577GluAla: 5.577 ± 0.091	0.962GluCys: 0.962 ± 0.039	3.22GluAsp: 3.22 ± 0.073	3.939GluGlu: 3.939 ± 0.093	2.393GluPhe: 2.393 ± 0.057	3.927GluGly: 3.927 ± 0.085	1.184GluHis: 1.184 ± 0.043	4.328GluIle: 4.328 ± 0.086	5.35GluLys: 5.35 ± 0.109	6.154GluLeu: 6.154 ± 0.114	1.794GluMet: 1.794 ± 0.053	3.287GluAsn: 3.287 ± 0.08	2.038GluPro: 2.038 ± 0.068	1.681GluGln: 1.681 ± 0.053	4.22GluArg: 4.22 ± 0.086	3.343GluSer: 3.343 ± 0.083	3.419GluThr: 3.419 ± 0.076	3.666GluVal: 3.666 ± 0.078	0.566GluTrp: 0.566 ± 0.03	2.861GluTyr: 2.861 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	4.097PheAla: 4.097 ± 0.077	0.994PheCys: 0.994 ± 0.041	2.947PheAsp: 2.947 ± 0.058	2.434PheGlu: 2.434 ± 0.065	1.932PhePhe: 1.932 ± 0.061	3.645PheGly: 3.645 ± 0.081	0.578PheHis: 0.578 ± 0.031	2.766PheIle: 2.766 ± 0.066	1.371PheLys: 1.371 ± 0.045	3.119PheLeu: 3.119 ± 0.073	0.988PheMet: 0.988 ± 0.039	1.312PheAsn: 1.312 ± 0.045	1.515PhePro: 1.515 ± 0.048	0.575PheGln: 0.575 ± 0.031	2.366PheArg: 2.366 ± 0.062	2.962PheSer: 2.962 ± 0.069	2.543PheThr: 2.543 ± 0.063	2.867PheVal: 2.867 ± 0.076	0.37PheTrp: 0.37 ± 0.022	1.64PheTyr: 1.64 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	7.186GlyAla: 7.186 ± 0.112	1.567GlyCys: 1.567 ± 0.054	4.968GlyAsp: 4.968 ± 0.093	5.184GlyGlu: 5.184 ± 0.09	3.207GlyPhe: 3.207 ± 0.065	6.357GlyGly: 6.357 ± 0.113	1.334GlyHis: 1.334 ± 0.05	5.983GlyIle: 5.983 ± 0.106	5.589GlyLys: 5.589 ± 0.115	5.721GlyLeu: 5.721 ± 0.114	2.43GlyMet: 2.43 ± 0.055	2.901GlyAsn: 2.901 ± 0.066	1.11GlyPro: 1.11 ± 0.046	1.615GlyGln: 1.615 ± 0.047	4.255GlyArg: 4.255 ± 0.092	5.028GlySer: 5.028 ± 0.093	4.818GlyThr: 4.818 ± 0.094	5.776GlyVal: 5.776 ± 0.11	0.707GlyTrp: 0.707 ± 0.031	3.271GlyTyr: 3.271 ± 0.065	0.004GlyXaa: 0.004 ± 0.002
His	1.427HisAla: 1.427 ± 0.051	0.318HisCys: 0.318 ± 0.023	1.069HisAsp: 1.069 ± 0.04	1.037HisGlu: 1.037 ± 0.042	0.75HisPhe: 0.75 ± 0.037	1.668HisGly: 1.668 ± 0.047	0.376HisHis: 0.376 ± 0.026	1.295HisIle: 1.295 ± 0.046	0.766HisLys: 0.766 ± 0.028	1.389HisLeu: 1.389 ± 0.043	0.419HisMet: 0.419 ± 0.025	0.619HisAsn: 0.619 ± 0.032	0.925HisPro: 0.925 ± 0.037	0.276HisGln: 0.276 ± 0.023	1.087HisArg: 1.087 ± 0.043	0.971HisSer: 0.971 ± 0.037	1.075HisThr: 1.075 ± 0.042	1.028HisVal: 1.028 ± 0.042	0.144HisTrp: 0.144 ± 0.015	0.624HisTyr: 0.624 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.304IleAla: 6.304 ± 0.11	1.417IleCys: 1.417 ± 0.043	4.021IleAsp: 4.021 ± 0.088	3.715IleGlu: 3.715 ± 0.085	2.648IlePhe: 2.648 ± 0.075	4.982IleGly: 4.982 ± 0.094	0.96IleHis: 0.96 ± 0.038	4.282IleIle: 4.282 ± 0.095	3.357IleLys: 3.357 ± 0.084	5.132IleLeu: 5.132 ± 0.109	1.626IleMet: 1.626 ± 0.05	2.311IleAsn: 2.311 ± 0.073	3.116IlePro: 3.116 ± 0.074	1.056IleGln: 1.056 ± 0.048	3.488IleArg: 3.488 ± 0.074	4.627IleSer: 4.627 ± 0.096	3.854IleThr: 3.854 ± 0.081	4.472IleVal: 4.472 ± 0.086	0.557IleTrp: 0.557 ± 0.032	2.427IleTyr: 2.427 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.149LysAla: 4.149 ± 0.077	0.775LysCys: 0.775 ± 0.04	2.736LysAsp: 2.736 ± 0.079	3.199LysGlu: 3.199 ± 0.085	1.788LysPhe: 1.788 ± 0.056	2.874LysGly: 2.874 ± 0.069	0.909LysHis: 0.909 ± 0.037	3.722LysIle: 3.722 ± 0.078	4.714LysLys: 4.714 ± 0.086	5.009LysLeu: 5.009 ± 0.087	1.738LysMet: 1.738 ± 0.049	2.914LysAsn: 2.914 ± 0.064	2.001LysPro: 2.001 ± 0.056	1.389LysGln: 1.389 ± 0.049	2.972LysArg: 2.972 ± 0.071	2.944LysSer: 2.944 ± 0.065	3.437LysThr: 3.437 ± 0.075	3.112LysVal: 3.112 ± 0.071	0.46LysTrp: 0.46 ± 0.028	2.911LysTyr: 2.911 ± 0.069	0.003LysXaa: 0.003 ± 0.002
Leu	8.18LeuAla: 8.18 ± 0.106	2.068LeuCys: 2.068 ± 0.056	5.267LeuAsp: 5.267 ± 0.099	4.799LeuGlu: 4.799 ± 0.078	3.733LeuPhe: 3.733 ± 0.08	6.68LeuGly: 6.68 ± 0.116	1.548LeuHis: 1.548 ± 0.051	5.576LeuIle: 5.576 ± 0.115	3.837LeuLys: 3.837 ± 0.08	7.975LeuLeu: 7.975 ± 0.136	2.219LeuMet: 2.219 ± 0.056	2.635LeuAsn: 2.635 ± 0.065	4.083LeuPro: 4.083 ± 0.093	1.41LeuGln: 1.41 ± 0.048	5.475LeuArg: 5.475 ± 0.099	6.388LeuSer: 6.388 ± 0.108	5.457LeuThr: 5.457 ± 0.086	5.26LeuVal: 5.26 ± 0.082	0.841LeuTrp: 0.841 ± 0.034	3.106LeuTyr: 3.106 ± 0.071	0.001LeuXaa: 0.001 ± 0.001
Met	2.007MetAla: 2.007 ± 0.055	0.373MetCys: 0.373 ± 0.021	1.132MetAsp: 1.132 ± 0.039	1.233MetGlu: 1.233 ± 0.045	0.937MetPhe: 0.937 ± 0.037	1.567MetGly: 1.567 ± 0.054	0.481MetHis: 0.481 ± 0.028	1.787MetIle: 1.787 ± 0.058	2.163MetLys: 2.163 ± 0.049	2.923MetLeu: 2.923 ± 0.071	0.756MetMet: 0.756 ± 0.034	1.297MetAsn: 1.297 ± 0.043	1.347MetPro: 1.347 ± 0.037	0.679MetGln: 0.679 ± 0.036	1.72MetArg: 1.72 ± 0.053	1.861MetSer: 1.861 ± 0.049	1.915MetThr: 1.915 ± 0.052	1.294MetVal: 1.294 ± 0.045	0.205MetTrp: 0.205 ± 0.019	0.884MetTyr: 0.884 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.416AsnAla: 3.416 ± 0.08	0.599AsnCys: 0.599 ± 0.034	2.105AsnAsp: 2.105 ± 0.061	2.128AsnGlu: 2.128 ± 0.052	1.38AsnPhe: 1.38 ± 0.043	3.407AsnGly: 3.407 ± 0.086	0.462AsnHis: 0.462 ± 0.025	2.803AsnIle: 2.803 ± 0.068	1.678AsnLys: 1.678 ± 0.055	2.518AsnLeu: 2.518 ± 0.062	1.037AsnMet: 1.037 ± 0.04	1.401AsnAsn: 1.401 ± 0.057	1.462AsnPro: 1.462 ± 0.046	0.674AsnGln: 0.674 ± 0.037	1.924AsnArg: 1.924 ± 0.057	2.041AsnSer: 2.041 ± 0.06	2.078AsnThr: 2.078 ± 0.059	2.53AsnVal: 2.53 ± 0.06	0.315AsnTrp: 0.315 ± 0.022	1.484AsnTyr: 1.484 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	4.007ProAla: 4.007 ± 0.084	0.539ProCys: 0.539 ± 0.029	3.159ProAsp: 3.159 ± 0.075	3.774ProGlu: 3.774 ± 0.087	1.539ProPhe: 1.539 ± 0.048	2.708ProGly: 2.708 ± 0.067	0.734ProHis: 0.734 ± 0.029	1.809ProIle: 1.809 ± 0.055	1.594ProLys: 1.594 ± 0.049	2.934ProLeu: 2.934 ± 0.072	0.87ProMet: 0.87 ± 0.033	1.044ProAsn: 1.044 ± 0.039	1.089ProPro: 1.089 ± 0.052	0.994ProGln: 0.994 ± 0.038	1.747ProArg: 1.747 ± 0.053	2.232ProSer: 2.232 ± 0.058	2.068ProThr: 2.068 ± 0.061	3.237ProVal: 3.237 ± 0.061	0.324ProTrp: 0.324 ± 0.026	1.444ProTyr: 1.444 ± 0.052	0.006ProXaa: 0.006 ± 0.003
Gln	1.472GlnAla: 1.472 ± 0.047	0.291GlnCys: 0.291 ± 0.023	0.793GlnAsp: 0.793 ± 0.036	0.983GlnGlu: 0.983 ± 0.045	0.768GlnPhe: 0.768 ± 0.036	1.13GlnGly: 1.13 ± 0.04	0.432GlnHis: 0.432 ± 0.025	1.417GlnIle: 1.417 ± 0.05	1.47GlnLys: 1.47 ± 0.046	1.919GlnLeu: 1.919 ± 0.052	0.643GlnMet: 0.643 ± 0.033	1.069GlnAsn: 1.069 ± 0.041	0.786GlnPro: 0.786 ± 0.041	0.609GlnGln: 0.609 ± 0.036	1.301GlnArg: 1.301 ± 0.048	1.347GlnSer: 1.347 ± 0.051	1.242GlnThr: 1.242 ± 0.047	1.126GlnVal: 1.126 ± 0.043	0.205GlnTrp: 0.205 ± 0.019	0.94GlnTyr: 0.94 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	5.531ArgAla: 5.531 ± 0.1	0.89ArgCys: 0.89 ± 0.044	3.324ArgAsp: 3.324 ± 0.069	4.166ArgGlu: 4.166 ± 0.088	2.423ArgPhe: 2.423 ± 0.071	3.981ArgGly: 3.981 ± 0.077	1.151ArgHis: 1.151 ± 0.042	3.987ArgIle: 3.987 ± 0.084	2.999ArgLys: 2.999 ± 0.068	5.609ArgLeu: 5.609 ± 0.104	1.735ArgMet: 1.735 ± 0.053	1.949ArgAsn: 1.949 ± 0.059	1.885ArgPro: 1.885 ± 0.061	1.468ArgGln: 1.468 ± 0.054	4.863ArgArg: 4.863 ± 0.105	3.363ArgSer: 3.363 ± 0.083	3.161ArgThr: 3.161 ± 0.065	3.664ArgVal: 3.664 ± 0.08	0.404ArgTrp: 0.404 ± 0.024	2.265ArgTyr: 2.265 ± 0.055	0.006ArgXaa: 0.006 ± 0.003
Ser	6.543SerAla: 6.543 ± 0.108	1.006SerCys: 1.006 ± 0.036	4.444SerAsp: 4.444 ± 0.098	4.015SerGlu: 4.015 ± 0.081	2.8SerPhe: 2.8 ± 0.061	5.958SerGly: 5.958 ± 0.099	1.087SerHis: 1.087 ± 0.044	3.106SerIle: 3.106 ± 0.077	2.665SerLys: 2.665 ± 0.06	5.202SerLeu: 5.202 ± 0.095	1.499SerMet: 1.499 ± 0.043	1.763SerAsn: 1.763 ± 0.06	2.292SerPro: 2.292 ± 0.055	1.245SerGln: 1.245 ± 0.043	3.43SerArg: 3.43 ± 0.076	3.602SerSer: 3.602 ± 0.097	2.938SerThr: 2.938 ± 0.074	5.361SerVal: 5.361 ± 0.116	0.455SerTrp: 0.455 ± 0.026	2.406SerTyr: 2.406 ± 0.057	0.003SerXaa: 0.003 ± 0.002
Thr	6.197ThrAla: 6.197 ± 0.089	0.59ThrCys: 0.59 ± 0.035	4.009ThrAsp: 4.009 ± 0.089	3.687ThrGlu: 3.687 ± 0.077	2.158ThrPhe: 2.158 ± 0.055	4.74ThrGly: 4.74 ± 0.099	1.053ThrHis: 1.053 ± 0.034	2.647ThrIle: 2.647 ± 0.074	2.342ThrLys: 2.342 ± 0.07	5.26ThrLeu: 5.26 ± 0.09	1.16ThrMet: 1.16 ± 0.036	1.579ThrAsn: 1.579 ± 0.052	2.824ThrPro: 2.824 ± 0.066	1.098ThrGln: 1.098 ± 0.039	2.369ThrArg: 2.369 ± 0.056	3.207ThrSer: 3.207 ± 0.076	2.809ThrThr: 2.809 ± 0.075	6.51ThrVal: 6.51 ± 0.122	0.407ThrTrp: 0.407 ± 0.026	2.048ThrTyr: 2.048 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	6.016ValAla: 6.016 ± 0.119	1.612ValCys: 1.612 ± 0.051	3.652ValAsp: 3.652 ± 0.081	3.698ValGlu: 3.698 ± 0.087	3.392ValPhe: 3.392 ± 0.088	5.283ValGly: 5.283 ± 0.117	1.102ValHis: 1.102 ± 0.044	5.317ValIle: 5.317 ± 0.094	3.854ValLys: 3.854 ± 0.083	6.685ValLeu: 6.685 ± 0.11	2.091ValMet: 2.091 ± 0.061	2.486ValAsn: 2.486 ± 0.057	3.107ValPro: 3.107 ± 0.071	1.144ValGln: 1.144 ± 0.041	4.241ValArg: 4.241 ± 0.083	5.063ValSer: 5.063 ± 0.094	4.817ValThr: 4.817 ± 0.096	4.711ValVal: 4.711 ± 0.095	0.749ValTrp: 0.749 ± 0.035	2.858ValTyr: 2.858 ± 0.068	0.003ValXaa: 0.003 ± 0.002
Trp	0.594TrpAla: 0.594 ± 0.031	0.192TrpCys: 0.192 ± 0.019	0.501TrpAsp: 0.501 ± 0.03	0.495TrpGlu: 0.495 ± 0.028	0.404TrpPhe: 0.404 ± 0.025	0.628TrpGly: 0.628 ± 0.034	0.212TrpHis: 0.212 ± 0.017	0.515TrpIle: 0.515 ± 0.03	0.453TrpLys: 0.453 ± 0.025	0.916TrpLeu: 0.916 ± 0.038	0.209TrpMet: 0.209 ± 0.018	0.392TrpAsn: 0.392 ± 0.023	0.152TrpPro: 0.152 ± 0.017	0.361TrpGln: 0.361 ± 0.027	0.593TrpArg: 0.593 ± 0.032	0.517TrpSer: 0.517 ± 0.027	0.437TrpThr: 0.437 ± 0.026	0.455TrpVal: 0.455 ± 0.028	0.123TrpTrp: 0.123 ± 0.013	0.358TrpTyr: 0.358 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.318TyrAla: 3.318 ± 0.071	0.68TyrCys: 0.68 ± 0.033	2.819TyrAsp: 2.819 ± 0.073	2.326TyrGlu: 2.326 ± 0.062	1.825TyrPhe: 1.825 ± 0.064	3.067TyrGly: 3.067 ± 0.075	0.658TyrHis: 0.658 ± 0.032	2.662TyrIle: 2.662 ± 0.058	1.6TyrLys: 1.6 ± 0.052	3.364TyrLeu: 3.364 ± 0.068	0.918TyrMet: 0.918 ± 0.04	1.576TyrAsn: 1.576 ± 0.051	1.546TyrPro: 1.546 ± 0.049	0.711TyrGln: 0.711 ± 0.032	2.604TyrArg: 2.604 ± 0.06	2.628TyrSer: 2.628 ± 0.072	2.587TyrThr: 2.587 ± 0.077	2.434TyrVal: 2.434 ± 0.062	0.304TyrTrp: 0.304 ± 0.023	1.803TyrTyr: 1.803 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.007XaaArg: 0.007 ± 0.003	0.001XaaSer: 0.001 ± 0.002	0.004XaaThr: 0.004 ± 0.003	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.042XaaXaa: 0.042 ± 0.01

Statistics based on 2237 proteins (673252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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