Amino acid dipepetide frequency for Rachicladosporium sp. CCFEE 5018

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.804AlaAla: 10.804 ± 0.054	1.045AlaCys: 1.045 ± 0.013	4.864AlaAsp: 4.864 ± 0.023	5.892AlaGlu: 5.892 ± 0.033	3.239AlaPhe: 3.239 ± 0.021	6.783AlaGly: 6.783 ± 0.035	2.001AlaHis: 2.001 ± 0.015	4.255AlaIle: 4.255 ± 0.027	4.788AlaLys: 4.788 ± 0.03	8.508AlaLeu: 8.508 ± 0.032	2.23AlaMet: 2.23 ± 0.018	3.12AlaAsn: 3.12 ± 0.02	5.667AlaPro: 5.667 ± 0.033	3.997AlaGln: 3.997 ± 0.025	5.596AlaArg: 5.596 ± 0.032	8.1AlaSer: 8.1 ± 0.044	6.325AlaThr: 6.325 ± 0.032	6.12AlaVal: 6.12 ± 0.028	1.279AlaTrp: 1.279 ± 0.012	2.363AlaTyr: 2.363 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.933CysAla: 0.933 ± 0.011	0.202CysCys: 0.202 ± 0.005	0.594CysAsp: 0.594 ± 0.008	0.562CysGlu: 0.562 ± 0.009	0.456CysPhe: 0.456 ± 0.008	0.885CysGly: 0.885 ± 0.013	0.287CysHis: 0.287 ± 0.007	0.611CysIle: 0.611 ± 0.01	0.498CysLys: 0.498 ± 0.007	1.051CysLeu: 1.051 ± 0.012	0.239CysMet: 0.239 ± 0.006	0.379CysAsn: 0.379 ± 0.007	0.571CysPro: 0.571 ± 0.01	0.376CysGln: 0.376 ± 0.007	0.654CysArg: 0.654 ± 0.011	0.767CysSer: 0.767 ± 0.009	0.677CysThr: 0.677 ± 0.009	0.713CysVal: 0.713 ± 0.009	0.178CysTrp: 0.178 ± 0.005	0.336CysTyr: 0.336 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	5.525AspAla: 5.525 ± 0.029	0.578AspCys: 0.578 ± 0.008	4.452AspAsp: 4.452 ± 0.034	4.64AspGlu: 4.64 ± 0.028	2.243AspPhe: 2.243 ± 0.019	4.301AspGly: 4.301 ± 0.024	1.295AspHis: 1.295 ± 0.012	2.643AspIle: 2.643 ± 0.018	2.168AspLys: 2.168 ± 0.019	5.253AspLeu: 5.253 ± 0.027	1.281AspMet: 1.281 ± 0.012	1.634AspAsn: 1.634 ± 0.014	3.196AspPro: 3.196 ± 0.019	1.749AspGln: 1.749 ± 0.016	3.168AspArg: 3.168 ± 0.023	4.012AspSer: 4.012 ± 0.025	3.026AspThr: 3.026 ± 0.02	3.948AspVal: 3.948 ± 0.023	0.884AspTrp: 0.884 ± 0.01	1.528AspTyr: 1.528 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.936GluAla: 5.936 ± 0.033	0.567GluCys: 0.567 ± 0.008	4.257GluAsp: 4.257 ± 0.029	5.111GluGlu: 5.111 ± 0.036	1.604GluPhe: 1.604 ± 0.015	4.263GluGly: 4.263 ± 0.027	1.477GluHis: 1.477 ± 0.016	2.791GluIle: 2.791 ± 0.019	3.427GluLys: 3.427 ± 0.031	5.163GluLeu: 5.163 ± 0.03	1.484GluMet: 1.484 ± 0.013	1.786GluAsn: 1.786 ± 0.014	2.615GluPro: 2.615 ± 0.019	2.538GluGln: 2.538 ± 0.02	4.281GluArg: 4.281 ± 0.032	3.983GluSer: 3.983 ± 0.025	3.354GluThr: 3.354 ± 0.021	3.98GluVal: 3.98 ± 0.024	0.835GluTrp: 0.835 ± 0.011	1.532GluTyr: 1.532 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.375PheAla: 3.375 ± 0.021	0.466PheCys: 0.466 ± 0.009	2.197PheAsp: 2.197 ± 0.015	2.036PheGlu: 2.036 ± 0.017	1.299PhePhe: 1.299 ± 0.014	2.807PheGly: 2.807 ± 0.022	0.766PheHis: 0.766 ± 0.008	1.463PheIle: 1.463 ± 0.016	1.309PheLys: 1.309 ± 0.013	2.938PheLeu: 2.938 ± 0.021	0.71PheMet: 0.71 ± 0.01	1.24PheAsn: 1.24 ± 0.014	1.676PhePro: 1.676 ± 0.014	1.121PheGln: 1.121 ± 0.013	1.76PheArg: 1.76 ± 0.015	2.542PheSer: 2.542 ± 0.019	2.165PheThr: 2.165 ± 0.017	2.23PheVal: 2.23 ± 0.015	0.559PheTrp: 0.559 ± 0.01	0.935PheTyr: 0.935 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	6.089GlyAla: 6.089 ± 0.031	0.781GlyCys: 0.781 ± 0.011	3.871GlyAsp: 3.871 ± 0.021	4.143GlyGlu: 4.143 ± 0.027	2.722GlyPhe: 2.722 ± 0.022	6.61GlyGly: 6.61 ± 0.049	1.674GlyHis: 1.674 ± 0.016	3.285GlyIle: 3.285 ± 0.025	3.826GlyLys: 3.826 ± 0.026	6.157GlyLeu: 6.157 ± 0.032	1.907GlyMet: 1.907 ± 0.017	2.509GlyAsn: 2.509 ± 0.019	3.202GlyPro: 3.202 ± 0.021	2.655GlyGln: 2.655 ± 0.021	4.346GlyArg: 4.346 ± 0.03	6.0GlySer: 6.0 ± 0.033	4.304GlyThr: 4.304 ± 0.026	4.75GlyVal: 4.75 ± 0.023	1.202GlyTrp: 1.202 ± 0.013	2.153GlyTyr: 2.153 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.223HisAla: 2.223 ± 0.018	0.322HisCys: 0.322 ± 0.006	1.424HisAsp: 1.424 ± 0.013	1.385HisGlu: 1.385 ± 0.013	0.88HisPhe: 0.88 ± 0.011	1.763HisGly: 1.763 ± 0.012	0.801HisHis: 0.801 ± 0.013	1.074HisIle: 1.074 ± 0.011	0.877HisLys: 0.877 ± 0.01	2.169HisLeu: 2.169 ± 0.019	0.496HisMet: 0.496 ± 0.007	0.791HisAsn: 0.791 ± 0.011	1.548HisPro: 1.548 ± 0.016	0.892HisGln: 0.892 ± 0.012	1.504HisArg: 1.504 ± 0.015	1.766HisSer: 1.766 ± 0.014	1.396HisThr: 1.396 ± 0.015	1.524HisVal: 1.524 ± 0.016	0.351HisTrp: 0.351 ± 0.007	0.666HisTyr: 0.666 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	4.49IleAla: 4.49 ± 0.024	0.644IleCys: 0.644 ± 0.01	2.832IleAsp: 2.832 ± 0.022	2.706IleGlu: 2.706 ± 0.02	1.648IlePhe: 1.648 ± 0.016	3.069IleGly: 3.069 ± 0.022	0.977IleHis: 0.977 ± 0.012	2.056IleIle: 2.056 ± 0.017	1.912IleLys: 1.912 ± 0.015	3.897IleLeu: 3.897 ± 0.023	0.944IleMet: 0.944 ± 0.011	1.569IleAsn: 1.569 ± 0.015	2.591IlePro: 2.591 ± 0.018	1.444IleGln: 1.444 ± 0.014	2.51IleArg: 2.51 ± 0.02	3.398IleSer: 3.398 ± 0.02	2.891IleThr: 2.891 ± 0.026	2.966IleVal: 2.966 ± 0.018	0.644IleTrp: 0.644 ± 0.01	1.228IleTyr: 1.228 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.736LysAla: 4.736 ± 0.03	0.443LysCys: 0.443 ± 0.007	2.646LysAsp: 2.646 ± 0.021	3.006LysGlu: 3.006 ± 0.026	1.233LysPhe: 1.233 ± 0.014	3.195LysGly: 3.195 ± 0.024	1.152LysHis: 1.152 ± 0.012	1.966LysIle: 1.966 ± 0.016	3.023LysLys: 3.023 ± 0.033	4.025LysLeu: 4.025 ± 0.026	0.989LysMet: 0.989 ± 0.011	1.352LysAsn: 1.352 ± 0.014	2.802LysPro: 2.802 ± 0.022	1.917LysGln: 1.917 ± 0.015	3.589LysArg: 3.589 ± 0.026	3.448LysSer: 3.448 ± 0.019	2.76LysThr: 2.76 ± 0.02	2.899LysVal: 2.899 ± 0.02	0.629LysTrp: 0.629 ± 0.011	1.251LysTyr: 1.251 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.448LeuAla: 8.448 ± 0.037	1.081LeuCys: 1.081 ± 0.013	5.148LeuAsp: 5.148 ± 0.026	5.33LeuGlu: 5.33 ± 0.03	2.918LeuPhe: 2.918 ± 0.019	5.88LeuGly: 5.88 ± 0.034	2.3LeuHis: 2.3 ± 0.018	3.615LeuIle: 3.615 ± 0.025	3.916LeuLys: 3.916 ± 0.027	8.089LeuLeu: 8.089 ± 0.044	1.694LeuMet: 1.694 ± 0.015	2.852LeuAsn: 2.852 ± 0.02	5.667LeuPro: 5.667 ± 0.033	3.879LeuGln: 3.879 ± 0.026	5.903LeuArg: 5.903 ± 0.03	6.844LeuSer: 6.844 ± 0.034	5.123LeuThr: 5.123 ± 0.027	5.1LeuVal: 5.1 ± 0.03	1.106LeuTrp: 1.106 ± 0.016	2.227LeuTyr: 2.227 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.016	0.227MetCys: 0.227 ± 0.006	1.223MetAsp: 1.223 ± 0.014	1.237MetGlu: 1.237 ± 0.015	0.7MetPhe: 0.7 ± 0.01	1.51MetGly: 1.51 ± 0.016	0.548MetHis: 0.548 ± 0.009	0.916MetIle: 0.916 ± 0.011	0.976MetLys: 0.976 ± 0.011	2.015MetLeu: 2.015 ± 0.02	0.561MetMet: 0.561 ± 0.009	0.725MetAsn: 0.725 ± 0.008	1.459MetPro: 1.459 ± 0.016	1.009MetGln: 1.009 ± 0.013	1.398MetArg: 1.398 ± 0.013	1.937MetSer: 1.937 ± 0.017	1.261MetThr: 1.261 ± 0.014	1.202MetVal: 1.202 ± 0.012	0.257MetTrp: 0.257 ± 0.006	0.551MetTyr: 0.551 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.443AsnAla: 3.443 ± 0.021	0.356AsnCys: 0.356 ± 0.008	1.887AsnAsp: 1.887 ± 0.015	1.817AsnGlu: 1.817 ± 0.015	1.185AsnPhe: 1.185 ± 0.014	3.285AsnGly: 3.285 ± 0.027	0.704AsnHis: 0.704 ± 0.009	1.68AsnIle: 1.68 ± 0.013	1.28AsnLys: 1.28 ± 0.012	2.791AsnLeu: 2.791 ± 0.022	0.745AsnMet: 0.745 ± 0.01	1.213AsnAsn: 1.213 ± 0.016	2.096AsnPro: 2.096 ± 0.019	0.996AsnGln: 0.996 ± 0.013	1.64AsnArg: 1.64 ± 0.016	2.34AsnSer: 2.34 ± 0.02	2.152AsnThr: 2.152 ± 0.018	2.232AsnVal: 2.232 ± 0.018	0.462AsnTrp: 0.462 ± 0.007	0.906AsnTyr: 0.906 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	6.135ProAla: 6.135 ± 0.037	0.424ProCys: 0.424 ± 0.008	3.114ProAsp: 3.114 ± 0.019	3.469ProGlu: 3.469 ± 0.023	1.839ProPhe: 1.839 ± 0.014	4.027ProGly: 4.027 ± 0.026	1.346ProHis: 1.346 ± 0.016	2.405ProIle: 2.405 ± 0.017	2.627ProLys: 2.627 ± 0.022	4.623ProLeu: 4.623 ± 0.025	1.155ProMet: 1.155 ± 0.012	2.011ProAsn: 2.011 ± 0.018	5.413ProPro: 5.413 ± 0.055	2.533ProGln: 2.533 ± 0.022	3.408ProArg: 3.408 ± 0.024	6.039ProSer: 6.039 ± 0.039	4.304ProThr: 4.304 ± 0.031	3.552ProVal: 3.552 ± 0.021	0.681ProTrp: 0.681 ± 0.01	1.505ProTyr: 1.505 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.847GlnAla: 3.847 ± 0.025	0.421GlnCys: 0.421 ± 0.008	2.083GlnAsp: 2.083 ± 0.015	2.095GlnGlu: 2.095 ± 0.017	1.068GlnPhe: 1.068 ± 0.011	2.493GlnGly: 2.493 ± 0.018	1.22GlnHis: 1.22 ± 0.014	1.769GlnIle: 1.769 ± 0.015	1.706GlnLys: 1.706 ± 0.017	3.329GlnLeu: 3.329 ± 0.022	0.916GlnMet: 0.916 ± 0.014	1.312GlnAsn: 1.312 ± 0.014	2.619GlnPro: 2.619 ± 0.024	2.77GlnGln: 2.77 ± 0.04	2.875GlnArg: 2.875 ± 0.022	3.25GlnSer: 3.25 ± 0.023	2.434GlnThr: 2.434 ± 0.021	2.195GlnVal: 2.195 ± 0.016	0.579GlnTrp: 0.579 ± 0.008	1.228GlnTyr: 1.228 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	5.284ArgAla: 5.284 ± 0.032	0.653ArgCys: 0.653 ± 0.008	3.496ArgAsp: 3.496 ± 0.023	4.097ArgGlu: 4.097 ± 0.03	1.942ArgPhe: 1.942 ± 0.017	3.912ArgGly: 3.912 ± 0.03	1.554ArgHis: 1.554 ± 0.014	2.687ArgIle: 2.687 ± 0.017	3.666ArgLys: 3.666 ± 0.022	5.403ArgLeu: 5.403 ± 0.029	1.43ArgMet: 1.43 ± 0.013	2.077ArgAsn: 2.077 ± 0.016	3.616ArgPro: 3.616 ± 0.027	2.762ArgGln: 2.762 ± 0.021	5.253ArgArg: 5.253 ± 0.036	4.979ArgSer: 4.979 ± 0.034	3.601ArgThr: 3.601 ± 0.024	3.486ArgVal: 3.486 ± 0.021	0.868ArgTrp: 0.868 ± 0.01	1.577ArgTyr: 1.577 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	7.655SerAla: 7.655 ± 0.039	0.726SerCys: 0.726 ± 0.011	4.29SerAsp: 4.29 ± 0.025	4.009SerGlu: 4.009 ± 0.026	2.629SerPhe: 2.629 ± 0.018	5.815SerGly: 5.815 ± 0.033	1.873SerHis: 1.873 ± 0.018	3.648SerIle: 3.648 ± 0.021	3.584SerLys: 3.584 ± 0.022	6.764SerLeu: 6.764 ± 0.031	1.77SerMet: 1.77 ± 0.016	2.789SerAsn: 2.789 ± 0.021	5.475SerPro: 5.475 ± 0.041	3.108SerGln: 3.108 ± 0.024	4.915SerArg: 4.915 ± 0.033	8.389SerSer: 8.389 ± 0.062	6.104SerThr: 6.104 ± 0.037	4.533SerVal: 4.533 ± 0.025	1.022SerTrp: 1.022 ± 0.012	2.021SerTyr: 2.021 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	6.34ThrAla: 6.34 ± 0.03	0.715ThrCys: 0.715 ± 0.011	2.924ThrAsp: 2.924 ± 0.02	3.051ThrGlu: 3.051 ± 0.022	2.197ThrPhe: 2.197 ± 0.018	4.391ThrGly: 4.391 ± 0.028	1.386ThrHis: 1.386 ± 0.013	2.958ThrIle: 2.958 ± 0.024	2.652ThrLys: 2.652 ± 0.02	5.61ThrLeu: 5.61 ± 0.036	1.254ThrMet: 1.254 ± 0.013	2.112ThrAsn: 2.112 ± 0.017	4.733ThrPro: 4.733 ± 0.035	2.278ThrGln: 2.278 ± 0.02	3.32ThrArg: 3.32 ± 0.019	5.926ThrSer: 5.926 ± 0.039	4.852ThrThr: 4.852 ± 0.045	3.827ThrVal: 3.827 ± 0.029	0.858ThrTrp: 0.858 ± 0.012	1.673ThrTyr: 1.673 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.826ValAla: 5.826 ± 0.029	0.744ValCys: 0.744 ± 0.01	3.712ValAsp: 3.712 ± 0.023	4.083ValGlu: 4.083 ± 0.024	2.215ValPhe: 2.215 ± 0.021	4.178ValGly: 4.178 ± 0.029	1.439ValHis: 1.439 ± 0.014	2.694ValIle: 2.694 ± 0.017	3.118ValLys: 3.118 ± 0.02	5.561ValLeu: 5.561 ± 0.029	1.366ValMet: 1.366 ± 0.014	2.177ValAsn: 2.177 ± 0.018	3.653ValPro: 3.653 ± 0.022	2.508ValGln: 2.508 ± 0.016	3.731ValArg: 3.731 ± 0.022	4.446ValSer: 4.446 ± 0.024	3.658ValThr: 3.658 ± 0.03	4.373ValVal: 4.373 ± 0.031	0.851ValTrp: 0.851 ± 0.012	1.716ValTyr: 1.716 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.09TrpAla: 1.09 ± 0.012	0.19TrpCys: 0.19 ± 0.005	0.841TrpAsp: 0.841 ± 0.011	0.81TrpGlu: 0.81 ± 0.01	0.488TrpPhe: 0.488 ± 0.008	0.863TrpGly: 0.863 ± 0.012	0.366TrpHis: 0.366 ± 0.007	0.655TrpIle: 0.655 ± 0.009	0.698TrpLys: 0.698 ± 0.009	1.337TrpLeu: 1.337 ± 0.014	0.342TrpMet: 0.342 ± 0.007	0.536TrpAsn: 0.536 ± 0.008	0.605TrpPro: 0.605 ± 0.009	0.647TrpGln: 0.647 ± 0.01	0.994TrpArg: 0.994 ± 0.013	1.029TrpSer: 1.029 ± 0.011	0.929TrpThr: 0.929 ± 0.012	0.834TrpVal: 0.834 ± 0.01	0.257TrpTrp: 0.257 ± 0.006	0.416TrpTyr: 0.416 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.019	0.381TyrCys: 0.381 ± 0.007	1.667TyrAsp: 1.667 ± 0.016	1.503TyrGlu: 1.503 ± 0.014	1.093TyrPhe: 1.093 ± 0.012	2.156TyrGly: 2.156 ± 0.021	0.686TyrHis: 0.686 ± 0.009	1.246TyrIle: 1.246 ± 0.011	1.011TyrLys: 1.011 ± 0.012	2.437TyrLeu: 2.437 ± 0.017	0.576TyrMet: 0.576 ± 0.009	1.028TyrAsn: 1.028 ± 0.012	1.405TyrPro: 1.405 ± 0.014	1.03TyrGln: 1.03 ± 0.012	1.498TyrArg: 1.498 ± 0.015	1.924TyrSer: 1.924 ± 0.019	1.745TyrThr: 1.745 ± 0.017	1.586TyrVal: 1.586 ± 0.015	0.421TyrTrp: 0.421 ± 0.007	0.885TyrTyr: 0.885 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 18035 proteins (8397328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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