Amino acid dipepetide frequency for Mycobacterium saskatchewanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.101AlaAla: 21.101 ± 0.188	1.021AlaCys: 1.021 ± 0.021	8.31AlaAsp: 8.31 ± 0.074	7.668AlaGlu: 7.668 ± 0.08	3.587AlaPhe: 3.587 ± 0.049	12.503AlaGly: 12.503 ± 0.096	2.635AlaHis: 2.635 ± 0.04	5.251AlaIle: 5.251 ± 0.053	2.884AlaLys: 2.884 ± 0.057	13.181AlaLeu: 13.181 ± 0.111	2.918AlaMet: 2.918 ± 0.04	2.674AlaAsn: 2.674 ± 0.048	6.58AlaPro: 6.58 ± 0.078	4.026AlaGln: 4.026 ± 0.052	9.2AlaArg: 9.2 ± 0.094	6.252AlaSer: 6.252 ± 0.057	7.107AlaThr: 7.107 ± 0.067	11.667AlaVal: 11.667 ± 0.098	1.679AlaTrp: 1.679 ± 0.035	2.355AlaTyr: 2.355 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.03	0.099CysCys: 0.099 ± 0.009	0.561CysAsp: 0.561 ± 0.018	0.438CysGlu: 0.438 ± 0.018	0.228CysPhe: 0.228 ± 0.012	0.988CysGly: 0.988 ± 0.029	0.192CysHis: 0.192 ± 0.011	0.272CysIle: 0.272 ± 0.012	0.142CysLys: 0.142 ± 0.009	0.687CysLeu: 0.687 ± 0.019	0.143CysMet: 0.143 ± 0.009	0.172CysAsn: 0.172 ± 0.01	0.528CysPro: 0.528 ± 0.019	0.206CysGln: 0.206 ± 0.01	0.623CysArg: 0.623 ± 0.021	0.454CysSer: 0.454 ± 0.016	0.482CysThr: 0.482 ± 0.021	0.681CysVal: 0.681 ± 0.022	0.133CysTrp: 0.133 ± 0.009	0.191CysTyr: 0.191 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.738AspAla: 7.738 ± 0.065	0.459AspCys: 0.459 ± 0.017	4.117AspAsp: 4.117 ± 0.063	3.957AspGlu: 3.957 ± 0.043	1.863AspPhe: 1.863 ± 0.032	5.839AspGly: 5.839 ± 0.067	1.452AspHis: 1.452 ± 0.027	2.528AspIle: 2.528 ± 0.042	1.255AspLys: 1.255 ± 0.03	5.936AspLeu: 5.936 ± 0.057	0.954AspMet: 0.954 ± 0.023	1.24AspAsn: 1.24 ± 0.027	4.435AspPro: 4.435 ± 0.061	1.681AspGln: 1.681 ± 0.036	4.613AspArg: 4.613 ± 0.064	2.751AspSer: 2.751 ± 0.055	3.011AspThr: 3.011 ± 0.044	5.278AspVal: 5.278 ± 0.054	0.954AspTrp: 0.954 ± 0.022	1.45AspTyr: 1.45 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.282GluAla: 6.282 ± 0.066	0.393GluCys: 0.393 ± 0.018	2.377GluAsp: 2.377 ± 0.041	2.483GluGlu: 2.483 ± 0.043	1.781GluPhe: 1.781 ± 0.034	3.394GluGly: 3.394 ± 0.056	1.478GluHis: 1.478 ± 0.03	2.525GluIle: 2.525 ± 0.043	1.248GluLys: 1.248 ± 0.034	6.475GluLeu: 6.475 ± 0.069	1.069GluMet: 1.069 ± 0.028	1.068GluAsn: 1.068 ± 0.025	3.054GluPro: 3.054 ± 0.053	2.058GluGln: 2.058 ± 0.036	4.645GluArg: 4.645 ± 0.06	2.656GluSer: 2.656 ± 0.044	2.564GluThr: 2.564 ± 0.043	4.307GluVal: 4.307 ± 0.052	0.742GluTrp: 0.742 ± 0.02	1.083GluTyr: 1.083 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.085PheAla: 4.085 ± 0.051	0.319PheCys: 0.319 ± 0.013	2.414PheAsp: 2.414 ± 0.04	1.586PheGlu: 1.586 ± 0.03	1.041PhePhe: 1.041 ± 0.032	3.553PheGly: 3.553 ± 0.055	0.665PheHis: 0.665 ± 0.022	1.028PheIle: 1.028 ± 0.026	0.546PheLys: 0.546 ± 0.018	2.561PheLeu: 2.561 ± 0.039	0.513PheMet: 0.513 ± 0.018	0.744PheAsn: 0.744 ± 0.025	1.503PhePro: 1.503 ± 0.027	0.709PheGln: 0.709 ± 0.02	1.744PheArg: 1.744 ± 0.033	1.743PheSer: 1.743 ± 0.033	1.982PheThr: 1.982 ± 0.038	2.689PheVal: 2.689 ± 0.042	0.431PheTrp: 0.431 ± 0.015	0.724PheTyr: 0.724 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.791GlyAla: 10.791 ± 0.099	0.84GlyCys: 0.84 ± 0.027	5.132GlyAsp: 5.132 ± 0.065	4.398GlyGlu: 4.398 ± 0.049	3.118GlyPhe: 3.118 ± 0.045	8.422GlyGly: 8.422 ± 0.164	2.167GlyHis: 2.167 ± 0.038	4.063GlyIle: 4.063 ± 0.049	2.344GlyLys: 2.344 ± 0.039	8.835GlyLeu: 8.835 ± 0.073	2.242GlyMet: 2.242 ± 0.039	2.01GlyAsn: 2.01 ± 0.06	4.971GlyPro: 4.971 ± 0.06	2.902GlyGln: 2.902 ± 0.04	6.696GlyArg: 6.696 ± 0.065	5.301GlySer: 5.301 ± 0.056	5.1GlyThr: 5.1 ± 0.062	7.686GlyVal: 7.686 ± 0.068	1.618GlyTrp: 1.618 ± 0.032	2.433GlyTyr: 2.433 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.617HisAla: 2.617 ± 0.036	0.221HisCys: 0.221 ± 0.012	1.389HisAsp: 1.389 ± 0.03	1.086HisGlu: 1.086 ± 0.031	0.72HisPhe: 0.72 ± 0.021	2.253HisGly: 2.253 ± 0.042	0.662HisHis: 0.662 ± 0.022	0.815HisIle: 0.815 ± 0.024	0.381HisLys: 0.381 ± 0.015	2.173HisLeu: 2.173 ± 0.039	0.353HisMet: 0.353 ± 0.014	0.503HisAsn: 0.503 ± 0.017	1.737HisPro: 1.737 ± 0.033	0.683HisGln: 0.683 ± 0.02	1.93HisArg: 1.93 ± 0.037	1.122HisSer: 1.122 ± 0.024	1.211HisThr: 1.211 ± 0.027	1.779HisVal: 1.779 ± 0.028	0.391HisTrp: 0.391 ± 0.015	0.557HisTyr: 0.557 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.05IleAla: 6.05 ± 0.071	0.391IleCys: 0.391 ± 0.017	3.257IleAsp: 3.257 ± 0.046	2.566IleGlu: 2.566 ± 0.038	1.019IlePhe: 1.019 ± 0.026	4.415IleGly: 4.415 ± 0.051	0.808IleHis: 0.808 ± 0.024	1.367IleIle: 1.367 ± 0.03	0.894IleLys: 0.894 ± 0.024	2.897IleLeu: 2.897 ± 0.043	0.612IleMet: 0.612 ± 0.021	1.142IleAsn: 1.142 ± 0.028	2.427IlePro: 2.427 ± 0.035	0.947IleGln: 0.947 ± 0.024	2.645IleArg: 2.645 ± 0.038	2.21IleSer: 2.21 ± 0.034	2.633IleThr: 2.633 ± 0.043	3.676IleVal: 3.676 ± 0.046	0.429IleTrp: 0.429 ± 0.017	0.798IleTyr: 0.798 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.629LysAla: 2.629 ± 0.047	0.117LysCys: 0.117 ± 0.007	1.058LysAsp: 1.058 ± 0.027	0.941LysGlu: 0.941 ± 0.026	0.619LysPhe: 0.619 ± 0.021	1.513LysGly: 1.513 ± 0.037	0.479LysHis: 0.479 ± 0.017	0.953LysIle: 0.953 ± 0.022	0.589LysLys: 0.589 ± 0.024	2.159LysLeu: 2.159 ± 0.041	0.468LysMet: 0.468 ± 0.018	0.507LysAsn: 0.507 ± 0.018	1.455LysPro: 1.455 ± 0.028	0.66LysGln: 0.66 ± 0.02	1.601LysArg: 1.601 ± 0.03	1.221LysSer: 1.221 ± 0.029	1.302LysThr: 1.302 ± 0.028	1.925LysVal: 1.925 ± 0.04	0.302LysTrp: 0.302 ± 0.013	0.475LysTyr: 0.475 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.157LeuAla: 14.157 ± 0.111	0.869LeuCys: 0.869 ± 0.023	6.46LeuAsp: 6.46 ± 0.062	4.374LeuGlu: 4.374 ± 0.051	2.695LeuPhe: 2.695 ± 0.043	8.83LeuGly: 8.83 ± 0.082	2.129LeuHis: 2.129 ± 0.038	4.042LeuIle: 4.042 ± 0.054	1.799LeuLys: 1.799 ± 0.036	9.697LeuLeu: 9.697 ± 0.094	1.749LeuMet: 1.749 ± 0.035	2.21LeuAsn: 2.21 ± 0.04	5.983LeuPro: 5.983 ± 0.063	2.559LeuGln: 2.559 ± 0.042	7.887LeuArg: 7.887 ± 0.074	5.725LeuSer: 5.725 ± 0.049	6.164LeuThr: 6.164 ± 0.06	8.419LeuVal: 8.419 ± 0.082	1.178LeuTrp: 1.178 ± 0.025	1.686LeuTyr: 1.686 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.648MetAla: 2.648 ± 0.034	0.187MetCys: 0.187 ± 0.01	0.871MetAsp: 0.871 ± 0.022	0.698MetGlu: 0.698 ± 0.019	0.636MetPhe: 0.636 ± 0.019	1.52MetGly: 1.52 ± 0.032	0.437MetHis: 0.437 ± 0.014	0.911MetIle: 0.911 ± 0.03	0.446MetLys: 0.446 ± 0.019	2.036MetLeu: 2.036 ± 0.034	0.407MetMet: 0.407 ± 0.016	0.497MetAsn: 0.497 ± 0.018	1.252MetPro: 1.252 ± 0.026	0.544MetGln: 0.544 ± 0.02	1.596MetArg: 1.596 ± 0.029	1.519MetSer: 1.519 ± 0.027	1.754MetThr: 1.754 ± 0.031	1.623MetVal: 1.623 ± 0.026	0.268MetTrp: 0.268 ± 0.012	0.347MetTyr: 0.347 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.805AsnAla: 2.805 ± 0.045	0.207AsnCys: 0.207 ± 0.011	1.261AsnAsp: 1.261 ± 0.03	0.994AsnGlu: 0.994 ± 0.022	0.756AsnPhe: 0.756 ± 0.023	2.17AsnGly: 2.17 ± 0.047	0.47AsnHis: 0.47 ± 0.016	0.937AsnIle: 0.937 ± 0.026	0.451AsnLys: 0.451 ± 0.02	2.14AsnLeu: 2.14 ± 0.039	0.431AsnMet: 0.431 ± 0.015	0.588AsnAsn: 0.588 ± 0.022	1.807AsnPro: 1.807 ± 0.036	0.656AsnGln: 0.656 ± 0.018	1.572AsnArg: 1.572 ± 0.033	1.174AsnSer: 1.174 ± 0.034	1.288AsnThr: 1.288 ± 0.033	1.845AsnVal: 1.845 ± 0.034	0.371AsnTrp: 0.371 ± 0.015	0.554AsnTyr: 0.554 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.744ProAla: 7.744 ± 0.074	0.317ProCys: 0.317 ± 0.013	4.448ProAsp: 4.448 ± 0.064	3.699ProGlu: 3.699 ± 0.054	1.698ProPhe: 1.698 ± 0.033	6.235ProGly: 6.235 ± 0.076	1.312ProHis: 1.312 ± 0.032	2.139ProIle: 2.139 ± 0.037	1.262ProLys: 1.262 ± 0.03	5.116ProLeu: 5.116 ± 0.058	1.205ProMet: 1.205 ± 0.029	1.333ProAsn: 1.333 ± 0.031	4.138ProPro: 4.138 ± 0.091	1.879ProGln: 1.879 ± 0.036	3.725ProArg: 3.725 ± 0.058	3.11ProSer: 3.11 ± 0.053	3.381ProThr: 3.381 ± 0.053	5.055ProVal: 5.055 ± 0.061	0.851ProTrp: 0.851 ± 0.026	1.229ProTyr: 1.229 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.671GlnAla: 3.671 ± 0.052	0.2GlnCys: 0.2 ± 0.012	1.194GlnAsp: 1.194 ± 0.025	1.113GlnGlu: 1.113 ± 0.027	1.009GlnPhe: 1.009 ± 0.027	1.995GlnGly: 1.995 ± 0.037	0.807GlnHis: 0.807 ± 0.022	1.421GlnIle: 1.421 ± 0.029	0.593GlnLys: 0.593 ± 0.02	3.567GlnLeu: 3.567 ± 0.044	0.664GlnMet: 0.664 ± 0.019	0.628GlnAsn: 0.628 ± 0.023	1.957GlnPro: 1.957 ± 0.037	1.22GlnGln: 1.22 ± 0.036	2.762GlnArg: 2.762 ± 0.045	1.583GlnSer: 1.583 ± 0.038	1.544GlnThr: 1.544 ± 0.03	2.427GlnVal: 2.427 ± 0.037	0.543GlnTrp: 0.543 ± 0.018	0.648GlnTyr: 0.648 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.903ArgAla: 8.903 ± 0.088	0.64ArgCys: 0.64 ± 0.021	4.358ArgAsp: 4.358 ± 0.055	3.87ArgGlu: 3.87 ± 0.052	2.495ArgPhe: 2.495 ± 0.038	5.563ArgGly: 5.563 ± 0.066	1.914ArgHis: 1.914 ± 0.032	3.426ArgIle: 3.426 ± 0.045	1.532ArgLys: 1.532 ± 0.028	7.895ArgLeu: 7.895 ± 0.077	1.763ArgMet: 1.763 ± 0.033	1.642ArgAsn: 1.642 ± 0.031	4.357ArgPro: 4.357 ± 0.074	2.473ArgGln: 2.473 ± 0.038	7.068ArgArg: 7.068 ± 0.086	3.95ArgSer: 3.95 ± 0.056	3.954ArgThr: 3.954 ± 0.05	5.876ArgVal: 5.876 ± 0.063	1.42ArgTrp: 1.42 ± 0.032	1.975ArgTyr: 1.975 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.041SerAla: 7.041 ± 0.075	0.412SerCys: 0.412 ± 0.016	3.115SerAsp: 3.115 ± 0.048	2.542SerGlu: 2.542 ± 0.046	1.657SerPhe: 1.657 ± 0.035	5.711SerGly: 5.711 ± 0.074	1.094SerHis: 1.094 ± 0.024	2.147SerIle: 2.147 ± 0.038	1.113SerLys: 1.113 ± 0.026	4.949SerLeu: 4.949 ± 0.058	1.298SerMet: 1.298 ± 0.028	1.138SerAsn: 1.138 ± 0.029	3.223SerPro: 3.223 ± 0.052	1.476SerGln: 1.476 ± 0.031	3.837SerArg: 3.837 ± 0.056	3.127SerSer: 3.127 ± 0.061	3.129SerThr: 3.129 ± 0.051	4.523SerVal: 4.523 ± 0.051	0.905SerTrp: 0.905 ± 0.023	1.26SerTyr: 1.26 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.66ThrAla: 7.66 ± 0.068	0.405ThrCys: 0.405 ± 0.015	3.417ThrAsp: 3.417 ± 0.044	2.991ThrGlu: 2.991 ± 0.047	1.793ThrPhe: 1.793 ± 0.037	5.797ThrGly: 5.797 ± 0.073	1.167ThrHis: 1.167 ± 0.026	2.337ThrIle: 2.337 ± 0.035	1.188ThrLys: 1.188 ± 0.028	5.498ThrLeu: 5.498 ± 0.058	1.207ThrMet: 1.207 ± 0.023	1.286ThrAsn: 1.286 ± 0.031	3.671ThrPro: 3.671 ± 0.048	1.47ThrGln: 1.47 ± 0.031	3.56ThrArg: 3.56 ± 0.048	2.984ThrSer: 2.984 ± 0.044	3.613ThrThr: 3.613 ± 0.055	5.499ThrVal: 5.499 ± 0.064	0.796ThrTrp: 0.796 ± 0.021	1.26ThrTyr: 1.26 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	11.578ValAla: 11.578 ± 0.092	0.808ValCys: 0.808 ± 0.026	5.602ValAsp: 5.602 ± 0.064	4.532ValGlu: 4.532 ± 0.052	2.562ValPhe: 2.562 ± 0.034	7.246ValGly: 7.246 ± 0.063	1.854ValHis: 1.854 ± 0.034	3.77ValIle: 3.77 ± 0.051	1.647ValLys: 1.647 ± 0.034	8.743ValLeu: 8.743 ± 0.082	1.601ValMet: 1.601 ± 0.035	2.179ValAsn: 2.179 ± 0.039	4.694ValPro: 4.694 ± 0.055	2.113ValGln: 2.113 ± 0.03	6.156ValArg: 6.156 ± 0.062	4.725ValSer: 4.725 ± 0.063	5.372ValThr: 5.372 ± 0.062	8.489ValVal: 8.489 ± 0.099	1.052ValTrp: 1.052 ± 0.027	1.538ValTyr: 1.538 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.524TrpAla: 1.524 ± 0.031	0.162TrpCys: 0.162 ± 0.01	0.8TrpAsp: 0.8 ± 0.022	0.68TrpGlu: 0.68 ± 0.02	0.499TrpPhe: 0.499 ± 0.017	1.038TrpGly: 1.038 ± 0.026	0.37TrpHis: 0.37 ± 0.016	0.591TrpIle: 0.591 ± 0.019	0.304TrpLys: 0.304 ± 0.015	1.704TrpLeu: 1.704 ± 0.037	0.325TrpMet: 0.325 ± 0.014	0.416TrpAsn: 0.416 ± 0.016	0.836TrpPro: 0.836 ± 0.024	0.58TrpGln: 0.58 ± 0.019	1.304TrpArg: 1.304 ± 0.026	0.945TrpSer: 0.945 ± 0.024	0.844TrpThr: 0.844 ± 0.021	1.153TrpVal: 1.153 ± 0.025	0.317TrpTrp: 0.317 ± 0.015	0.344TrpTyr: 0.344 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.48TyrAla: 2.48 ± 0.043	0.248TyrCys: 0.248 ± 0.014	1.371TyrAsp: 1.371 ± 0.025	1.064TyrGlu: 1.064 ± 0.028	0.805TyrPhe: 0.805 ± 0.023	2.085TyrGly: 2.085 ± 0.039	0.488TyrHis: 0.488 ± 0.017	0.659TyrIle: 0.659 ± 0.02	0.355TyrLys: 0.355 ± 0.015	2.363TyrLeu: 2.363 ± 0.044	0.274TyrMet: 0.274 ± 0.012	0.502TyrAsn: 0.502 ± 0.017	1.268TyrPro: 1.268 ± 0.029	0.703TyrGln: 0.703 ± 0.025	1.911TyrArg: 1.911 ± 0.037	1.144TyrSer: 1.144 ± 0.024	1.165TyrThr: 1.165 ± 0.028	1.663TyrVal: 1.663 ± 0.033	0.356TyrTrp: 0.356 ± 0.014	0.526TyrTyr: 0.526 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5294 proteins (1722884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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