Amino acid dipepetide frequency for Melghirimyces thermohalophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.838AlaAla: 7.838 ± 0.117	0.702AlaCys: 0.702 ± 0.03	4.438AlaAsp: 4.438 ± 0.081	5.647AlaGlu: 5.647 ± 0.088	3.216AlaPhe: 3.216 ± 0.066	7.014AlaGly: 7.014 ± 0.1	1.618AlaHis: 1.618 ± 0.047	4.9AlaIle: 4.9 ± 0.081	3.733AlaLys: 3.733 ± 0.074	8.382AlaLeu: 8.382 ± 0.11	2.233AlaMet: 2.233 ± 0.054	1.95AlaAsn: 1.95 ± 0.042	2.817AlaPro: 2.817 ± 0.062	2.813AlaGln: 2.813 ± 0.059	4.801AlaArg: 4.801 ± 0.078	4.114AlaSer: 4.114 ± 0.073	3.521AlaThr: 3.521 ± 0.07	7.006AlaVal: 7.006 ± 0.085	1.046AlaTrp: 1.046 ± 0.039	2.266AlaTyr: 2.266 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.529CysAla: 0.529 ± 0.027	0.129CysCys: 0.129 ± 0.011	0.437CysAsp: 0.437 ± 0.022	0.39CysGlu: 0.39 ± 0.022	0.299CysPhe: 0.299 ± 0.02	0.796CysGly: 0.796 ± 0.03	0.227CysHis: 0.227 ± 0.016	0.426CysIle: 0.426 ± 0.023	0.242CysLys: 0.242 ± 0.018	0.755CysLeu: 0.755 ± 0.032	0.156CysMet: 0.156 ± 0.013	0.214CysAsn: 0.214 ± 0.014	0.464CysPro: 0.464 ± 0.024	0.28CysGln: 0.28 ± 0.016	0.6CysArg: 0.6 ± 0.027	0.476CysSer: 0.476 ± 0.022	0.387CysThr: 0.387 ± 0.024	0.456CysVal: 0.456 ± 0.022	0.101CysTrp: 0.101 ± 0.01	0.249CysTyr: 0.249 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.628AspAla: 3.628 ± 0.073	0.375AspCys: 0.375 ± 0.02	2.364AspAsp: 2.364 ± 0.056	3.955AspGlu: 3.955 ± 0.078	1.906AspPhe: 1.906 ± 0.051	4.046AspGly: 4.046 ± 0.074	1.406AspHis: 1.406 ± 0.038	2.585AspIle: 2.585 ± 0.06	2.067AspLys: 2.067 ± 0.059	5.368AspLeu: 5.368 ± 0.072	1.234AspMet: 1.234 ± 0.037	1.169AspAsn: 1.169 ± 0.034	3.225AspPro: 3.225 ± 0.068	2.534AspGln: 2.534 ± 0.057	4.254AspArg: 4.254 ± 0.075	2.453AspSer: 2.453 ± 0.056	2.389AspThr: 2.389 ± 0.049	3.82AspVal: 3.82 ± 0.062	0.952AspTrp: 0.952 ± 0.034	1.611AspTyr: 1.611 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.707GluAla: 6.707 ± 0.099	0.364GluCys: 0.364 ± 0.022	3.336GluAsp: 3.336 ± 0.066	7.906GluGlu: 7.906 ± 0.136	1.587GluPhe: 1.587 ± 0.047	5.623GluGly: 5.623 ± 0.079	1.504GluHis: 1.504 ± 0.038	4.111GluIle: 4.111 ± 0.074	5.173GluLys: 5.173 ± 0.085	6.492GluLeu: 6.492 ± 0.081	2.171GluMet: 2.171 ± 0.048	2.223GluAsn: 2.223 ± 0.046	2.593GluPro: 2.593 ± 0.055	3.75GluGln: 3.75 ± 0.078	4.978GluArg: 4.978 ± 0.093	3.262GluSer: 3.262 ± 0.061	3.941GluThr: 3.941 ± 0.069	5.542GluVal: 5.542 ± 0.071	1.085GluTrp: 1.085 ± 0.035	1.668GluTyr: 1.668 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.035PheAla: 3.035 ± 0.057	0.367PheCys: 0.367 ± 0.023	1.997PheAsp: 1.997 ± 0.052	2.022PheGlu: 2.022 ± 0.046	2.004PhePhe: 2.004 ± 0.056	3.163PheGly: 3.163 ± 0.073	1.058PheHis: 1.058 ± 0.036	2.228PheIle: 2.228 ± 0.052	1.191PheLys: 1.191 ± 0.033	4.238PheLeu: 4.238 ± 0.081	0.861PheMet: 0.861 ± 0.035	1.118PheAsn: 1.118 ± 0.039	1.91PhePro: 1.91 ± 0.044	1.62PheGln: 1.62 ± 0.043	2.331PheArg: 2.331 ± 0.051	2.68PheSer: 2.68 ± 0.055	2.153PheThr: 2.153 ± 0.047	2.668PheVal: 2.668 ± 0.055	0.53PheTrp: 0.53 ± 0.026	1.323PheTyr: 1.323 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.963GlyAla: 5.963 ± 0.097	0.799GlyCys: 0.799 ± 0.03	3.891GlyAsp: 3.891 ± 0.077	5.698GlyGlu: 5.698 ± 0.08	3.284GlyPhe: 3.284 ± 0.067	6.432GlyGly: 6.432 ± 0.113	1.651GlyHis: 1.651 ± 0.046	5.371GlyIle: 5.371 ± 0.075	4.722GlyLys: 4.722 ± 0.078	7.968GlyLeu: 7.968 ± 0.106	2.718GlyMet: 2.718 ± 0.056	2.343GlyAsn: 2.343 ± 0.049	2.563GlyPro: 2.563 ± 0.052	2.659GlyGln: 2.659 ± 0.056	4.515GlyArg: 4.515 ± 0.073	4.487GlySer: 4.487 ± 0.069	4.346GlyThr: 4.346 ± 0.063	6.653GlyVal: 6.653 ± 0.079	1.443GlyTrp: 1.443 ± 0.042	2.626GlyTyr: 2.626 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.48HisAla: 1.48 ± 0.047	0.233HisCys: 0.233 ± 0.016	0.881HisAsp: 0.881 ± 0.035	1.17HisGlu: 1.17 ± 0.037	1.017HisPhe: 1.017 ± 0.034	1.751HisGly: 1.751 ± 0.046	0.794HisHis: 0.794 ± 0.034	1.27HisIle: 1.27 ± 0.035	0.718HisLys: 0.718 ± 0.026	2.711HisLeu: 2.711 ± 0.055	0.54HisMet: 0.54 ± 0.021	0.556HisAsn: 0.556 ± 0.025	1.831HisPro: 1.831 ± 0.049	1.124HisGln: 1.124 ± 0.036	1.873HisArg: 1.873 ± 0.042	1.186HisSer: 1.186 ± 0.037	1.096HisThr: 1.096 ± 0.037	1.581HisVal: 1.581 ± 0.036	0.33HisTrp: 0.33 ± 0.019	0.75HisTyr: 0.75 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	4.998IleAla: 4.998 ± 0.077	0.525IleCys: 0.525 ± 0.025	3.195IleAsp: 3.195 ± 0.065	3.178IleGlu: 3.178 ± 0.069	2.117IlePhe: 2.117 ± 0.054	5.268IleGly: 5.268 ± 0.087	1.706IleHis: 1.706 ± 0.04	2.873IleIle: 2.873 ± 0.066	2.077IleLys: 2.077 ± 0.046	5.98IleLeu: 5.98 ± 0.084	1.205IleMet: 1.205 ± 0.038	1.75IleAsn: 1.75 ± 0.05	3.408IlePro: 3.408 ± 0.071	2.724IleGln: 2.724 ± 0.056	4.445IleArg: 4.445 ± 0.078	3.39IleSer: 3.39 ± 0.065	3.245IleThr: 3.245 ± 0.064	3.856IleVal: 3.856 ± 0.07	0.641IleTrp: 0.641 ± 0.027	1.674IleTyr: 1.674 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.827LysAla: 3.827 ± 0.066	0.205LysCys: 0.205 ± 0.015	2.471LysAsp: 2.471 ± 0.056	5.279LysGlu: 5.279 ± 0.081	0.941LysPhe: 0.941 ± 0.026	4.186LysGly: 4.186 ± 0.072	0.918LysHis: 0.918 ± 0.03	2.326LysIle: 2.326 ± 0.052	3.843LysLys: 3.843 ± 0.093	3.917LysLeu: 3.917 ± 0.067	1.563LysMet: 1.563 ± 0.046	1.686LysAsn: 1.686 ± 0.041	2.126LysPro: 2.126 ± 0.05	2.444LysGln: 2.444 ± 0.064	3.542LysArg: 3.542 ± 0.058	2.265LysSer: 2.265 ± 0.051	2.572LysThr: 2.572 ± 0.047	3.753LysVal: 3.753 ± 0.08	0.732LysTrp: 0.732 ± 0.025	1.259LysTyr: 1.259 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.697LeuAla: 8.697 ± 0.106	0.752LeuCys: 0.752 ± 0.026	5.362LeuAsp: 5.362 ± 0.081	6.884LeuGlu: 6.884 ± 0.094	4.753LeuPhe: 4.753 ± 0.089	7.424LeuGly: 7.424 ± 0.115	2.232LeuHis: 2.232 ± 0.046	6.209LeuIle: 6.209 ± 0.107	5.287LeuLys: 5.287 ± 0.083	11.056LeuLeu: 11.056 ± 0.17	2.6LeuMet: 2.6 ± 0.064	3.222LeuAsn: 3.222 ± 0.059	4.881LeuPro: 4.881 ± 0.075	3.728LeuGln: 3.728 ± 0.07	5.614LeuArg: 5.614 ± 0.087	6.71LeuSer: 6.71 ± 0.084	5.731LeuThr: 5.731 ± 0.083	7.25LeuVal: 7.25 ± 0.095	1.169LeuTrp: 1.169 ± 0.043	2.834LeuTyr: 2.834 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.494MetAla: 2.494 ± 0.054	0.149MetCys: 0.149 ± 0.012	1.627MetAsp: 1.627 ± 0.044	2.279MetGlu: 2.279 ± 0.057	0.856MetPhe: 0.856 ± 0.033	2.197MetGly: 2.197 ± 0.043	0.397MetHis: 0.397 ± 0.021	1.775MetIle: 1.775 ± 0.05	1.905MetLys: 1.905 ± 0.046	2.37MetLeu: 2.37 ± 0.049	0.95MetMet: 0.95 ± 0.034	1.06MetAsn: 1.06 ± 0.035	1.122MetPro: 1.122 ± 0.036	0.841MetGln: 0.841 ± 0.032	1.389MetArg: 1.389 ± 0.043	1.488MetSer: 1.488 ± 0.04	1.592MetThr: 1.592 ± 0.042	2.233MetVal: 2.233 ± 0.047	0.265MetTrp: 0.265 ± 0.018	0.622MetTyr: 0.622 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.087AsnAla: 2.087 ± 0.045	0.224AsnCys: 0.224 ± 0.016	1.233AsnAsp: 1.233 ± 0.039	1.646AsnGlu: 1.646 ± 0.046	0.892AsnPhe: 0.892 ± 0.033	2.323AsnGly: 2.323 ± 0.059	0.802AsnHis: 0.802 ± 0.033	1.778AsnIle: 1.778 ± 0.048	1.265AsnLys: 1.265 ± 0.042	2.955AsnLeu: 2.955 ± 0.053	0.812AsnMet: 0.812 ± 0.031	0.931AsnAsn: 0.931 ± 0.031	1.975AsnPro: 1.975 ± 0.047	1.515AsnGln: 1.515 ± 0.039	2.752AsnArg: 2.752 ± 0.062	1.328AsnSer: 1.328 ± 0.039	1.393AsnThr: 1.393 ± 0.037	1.871AsnVal: 1.871 ± 0.043	0.424AsnTrp: 0.424 ± 0.022	0.795AsnTyr: 0.795 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.472ProAla: 3.472 ± 0.07	0.301ProCys: 0.301 ± 0.019	3.019ProAsp: 3.019 ± 0.063	4.171ProGlu: 4.171 ± 0.068	2.122ProPhe: 2.122 ± 0.056	3.817ProGly: 3.817 ± 0.074	1.147ProHis: 1.147 ± 0.033	2.459ProIle: 2.459 ± 0.053	1.946ProLys: 1.946 ± 0.05	4.539ProLeu: 4.539 ± 0.073	1.158ProMet: 1.158 ± 0.036	1.119ProAsn: 1.119 ± 0.038	1.977ProPro: 1.977 ± 0.053	1.644ProGln: 1.644 ± 0.041	2.472ProArg: 2.472 ± 0.056	2.673ProSer: 2.673 ± 0.057	2.187ProThr: 2.187 ± 0.044	4.162ProVal: 4.162 ± 0.08	0.635ProTrp: 0.635 ± 0.03	1.448ProTyr: 1.448 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.682GlnAla: 3.682 ± 0.068	0.21GlnCys: 0.21 ± 0.014	1.703GlnAsp: 1.703 ± 0.046	3.149GlnGlu: 3.149 ± 0.072	1.368GlnPhe: 1.368 ± 0.038	3.032GlnGly: 3.032 ± 0.059	0.857GlnHis: 0.857 ± 0.029	2.075GlnIle: 2.075 ± 0.051	2.26GlnLys: 2.26 ± 0.052	4.179GlnLeu: 4.179 ± 0.075	1.222GlnMet: 1.222 ± 0.033	1.132GlnAsn: 1.132 ± 0.041	1.946GlnPro: 1.946 ± 0.047	2.121GlnGln: 2.121 ± 0.062	2.431GlnArg: 2.431 ± 0.059	2.137GlnSer: 2.137 ± 0.054	2.068GlnThr: 2.068 ± 0.045	3.582GlnVal: 3.582 ± 0.069	0.609GlnTrp: 0.609 ± 0.024	1.113GlnTyr: 1.113 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.918ArgAla: 3.918 ± 0.078	0.438ArgCys: 0.438 ± 0.022	3.02ArgAsp: 3.02 ± 0.061	5.628ArgGlu: 5.628 ± 0.094	2.792ArgPhe: 2.792 ± 0.058	4.12ArgGly: 4.12 ± 0.072	1.458ArgHis: 1.458 ± 0.045	4.046ArgIle: 4.046 ± 0.072	3.675ArgLys: 3.675 ± 0.069	7.219ArgLeu: 7.219 ± 0.103	2.072ArgMet: 2.072 ± 0.052	1.907ArgAsn: 1.907 ± 0.045	2.593ArgPro: 2.593 ± 0.052	2.827ArgGln: 2.827 ± 0.057	4.7ArgArg: 4.7 ± 0.084	3.542ArgSer: 3.542 ± 0.069	2.782ArgThr: 2.782 ± 0.055	4.806ArgVal: 4.806 ± 0.081	1.19ArgTrp: 1.19 ± 0.032	2.228ArgTyr: 2.228 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.965SerAla: 3.965 ± 0.074	0.428SerCys: 0.428 ± 0.022	2.824SerAsp: 2.824 ± 0.07	3.296SerGlu: 3.296 ± 0.067	2.551SerPhe: 2.551 ± 0.055	4.82SerGly: 4.82 ± 0.075	1.283SerHis: 1.283 ± 0.036	3.319SerIle: 3.319 ± 0.059	2.274SerLys: 2.274 ± 0.056	6.229SerLeu: 6.229 ± 0.09	1.664SerMet: 1.664 ± 0.04	1.448SerAsn: 1.448 ± 0.039	2.74SerPro: 2.74 ± 0.055	2.018SerGln: 2.018 ± 0.046	3.7SerArg: 3.7 ± 0.071	3.163SerSer: 3.163 ± 0.071	2.684SerThr: 2.684 ± 0.055	4.01SerVal: 4.01 ± 0.067	0.744SerTrp: 0.744 ± 0.028	1.548SerTyr: 1.548 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.559ThrAla: 4.559 ± 0.078	0.411ThrCys: 0.411 ± 0.025	2.785ThrAsp: 2.785 ± 0.055	3.358ThrGlu: 3.358 ± 0.066	2.097ThrPhe: 2.097 ± 0.047	5.076ThrGly: 5.076 ± 0.078	1.109ThrHis: 1.109 ± 0.037	2.883ThrIle: 2.883 ± 0.055	1.807ThrLys: 1.807 ± 0.051	5.51ThrLeu: 5.51 ± 0.075	1.238ThrMet: 1.238 ± 0.041	1.331ThrAsn: 1.331 ± 0.04	2.823ThrPro: 2.823 ± 0.058	1.582ThrGln: 1.582 ± 0.047	2.969ThrArg: 2.969 ± 0.065	2.738ThrSer: 2.738 ± 0.054	2.461ThrThr: 2.461 ± 0.057	4.473ThrVal: 4.473 ± 0.07	0.645ThrTrp: 0.645 ± 0.033	1.53ThrTyr: 1.53 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.249ValAla: 6.249 ± 0.091	0.652ValCys: 0.652 ± 0.027	4.577ValAsp: 4.577 ± 0.078	5.652ValGlu: 5.652 ± 0.094	2.862ValPhe: 2.862 ± 0.062	5.629ValGly: 5.629 ± 0.079	1.64ValHis: 1.64 ± 0.039	4.979ValIle: 4.979 ± 0.088	3.779ValLys: 3.779 ± 0.066	7.631ValLeu: 7.631 ± 0.103	2.045ValMet: 2.045 ± 0.047	2.454ValAsn: 2.454 ± 0.055	3.485ValPro: 3.485 ± 0.06	2.811ValGln: 2.811 ± 0.056	4.306ValArg: 4.306 ± 0.068	4.416ValSer: 4.416 ± 0.073	4.578ValThr: 4.578 ± 0.079	5.988ValVal: 5.988 ± 0.093	0.914ValTrp: 0.914 ± 0.036	2.103ValTyr: 2.103 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.899TrpAla: 0.899 ± 0.038	0.097TrpCys: 0.097 ± 0.011	0.655TrpAsp: 0.655 ± 0.023	0.99TrpGlu: 0.99 ± 0.033	0.645TrpPhe: 0.645 ± 0.027	0.989TrpGly: 0.989 ± 0.033	0.233TrpHis: 0.233 ± 0.017	1.075TrpIle: 1.075 ± 0.038	0.804TrpLys: 0.804 ± 0.034	1.688TrpLeu: 1.688 ± 0.047	0.506TrpMet: 0.506 ± 0.022	0.533TrpAsn: 0.533 ± 0.025	0.463TrpPro: 0.463 ± 0.021	0.476TrpGln: 0.476 ± 0.025	0.732TrpArg: 0.732 ± 0.032	0.786TrpSer: 0.786 ± 0.031	0.748TrpThr: 0.748 ± 0.032	1.165TrpVal: 1.165 ± 0.045	0.286TrpTrp: 0.286 ± 0.021	0.378TrpTyr: 0.378 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.028TyrAla: 2.028 ± 0.037	0.253TyrCys: 0.253 ± 0.019	1.529TyrAsp: 1.529 ± 0.04	1.717TyrGlu: 1.717 ± 0.041	1.188TyrPhe: 1.188 ± 0.041	2.425TyrGly: 2.425 ± 0.052	0.852TyrHis: 0.852 ± 0.037	1.565TyrIle: 1.565 ± 0.045	1.089TyrLys: 1.089 ± 0.039	3.207TyrLeu: 3.207 ± 0.068	0.664TyrMet: 0.664 ± 0.029	0.858TyrAsn: 0.858 ± 0.033	1.527TyrPro: 1.527 ± 0.042	1.363TyrGln: 1.363 ± 0.044	2.557TyrArg: 2.557 ± 0.061	1.414TyrSer: 1.414 ± 0.039	1.51TyrThr: 1.51 ± 0.041	1.872TyrVal: 1.872 ± 0.048	0.407TyrTrp: 0.407 ± 0.021	1.015TyrTyr: 1.015 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3229 proteins (911684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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