Amino acid dipepetide frequency for Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542) (Torula yeast) (Candida utilis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.442AlaAla: 4.442 ± 0.065
0.717AlaCys: 0.717 ± 0.019
3.091AlaAsp: 3.091 ± 0.039
3.747AlaGlu: 3.747 ± 0.045
2.491AlaPhe: 2.491 ± 0.037
3.5AlaGly: 3.5 ± 0.038
1.314AlaHis: 1.314 ± 0.024
3.982AlaIle: 3.982 ± 0.042
4.175AlaLys: 4.175 ± 0.047
6.501AlaLeu: 6.501 ± 0.059
1.382AlaMet: 1.382 ± 0.023
2.809AlaAsn: 2.809 ± 0.032
2.606AlaPro: 2.606 ± 0.049
2.733AlaGln: 2.733 ± 0.041
2.75AlaArg: 2.75 ± 0.041
5.191AlaSer: 5.191 ± 0.061
3.797AlaThr: 3.797 ± 0.042
4.148AlaVal: 4.148 ± 0.04
0.586AlaTrp: 0.586 ± 0.015
1.835AlaTyr: 1.835 ± 0.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.76CysAla: 0.76 ± 0.018
0.268CysCys: 0.268 ± 0.012
0.731CysAsp: 0.731 ± 0.019
0.622CysGlu: 0.622 ± 0.015
0.617CysPhe: 0.617 ± 0.015
0.916CysGly: 0.916 ± 0.023
0.328CysHis: 0.328 ± 0.011
0.794CysIle: 0.794 ± 0.02
0.606CysLys: 0.606 ± 0.017
1.213CysLeu: 1.213 ± 0.024
0.24CysMet: 0.24 ± 0.009
0.487CysAsn: 0.487 ± 0.016
0.516CysPro: 0.516 ± 0.016
0.382CysGln: 0.382 ± 0.014
0.462CysArg: 0.462 ± 0.013
1.029CysSer: 1.029 ± 0.021
0.641CysThr: 0.641 ± 0.016
0.874CysVal: 0.874 ± 0.02
0.16CysTrp: 0.16 ± 0.009
0.405CysTyr: 0.405 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.626AspAla: 3.626 ± 0.043
0.627AspCys: 0.627 ± 0.018
5.379AspAsp: 5.379 ± 0.063
5.533AspGlu: 5.533 ± 0.059
2.652AspPhe: 2.652 ± 0.034
3.379AspGly: 3.379 ± 0.036
1.232AspHis: 1.232 ± 0.022
3.957AspIle: 3.957 ± 0.044
3.404AspLys: 3.404 ± 0.034
5.796AspLeu: 5.796 ± 0.048
1.141AspMet: 1.141 ± 0.023
2.629AspAsn: 2.629 ± 0.032
2.612AspPro: 2.612 ± 0.032
1.99AspGln: 1.99 ± 0.028
2.233AspArg: 2.233 ± 0.03
4.782AspSer: 4.782 ± 0.048
3.116AspThr: 3.116 ± 0.038
4.206AspVal: 4.206 ± 0.047
0.684AspTrp: 0.684 ± 0.02
2.176AspTyr: 2.176 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
4.049GluAla: 4.049 ± 0.05
0.648GluCys: 0.648 ± 0.015
4.687GluAsp: 4.687 ± 0.054
6.228GluGlu: 6.228 ± 0.088
2.843GluPhe: 2.843 ± 0.034
3.12GluGly: 3.12 ± 0.039
1.442GluHis: 1.442 ± 0.027
3.918GluIle: 3.918 ± 0.041
4.599GluLys: 4.599 ± 0.054
6.94GluLeu: 6.94 ± 0.063
1.376GluMet: 1.376 ± 0.026
3.026GluAsn: 3.026 ± 0.04
2.38GluPro: 2.38 ± 0.035
3.018GluGln: 3.018 ± 0.036
3.245GluArg: 3.245 ± 0.042
5.017GluSer: 5.017 ± 0.054
3.786GluThr: 3.786 ± 0.056
4.055GluVal: 4.055 ± 0.038
0.721GluTrp: 0.721 ± 0.018
2.259GluTyr: 2.259 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
2.674PheAla: 2.674 ± 0.037
0.532PheCys: 0.532 ± 0.016
2.904PheAsp: 2.904 ± 0.03
2.915PheGlu: 2.915 ± 0.035
2.046PhePhe: 2.046 ± 0.035
2.834PheGly: 2.834 ± 0.051
1.006PheHis: 1.006 ± 0.02
2.753PheIle: 2.753 ± 0.039
2.958PheLys: 2.958 ± 0.035
3.951PheLeu: 3.951 ± 0.041
0.871PheMet: 0.871 ± 0.02
2.331PheAsn: 2.331 ± 0.029
1.736PhePro: 1.736 ± 0.03
1.802PheGln: 1.802 ± 0.025
1.613PheArg: 1.613 ± 0.025
3.221PheSer: 3.221 ± 0.04
2.644PheThr: 2.644 ± 0.032
2.905PheVal: 2.905 ± 0.04
0.514PheTrp: 0.514 ± 0.014
1.485PheTyr: 1.485 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
3.595GlyAla: 3.595 ± 0.044
0.754GlyCys: 0.754 ± 0.017
3.396GlyAsp: 3.396 ± 0.04
3.532GlyGlu: 3.532 ± 0.039
2.745GlyPhe: 2.745 ± 0.039
3.765GlyGly: 3.765 ± 0.062
1.237GlyHis: 1.237 ± 0.021
3.508GlyIle: 3.508 ± 0.044
3.4GlyLys: 3.4 ± 0.039
5.32GlyLeu: 5.32 ± 0.051
1.037GlyMet: 1.037 ± 0.023
2.28GlyAsn: 2.28 ± 0.029
1.815GlyPro: 1.815 ± 0.029
1.892GlyGln: 1.892 ± 0.031
2.323GlyArg: 2.323 ± 0.035
5.039GlySer: 5.039 ± 0.06
3.247GlyThr: 3.247 ± 0.045
4.098GlyVal: 4.098 ± 0.049
0.723GlyTrp: 0.723 ± 0.019
2.179GlyTyr: 2.179 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
1.181HisAla: 1.181 ± 0.019
0.345HisCys: 0.345 ± 0.011
1.249HisAsp: 1.249 ± 0.024
1.322HisGlu: 1.322 ± 0.024
0.943HisPhe: 0.943 ± 0.021
1.371HisGly: 1.371 ± 0.025
0.758HisHis: 0.758 ± 0.022
1.344HisIle: 1.344 ± 0.026
1.279HisLys: 1.279 ± 0.025
2.166HisLeu: 2.166 ± 0.03
0.44HisMet: 0.44 ± 0.013
0.946HisAsn: 0.946 ± 0.017
1.116HisPro: 1.116 ± 0.023
0.955HisGln: 0.955 ± 0.021
1.18HisArg: 1.18 ± 0.024
1.886HisSer: 1.886 ± 0.026
1.162HisThr: 1.162 ± 0.021
1.32HisVal: 1.32 ± 0.023
0.284HisTrp: 0.284 ± 0.01
0.846HisTyr: 0.846 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
3.974IleAla: 3.974 ± 0.047
0.791IleCys: 0.791 ± 0.018
3.826IleAsp: 3.826 ± 0.039
3.716IleGlu: 3.716 ± 0.045
2.479IlePhe: 2.479 ± 0.033
3.438IleGly: 3.438 ± 0.045
1.391IleHis: 1.391 ± 0.023
3.381IleIle: 3.381 ± 0.041
3.712IleLys: 3.712 ± 0.046
5.399IleLeu: 5.399 ± 0.057
1.18IleMet: 1.18 ± 0.024
2.867IleAsn: 2.867 ± 0.033
3.157IlePro: 3.157 ± 0.036
2.301IleGln: 2.301 ± 0.031
2.616IleArg: 2.616 ± 0.033
4.979IleSer: 4.979 ± 0.042
3.725IleThr: 3.725 ± 0.04
4.142IleVal: 4.142 ± 0.042
0.678IleTrp: 0.678 ± 0.018
1.855IleTyr: 1.855 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.995LysAla: 3.995 ± 0.043
0.673LysCys: 0.673 ± 0.018
3.83LysAsp: 3.83 ± 0.04
4.606LysGlu: 4.606 ± 0.053
2.803LysPhe: 2.803 ± 0.035
3.07LysGly: 3.07 ± 0.037
1.442LysHis: 1.442 ± 0.027
3.748LysIle: 3.748 ± 0.041
5.405LysLys: 5.405 ± 0.073
6.617LysLeu: 6.617 ± 0.059
1.279LysMet: 1.279 ± 0.027
3.03LysAsn: 3.03 ± 0.035
2.822LysPro: 2.822 ± 0.041
2.688LysGln: 2.688 ± 0.035
3.909LysArg: 3.909 ± 0.051
4.952LysSer: 4.952 ± 0.048
3.722LysThr: 3.722 ± 0.036
4.121LysVal: 4.121 ± 0.047
0.734LysTrp: 0.734 ± 0.018
2.323LysTyr: 2.323 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
6.078LeuAla: 6.078 ± 0.06
1.244LeuCys: 1.244 ± 0.023
5.681LeuAsp: 5.681 ± 0.052
6.506LeuGlu: 6.506 ± 0.059
4.197LeuPhe: 4.197 ± 0.046
5.01LeuGly: 5.01 ± 0.054
2.046LeuHis: 2.046 ± 0.029
5.583LeuIle: 5.583 ± 0.056
7.207LeuLys: 7.207 ± 0.059
9.371LeuLeu: 9.371 ± 0.081
1.999LeuMet: 1.999 ± 0.036
4.931LeuAsn: 4.931 ± 0.044
4.38LeuPro: 4.38 ± 0.046
4.315LeuGln: 4.315 ± 0.047
4.677LeuArg: 4.677 ± 0.053
8.329LeuSer: 8.329 ± 0.061
5.635LeuThr: 5.635 ± 0.052
6.117LeuVal: 6.117 ± 0.053
1.015LeuTrp: 1.015 ± 0.021
3.09LeuTyr: 3.09 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
1.51MetAla: 1.51 ± 0.025
0.271MetCys: 0.271 ± 0.012
1.3MetAsp: 1.3 ± 0.023
1.227MetGlu: 1.227 ± 0.025
0.909MetPhe: 0.909 ± 0.019
1.177MetGly: 1.177 ± 0.022
0.293MetHis: 0.293 ± 0.01
1.154MetIle: 1.154 ± 0.02
1.373MetLys: 1.373 ± 0.028
1.79MetLeu: 1.79 ± 0.03
0.524MetMet: 0.524 ± 0.014
1.079MetAsn: 1.079 ± 0.023
0.737MetPro: 0.737 ± 0.016
0.564MetGln: 0.564 ± 0.015
0.924MetArg: 0.924 ± 0.023
1.995MetSer: 1.995 ± 0.027
1.256MetThr: 1.256 ± 0.021
1.285MetVal: 1.285 ± 0.024
0.182MetTrp: 0.182 ± 0.008
0.6MetTyr: 0.6 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.961AsnAla: 2.961 ± 0.032
0.534AsnCys: 0.534 ± 0.015
3.061AsnAsp: 3.061 ± 0.036
3.149AsnGlu: 3.149 ± 0.039
2.042AsnPhe: 2.042 ± 0.031
3.069AsnGly: 3.069 ± 0.04
1.011AsnHis: 1.011 ± 0.022
2.718AsnIle: 2.718 ± 0.03
2.833AsnLys: 2.833 ± 0.037
4.129AsnLeu: 4.129 ± 0.043
0.93AsnMet: 0.93 ± 0.019
2.555AsnAsn: 2.555 ± 0.047
2.094AsnPro: 2.094 ± 0.028
1.563AsnGln: 1.563 ± 0.028
1.896AsnArg: 1.896 ± 0.027
3.863AsnSer: 3.863 ± 0.044
2.659AsnThr: 2.659 ± 0.034
3.267AsnVal: 3.267 ± 0.038
0.604AsnTrp: 0.604 ± 0.017
1.663AsnTyr: 1.663 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
2.406ProAla: 2.406 ± 0.039
0.359ProCys: 0.359 ± 0.013
2.297ProAsp: 2.297 ± 0.03
3.11ProGlu: 3.11 ± 0.034
1.905ProPhe: 1.905 ± 0.031
2.2ProGly: 2.2 ± 0.031
0.945ProHis: 0.945 ± 0.023
2.396ProIle: 2.396 ± 0.031
2.819ProLys: 2.819 ± 0.037
4.314ProLeu: 4.314 ± 0.045
0.879ProMet: 0.879 ± 0.019
1.91ProAsn: 1.91 ± 0.032
2.474ProPro: 2.474 ± 0.066
2.209ProGln: 2.209 ± 0.046
1.911ProArg: 1.911 ± 0.032
4.01ProSer: 4.01 ± 0.055
2.684ProThr: 2.684 ± 0.035
3.115ProVal: 3.115 ± 0.046
0.5ProTrp: 0.5 ± 0.013
1.381ProTyr: 1.381 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
2.391GlnAla: 2.391 ± 0.036
0.489GlnCys: 0.489 ± 0.015
2.07GlnAsp: 2.07 ± 0.028
2.612GlnGlu: 2.612 ± 0.037
1.855GlnPhe: 1.855 ± 0.028
2.125GlnGly: 2.125 ± 0.036
1.052GlnHis: 1.052 ± 0.022
2.187GlnIle: 2.187 ± 0.029
2.398GlnLys: 2.398 ± 0.034
4.475GlnLeu: 4.475 ± 0.047
0.881GlnMet: 0.881 ± 0.018
1.702GlnAsn: 1.702 ± 0.026
1.79GlnPro: 1.79 ± 0.042
3.57GlnGln: 3.57 ± 0.122
2.389GlnArg: 2.389 ± 0.034
3.176GlnSer: 3.176 ± 0.039
2.075GlnThr: 2.075 ± 0.029
2.528GlnVal: 2.528 ± 0.036
0.506GlnTrp: 0.506 ± 0.014
1.399GlnTyr: 1.399 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.944ArgAla: 2.944 ± 0.038
0.618ArgCys: 0.618 ± 0.018
2.799ArgAsp: 2.799 ± 0.036
3.077ArgGlu: 3.077 ± 0.039
2.086ArgPhe: 2.086 ± 0.026
2.49ArgGly: 2.49 ± 0.036
1.099ArgHis: 1.099 ± 0.023
2.726ArgIle: 2.726 ± 0.035
3.081ArgLys: 3.081 ± 0.043
4.535ArgLeu: 4.535 ± 0.047
0.921ArgMet: 0.921 ± 0.019
2.027ArgAsn: 2.027 ± 0.027
1.84ArgPro: 1.84 ± 0.031
1.899ArgGln: 1.899 ± 0.029
2.952ArgArg: 2.952 ± 0.046
3.673ArgSer: 3.673 ± 0.041
2.487ArgThr: 2.487 ± 0.037
2.904ArgVal: 2.904 ± 0.038
0.534ArgTrp: 0.534 ± 0.015
1.589ArgTyr: 1.589 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
4.913SerAla: 4.913 ± 0.057
0.94SerCys: 0.94 ± 0.019
4.467SerAsp: 4.467 ± 0.046
4.746SerGlu: 4.746 ± 0.057
3.56SerPhe: 3.56 ± 0.044
4.523SerGly: 4.523 ± 0.063
1.904SerHis: 1.904 ± 0.032
5.115SerIle: 5.115 ± 0.05
5.68SerLys: 5.68 ± 0.057
8.373SerLeu: 8.373 ± 0.061
1.735SerMet: 1.735 ± 0.026
4.056SerAsn: 4.056 ± 0.047
3.76SerPro: 3.76 ± 0.059
3.474SerGln: 3.474 ± 0.037
3.667SerArg: 3.667 ± 0.044
9.177SerSer: 9.177 ± 0.125
5.929SerThr: 5.929 ± 0.061
5.261SerVal: 5.261 ± 0.046
0.92SerTrp: 0.92 ± 0.02
2.527SerTyr: 2.527 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
3.697ThrAla: 3.697 ± 0.046
0.66ThrCys: 0.66 ± 0.015
3.092ThrAsp: 3.092 ± 0.038
3.32ThrGlu: 3.32 ± 0.04
2.517ThrPhe: 2.517 ± 0.029
3.602ThrGly: 3.602 ± 0.047
1.261ThrHis: 1.261 ± 0.023
3.537ThrIle: 3.537 ± 0.04
3.666ThrLys: 3.666 ± 0.038
5.718ThrLeu: 5.718 ± 0.048
1.182ThrMet: 1.182 ± 0.025
2.685ThrAsn: 2.685 ± 0.033
3.155ThrPro: 3.155 ± 0.041
2.132ThrGln: 2.132 ± 0.032
2.623ThrArg: 2.623 ± 0.035
5.409ThrSer: 5.409 ± 0.068
4.352ThrThr: 4.352 ± 0.079
4.352ThrVal: 4.352 ± 0.056
0.636ThrTrp: 0.636 ± 0.016
1.686ThrTyr: 1.686 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
3.994ValAla: 3.994 ± 0.045
0.855ValCys: 0.855 ± 0.02
4.368ValAsp: 4.368 ± 0.042
4.732ValGlu: 4.732 ± 0.05
2.922ValPhe: 2.922 ± 0.035
3.627ValGly: 3.627 ± 0.039
1.33ValHis: 1.33 ± 0.023
4.063ValIle: 4.063 ± 0.041
4.389ValLys: 4.389 ± 0.045
6.504ValLeu: 6.504 ± 0.055
1.276ValMet: 1.276 ± 0.025
2.902ValAsn: 2.902 ± 0.036
3.103ValPro: 3.103 ± 0.038
2.491ValGln: 2.491 ± 0.031
2.721ValArg: 2.721 ± 0.031
5.481ValSer: 5.481 ± 0.048
3.681ValThr: 3.681 ± 0.043
4.792ValVal: 4.792 ± 0.055
0.709ValTrp: 0.709 ± 0.018
2.197ValTyr: 2.197 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.642TrpAla: 0.642 ± 0.018
0.222TrpCys: 0.222 ± 0.008
0.768TrpAsp: 0.768 ± 0.018
0.642TrpGlu: 0.642 ± 0.017
0.57TrpPhe: 0.57 ± 0.017
0.616TrpGly: 0.616 ± 0.017
0.214TrpHis: 0.214 ± 0.009
0.735TrpIle: 0.735 ± 0.018
0.786TrpLys: 0.786 ± 0.021
1.082TrpLeu: 1.082 ± 0.023
0.245TrpMet: 0.245 ± 0.01
0.653TrpAsn: 0.653 ± 0.016
0.339TrpPro: 0.339 ± 0.012
0.356TrpGln: 0.356 ± 0.013
0.65TrpArg: 0.65 ± 0.016
0.918TrpSer: 0.918 ± 0.023
0.665TrpThr: 0.665 ± 0.016
0.638TrpVal: 0.638 ± 0.013
0.183TrpTrp: 0.183 ± 0.009
0.395TrpTyr: 0.395 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.961TyrAla: 1.961 ± 0.029
0.505TyrCys: 0.505 ± 0.015
2.158TyrAsp: 2.158 ± 0.031
2.017TyrGlu: 2.017 ± 0.03
1.513TyrPhe: 1.513 ± 0.025
2.053TyrGly: 2.053 ± 0.032
0.787TyrHis: 0.787 ± 0.017
2.004TyrIle: 2.004 ± 0.026
1.996TyrLys: 1.996 ± 0.03
3.219TyrLeu: 3.219 ± 0.034
0.631TyrMet: 0.631 ± 0.016
1.697TyrAsn: 1.697 ± 0.028
1.392TyrPro: 1.392 ± 0.027
1.34TyrGln: 1.34 ± 0.027
1.54TyrArg: 1.54 ± 0.027
2.601TyrSer: 2.601 ± 0.032
2.019TyrThr: 2.019 ± 0.035
2.01TyrVal: 2.01 ± 0.032
0.444TyrTrp: 0.444 ± 0.012
1.301TyrTyr: 1.301 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5994 proteins (2597173 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski