Amino acid dipepetide frequency for Bacteroides sp. CAG:770

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.893AlaAla: 7.893 ± 0.152	1.019AlaCys: 1.019 ± 0.04	5.247AlaAsp: 5.247 ± 0.087	5.591AlaGlu: 5.591 ± 0.107	3.225AlaPhe: 3.225 ± 0.068	6.451AlaGly: 6.451 ± 0.089	1.22AlaHis: 1.22 ± 0.042	4.632AlaIle: 4.632 ± 0.098	4.714AlaLys: 4.714 ± 0.085	7.113AlaLeu: 7.113 ± 0.102	2.065AlaMet: 2.065 ± 0.055	2.982AlaAsn: 2.982 ± 0.06	2.592AlaPro: 2.592 ± 0.062	2.236AlaGln: 2.236 ± 0.06	3.313AlaArg: 3.313 ± 0.061	5.429AlaSer: 5.429 ± 0.106	3.784AlaThr: 3.784 ± 0.081	5.859AlaVal: 5.859 ± 0.086	0.814AlaTrp: 0.814 ± 0.032	2.841AlaTyr: 2.841 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.038	0.218CysCys: 0.218 ± 0.016	0.837CysAsp: 0.837 ± 0.037	0.728CysGlu: 0.728 ± 0.03	0.565CysPhe: 0.565 ± 0.026	1.278CysGly: 1.278 ± 0.047	0.278CysHis: 0.278 ± 0.024	0.896CysIle: 0.896 ± 0.037	0.733CysLys: 0.733 ± 0.031	1.039CysLeu: 1.039 ± 0.038	0.295CysMet: 0.295 ± 0.02	0.565CysAsn: 0.565 ± 0.031	0.64CysPro: 0.64 ± 0.033	0.346CysGln: 0.346 ± 0.021	0.743CysArg: 0.743 ± 0.031	0.951CysSer: 0.951 ± 0.04	0.638CysThr: 0.638 ± 0.032	0.848CysVal: 0.848 ± 0.036	0.158CysTrp: 0.158 ± 0.015	0.538CysTyr: 0.538 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.66AspAla: 4.66 ± 0.087	0.751AspCys: 0.751 ± 0.035	2.99AspAsp: 2.99 ± 0.072	4.039AspGlu: 4.039 ± 0.08	3.265AspPhe: 3.265 ± 0.072	5.347AspGly: 5.347 ± 0.107	0.86AspHis: 0.86 ± 0.038	4.682AspIle: 4.682 ± 0.08	4.348AspLys: 4.348 ± 0.073	4.588AspLeu: 4.588 ± 0.075	1.905AspMet: 1.905 ± 0.044	3.013AspAsn: 3.013 ± 0.065	2.262AspPro: 2.262 ± 0.052	1.18AspGln: 1.18 ± 0.039	2.884AspArg: 2.884 ± 0.058	3.885AspSer: 3.885 ± 0.093	2.795AspThr: 2.795 ± 0.059	4.087AspVal: 4.087 ± 0.073	0.929AspTrp: 0.929 ± 0.036	2.885AspTyr: 2.885 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.99GluAla: 4.99 ± 0.098	0.721GluCys: 0.721 ± 0.034	3.667GluAsp: 3.667 ± 0.074	4.149GluGlu: 4.149 ± 0.097	2.744GluPhe: 2.744 ± 0.057	4.319GluGly: 4.319 ± 0.086	1.087GluHis: 1.087 ± 0.037	4.314GluIle: 4.314 ± 0.074	4.922GluLys: 4.922 ± 0.094	5.295GluLeu: 5.295 ± 0.095	1.888GluMet: 1.888 ± 0.048	3.373GluAsn: 3.373 ± 0.074	2.02GluPro: 2.02 ± 0.06	1.807GluGln: 1.807 ± 0.059	2.941GluArg: 2.941 ± 0.07	3.666GluSer: 3.666 ± 0.078	3.31GluThr: 3.31 ± 0.066	4.039GluVal: 4.039 ± 0.071	0.799GluTrp: 0.799 ± 0.035	2.695GluTyr: 2.695 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	3.466PheAla: 3.466 ± 0.069	0.678PheCys: 0.678 ± 0.03	2.942PheAsp: 2.942 ± 0.058	2.329PheGlu: 2.329 ± 0.055	1.932PhePhe: 1.932 ± 0.06	3.664PheGly: 3.664 ± 0.079	0.741PheHis: 0.741 ± 0.03	2.89PheIle: 2.89 ± 0.078	2.365PheLys: 2.365 ± 0.056	3.524PheLeu: 3.524 ± 0.076	1.285PheMet: 1.285 ± 0.043	2.227PheAsn: 2.227 ± 0.053	1.705PhePro: 1.705 ± 0.053	1.064PheGln: 1.064 ± 0.034	2.528PheArg: 2.528 ± 0.051	3.605PheSer: 3.605 ± 0.072	2.653PheThr: 2.653 ± 0.066	2.946PheVal: 2.946 ± 0.067	0.591PheTrp: 0.591 ± 0.024	1.754PheTyr: 1.754 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.103GlyAla: 5.103 ± 0.087	1.087GlyCys: 1.087 ± 0.04	3.986GlyAsp: 3.986 ± 0.074	4.503GlyGlu: 4.503 ± 0.076	3.285GlyPhe: 3.285 ± 0.075	5.21GlyGly: 5.21 ± 0.104	1.446GlyHis: 1.446 ± 0.044	5.282GlyIle: 5.282 ± 0.085	5.808GlyLys: 5.808 ± 0.101	6.059GlyLeu: 6.059 ± 0.099	2.106GlyMet: 2.106 ± 0.06	3.626GlyAsn: 3.626 ± 0.066	1.607GlyPro: 1.607 ± 0.047	2.112GlyGln: 2.112 ± 0.052	3.509GlyArg: 3.509 ± 0.075	4.658GlySer: 4.658 ± 0.101	4.564GlyThr: 4.564 ± 0.087	5.222GlyVal: 5.222 ± 0.087	1.087GlyTrp: 1.087 ± 0.038	3.592GlyTyr: 3.592 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.987HisAla: 0.987 ± 0.036	0.268HisCys: 0.268 ± 0.019	1.021HisAsp: 1.021 ± 0.038	0.956HisGlu: 0.956 ± 0.039	0.933HisPhe: 0.933 ± 0.037	1.251HisGly: 1.251 ± 0.045	0.413HisHis: 0.413 ± 0.028	1.294HisIle: 1.294 ± 0.045	0.938HisLys: 0.938 ± 0.033	1.459HisLeu: 1.459 ± 0.048	0.313HisMet: 0.313 ± 0.019	0.848HisAsn: 0.848 ± 0.032	0.866HisPro: 0.866 ± 0.035	0.41HisGln: 0.41 ± 0.024	0.827HisArg: 0.827 ± 0.031	1.055HisSer: 1.055 ± 0.037	0.853HisThr: 0.853 ± 0.037	1.072HisVal: 1.072 ± 0.035	0.204HisTrp: 0.204 ± 0.014	0.819HisTyr: 0.819 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.13IleAla: 5.13 ± 0.094	0.97IleCys: 0.97 ± 0.035	4.914IleAsp: 4.914 ± 0.09	3.836IleGlu: 3.836 ± 0.075	2.726IlePhe: 2.726 ± 0.069	4.485IleGly: 4.485 ± 0.099	1.069IleHis: 1.069 ± 0.041	4.155IleIle: 4.155 ± 0.097	3.434IleLys: 3.434 ± 0.073	5.451IleLeu: 5.451 ± 0.102	1.515IleMet: 1.515 ± 0.045	2.751IleAsn: 2.751 ± 0.068	2.986IlePro: 2.986 ± 0.07	1.646IleGln: 1.646 ± 0.046	3.364IleArg: 3.364 ± 0.071	5.057IleSer: 5.057 ± 0.083	3.605IleThr: 3.605 ± 0.062	4.544IleVal: 4.544 ± 0.084	0.719IleTrp: 0.719 ± 0.03	2.431IleTyr: 2.431 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.139LysAla: 5.139 ± 0.088	0.621LysCys: 0.621 ± 0.028	4.123LysAsp: 4.123 ± 0.081	4.592LysGlu: 4.592 ± 0.107	2.666LysPhe: 2.666 ± 0.065	4.36LysGly: 4.36 ± 0.087	0.985LysHis: 0.985 ± 0.035	4.168LysIle: 4.168 ± 0.071	4.27LysLys: 4.27 ± 0.086	4.767LysLeu: 4.767 ± 0.081	2.245LysMet: 2.245 ± 0.054	3.12LysAsn: 3.12 ± 0.064	2.248LysPro: 2.248 ± 0.061	1.638LysGln: 1.638 ± 0.043	2.677LysArg: 2.677 ± 0.057	4.007LysSer: 4.007 ± 0.074	3.706LysThr: 3.706 ± 0.08	4.806LysVal: 4.806 ± 0.091	0.864LysTrp: 0.864 ± 0.031	2.975LysTyr: 2.975 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	6.834LeuAla: 6.834 ± 0.093	1.248LeuCys: 1.248 ± 0.045	5.01LeuAsp: 5.01 ± 0.078	4.929LeuGlu: 4.929 ± 0.1	3.569LeuPhe: 3.569 ± 0.08	5.886LeuGly: 5.886 ± 0.099	1.37LeuHis: 1.37 ± 0.055	4.61LeuIle: 4.61 ± 0.084	5.87LeuLys: 5.87 ± 0.082	6.838LeuLeu: 6.838 ± 0.116	2.483LeuMet: 2.483 ± 0.056	3.751LeuAsn: 3.751 ± 0.088	3.622LeuPro: 3.622 ± 0.068	2.398LeuGln: 2.398 ± 0.06	4.122LeuArg: 4.122 ± 0.083	6.7LeuSer: 6.7 ± 0.114	5.266LeuThr: 5.266 ± 0.088	5.126LeuVal: 5.126 ± 0.091	0.912LeuTrp: 0.912 ± 0.037	3.197LeuTyr: 3.197 ± 0.064	0.001LeuXaa: 0.001 ± 0.001
Met	2.434MetAla: 2.434 ± 0.064	0.261MetCys: 0.261 ± 0.018	1.641MetAsp: 1.641 ± 0.049	1.7MetGlu: 1.7 ± 0.051	1.15MetPhe: 1.15 ± 0.036	1.702MetGly: 1.702 ± 0.05	0.395MetHis: 0.395 ± 0.022	1.655MetIle: 1.655 ± 0.05	2.325MetLys: 2.325 ± 0.058	2.487MetLeu: 2.487 ± 0.07	0.868MetMet: 0.868 ± 0.038	1.436MetAsn: 1.436 ± 0.043	1.276MetPro: 1.276 ± 0.039	0.784MetGln: 0.784 ± 0.035	1.346MetArg: 1.346 ± 0.041	2.227MetSer: 2.227 ± 0.06	1.861MetThr: 1.861 ± 0.057	1.681MetVal: 1.681 ± 0.053	0.259MetTrp: 0.259 ± 0.017	0.868MetTyr: 0.868 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.029AsnAla: 4.029 ± 0.077	0.545AsnCys: 0.545 ± 0.026	2.715AsnAsp: 2.715 ± 0.06	2.433AsnGlu: 2.433 ± 0.059	2.002AsnPhe: 2.002 ± 0.061	3.747AsnGly: 3.747 ± 0.081	0.773AsnHis: 0.773 ± 0.033	3.333AsnIle: 3.333 ± 0.067	2.477AsnLys: 2.477 ± 0.058	3.729AsnLeu: 3.729 ± 0.065	1.237AsnMet: 1.237 ± 0.041	2.105AsnAsn: 2.105 ± 0.063	2.331AsnPro: 2.331 ± 0.053	1.186AsnGln: 1.186 ± 0.043	1.958AsnArg: 1.958 ± 0.058	2.818AsnSer: 2.818 ± 0.067	2.498AsnThr: 2.498 ± 0.062	3.841AsnVal: 3.841 ± 0.073	0.62AsnTrp: 0.62 ± 0.03	2.005AsnTyr: 2.005 ± 0.054	0.001AsnXaa: 0.001 ± 0.001
Pro	3.279ProAla: 3.279 ± 0.066	0.403ProCys: 0.403 ± 0.024	3.002ProAsp: 3.002 ± 0.067	3.853ProGlu: 3.853 ± 0.085	1.771ProPhe: 1.771 ± 0.046	2.787ProGly: 2.787 ± 0.065	0.641ProHis: 0.641 ± 0.027	1.918ProIle: 1.918 ± 0.051	1.924ProLys: 1.924 ± 0.058	2.901ProLeu: 2.901 ± 0.065	0.972ProMet: 0.972 ± 0.038	1.356ProAsn: 1.356 ± 0.043	0.706ProPro: 0.706 ± 0.034	1.15ProGln: 1.15 ± 0.042	1.324ProArg: 1.324 ± 0.045	2.792ProSer: 2.792 ± 0.067	1.717ProThr: 1.717 ± 0.046	3.407ProVal: 3.407 ± 0.063	0.438ProTrp: 0.438 ± 0.023	1.687ProTyr: 1.687 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.016GlnAla: 2.016 ± 0.047	0.357GlnCys: 0.357 ± 0.023	1.502GlnAsp: 1.502 ± 0.043	1.696GlnGlu: 1.696 ± 0.047	1.222GlnPhe: 1.222 ± 0.041	1.659GlnGly: 1.659 ± 0.045	0.453GlnHis: 0.453 ± 0.024	1.987GlnIle: 1.987 ± 0.051	1.924GlnLys: 1.924 ± 0.055	2.249GlnLeu: 2.249 ± 0.056	0.871GlnMet: 0.871 ± 0.034	1.387GlnAsn: 1.387 ± 0.046	1.014GlnPro: 1.014 ± 0.038	0.934GlnGln: 0.934 ± 0.039	1.215GlnArg: 1.215 ± 0.041	1.642GlnSer: 1.642 ± 0.045	1.66GlnThr: 1.66 ± 0.052	1.77GlnVal: 1.77 ± 0.049	0.379GlnTrp: 0.379 ± 0.022	1.194GlnTyr: 1.194 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.965ArgAla: 2.965 ± 0.062	0.554ArgCys: 0.554 ± 0.028	2.584ArgAsp: 2.584 ± 0.056	2.937ArgGlu: 2.937 ± 0.065	2.222ArgPhe: 2.222 ± 0.05	2.791ArgGly: 2.791 ± 0.063	0.998ArgHis: 0.998 ± 0.036	3.462ArgIle: 3.462 ± 0.076	3.505ArgLys: 3.505 ± 0.079	4.265ArgLeu: 4.265 ± 0.072	1.481ArgMet: 1.481 ± 0.043	2.419ArgAsn: 2.419 ± 0.053	1.82ArgPro: 1.82 ± 0.047	1.66ArgGln: 1.66 ± 0.056	2.549ArgArg: 2.549 ± 0.063	2.673ArgSer: 2.673 ± 0.068	2.604ArgThr: 2.604 ± 0.054	2.719ArgVal: 2.719 ± 0.054	0.663ArgTrp: 0.663 ± 0.031	2.218ArgTyr: 2.218 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	5.572SerAla: 5.572 ± 0.085	1.077SerCys: 1.077 ± 0.044	4.381SerAsp: 4.381 ± 0.071	4.245SerGlu: 4.245 ± 0.083	3.323SerPhe: 3.323 ± 0.084	5.862SerGly: 5.862 ± 0.113	1.153SerHis: 1.153 ± 0.04	4.272SerIle: 4.272 ± 0.076	3.568SerLys: 3.568 ± 0.076	6.271SerLeu: 6.271 ± 0.108	2.143SerMet: 2.143 ± 0.062	2.486SerAsn: 2.486 ± 0.055	2.505SerPro: 2.505 ± 0.058	1.882SerGln: 1.882 ± 0.049	3.288SerArg: 3.288 ± 0.068	5.04SerSer: 5.04 ± 0.119	3.112SerThr: 3.112 ± 0.07	5.105SerVal: 5.105 ± 0.094	0.985SerTrp: 0.985 ± 0.033	3.023SerTyr: 3.023 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	4.442ThrAla: 4.442 ± 0.077	0.631ThrCys: 0.631 ± 0.03	3.56ThrAsp: 3.56 ± 0.061	3.192ThrGlu: 3.192 ± 0.076	2.718ThrPhe: 2.718 ± 0.057	4.799ThrGly: 4.799 ± 0.09	0.823ThrHis: 0.823 ± 0.032	3.538ThrIle: 3.538 ± 0.08	2.845ThrLys: 2.845 ± 0.06	5.05ThrLeu: 5.05 ± 0.079	1.333ThrMet: 1.333 ± 0.042	1.929ThrAsn: 1.929 ± 0.067	2.65ThrPro: 2.65 ± 0.065	1.298ThrGln: 1.298 ± 0.041	2.235ThrArg: 2.235 ± 0.053	3.594ThrSer: 3.594 ± 0.08	2.917ThrThr: 2.917 ± 0.072	4.36ThrVal: 4.36 ± 0.081	0.703ThrTrp: 0.703 ± 0.032	2.356ThrTyr: 2.356 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	5.335ValAla: 5.335 ± 0.084	1.024ValCys: 1.024 ± 0.038	3.63ValAsp: 3.63 ± 0.071	3.961ValGlu: 3.961 ± 0.077	2.941ValPhe: 2.941 ± 0.065	4.133ValGly: 4.133 ± 0.087	1.065ValHis: 1.065 ± 0.038	4.574ValIle: 4.574 ± 0.083	4.65ValLys: 4.65 ± 0.086	6.037ValLeu: 6.037 ± 0.086	1.89ValMet: 1.89 ± 0.058	4.05ValAsn: 4.05 ± 0.071	3.109ValPro: 3.109 ± 0.064	1.752ValGln: 1.752 ± 0.046	3.537ValArg: 3.537 ± 0.069	5.584ValSer: 5.584 ± 0.099	4.33ValThr: 4.33 ± 0.071	4.676ValVal: 4.676 ± 0.098	0.779ValTrp: 0.779 ± 0.032	2.491ValTyr: 2.491 ± 0.056	0.001ValXaa: 0.001 ± 0.001
Trp	0.819TrpAla: 0.819 ± 0.034	0.224TrpCys: 0.224 ± 0.016	0.761TrpAsp: 0.761 ± 0.037	0.719TrpGlu: 0.719 ± 0.028	0.656TrpPhe: 0.656 ± 0.032	0.894TrpGly: 0.894 ± 0.039	0.278TrpHis: 0.278 ± 0.018	0.698TrpIle: 0.698 ± 0.039	0.9TrpLys: 0.9 ± 0.036	1.113TrpLeu: 1.113 ± 0.042	0.371TrpMet: 0.371 ± 0.023	0.757TrpAsn: 0.757 ± 0.033	0.337TrpPro: 0.337 ± 0.02	0.468TrpGln: 0.468 ± 0.025	0.609TrpArg: 0.609 ± 0.032	0.851TrpSer: 0.851 ± 0.035	0.819TrpThr: 0.819 ± 0.036	0.644TrpVal: 0.644 ± 0.029	0.22TrpTrp: 0.22 ± 0.016	0.542TrpTyr: 0.542 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.984TyrAla: 2.984 ± 0.062	0.58TyrCys: 0.58 ± 0.028	2.84TyrAsp: 2.84 ± 0.067	2.357TyrGlu: 2.357 ± 0.066	1.977TyrPhe: 1.977 ± 0.057	3.228TyrGly: 3.228 ± 0.072	0.733TyrHis: 0.733 ± 0.032	2.424TyrIle: 2.424 ± 0.064	2.458TyrLys: 2.458 ± 0.063	3.509TyrLeu: 3.509 ± 0.074	1.09TyrMet: 1.09 ± 0.03	2.201TyrAsn: 2.201 ± 0.062	1.735TyrPro: 1.735 ± 0.048	1.179TyrGln: 1.179 ± 0.04	2.12TyrArg: 2.12 ± 0.051	3.06TyrSer: 3.06 ± 0.071	2.282TyrThr: 2.282 ± 0.059	2.798TyrVal: 2.798 ± 0.069	0.559TyrTrp: 0.559 ± 0.03	1.99TyrTyr: 1.99 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.005

Statistics based on 2085 proteins (776372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---