Amino acid dipepetide frequency for Bowmanella sp. JS7-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.505AlaAla: 9.505 ± 0.109
1.105AlaCys: 1.105 ± 0.039
5.901AlaAsp: 5.901 ± 0.086
6.272AlaGlu: 6.272 ± 0.091
3.594AlaPhe: 3.594 ± 0.072
7.285AlaGly: 7.285 ± 0.096
1.95AlaHis: 1.95 ± 0.048
5.715AlaIle: 5.715 ± 0.086
4.345AlaLys: 4.345 ± 0.084
11.084AlaLeu: 11.084 ± 0.128
2.999AlaMet: 2.999 ± 0.062
3.983AlaAsn: 3.983 ± 0.067
3.315AlaPro: 3.315 ± 0.063
4.762AlaGln: 4.762 ± 0.078
4.892AlaArg: 4.892 ± 0.077
5.753AlaSer: 5.753 ± 0.079
4.633AlaThr: 4.633 ± 0.071
6.351AlaVal: 6.351 ± 0.089
1.105AlaTrp: 1.105 ± 0.035
2.633AlaTyr: 2.633 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.925CysAla: 0.925 ± 0.033
0.16CysCys: 0.16 ± 0.013
0.622CysAsp: 0.622 ± 0.027
0.591CysGlu: 0.591 ± 0.025
0.388CysPhe: 0.388 ± 0.018
0.861CysGly: 0.861 ± 0.037
0.335CysHis: 0.335 ± 0.019
0.529CysIle: 0.529 ± 0.025
0.358CysLys: 0.358 ± 0.021
0.997CysLeu: 0.997 ± 0.032
0.225CysMet: 0.225 ± 0.017
0.311CysAsn: 0.311 ± 0.016
0.465CysPro: 0.465 ± 0.023
0.535CysGln: 0.535 ± 0.025
0.495CysArg: 0.495 ± 0.025
0.635CysSer: 0.635 ± 0.026
0.42CysThr: 0.42 ± 0.022
0.693CysVal: 0.693 ± 0.031
0.145CysTrp: 0.145 ± 0.013
0.312CysTyr: 0.312 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.822AspAla: 5.822 ± 0.079
0.549AspCys: 0.549 ± 0.027
3.478AspAsp: 3.478 ± 0.076
3.954AspGlu: 3.954 ± 0.065
2.581AspPhe: 2.581 ± 0.051
4.329AspGly: 4.329 ± 0.08
1.038AspHis: 1.038 ± 0.038
3.95AspIle: 3.95 ± 0.073
3.096AspLys: 3.096 ± 0.069
5.164AspLeu: 5.164 ± 0.072
1.756AspMet: 1.756 ± 0.046
2.531AspAsn: 2.531 ± 0.053
2.298AspPro: 2.298 ± 0.056
1.967AspGln: 1.967 ± 0.045
2.113AspArg: 2.113 ± 0.049
3.233AspSer: 3.233 ± 0.069
2.779AspThr: 2.779 ± 0.057
4.352AspVal: 4.352 ± 0.061
0.993AspTrp: 0.993 ± 0.032
2.164AspTyr: 2.164 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.91GluAla: 4.91 ± 0.09
0.426GluCys: 0.426 ± 0.018
2.702GluAsp: 2.702 ± 0.06
2.922GluGlu: 2.922 ± 0.066
2.356GluPhe: 2.356 ± 0.046
3.21GluGly: 3.21 ± 0.06
1.506GluHis: 1.506 ± 0.042
3.38GluIle: 3.38 ± 0.064
2.943GluLys: 2.943 ± 0.06
6.64GluLeu: 6.64 ± 0.101
1.575GluMet: 1.575 ± 0.041
2.15GluAsn: 2.15 ± 0.049
2.021GluPro: 2.021 ± 0.052
4.616GluGln: 4.616 ± 0.089
3.379GluArg: 3.379 ± 0.062
3.055GluSer: 3.055 ± 0.058
2.572GluThr: 2.572 ± 0.06
3.821GluVal: 3.821 ± 0.067
0.648GluTrp: 0.648 ± 0.024
1.684GluTyr: 1.684 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.181PheAla: 4.181 ± 0.071
0.469PheCys: 0.469 ± 0.026
2.98PheAsp: 2.98 ± 0.061
2.377PheGlu: 2.377 ± 0.05
1.588PhePhe: 1.588 ± 0.05
3.097PheGly: 3.097 ± 0.057
0.826PheHis: 0.826 ± 0.026
2.453PheIle: 2.453 ± 0.058
1.583PheLys: 1.583 ± 0.042
3.165PheLeu: 3.165 ± 0.06
0.98PheMet: 0.98 ± 0.031
1.984PheAsn: 1.984 ± 0.046
1.389PhePro: 1.389 ± 0.035
1.219PheGln: 1.219 ± 0.033
1.764PheArg: 1.764 ± 0.045
3.194PheSer: 3.194 ± 0.059
2.268PheThr: 2.268 ± 0.045
2.858PheVal: 2.858 ± 0.061
0.568PheTrp: 0.568 ± 0.025
1.323PheTyr: 1.323 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.687GlyAla: 5.687 ± 0.099
0.861GlyCys: 0.861 ± 0.032
4.046GlyAsp: 4.046 ± 0.074
4.242GlyGlu: 4.242 ± 0.066
3.357GlyPhe: 3.357 ± 0.065
4.897GlyGly: 4.897 ± 0.101
1.673GlyHis: 1.673 ± 0.043
4.488GlyIle: 4.488 ± 0.082
3.935GlyLys: 3.935 ± 0.075
7.398GlyLeu: 7.398 ± 0.095
2.255GlyMet: 2.255 ± 0.055
2.729GlyAsn: 2.729 ± 0.054
1.76GlyPro: 1.76 ± 0.043
3.387GlyGln: 3.387 ± 0.054
3.316GlyArg: 3.316 ± 0.065
4.036GlySer: 4.036 ± 0.067
3.312GlyThr: 3.312 ± 0.067
5.136GlyVal: 5.136 ± 0.073
1.065GlyTrp: 1.065 ± 0.035
2.517GlyTyr: 2.517 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.035HisAla: 2.035 ± 0.05
0.323HisCys: 0.323 ± 0.019
1.144HisAsp: 1.144 ± 0.031
1.079HisGlu: 1.079 ± 0.033
1.105HisPhe: 1.105 ± 0.031
1.761HisGly: 1.761 ± 0.043
0.663HisHis: 0.663 ± 0.03
1.527HisIle: 1.527 ± 0.039
1.002HisLys: 1.002 ± 0.032
2.335HisLeu: 2.335 ± 0.05
0.598HisMet: 0.598 ± 0.025
0.911HisAsn: 0.911 ± 0.032
1.303HisPro: 1.303 ± 0.036
1.304HisGln: 1.304 ± 0.038
1.124HisArg: 1.124 ± 0.034
1.472HisSer: 1.472 ± 0.039
1.119HisThr: 1.119 ± 0.031
1.314HisVal: 1.314 ± 0.038
0.45HisTrp: 0.45 ± 0.019
0.892HisTyr: 0.892 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.304IleAla: 6.304 ± 0.086
0.611IleCys: 0.611 ± 0.027
3.835IleAsp: 3.835 ± 0.07
3.936IleGlu: 3.936 ± 0.073
1.958IlePhe: 1.958 ± 0.049
4.47IleGly: 4.47 ± 0.076
1.166IleHis: 1.166 ± 0.035
2.946IleIle: 2.946 ± 0.069
2.586IleLys: 2.586 ± 0.056
4.852IleLeu: 4.852 ± 0.083
1.24IleMet: 1.24 ± 0.034
2.728IleAsn: 2.728 ± 0.055
2.489IlePro: 2.489 ± 0.059
2.312IleGln: 2.312 ± 0.045
3.014IleArg: 3.014 ± 0.057
4.155IleSer: 4.155 ± 0.069
3.107IleThr: 3.107 ± 0.059
3.713IleVal: 3.713 ± 0.071
0.602IleTrp: 0.602 ± 0.024
1.487IleTyr: 1.487 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.472LysAla: 4.472 ± 0.093
0.241LysCys: 0.241 ± 0.017
2.345LysAsp: 2.345 ± 0.06
2.096LysGlu: 2.096 ± 0.057
1.42LysPhe: 1.42 ± 0.042
2.823LysGly: 2.823 ± 0.059
1.099LysHis: 1.099 ± 0.036
2.484LysIle: 2.484 ± 0.055
2.104LysLys: 2.104 ± 0.056
4.662LysLeu: 4.662 ± 0.075
1.154LysMet: 1.154 ± 0.033
1.605LysAsn: 1.605 ± 0.047
2.18LysPro: 2.18 ± 0.057
2.71LysGln: 2.71 ± 0.057
2.605LysArg: 2.605 ± 0.056
2.402LysSer: 2.402 ± 0.054
2.409LysThr: 2.409 ± 0.05
3.268LysVal: 3.268 ± 0.065
0.483LysTrp: 0.483 ± 0.022
1.156LysTyr: 1.156 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
11.479LeuAla: 11.479 ± 0.122
1.132LeuCys: 1.132 ± 0.038
6.048LeuAsp: 6.048 ± 0.088
5.228LeuGlu: 5.228 ± 0.088
4.249LeuPhe: 4.249 ± 0.079
6.975LeuGly: 6.975 ± 0.099
2.474LeuHis: 2.474 ± 0.045
5.859LeuIle: 5.859 ± 0.094
4.371LeuLys: 4.371 ± 0.073
11.662LeuLeu: 11.662 ± 0.184
2.741LeuMet: 2.741 ± 0.049
4.445LeuAsn: 4.445 ± 0.06
5.105LeuPro: 5.105 ± 0.075
5.263LeuGln: 5.263 ± 0.097
5.447LeuArg: 5.447 ± 0.075
7.38LeuSer: 7.38 ± 0.092
6.228LeuThr: 6.228 ± 0.087
7.116LeuVal: 7.116 ± 0.089
1.165LeuTrp: 1.165 ± 0.042
2.74LeuTyr: 2.74 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.828MetAla: 2.828 ± 0.052
0.211MetCys: 0.211 ± 0.016
1.351MetAsp: 1.351 ± 0.04
1.092MetGlu: 1.092 ± 0.038
0.829MetPhe: 0.829 ± 0.029
1.789MetGly: 1.789 ± 0.046
0.66MetHis: 0.66 ± 0.027
1.214MetIle: 1.214 ± 0.037
1.142MetLys: 1.142 ± 0.039
3.201MetLeu: 3.201 ± 0.064
0.756MetMet: 0.756 ± 0.031
0.924MetAsn: 0.924 ± 0.032
1.373MetPro: 1.373 ± 0.038
1.89MetGln: 1.89 ± 0.042
1.494MetArg: 1.494 ± 0.04
1.749MetSer: 1.749 ± 0.043
1.479MetThr: 1.479 ± 0.046
1.699MetVal: 1.699 ± 0.043
0.28MetTrp: 0.28 ± 0.017
0.576MetTyr: 0.576 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.709AsnAla: 3.709 ± 0.067
0.384AsnCys: 0.384 ± 0.021
2.149AsnAsp: 2.149 ± 0.052
2.02AsnGlu: 2.02 ± 0.043
1.439AsnPhe: 1.439 ± 0.039
3.102AsnGly: 3.102 ± 0.063
0.901AsnHis: 0.901 ± 0.028
2.356AsnIle: 2.356 ± 0.05
1.783AsnLys: 1.783 ± 0.041
3.981AsnLeu: 3.981 ± 0.064
1.041AsnMet: 1.041 ± 0.033
1.708AsnAsn: 1.708 ± 0.054
2.18AsnPro: 2.18 ± 0.047
2.267AsnGln: 2.267 ± 0.05
2.004AsnArg: 2.004 ± 0.046
2.115AsnSer: 2.115 ± 0.048
1.973AsnThr: 1.973 ± 0.052
2.587AsnVal: 2.587 ± 0.054
0.674AsnTrp: 0.674 ± 0.03
1.185AsnTyr: 1.185 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
4.366ProAla: 4.366 ± 0.079
0.329ProCys: 0.329 ± 0.021
2.84ProAsp: 2.84 ± 0.052
2.81ProGlu: 2.81 ± 0.057
1.721ProPhe: 1.721 ± 0.045
2.878ProGly: 2.878 ± 0.061
0.91ProHis: 0.91 ± 0.031
2.024ProIle: 2.024 ± 0.045
1.61ProLys: 1.61 ± 0.043
4.437ProLeu: 4.437 ± 0.069
1.022ProMet: 1.022 ± 0.031
1.534ProAsn: 1.534 ± 0.042
1.304ProPro: 1.304 ± 0.044
2.096ProGln: 2.096 ± 0.049
1.677ProArg: 1.677 ± 0.039
2.177ProSer: 2.177 ± 0.047
2.035ProThr: 2.035 ± 0.048
3.422ProVal: 3.422 ± 0.074
0.517ProTrp: 0.517 ± 0.023
1.267ProTyr: 1.267 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.647GlnAla: 5.647 ± 0.092
0.445GlnCys: 0.445 ± 0.025
2.61GlnAsp: 2.61 ± 0.054
2.25GlnGlu: 2.25 ± 0.052
2.003GlnPhe: 2.003 ± 0.044
3.442GlnGly: 3.442 ± 0.054
1.629GlnHis: 1.629 ± 0.049
2.932GlnIle: 2.932 ± 0.064
1.893GlnLys: 1.893 ± 0.048
6.126GlnLeu: 6.126 ± 0.091
1.264GlnMet: 1.264 ± 0.035
1.656GlnAsn: 1.656 ± 0.045
2.221GlnPro: 2.221 ± 0.054
4.728GlnGln: 4.728 ± 0.096
3.276GlnArg: 3.276 ± 0.065
2.969GlnSer: 2.969 ± 0.06
2.733GlnThr: 2.733 ± 0.054
3.551GlnVal: 3.551 ± 0.064
0.774GlnTrp: 0.774 ± 0.031
1.394GlnTyr: 1.394 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
4.303ArgAla: 4.303 ± 0.076
0.512ArgCys: 0.512 ± 0.025
2.982ArgAsp: 2.982 ± 0.059
3.284ArgGlu: 3.284 ± 0.063
2.488ArgPhe: 2.488 ± 0.049
2.945ArgGly: 2.945 ± 0.062
1.421ArgHis: 1.421 ± 0.041
3.288ArgIle: 3.288 ± 0.057
2.233ArgLys: 2.233 ± 0.057
5.798ArgLeu: 5.798 ± 0.085
1.323ArgMet: 1.323 ± 0.036
1.953ArgAsn: 1.953 ± 0.045
1.758ArgPro: 1.758 ± 0.042
2.984ArgGln: 2.984 ± 0.061
2.814ArgArg: 2.814 ± 0.059
2.683ArgSer: 2.683 ± 0.053
2.196ArgThr: 2.196 ± 0.049
3.536ArgVal: 3.536 ± 0.068
0.824ArgTrp: 0.824 ± 0.034
1.937ArgTyr: 1.937 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.109SerAla: 6.109 ± 0.078
0.543SerCys: 0.543 ± 0.024
3.617SerAsp: 3.617 ± 0.067
3.503SerGlu: 3.503 ± 0.057
2.412SerPhe: 2.412 ± 0.051
4.949SerGly: 4.949 ± 0.079
1.439SerHis: 1.439 ± 0.047
3.238SerIle: 3.238 ± 0.067
2.513SerLys: 2.513 ± 0.053
6.618SerLeu: 6.618 ± 0.078
1.669SerMet: 1.669 ± 0.049
2.246SerAsn: 2.246 ± 0.055
2.359SerPro: 2.359 ± 0.058
3.027SerGln: 3.027 ± 0.051
3.163SerArg: 3.163 ± 0.071
3.61SerSer: 3.61 ± 0.071
2.814SerThr: 2.814 ± 0.064
4.497SerVal: 4.497 ± 0.075
0.874SerTrp: 0.874 ± 0.028
1.776SerTyr: 1.776 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.54ThrAla: 4.54 ± 0.081
0.437ThrCys: 0.437 ± 0.02
3.087ThrAsp: 3.087 ± 0.059
2.845ThrGlu: 2.845 ± 0.056
2.019ThrPhe: 2.019 ± 0.044
3.9ThrGly: 3.9 ± 0.068
1.184ThrHis: 1.184 ± 0.031
2.776ThrIle: 2.776 ± 0.055
1.575ThrLys: 1.575 ± 0.039
6.565ThrLeu: 6.565 ± 0.093
1.008ThrMet: 1.008 ± 0.034
1.824ThrAsn: 1.824 ± 0.048
2.697ThrPro: 2.697 ± 0.056
2.397ThrGln: 2.397 ± 0.052
2.5ThrArg: 2.5 ± 0.049
3.059ThrSer: 3.059 ± 0.063
2.531ThrThr: 2.531 ± 0.058
3.5ThrVal: 3.5 ± 0.066
0.564ThrTrp: 0.564 ± 0.023
1.476ThrTyr: 1.476 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.807ValAla: 6.807 ± 0.08
0.756ValCys: 0.756 ± 0.026
4.201ValAsp: 4.201 ± 0.067
4.037ValGlu: 4.037 ± 0.064
2.745ValPhe: 2.745 ± 0.059
4.577ValGly: 4.577 ± 0.081
1.391ValHis: 1.391 ± 0.038
4.338ValIle: 4.338 ± 0.079
3.188ValLys: 3.188 ± 0.064
6.959ValLeu: 6.959 ± 0.09
1.9ValMet: 1.9 ± 0.042
2.952ValAsn: 2.952 ± 0.066
2.786ValPro: 2.786 ± 0.059
2.712ValGln: 2.712 ± 0.049
3.469ValArg: 3.469 ± 0.061
4.774ValSer: 4.774 ± 0.076
3.97ValThr: 3.97 ± 0.079
5.335ValVal: 5.335 ± 0.089
0.799ValTrp: 0.799 ± 0.028
1.866ValTyr: 1.866 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.035
0.161TrpCys: 0.161 ± 0.015
0.599TrpAsp: 0.599 ± 0.028
0.501TrpGlu: 0.501 ± 0.022
0.623TrpPhe: 0.623 ± 0.024
0.753TrpGly: 0.753 ± 0.028
0.45TrpHis: 0.45 ± 0.023
0.67TrpIle: 0.67 ± 0.031
0.376TrpLys: 0.376 ± 0.022
1.982TrpLeu: 1.982 ± 0.051
0.388TrpMet: 0.388 ± 0.023
0.407TrpAsn: 0.407 ± 0.022
0.525TrpPro: 0.525 ± 0.026
1.367TrpGln: 1.367 ± 0.045
0.859TrpArg: 0.859 ± 0.034
0.653TrpSer: 0.653 ± 0.03
0.523TrpThr: 0.523 ± 0.024
0.858TrpVal: 0.858 ± 0.031
0.243TrpTrp: 0.243 ± 0.015
0.425TrpTyr: 0.425 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.665TyrAla: 2.665 ± 0.056
0.346TyrCys: 0.346 ± 0.019
1.61TyrAsp: 1.61 ± 0.043
1.477TyrGlu: 1.477 ± 0.039
1.394TyrPhe: 1.394 ± 0.036
2.056TyrGly: 2.056 ± 0.051
0.746TyrHis: 0.746 ± 0.028
1.342TyrIle: 1.342 ± 0.037
1.083TyrLys: 1.083 ± 0.041
3.481TyrLeu: 3.481 ± 0.062
0.643TyrMet: 0.643 ± 0.029
0.978TyrAsn: 0.978 ± 0.032
1.447TyrPro: 1.447 ± 0.038
1.999TyrGln: 1.999 ± 0.045
1.857TyrArg: 1.857 ± 0.05
1.871TyrSer: 1.871 ± 0.051
1.38TyrThr: 1.38 ± 0.04
1.956TyrVal: 1.956 ± 0.041
0.479TyrTrp: 0.479 ± 0.025
1.026TyrTyr: 1.026 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2974 proteins (973382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski