Amino acid dipepetide frequency for Bacteroides sp. CAG:530

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.785AlaAla: 5.785 ± 0.094	1.106AlaCys: 1.106 ± 0.032	4.524AlaAsp: 4.524 ± 0.075	4.957AlaGlu: 4.957 ± 0.082	3.165AlaPhe: 3.165 ± 0.057	4.907AlaGly: 4.907 ± 0.083	1.248AlaHis: 1.248 ± 0.04	4.767AlaIle: 4.767 ± 0.086	4.43AlaLys: 4.43 ± 0.082	6.558AlaLeu: 6.558 ± 0.097	2.023AlaMet: 2.023 ± 0.053	3.338AlaAsn: 3.338 ± 0.058	2.285AlaPro: 2.285 ± 0.057	2.736AlaGln: 2.736 ± 0.057	2.883AlaArg: 2.883 ± 0.065	4.653AlaSer: 4.653 ± 0.082	3.95AlaThr: 3.95 ± 0.072	4.704AlaVal: 4.704 ± 0.078	0.847AlaTrp: 0.847 ± 0.028	3.128AlaTyr: 3.128 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.836CysAla: 0.836 ± 0.03	0.208CysCys: 0.208 ± 0.015	0.677CysAsp: 0.677 ± 0.026	0.695CysGlu: 0.695 ± 0.028	0.692CysPhe: 0.692 ± 0.028	1.133CysGly: 1.133 ± 0.039	0.294CysHis: 0.294 ± 0.018	0.947CysIle: 0.947 ± 0.032	0.778CysLys: 0.778 ± 0.027	1.202CysLeu: 1.202 ± 0.034	0.367CysMet: 0.367 ± 0.019	0.627CysAsn: 0.627 ± 0.027	0.598CysPro: 0.598 ± 0.025	0.376CysGln: 0.376 ± 0.019	0.597CysArg: 0.597 ± 0.023	0.854CysSer: 0.854 ± 0.028	0.7CysThr: 0.7 ± 0.026	0.862CysVal: 0.862 ± 0.032	0.151CysTrp: 0.151 ± 0.013	0.539CysTyr: 0.539 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.168AspAla: 4.168 ± 0.072	0.665AspCys: 0.665 ± 0.023	3.024AspAsp: 3.024 ± 0.061	4.107AspGlu: 4.107 ± 0.068	3.08AspPhe: 3.08 ± 0.057	4.392AspGly: 4.392 ± 0.075	0.846AspHis: 0.846 ± 0.028	4.115AspIle: 4.115 ± 0.071	4.255AspLys: 4.255 ± 0.07	4.66AspLeu: 4.66 ± 0.081	1.759AspMet: 1.759 ± 0.04	3.076AspAsn: 3.076 ± 0.059	1.886AspPro: 1.886 ± 0.047	1.225AspGln: 1.225 ± 0.036	2.36AspArg: 2.36 ± 0.05	3.177AspSer: 3.177 ± 0.065	2.771AspThr: 2.771 ± 0.059	3.749AspVal: 3.749 ± 0.064	0.911AspTrp: 0.911 ± 0.032	3.01AspTyr: 3.01 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.016GluAla: 5.016 ± 0.088	0.717GluCys: 0.717 ± 0.028	3.234GluAsp: 3.234 ± 0.058	4.781GluGlu: 4.781 ± 0.091	2.568GluPhe: 2.568 ± 0.056	4.101GluGly: 4.101 ± 0.063	1.279GluHis: 1.279 ± 0.042	4.204GluIle: 4.204 ± 0.073	5.167GluLys: 5.167 ± 0.081	5.806GluLeu: 5.806 ± 0.092	2.008GluMet: 2.008 ± 0.045	3.521GluAsn: 3.521 ± 0.062	1.744GluPro: 1.744 ± 0.044	2.606GluGln: 2.606 ± 0.051	3.045GluArg: 3.045 ± 0.067	3.105GluSer: 3.105 ± 0.062	3.216GluThr: 3.216 ± 0.054	4.229GluVal: 4.229 ± 0.071	0.836GluTrp: 0.836 ± 0.031	2.613GluTyr: 2.613 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.992PheAla: 2.992 ± 0.062	0.715PheCys: 0.715 ± 0.027	2.892PheAsp: 2.892 ± 0.05	2.446PheGlu: 2.446 ± 0.059	2.141PhePhe: 2.141 ± 0.061	3.202PheGly: 3.202 ± 0.057	0.877PheHis: 0.877 ± 0.032	3.116PheIle: 3.116 ± 0.065	2.595PheLys: 2.595 ± 0.051	3.76PheLeu: 3.76 ± 0.065	1.347PheMet: 1.347 ± 0.034	2.417PheAsn: 2.417 ± 0.055	1.665PhePro: 1.665 ± 0.043	1.257PheGln: 1.257 ± 0.036	2.053PheArg: 2.053 ± 0.048	3.419PheSer: 3.419 ± 0.064	2.764PheThr: 2.764 ± 0.053	3.007PheVal: 3.007 ± 0.063	0.533PheTrp: 0.533 ± 0.023	1.964PheTyr: 1.964 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.53GlyAla: 4.53 ± 0.085	0.987GlyCys: 0.987 ± 0.034	3.576GlyAsp: 3.576 ± 0.061	3.993GlyGlu: 3.993 ± 0.069	3.201GlyPhe: 3.201 ± 0.069	4.731GlyGly: 4.731 ± 0.077	1.35GlyHis: 1.35 ± 0.037	5.078GlyIle: 5.078 ± 0.095	5.289GlyLys: 5.289 ± 0.081	5.709GlyLeu: 5.709 ± 0.083	2.194GlyMet: 2.194 ± 0.044	3.605GlyAsn: 3.605 ± 0.062	1.256GlyPro: 1.256 ± 0.035	1.993GlyGln: 1.993 ± 0.048	2.759GlyArg: 2.759 ± 0.059	4.015GlySer: 4.015 ± 0.077	4.144GlyThr: 4.144 ± 0.068	5.021GlyVal: 5.021 ± 0.07	1.006GlyTrp: 1.006 ± 0.033	3.541GlyTyr: 3.541 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.206HisAla: 1.206 ± 0.036	0.306HisCys: 0.306 ± 0.016	1.023HisAsp: 1.023 ± 0.036	1.069HisGlu: 1.069 ± 0.034	1.011HisPhe: 1.011 ± 0.029	1.26HisGly: 1.26 ± 0.04	0.523HisHis: 0.523 ± 0.028	1.438HisIle: 1.438 ± 0.041	1.062HisLys: 1.062 ± 0.036	1.742HisLeu: 1.742 ± 0.043	0.37HisMet: 0.37 ± 0.019	0.997HisAsn: 0.997 ± 0.034	1.071HisPro: 1.071 ± 0.037	0.637HisGln: 0.637 ± 0.028	0.919HisArg: 0.919 ± 0.027	1.156HisSer: 1.156 ± 0.04	1.104HisThr: 1.104 ± 0.033	1.138HisVal: 1.138 ± 0.034	0.241HisTrp: 0.241 ± 0.016	0.94HisTyr: 0.94 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.031IleAla: 5.031 ± 0.081	0.984IleCys: 0.984 ± 0.033	4.388IleAsp: 4.388 ± 0.063	4.459IleGlu: 4.459 ± 0.08	2.638IlePhe: 2.638 ± 0.055	4.636IleGly: 4.636 ± 0.078	1.283IleHis: 1.283 ± 0.036	4.418IleIle: 4.418 ± 0.088	4.26IleLys: 4.26 ± 0.076	5.419IleLeu: 5.419 ± 0.084	1.607IleMet: 1.607 ± 0.051	3.435IleAsn: 3.435 ± 0.062	2.948IlePro: 2.948 ± 0.054	2.084IleGln: 2.084 ± 0.047	3.18IleArg: 3.18 ± 0.049	4.541IleSer: 4.541 ± 0.08	3.977IleThr: 3.977 ± 0.069	4.47IleVal: 4.47 ± 0.076	0.688IleTrp: 0.688 ± 0.028	2.717IleTyr: 2.717 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.152LysAla: 5.152 ± 0.089	0.642LysCys: 0.642 ± 0.025	4.359LysAsp: 4.359 ± 0.065	5.612LysGlu: 5.612 ± 0.084	2.286LysPhe: 2.286 ± 0.05	4.567LysGly: 4.567 ± 0.075	1.353LysHis: 1.353 ± 0.039	3.971LysIle: 3.971 ± 0.074	5.284LysLys: 5.284 ± 0.078	5.54LysLeu: 5.54 ± 0.071	2.233LysMet: 2.233 ± 0.049	3.816LysAsn: 3.816 ± 0.064	2.252LysPro: 2.252 ± 0.051	2.644LysGln: 2.644 ± 0.053	3.186LysArg: 3.186 ± 0.062	3.474LysSer: 3.474 ± 0.058	3.608LysThr: 3.608 ± 0.064	4.613LysVal: 4.613 ± 0.072	0.845LysTrp: 0.845 ± 0.029	3.113LysTyr: 3.113 ± 0.053	0.002LysXaa: 0.002 ± 0.002
Leu	6.227LeuAla: 6.227 ± 0.098	1.373LeuCys: 1.373 ± 0.039	4.666LeuAsp: 4.666 ± 0.074	4.582LeuGlu: 4.582 ± 0.073	4.245LeuPhe: 4.245 ± 0.079	5.52LeuGly: 5.52 ± 0.087	1.859LeuHis: 1.859 ± 0.043	5.311LeuIle: 5.311 ± 0.097	6.463LeuLys: 6.463 ± 0.083	8.213LeuLeu: 8.213 ± 0.127	2.524LeuMet: 2.524 ± 0.058	4.785LeuAsn: 4.785 ± 0.076	3.97LeuPro: 3.97 ± 0.066	3.304LeuGln: 3.304 ± 0.067	4.085LeuArg: 4.085 ± 0.063	6.587LeuSer: 6.587 ± 0.086	5.143LeuThr: 5.143 ± 0.079	4.921LeuVal: 4.921 ± 0.078	1.022LeuTrp: 1.022 ± 0.033	3.555LeuTyr: 3.555 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.306MetAla: 2.306 ± 0.058	0.268MetCys: 0.268 ± 0.016	1.515MetAsp: 1.515 ± 0.035	1.776MetGlu: 1.776 ± 0.045	1.038MetPhe: 1.038 ± 0.029	1.906MetGly: 1.906 ± 0.042	0.502MetHis: 0.502 ± 0.024	1.667MetIle: 1.667 ± 0.036	2.597MetLys: 2.597 ± 0.046	2.659MetLeu: 2.659 ± 0.066	0.854MetMet: 0.854 ± 0.031	1.721MetAsn: 1.721 ± 0.045	1.233MetPro: 1.233 ± 0.035	1.12MetGln: 1.12 ± 0.031	1.427MetArg: 1.427 ± 0.037	1.712MetSer: 1.712 ± 0.047	1.537MetThr: 1.537 ± 0.039	1.662MetVal: 1.662 ± 0.041	0.272MetTrp: 0.272 ± 0.017	0.917MetTyr: 0.917 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.76AsnAla: 3.76 ± 0.065	0.562AsnCys: 0.562 ± 0.027	2.88AsnAsp: 2.88 ± 0.057	3.143AsnGlu: 3.143 ± 0.062	2.226AsnPhe: 2.226 ± 0.052	4.101AsnGly: 4.101 ± 0.078	1.006AsnHis: 1.006 ± 0.037	3.866AsnIle: 3.866 ± 0.071	3.528AsnLys: 3.528 ± 0.062	4.418AsnLeu: 4.418 ± 0.079	1.469AsnMet: 1.469 ± 0.038	2.831AsnAsn: 2.831 ± 0.063	2.488AsnPro: 2.488 ± 0.055	1.658AsnGln: 1.658 ± 0.044	2.379AsnArg: 2.379 ± 0.047	2.904AsnSer: 2.904 ± 0.059	2.857AsnThr: 2.857 ± 0.062	3.576AsnVal: 3.576 ± 0.066	0.675AsnTrp: 0.675 ± 0.026	2.477AsnTyr: 2.477 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.597ProAla: 2.597 ± 0.066	0.397ProCys: 0.397 ± 0.024	2.447ProAsp: 2.447 ± 0.051	3.218ProGlu: 3.218 ± 0.067	1.732ProPhe: 1.732 ± 0.039	2.338ProGly: 2.338 ± 0.055	0.701ProHis: 0.701 ± 0.029	2.408ProIle: 2.408 ± 0.046	2.083ProLys: 2.083 ± 0.048	3.078ProLeu: 3.078 ± 0.053	1.006ProMet: 1.006 ± 0.032	1.831ProAsn: 1.831 ± 0.043	0.686ProPro: 0.686 ± 0.031	1.48ProGln: 1.48 ± 0.037	1.228ProArg: 1.228 ± 0.032	2.345ProSer: 2.345 ± 0.048	2.045ProThr: 2.045 ± 0.048	2.697ProVal: 2.697 ± 0.055	0.462ProTrp: 0.462 ± 0.024	1.78ProTyr: 1.78 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.476GlnAla: 2.476 ± 0.058	0.363GlnCys: 0.363 ± 0.019	1.516GlnAsp: 1.516 ± 0.039	2.086GlnGlu: 2.086 ± 0.048	1.359GlnPhe: 1.359 ± 0.038	2.046GlnGly: 2.046 ± 0.052	0.677GlnHis: 0.677 ± 0.028	2.338GlnIle: 2.338 ± 0.048	2.498GlnLys: 2.498 ± 0.048	3.232GlnLeu: 3.232 ± 0.062	1.095GlnMet: 1.095 ± 0.031	1.918GlnAsn: 1.918 ± 0.051	1.236GlnPro: 1.236 ± 0.035	1.505GlnGln: 1.505 ± 0.046	1.611GlnArg: 1.611 ± 0.04	2.031GlnSer: 2.031 ± 0.048	1.976GlnThr: 1.976 ± 0.046	2.097GlnVal: 2.097 ± 0.047	0.474GlnTrp: 0.474 ± 0.026	1.48GlnTyr: 1.48 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.713ArgAla: 2.713 ± 0.051	0.491ArgCys: 0.491 ± 0.022	2.108ArgAsp: 2.108 ± 0.047	2.702ArgGlu: 2.702 ± 0.057	2.331ArgPhe: 2.331 ± 0.046	2.446ArgGly: 2.446 ± 0.062	0.934ArgHis: 0.934 ± 0.031	3.508ArgIle: 3.508 ± 0.071	3.239ArgLys: 3.239 ± 0.067	4.35ArgLeu: 4.35 ± 0.06	1.457ArgMet: 1.457 ± 0.035	2.421ArgAsn: 2.421 ± 0.049	1.566ArgPro: 1.566 ± 0.054	1.673ArgGln: 1.673 ± 0.048	2.158ArgArg: 2.158 ± 0.054	2.352ArgSer: 2.352 ± 0.058	2.376ArgThr: 2.376 ± 0.05	2.612ArgVal: 2.612 ± 0.047	0.666ArgTrp: 0.666 ± 0.028	2.183ArgTyr: 2.183 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.393SerAla: 4.393 ± 0.073	0.894SerCys: 0.894 ± 0.03	3.565SerAsp: 3.565 ± 0.066	3.595SerGlu: 3.595 ± 0.051	3.241SerPhe: 3.241 ± 0.062	4.483SerGly: 4.483 ± 0.069	1.164SerHis: 1.164 ± 0.037	4.224SerIle: 4.224 ± 0.066	3.664SerLys: 3.664 ± 0.065	5.887SerLeu: 5.887 ± 0.09	1.623SerMet: 1.623 ± 0.042	2.874SerAsn: 2.874 ± 0.064	2.166SerPro: 2.166 ± 0.048	1.946SerGln: 1.946 ± 0.044	2.674SerArg: 2.674 ± 0.06	4.017SerSer: 4.017 ± 0.087	3.414SerThr: 3.414 ± 0.066	4.56SerVal: 4.56 ± 0.073	0.86SerTrp: 0.86 ± 0.037	2.877SerTyr: 2.877 ± 0.062	0.001SerXaa: 0.001 ± 0.001
Thr	4.122ThrAla: 4.122 ± 0.061	0.637ThrCys: 0.637 ± 0.026	3.645ThrAsp: 3.645 ± 0.059	3.326ThrGlu: 3.326 ± 0.063	2.685ThrPhe: 2.685 ± 0.055	3.985ThrGly: 3.985 ± 0.07	1.075ThrHis: 1.075 ± 0.032	3.746ThrIle: 3.746 ± 0.06	2.917ThrLys: 2.917 ± 0.065	5.397ThrLeu: 5.397 ± 0.076	1.355ThrMet: 1.355 ± 0.037	2.554ThrAsn: 2.554 ± 0.063	2.759ThrPro: 2.759 ± 0.053	1.778ThrGln: 1.778 ± 0.044	2.161ThrArg: 2.161 ± 0.041	3.409ThrSer: 3.409 ± 0.056	3.071ThrThr: 3.071 ± 0.066	3.91ThrVal: 3.91 ± 0.072	0.68ThrTrp: 0.68 ± 0.026	2.477ThrTyr: 2.477 ± 0.055	0.001ThrXaa: 0.001 ± 0.001
Val	4.79ValAla: 4.79 ± 0.081	1.033ValCys: 1.033 ± 0.034	3.876ValAsp: 3.876 ± 0.076	4.067ValGlu: 4.067 ± 0.066	2.867ValPhe: 2.867 ± 0.058	4.176ValGly: 4.176 ± 0.082	1.08ValHis: 1.08 ± 0.035	4.348ValIle: 4.348 ± 0.067	4.521ValLys: 4.521 ± 0.074	5.774ValLeu: 5.774 ± 0.077	1.786ValMet: 1.786 ± 0.046	3.472ValAsn: 3.472 ± 0.055	2.543ValPro: 2.543 ± 0.051	1.972ValGln: 1.972 ± 0.044	2.888ValArg: 2.888 ± 0.056	4.75ValSer: 4.75 ± 0.077	3.768ValThr: 3.768 ± 0.073	4.51ValVal: 4.51 ± 0.091	0.765ValTrp: 0.765 ± 0.026	2.725ValTyr: 2.725 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.779TrpAla: 0.779 ± 0.031	0.206TrpCys: 0.206 ± 0.015	0.7TrpAsp: 0.7 ± 0.026	0.755TrpGlu: 0.755 ± 0.028	0.549TrpPhe: 0.549 ± 0.027	0.963TrpGly: 0.963 ± 0.032	0.306TrpHis: 0.306 ± 0.017	0.795TrpIle: 0.795 ± 0.035	0.994TrpLys: 0.994 ± 0.034	1.178TrpLeu: 1.178 ± 0.04	0.456TrpMet: 0.456 ± 0.02	0.863TrpAsn: 0.863 ± 0.031	0.275TrpPro: 0.275 ± 0.019	0.486TrpGln: 0.486 ± 0.026	0.557TrpArg: 0.557 ± 0.022	0.741TrpSer: 0.741 ± 0.028	0.679TrpThr: 0.679 ± 0.025	0.734TrpVal: 0.734 ± 0.031	0.167TrpTrp: 0.167 ± 0.013	0.539TrpTyr: 0.539 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.117TyrAla: 3.117 ± 0.054	0.58TyrCys: 0.58 ± 0.023	2.621TyrAsp: 2.621 ± 0.056	2.425TyrGlu: 2.425 ± 0.054	2.107TyrPhe: 2.107 ± 0.04	3.084TyrGly: 3.084 ± 0.063	0.859TyrHis: 0.859 ± 0.034	2.899TyrIle: 2.899 ± 0.051	2.925TyrLys: 2.925 ± 0.052	3.77TyrLeu: 3.77 ± 0.06	1.157TyrMet: 1.157 ± 0.035	2.701TyrAsn: 2.701 ± 0.061	1.932TyrPro: 1.932 ± 0.051	1.536TyrGln: 1.536 ± 0.043	2.134TyrArg: 2.134 ± 0.046	2.88TyrSer: 2.88 ± 0.06	2.591TyrThr: 2.591 ± 0.059	2.638TyrVal: 2.638 ± 0.047	0.622TyrTrp: 0.622 ± 0.024	2.225TyrTyr: 2.225 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 2669 proteins (984630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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