Amino acid dipepetide frequency for Xanthomonas phage Xoo-sp14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.193AlaAla: 9.193 ± 0.702
0.653AlaCys: 0.653 ± 0.087
5.221AlaAsp: 5.221 ± 0.271
5.803AlaGlu: 5.803 ± 0.291
2.923AlaPhe: 2.923 ± 0.191
5.888AlaGly: 5.888 ± 0.566
1.575AlaHis: 1.575 ± 0.136
4.739AlaIle: 4.739 ± 0.256
4.426AlaLys: 4.426 ± 0.283
7.988AlaLeu: 7.988 ± 0.329
3.235AlaMet: 3.235 ± 0.213
3.675AlaAsn: 3.675 ± 0.244
3.802AlaPro: 3.802 ± 0.338
3.178AlaGln: 3.178 ± 0.287
4.866AlaArg: 4.866 ± 0.297
5.079AlaSer: 5.079 ± 0.282
5.264AlaThr: 5.264 ± 0.248
5.859AlaVal: 5.859 ± 0.293
0.78AlaTrp: 0.78 ± 0.104
2.582AlaTyr: 2.582 ± 0.179
0.0AlaXaa: 0.0 ± 0.0
Cys
0.511CysAla: 0.511 ± 0.081
0.227CysCys: 0.227 ± 0.057
0.397CysAsp: 0.397 ± 0.066
0.397CysGlu: 0.397 ± 0.072
0.326CysPhe: 0.326 ± 0.068
0.624CysGly: 0.624 ± 0.086
0.284CysHis: 0.284 ± 0.065
0.383CysIle: 0.383 ± 0.074
0.497CysLys: 0.497 ± 0.083
0.553CysLeu: 0.553 ± 0.09
0.199CysMet: 0.199 ± 0.047
0.255CysAsn: 0.255 ± 0.063
0.511CysPro: 0.511 ± 0.09
0.213CysGln: 0.213 ± 0.051
0.411CysArg: 0.411 ± 0.079
0.383CysSer: 0.383 ± 0.075
0.482CysThr: 0.482 ± 0.074
0.497CysVal: 0.497 ± 0.089
0.113CysTrp: 0.113 ± 0.037
0.227CysTyr: 0.227 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
5.008AspAla: 5.008 ± 0.263
0.525AspCys: 0.525 ± 0.1
4.256AspAsp: 4.256 ± 0.28
3.944AspGlu: 3.944 ± 0.31
2.88AspPhe: 2.88 ± 0.187
5.264AspGly: 5.264 ± 0.293
1.362AspHis: 1.362 ± 0.163
3.419AspIle: 3.419 ± 0.215
2.951AspLys: 2.951 ± 0.224
6.015AspLeu: 6.015 ± 0.369
1.986AspMet: 1.986 ± 0.165
2.965AspAsn: 2.965 ± 0.239
3.121AspPro: 3.121 ± 0.197
1.958AspGln: 1.958 ± 0.146
4.455AspArg: 4.455 ± 0.37
3.221AspSer: 3.221 ± 0.208
3.221AspThr: 3.221 ± 0.217
4.426AspVal: 4.426 ± 0.285
0.993AspTrp: 0.993 ± 0.102
2.469AspTyr: 2.469 ± 0.188
0.0AspXaa: 0.0 ± 0.0
Glu
5.859GluAla: 5.859 ± 0.319
0.511GluCys: 0.511 ± 0.078
4.426GluAsp: 4.426 ± 0.28
4.767GluGlu: 4.767 ± 0.358
2.327GluPhe: 2.327 ± 0.206
4.058GluGly: 4.058 ± 0.248
1.518GluHis: 1.518 ± 0.15
4.157GluIle: 4.157 ± 0.262
3.32GluLys: 3.32 ± 0.277
6.555GluLeu: 6.555 ± 0.405
2.043GluMet: 2.043 ± 0.158
2.653GluAsn: 2.653 ± 0.209
2.284GluPro: 2.284 ± 0.16
3.05GluGln: 3.05 ± 0.222
3.774GluArg: 3.774 ± 0.296
3.192GluSer: 3.192 ± 0.214
3.433GluThr: 3.433 ± 0.247
4.951GluVal: 4.951 ± 0.331
0.681GluTrp: 0.681 ± 0.095
2.029GluTyr: 2.029 ± 0.166
0.0GluXaa: 0.0 ± 0.0
Phe
3.221PheAla: 3.221 ± 0.224
0.298PheCys: 0.298 ± 0.063
3.348PheAsp: 3.348 ± 0.192
2.568PheGlu: 2.568 ± 0.205
1.603PhePhe: 1.603 ± 0.154
3.093PheGly: 3.093 ± 0.217
0.908PheHis: 0.908 ± 0.141
2.128PheIle: 2.128 ± 0.144
1.887PheLys: 1.887 ± 0.135
2.724PheLeu: 2.724 ± 0.202
0.979PheMet: 0.979 ± 0.106
1.915PheAsn: 1.915 ± 0.169
1.66PhePro: 1.66 ± 0.169
1.22PheGln: 1.22 ± 0.138
2.057PheArg: 2.057 ± 0.183
2.596PheSer: 2.596 ± 0.199
2.341PheThr: 2.341 ± 0.185
2.866PheVal: 2.866 ± 0.209
0.355PheTrp: 0.355 ± 0.074
1.263PheTyr: 1.263 ± 0.124
0.0PheXaa: 0.0 ± 0.0
Gly
5.476GlyAla: 5.476 ± 0.436
0.468GlyCys: 0.468 ± 0.092
4.015GlyAsp: 4.015 ± 0.224
4.696GlyGlu: 4.696 ± 0.317
2.781GlyPhe: 2.781 ± 0.211
5.221GlyGly: 5.221 ± 0.701
1.319GlyHis: 1.319 ± 0.137
3.504GlyIle: 3.504 ± 0.234
4.143GlyLys: 4.143 ± 0.24
5.377GlyLeu: 5.377 ± 0.326
2.142GlyMet: 2.142 ± 0.187
3.334GlyAsn: 3.334 ± 0.303
2.27GlyPro: 2.27 ± 0.183
2.469GlyGln: 2.469 ± 0.161
4.398GlyArg: 4.398 ± 0.294
4.469GlySer: 4.469 ± 0.331
4.214GlyThr: 4.214 ± 0.257
4.554GlyVal: 4.554 ± 0.295
0.837GlyTrp: 0.837 ± 0.118
2.483GlyTyr: 2.483 ± 0.177
0.0GlyXaa: 0.0 ± 0.0
His
1.561HisAla: 1.561 ± 0.15
0.284HisCys: 0.284 ± 0.053
1.263HisAsp: 1.263 ± 0.163
1.234HisGlu: 1.234 ± 0.13
0.951HisPhe: 0.951 ± 0.127
1.646HisGly: 1.646 ± 0.173
0.525HisHis: 0.525 ± 0.085
1.248HisIle: 1.248 ± 0.134
0.922HisLys: 0.922 ± 0.119
2.043HisLeu: 2.043 ± 0.217
0.653HisMet: 0.653 ± 0.097
0.865HisAsn: 0.865 ± 0.126
0.993HisPro: 0.993 ± 0.13
0.837HisGln: 0.837 ± 0.095
1.688HisArg: 1.688 ± 0.187
1.163HisSer: 1.163 ± 0.117
0.851HisThr: 0.851 ± 0.086
1.39HisVal: 1.39 ± 0.143
0.27HisTrp: 0.27 ± 0.072
0.837HisTyr: 0.837 ± 0.108
0.0HisXaa: 0.0 ± 0.0
Ile
4.81IleAla: 4.81 ± 0.267
0.553IleCys: 0.553 ± 0.093
3.689IleAsp: 3.689 ± 0.265
4.27IleGlu: 4.27 ± 0.263
2.1IlePhe: 2.1 ± 0.178
3.788IleGly: 3.788 ± 0.212
1.376IleHis: 1.376 ± 0.174
2.525IleIle: 2.525 ± 0.229
2.61IleLys: 2.61 ± 0.214
3.745IleLeu: 3.745 ± 0.243
1.319IleMet: 1.319 ± 0.126
2.908IleAsn: 2.908 ± 0.215
2.653IlePro: 2.653 ± 0.19
2.029IleGln: 2.029 ± 0.169
3.022IleArg: 3.022 ± 0.193
3.916IleSer: 3.916 ± 0.233
3.462IleThr: 3.462 ± 0.204
3.433IleVal: 3.433 ± 0.231
0.482IleTrp: 0.482 ± 0.08
1.745IleTyr: 1.745 ± 0.163
0.0IleXaa: 0.0 ± 0.0
Lys
4.639LysAla: 4.639 ± 0.216
0.213LysCys: 0.213 ± 0.058
3.476LysAsp: 3.476 ± 0.205
3.504LysGlu: 3.504 ± 0.228
2.114LysPhe: 2.114 ± 0.178
3.093LysGly: 3.093 ± 0.207
1.064LysHis: 1.064 ± 0.134
2.908LysIle: 2.908 ± 0.192
2.355LysLys: 2.355 ± 0.247
5.689LysLeu: 5.689 ± 0.271
1.561LysMet: 1.561 ± 0.152
2.029LysAsn: 2.029 ± 0.17
2.313LysPro: 2.313 ± 0.21
1.702LysGln: 1.702 ± 0.147
2.88LysArg: 2.88 ± 0.211
2.724LysSer: 2.724 ± 0.234
2.54LysThr: 2.54 ± 0.212
3.873LysVal: 3.873 ± 0.246
0.497LysTrp: 0.497 ± 0.09
1.873LysTyr: 1.873 ± 0.163
0.0LysXaa: 0.0 ± 0.0
Leu
7.902LeuAla: 7.902 ± 0.377
0.61LeuCys: 0.61 ± 0.092
5.59LeuAsp: 5.59 ± 0.301
5.732LeuGlu: 5.732 ± 0.342
3.107LeuPhe: 3.107 ± 0.224
5.817LeuGly: 5.817 ± 0.304
1.646LeuHis: 1.646 ± 0.155
4.866LeuIle: 4.866 ± 0.264
4.767LeuLys: 4.767 ± 0.254
7.108LeuLeu: 7.108 ± 0.419
2.696LeuMet: 2.696 ± 0.178
4.696LeuAsn: 4.696 ± 0.26
4.682LeuPro: 4.682 ± 0.275
2.667LeuGln: 2.667 ± 0.181
5.32LeuArg: 5.32 ± 0.33
5.349LeuSer: 5.349 ± 0.282
6.001LeuThr: 6.001 ± 0.309
6.242LeuVal: 6.242 ± 0.319
0.752LeuTrp: 0.752 ± 0.112
2.894LeuTyr: 2.894 ± 0.214
0.0LeuXaa: 0.0 ± 0.0
Met
3.192MetAla: 3.192 ± 0.243
0.17MetCys: 0.17 ± 0.043
1.859MetAsp: 1.859 ± 0.166
2.142MetGlu: 2.142 ± 0.183
1.334MetPhe: 1.334 ± 0.133
1.759MetGly: 1.759 ± 0.18
0.624MetHis: 0.624 ± 0.094
1.504MetIle: 1.504 ± 0.117
1.39MetLys: 1.39 ± 0.168
2.724MetLeu: 2.724 ± 0.221
0.951MetMet: 0.951 ± 0.144
1.291MetAsn: 1.291 ± 0.122
1.376MetPro: 1.376 ± 0.124
1.007MetGln: 1.007 ± 0.112
1.802MetArg: 1.802 ± 0.135
2.369MetSer: 2.369 ± 0.167
1.773MetThr: 1.773 ± 0.148
2.227MetVal: 2.227 ± 0.177
0.199MetTrp: 0.199 ± 0.061
0.709MetTyr: 0.709 ± 0.099
0.0MetXaa: 0.0 ± 0.0
Asn
3.802AsnAla: 3.802 ± 0.216
0.284AsnCys: 0.284 ± 0.067
2.511AsnAsp: 2.511 ± 0.199
2.568AsnGlu: 2.568 ± 0.177
1.617AsnPhe: 1.617 ± 0.155
3.462AsnGly: 3.462 ± 0.235
0.823AsnHis: 0.823 ± 0.117
2.511AsnIle: 2.511 ± 0.164
2.383AsnLys: 2.383 ± 0.201
4.27AsnLeu: 4.27 ± 0.259
1.263AsnMet: 1.263 ± 0.127
2.0AsnAsn: 2.0 ± 0.182
2.511AsnPro: 2.511 ± 0.219
1.646AsnGln: 1.646 ± 0.149
2.681AsnArg: 2.681 ± 0.204
2.908AsnSer: 2.908 ± 0.248
2.908AsnThr: 2.908 ± 0.223
3.49AsnVal: 3.49 ± 0.273
0.553AsnTrp: 0.553 ± 0.086
1.617AsnTyr: 1.617 ± 0.175
0.0AsnXaa: 0.0 ± 0.0
Pro
4.412ProAla: 4.412 ± 0.261
0.199ProCys: 0.199 ± 0.057
2.54ProAsp: 2.54 ± 0.208
3.334ProGlu: 3.334 ± 0.246
1.717ProPhe: 1.717 ± 0.142
2.596ProGly: 2.596 ± 0.249
1.036ProHis: 1.036 ± 0.175
2.497ProIle: 2.497 ± 0.186
2.426ProLys: 2.426 ± 0.177
4.1ProLeu: 4.1 ± 0.236
1.178ProMet: 1.178 ± 0.116
2.128ProAsn: 2.128 ± 0.168
1.802ProPro: 1.802 ± 0.189
1.291ProGln: 1.291 ± 0.131
2.525ProArg: 2.525 ± 0.186
2.866ProSer: 2.866 ± 0.225
3.05ProThr: 3.05 ± 0.19
3.362ProVal: 3.362 ± 0.222
0.553ProTrp: 0.553 ± 0.101
1.39ProTyr: 1.39 ± 0.137
0.0ProXaa: 0.0 ± 0.0
Gln
3.022GlnAla: 3.022 ± 0.256
0.369GlnCys: 0.369 ± 0.067
1.745GlnAsp: 1.745 ± 0.151
2.029GlnGlu: 2.029 ± 0.166
1.248GlnPhe: 1.248 ± 0.132
2.114GlnGly: 2.114 ± 0.158
0.766GlnHis: 0.766 ± 0.103
1.844GlnIle: 1.844 ± 0.158
1.518GlnLys: 1.518 ± 0.155
3.76GlnLeu: 3.76 ± 0.227
1.021GlnMet: 1.021 ± 0.13
1.39GlnAsn: 1.39 ± 0.142
1.447GlnPro: 1.447 ± 0.158
1.348GlnGln: 1.348 ± 0.151
2.681GlnArg: 2.681 ± 0.201
1.844GlnSer: 1.844 ± 0.159
1.986GlnThr: 1.986 ± 0.15
2.653GlnVal: 2.653 ± 0.26
0.44GlnTrp: 0.44 ± 0.08
1.362GlnTyr: 1.362 ± 0.131
0.0GlnXaa: 0.0 ± 0.0
Arg
4.98ArgAla: 4.98 ± 0.295
0.355ArgCys: 0.355 ± 0.066
4.469ArgAsp: 4.469 ± 0.478
3.731ArgGlu: 3.731 ± 0.245
2.582ArgPhe: 2.582 ± 0.154
3.575ArgGly: 3.575 ± 0.276
1.277ArgHis: 1.277 ± 0.158
3.121ArgIle: 3.121 ± 0.21
2.979ArgLys: 2.979 ± 0.196
6.072ArgLeu: 6.072 ± 0.286
2.171ArgMet: 2.171 ± 0.179
2.752ArgAsn: 2.752 ± 0.186
2.227ArgPro: 2.227 ± 0.211
2.071ArgGln: 2.071 ± 0.154
4.455ArgArg: 4.455 ± 0.365
3.717ArgSer: 3.717 ± 0.212
3.348ArgThr: 3.348 ± 0.229
4.043ArgVal: 4.043 ± 0.254
0.709ArgTrp: 0.709 ± 0.101
2.767ArgTyr: 2.767 ± 0.211
0.0ArgXaa: 0.0 ± 0.0
Ser
5.164SerAla: 5.164 ± 0.405
0.426SerCys: 0.426 ± 0.083
3.987SerAsp: 3.987 ± 0.227
3.433SerGlu: 3.433 ± 0.19
2.582SerPhe: 2.582 ± 0.192
4.299SerGly: 4.299 ± 0.293
1.206SerHis: 1.206 ± 0.136
3.462SerIle: 3.462 ± 0.238
3.15SerLys: 3.15 ± 0.216
4.923SerLeu: 4.923 ± 0.309
1.788SerMet: 1.788 ± 0.147
2.823SerAsn: 2.823 ± 0.204
2.696SerPro: 2.696 ± 0.197
1.802SerGln: 1.802 ± 0.181
3.731SerArg: 3.731 ± 0.255
3.561SerSer: 3.561 ± 0.205
3.958SerThr: 3.958 ± 0.234
4.554SerVal: 4.554 ± 0.245
0.653SerTrp: 0.653 ± 0.082
2.029SerTyr: 2.029 ± 0.163
0.0SerXaa: 0.0 ± 0.0
Thr
5.647ThrAla: 5.647 ± 0.313
0.27ThrCys: 0.27 ± 0.06
3.958ThrAsp: 3.958 ± 0.227
3.49ThrGlu: 3.49 ± 0.246
2.412ThrPhe: 2.412 ± 0.205
4.568ThrGly: 4.568 ± 0.264
1.348ThrHis: 1.348 ± 0.147
3.164ThrIle: 3.164 ± 0.236
3.334ThrLys: 3.334 ± 0.235
5.235ThrLeu: 5.235 ± 0.289
1.532ThrMet: 1.532 ± 0.143
2.625ThrAsn: 2.625 ± 0.162
3.476ThrPro: 3.476 ± 0.201
1.859ThrGln: 1.859 ± 0.169
3.745ThrArg: 3.745 ± 0.21
3.291ThrSer: 3.291 ± 0.236
3.604ThrThr: 3.604 ± 0.302
3.816ThrVal: 3.816 ± 0.231
0.667ThrTrp: 0.667 ± 0.097
1.972ThrTyr: 1.972 ± 0.182
0.0ThrXaa: 0.0 ± 0.0
Val
5.519ValAla: 5.519 ± 0.279
0.61ValCys: 0.61 ± 0.098
4.937ValAsp: 4.937 ± 0.213
5.278ValGlu: 5.278 ± 0.299
2.639ValPhe: 2.639 ± 0.19
4.611ValGly: 4.611 ± 0.28
1.234ValHis: 1.234 ± 0.124
4.058ValIle: 4.058 ± 0.247
3.774ValLys: 3.774 ± 0.245
5.363ValLeu: 5.363 ± 0.273
2.0ValMet: 2.0 ± 0.183
3.093ValAsn: 3.093 ± 0.196
3.05ValPro: 3.05 ± 0.217
2.497ValGln: 2.497 ± 0.218
4.313ValArg: 4.313 ± 0.242
4.625ValSer: 4.625 ± 0.26
4.724ValThr: 4.724 ± 0.296
5.221ValVal: 5.221 ± 0.338
0.638ValTrp: 0.638 ± 0.102
2.653ValTyr: 2.653 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.724TrpAla: 0.724 ± 0.096
0.213TrpCys: 0.213 ± 0.057
0.638TrpAsp: 0.638 ± 0.111
0.752TrpGlu: 0.752 ± 0.087
0.511TrpPhe: 0.511 ± 0.086
0.397TrpGly: 0.397 ± 0.074
0.369TrpHis: 0.369 ± 0.064
0.596TrpIle: 0.596 ± 0.093
0.567TrpLys: 0.567 ± 0.085
1.064TrpLeu: 1.064 ± 0.129
0.397TrpMet: 0.397 ± 0.077
0.61TrpAsn: 0.61 ± 0.107
0.355TrpPro: 0.355 ± 0.065
0.426TrpGln: 0.426 ± 0.072
0.653TrpArg: 0.653 ± 0.103
0.681TrpSer: 0.681 ± 0.1
0.638TrpThr: 0.638 ± 0.096
0.709TrpVal: 0.709 ± 0.1
0.156TrpTrp: 0.156 ± 0.054
0.312TrpTyr: 0.312 ± 0.067
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.086TyrAla: 2.086 ± 0.165
0.255TyrCys: 0.255 ± 0.054
2.114TyrAsp: 2.114 ± 0.214
1.915TyrGlu: 1.915 ± 0.162
1.277TyrPhe: 1.277 ± 0.143
2.298TyrGly: 2.298 ± 0.203
0.965TyrHis: 0.965 ± 0.102
1.802TyrIle: 1.802 ± 0.158
1.646TyrLys: 1.646 ± 0.16
3.135TyrLeu: 3.135 ± 0.22
1.277TyrMet: 1.277 ± 0.18
1.802TyrAsn: 1.802 ± 0.199
1.773TyrPro: 1.773 ± 0.189
1.319TyrGln: 1.319 ± 0.149
1.958TyrArg: 1.958 ± 0.186
2.27TyrSer: 2.27 ± 0.171
2.213TyrThr: 2.213 ± 0.157
2.667TyrVal: 2.667 ± 0.252
0.44TyrTrp: 0.44 ± 0.082
1.135TyrTyr: 1.135 ± 0.133
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 251 proteins (70486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski