Amino acid dipepetide frequency for Staphylococcus phage P240

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.911AlaAla: 2.911 ± 0.734
0.213AlaCys: 0.213 ± 0.13
2.84AlaAsp: 2.84 ± 0.435
4.189AlaGlu: 4.189 ± 0.477
1.704AlaPhe: 1.704 ± 0.278
3.55AlaGly: 3.55 ± 0.61
1.136AlaHis: 1.136 ± 0.257
4.615AlaIle: 4.615 ± 0.673
6.105AlaLys: 6.105 ± 1.19
5.04AlaLeu: 5.04 ± 0.759
1.633AlaMet: 1.633 ± 0.326
4.26AlaAsn: 4.26 ± 0.884
1.633AlaPro: 1.633 ± 0.367
1.562AlaGln: 1.562 ± 0.356
2.343AlaArg: 2.343 ± 0.332
4.827AlaSer: 4.827 ± 0.7
3.195AlaThr: 3.195 ± 0.464
2.769AlaVal: 2.769 ± 0.463
1.136AlaTrp: 1.136 ± 0.334
2.698AlaTyr: 2.698 ± 0.516
0.0AlaXaa: 0.0 ± 0.0
Cys
0.142CysAla: 0.142 ± 0.094
0.0CysCys: 0.0 ± 0.0
0.071CysAsp: 0.071 ± 0.07
0.284CysGlu: 0.284 ± 0.18
0.284CysPhe: 0.284 ± 0.167
0.284CysGly: 0.284 ± 0.131
0.213CysHis: 0.213 ± 0.127
0.426CysIle: 0.426 ± 0.154
0.568CysLys: 0.568 ± 0.207
0.497CysLeu: 0.497 ± 0.201
0.142CysMet: 0.142 ± 0.102
0.0CysAsn: 0.0 ± 0.0
0.071CysPro: 0.071 ± 0.066
0.213CysGln: 0.213 ± 0.117
0.355CysArg: 0.355 ± 0.199
0.142CysSer: 0.142 ± 0.093
0.213CysThr: 0.213 ± 0.121
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.284CysTyr: 0.284 ± 0.115
0.0CysXaa: 0.0 ± 0.0
Asp
2.982AspAla: 2.982 ± 0.515
0.142AspCys: 0.142 ± 0.108
3.479AspAsp: 3.479 ± 0.63
4.544AspGlu: 4.544 ± 0.723
3.337AspPhe: 3.337 ± 0.588
3.337AspGly: 3.337 ± 0.625
0.781AspHis: 0.781 ± 0.215
5.395AspIle: 5.395 ± 0.539
7.383AspLys: 7.383 ± 0.682
5.537AspLeu: 5.537 ± 0.614
2.343AspMet: 2.343 ± 0.408
2.911AspAsn: 2.911 ± 0.389
1.136AspPro: 1.136 ± 0.314
1.704AspGln: 1.704 ± 0.319
1.988AspArg: 1.988 ± 0.295
3.55AspSer: 3.55 ± 0.507
3.763AspThr: 3.763 ± 0.524
3.692AspVal: 3.692 ± 0.435
0.781AspTrp: 0.781 ± 0.22
3.195AspTyr: 3.195 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
4.686GluAla: 4.686 ± 0.453
0.426GluCys: 0.426 ± 0.178
4.756GluAsp: 4.756 ± 0.67
8.235GluGlu: 8.235 ± 1.353
3.053GluPhe: 3.053 ± 0.598
3.408GluGly: 3.408 ± 0.44
0.852GluHis: 0.852 ± 0.294
5.679GluIle: 5.679 ± 0.904
8.519GluLys: 8.519 ± 0.977
7.17GluLeu: 7.17 ± 0.708
1.988GluMet: 1.988 ± 0.383
5.111GluAsn: 5.111 ± 0.624
1.065GluPro: 1.065 ± 0.249
3.124GluGln: 3.124 ± 0.444
3.124GluArg: 3.124 ± 0.523
3.834GluSer: 3.834 ± 0.537
3.976GluThr: 3.976 ± 0.608
4.402GluVal: 4.402 ± 0.482
1.136GluTrp: 1.136 ± 0.2
2.911GluTyr: 2.911 ± 0.657
0.0GluXaa: 0.0 ± 0.0
Phe
1.917PheAla: 1.917 ± 0.332
0.355PheCys: 0.355 ± 0.161
3.337PheAsp: 3.337 ± 0.45
3.124PheGlu: 3.124 ± 0.46
0.923PhePhe: 0.923 ± 0.231
2.982PheGly: 2.982 ± 0.557
0.639PheHis: 0.639 ± 0.211
3.408PheIle: 3.408 ± 0.657
4.26PheLys: 4.26 ± 0.684
2.13PheLeu: 2.13 ± 0.345
1.065PheMet: 1.065 ± 0.223
3.834PheAsn: 3.834 ± 0.584
0.923PhePro: 0.923 ± 0.273
1.065PheGln: 1.065 ± 0.215
0.994PheArg: 0.994 ± 0.231
1.775PheSer: 1.775 ± 0.327
1.633PheThr: 1.633 ± 0.343
1.988PheVal: 1.988 ± 0.413
0.355PheTrp: 0.355 ± 0.158
1.988PheTyr: 1.988 ± 0.368
0.0PheXaa: 0.0 ± 0.0
Gly
4.118GlyAla: 4.118 ± 0.893
0.284GlyCys: 0.284 ± 0.127
3.834GlyAsp: 3.834 ± 0.532
3.621GlyGlu: 3.621 ± 0.391
2.414GlyPhe: 2.414 ± 0.357
5.466GlyGly: 5.466 ± 1.086
1.491GlyHis: 1.491 ± 0.358
3.692GlyIle: 3.692 ± 0.501
5.892GlyLys: 5.892 ± 0.638
5.608GlyLeu: 5.608 ± 0.905
1.278GlyMet: 1.278 ± 0.386
3.266GlyAsn: 3.266 ± 0.604
0.994GlyPro: 0.994 ± 0.219
1.633GlyGln: 1.633 ± 0.384
2.059GlyArg: 2.059 ± 0.392
3.834GlySer: 3.834 ± 0.524
3.55GlyThr: 3.55 ± 0.536
4.331GlyVal: 4.331 ± 0.669
1.065GlyTrp: 1.065 ± 0.3
2.556GlyTyr: 2.556 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.234
0.071HisCys: 0.071 ± 0.066
0.71HisAsp: 0.71 ± 0.289
1.278HisGlu: 1.278 ± 0.278
0.71HisPhe: 0.71 ± 0.173
1.136HisGly: 1.136 ± 0.293
0.355HisHis: 0.355 ± 0.177
1.42HisIle: 1.42 ± 0.4
1.633HisLys: 1.633 ± 0.341
1.42HisLeu: 1.42 ± 0.261
0.213HisMet: 0.213 ± 0.117
0.994HisAsn: 0.994 ± 0.266
0.852HisPro: 0.852 ± 0.184
0.639HisGln: 0.639 ± 0.165
0.71HisArg: 0.71 ± 0.217
1.207HisSer: 1.207 ± 0.241
1.065HisThr: 1.065 ± 0.251
0.639HisVal: 0.639 ± 0.235
0.284HisTrp: 0.284 ± 0.147
1.136HisTyr: 1.136 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
4.189IleAla: 4.189 ± 0.512
0.355IleCys: 0.355 ± 0.185
5.04IleAsp: 5.04 ± 0.702
5.537IleGlu: 5.537 ± 0.687
2.272IlePhe: 2.272 ± 0.558
3.692IleGly: 3.692 ± 0.539
1.704IleHis: 1.704 ± 0.315
4.473IleIle: 4.473 ± 0.756
8.306IleLys: 8.306 ± 0.847
4.827IleLeu: 4.827 ± 0.604
1.491IleMet: 1.491 ± 0.32
5.111IleAsn: 5.111 ± 0.517
2.272IlePro: 2.272 ± 0.33
1.846IleGln: 1.846 ± 0.318
3.266IleArg: 3.266 ± 0.444
4.756IleSer: 4.756 ± 0.519
4.331IleThr: 4.331 ± 0.535
3.976IleVal: 3.976 ± 0.649
0.426IleTrp: 0.426 ± 0.191
2.769IleTyr: 2.769 ± 0.509
0.0IleXaa: 0.0 ± 0.0
Lys
7.667LysAla: 7.667 ± 1.08
0.142LysCys: 0.142 ± 0.094
5.821LysAsp: 5.821 ± 0.586
8.803LysGlu: 8.803 ± 0.861
2.272LysPhe: 2.272 ± 0.361
5.182LysGly: 5.182 ± 0.888
1.846LysHis: 1.846 ± 0.417
6.034LysIle: 6.034 ± 0.68
8.022LysLys: 8.022 ± 1.011
8.519LysLeu: 8.519 ± 0.888
2.982LysMet: 2.982 ± 0.452
6.247LysAsn: 6.247 ± 0.749
2.485LysPro: 2.485 ± 0.37
4.969LysGln: 4.969 ± 0.569
3.763LysArg: 3.763 ± 0.679
6.247LysSer: 6.247 ± 1.185
5.182LysThr: 5.182 ± 0.534
5.466LysVal: 5.466 ± 0.657
2.059LysTrp: 2.059 ± 0.432
5.324LysTyr: 5.324 ± 0.657
0.0LysXaa: 0.0 ± 0.0
Leu
4.827LeuAla: 4.827 ± 0.74
0.497LeuCys: 0.497 ± 0.212
5.466LeuAsp: 5.466 ± 0.88
6.46LeuGlu: 6.46 ± 0.662
2.982LeuPhe: 2.982 ± 0.424
4.402LeuGly: 4.402 ± 0.912
1.278LeuHis: 1.278 ± 0.332
5.324LeuIle: 5.324 ± 0.673
8.164LeuLys: 8.164 ± 1.094
6.744LeuLeu: 6.744 ± 0.865
1.633LeuMet: 1.633 ± 0.283
5.679LeuAsn: 5.679 ± 0.576
3.053LeuPro: 3.053 ± 0.481
2.982LeuGln: 2.982 ± 0.563
3.55LeuArg: 3.55 ± 0.463
5.679LeuSer: 5.679 ± 0.657
5.04LeuThr: 5.04 ± 0.598
3.763LeuVal: 3.763 ± 0.427
0.426LeuTrp: 0.426 ± 0.194
3.692LeuTyr: 3.692 ± 0.716
0.0LeuXaa: 0.0 ± 0.0
Met
1.207MetAla: 1.207 ± 0.275
0.213MetCys: 0.213 ± 0.118
1.065MetAsp: 1.065 ± 0.27
1.136MetGlu: 1.136 ± 0.297
0.923MetPhe: 0.923 ± 0.201
1.562MetGly: 1.562 ± 0.464
0.355MetHis: 0.355 ± 0.156
1.278MetIle: 1.278 ± 0.241
2.84MetLys: 2.84 ± 0.496
1.988MetLeu: 1.988 ± 0.488
0.426MetMet: 0.426 ± 0.141
1.917MetAsn: 1.917 ± 0.408
0.923MetPro: 0.923 ± 0.226
1.704MetGln: 1.704 ± 0.393
0.923MetArg: 0.923 ± 0.23
2.059MetSer: 2.059 ± 0.341
2.272MetThr: 2.272 ± 0.332
1.065MetVal: 1.065 ± 0.225
0.284MetTrp: 0.284 ± 0.134
0.923MetTyr: 0.923 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
3.479AsnAla: 3.479 ± 0.536
0.142AsnCys: 0.142 ± 0.092
3.834AsnAsp: 3.834 ± 0.442
4.969AsnGlu: 4.969 ± 0.679
2.059AsnPhe: 2.059 ± 0.4
4.473AsnGly: 4.473 ± 0.658
0.994AsnHis: 0.994 ± 0.249
4.969AsnIle: 4.969 ± 0.527
6.673AsnLys: 6.673 ± 0.694
5.04AsnLeu: 5.04 ± 0.558
1.136AsnMet: 1.136 ± 0.255
4.544AsnAsn: 4.544 ± 0.899
2.414AsnPro: 2.414 ± 0.39
2.982AsnGln: 2.982 ± 0.44
2.84AsnArg: 2.84 ± 0.481
4.473AsnSer: 4.473 ± 0.665
4.047AsnThr: 4.047 ± 0.413
3.266AsnVal: 3.266 ± 0.499
1.207AsnTrp: 1.207 ± 0.342
2.769AsnTyr: 2.769 ± 0.556
0.0AsnXaa: 0.0 ± 0.0
Pro
1.136ProAla: 1.136 ± 0.238
0.284ProCys: 0.284 ± 0.125
1.278ProAsp: 1.278 ± 0.277
1.988ProGlu: 1.988 ± 0.434
1.207ProPhe: 1.207 ± 0.306
1.775ProGly: 1.775 ± 0.337
0.355ProHis: 0.355 ± 0.155
1.491ProIle: 1.491 ± 0.302
2.414ProLys: 2.414 ± 0.5
2.556ProLeu: 2.556 ± 0.495
0.639ProMet: 0.639 ± 0.226
2.201ProAsn: 2.201 ± 0.364
0.71ProPro: 0.71 ± 0.226
1.136ProGln: 1.136 ± 0.272
1.349ProArg: 1.349 ± 0.224
2.343ProSer: 2.343 ± 0.359
1.562ProThr: 1.562 ± 0.354
1.42ProVal: 1.42 ± 0.44
0.355ProTrp: 0.355 ± 0.13
1.207ProTyr: 1.207 ± 0.334
0.0ProXaa: 0.0 ± 0.0
Gln
2.698GlnAla: 2.698 ± 0.383
0.142GlnCys: 0.142 ± 0.097
2.272GlnAsp: 2.272 ± 0.367
2.84GlnGlu: 2.84 ± 0.436
1.491GlnPhe: 1.491 ± 0.267
2.201GlnGly: 2.201 ± 0.409
0.781GlnHis: 0.781 ± 0.172
3.124GlnIle: 3.124 ± 0.454
2.911GlnLys: 2.911 ± 0.401
3.834GlnLeu: 3.834 ± 0.469
0.994GlnMet: 0.994 ± 0.293
2.343GlnAsn: 2.343 ± 0.54
0.994GlnPro: 0.994 ± 0.265
1.349GlnGln: 1.349 ± 0.386
1.917GlnArg: 1.917 ± 0.383
2.343GlnSer: 2.343 ± 0.37
1.42GlnThr: 1.42 ± 0.382
2.13GlnVal: 2.13 ± 0.357
0.426GlnTrp: 0.426 ± 0.171
1.704GlnTyr: 1.704 ± 0.348
0.0GlnXaa: 0.0 ± 0.0
Arg
2.414ArgAla: 2.414 ± 0.445
0.0ArgCys: 0.0 ± 0.0
3.337ArgAsp: 3.337 ± 0.327
2.13ArgGlu: 2.13 ± 0.385
2.272ArgPhe: 2.272 ± 0.388
1.917ArgGly: 1.917 ± 0.324
0.71ArgHis: 0.71 ± 0.219
3.408ArgIle: 3.408 ± 0.487
4.189ArgLys: 4.189 ± 0.495
3.408ArgLeu: 3.408 ± 0.609
0.852ArgMet: 0.852 ± 0.232
2.698ArgAsn: 2.698 ± 0.404
0.639ArgPro: 0.639 ± 0.232
1.491ArgGln: 1.491 ± 0.296
1.775ArgArg: 1.775 ± 0.421
1.562ArgSer: 1.562 ± 0.347
2.485ArgThr: 2.485 ± 0.374
1.988ArgVal: 1.988 ± 0.335
0.426ArgTrp: 0.426 ± 0.167
2.13ArgTyr: 2.13 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
3.834SerAla: 3.834 ± 0.797
0.213SerCys: 0.213 ± 0.123
4.686SerAsp: 4.686 ± 0.498
5.253SerGlu: 5.253 ± 0.629
2.769SerPhe: 2.769 ± 0.496
4.686SerGly: 4.686 ± 0.835
0.639SerHis: 0.639 ± 0.162
3.976SerIle: 3.976 ± 0.461
6.531SerLys: 6.531 ± 0.988
4.189SerLeu: 4.189 ± 0.509
1.917SerMet: 1.917 ± 0.416
4.615SerAsn: 4.615 ± 0.62
1.846SerPro: 1.846 ± 0.392
2.982SerGln: 2.982 ± 0.467
2.272SerArg: 2.272 ± 0.448
3.905SerSer: 3.905 ± 0.663
3.195SerThr: 3.195 ± 0.539
3.834SerVal: 3.834 ± 0.58
0.781SerTrp: 0.781 ± 0.185
2.272SerTyr: 2.272 ± 0.405
0.0SerXaa: 0.0 ± 0.0
Thr
3.408ThrAla: 3.408 ± 0.501
0.142ThrCys: 0.142 ± 0.101
3.266ThrAsp: 3.266 ± 0.506
4.118ThrGlu: 4.118 ± 0.568
2.769ThrPhe: 2.769 ± 0.398
3.834ThrGly: 3.834 ± 0.509
1.42ThrHis: 1.42 ± 0.351
4.473ThrIle: 4.473 ± 0.525
4.969ThrLys: 4.969 ± 0.625
4.189ThrLeu: 4.189 ± 0.454
0.994ThrMet: 0.994 ± 0.247
3.266ThrAsn: 3.266 ± 0.422
2.272ThrPro: 2.272 ± 0.315
1.917ThrGln: 1.917 ± 0.297
1.562ThrArg: 1.562 ± 0.261
3.408ThrSer: 3.408 ± 0.457
2.911ThrThr: 2.911 ± 0.409
4.473ThrVal: 4.473 ± 0.513
0.426ThrTrp: 0.426 ± 0.194
2.343ThrTyr: 2.343 ± 0.467
0.0ThrXaa: 0.0 ± 0.0
Val
2.84ValAla: 2.84 ± 0.464
0.213ValCys: 0.213 ± 0.123
4.047ValAsp: 4.047 ± 0.623
4.969ValGlu: 4.969 ± 0.514
2.343ValPhe: 2.343 ± 0.453
3.479ValGly: 3.479 ± 0.533
0.852ValHis: 0.852 ± 0.209
3.905ValIle: 3.905 ± 0.507
4.898ValLys: 4.898 ± 0.703
4.331ValLeu: 4.331 ± 0.555
1.42ValMet: 1.42 ± 0.293
3.763ValAsn: 3.763 ± 0.534
1.562ValPro: 1.562 ± 0.341
2.13ValGln: 2.13 ± 0.338
2.485ValArg: 2.485 ± 0.481
4.047ValSer: 4.047 ± 0.549
3.053ValThr: 3.053 ± 0.574
2.982ValVal: 2.982 ± 0.406
0.497ValTrp: 0.497 ± 0.183
1.846ValTyr: 1.846 ± 0.394
0.0ValXaa: 0.0 ± 0.0
Trp
0.568TrpAla: 0.568 ± 0.176
0.0TrpCys: 0.0 ± 0.0
0.426TrpAsp: 0.426 ± 0.208
0.852TrpGlu: 0.852 ± 0.264
1.278TrpPhe: 1.278 ± 0.319
0.568TrpGly: 0.568 ± 0.224
0.0TrpHis: 0.0 ± 0.0
1.136TrpIle: 1.136 ± 0.305
0.71TrpLys: 0.71 ± 0.199
1.136TrpLeu: 1.136 ± 0.244
0.355TrpMet: 0.355 ± 0.154
0.994TrpAsn: 0.994 ± 0.231
0.355TrpPro: 0.355 ± 0.228
0.497TrpGln: 0.497 ± 0.144
0.497TrpArg: 0.497 ± 0.221
1.136TrpSer: 1.136 ± 0.398
0.639TrpThr: 0.639 ± 0.193
0.923TrpVal: 0.923 ± 0.232
0.142TrpTrp: 0.142 ± 0.115
0.639TrpTyr: 0.639 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.414TyrAla: 2.414 ± 0.299
0.355TyrCys: 0.355 ± 0.144
2.414TyrAsp: 2.414 ± 0.494
3.124TyrGlu: 3.124 ± 0.655
1.633TyrPhe: 1.633 ± 0.403
3.053TyrGly: 3.053 ± 0.549
0.994TyrHis: 0.994 ± 0.35
2.485TyrIle: 2.485 ± 0.498
4.047TyrLys: 4.047 ± 0.514
3.479TyrLeu: 3.479 ± 0.493
1.491TyrMet: 1.491 ± 0.276
2.556TyrAsn: 2.556 ± 0.575
1.207TyrPro: 1.207 ± 0.292
1.988TyrGln: 1.988 ± 0.288
2.059TyrArg: 2.059 ± 0.456
3.266TyrSer: 3.266 ± 0.4
2.627TyrThr: 2.627 ± 0.508
2.556TyrVal: 2.556 ± 0.441
0.639TyrTrp: 0.639 ± 0.198
1.704TyrTyr: 1.704 ± 0.433
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski