Amino acid dipepetide frequency for Prevotella marshii DSM 16973 = JCM 13450

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.276AlaAla: 6.276 ± 0.135	1.128AlaCys: 1.128 ± 0.039	4.85AlaAsp: 4.85 ± 0.097	4.742AlaGlu: 4.742 ± 0.091	3.622AlaPhe: 3.622 ± 0.078	5.35AlaGly: 5.35 ± 0.088	1.635AlaHis: 1.635 ± 0.051	4.907AlaIle: 4.907 ± 0.093	4.479AlaLys: 4.479 ± 0.097	7.31AlaLeu: 7.31 ± 0.107	2.159AlaMet: 2.159 ± 0.063	3.121AlaAsn: 3.121 ± 0.073	2.552AlaPro: 2.552 ± 0.064	2.982AlaGln: 2.982 ± 0.071	3.684AlaArg: 3.684 ± 0.083	4.122AlaSer: 4.122 ± 0.084	4.635AlaThr: 4.635 ± 0.111	5.141AlaVal: 5.141 ± 0.09	0.813AlaTrp: 0.813 ± 0.034	3.073AlaTyr: 3.073 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.911CysAla: 0.911 ± 0.037	0.204CysCys: 0.204 ± 0.017	0.737CysAsp: 0.737 ± 0.034	0.665CysGlu: 0.665 ± 0.034	0.631CysPhe: 0.631 ± 0.031	1.088CysGly: 1.088 ± 0.041	0.392CysHis: 0.392 ± 0.027	0.945CysIle: 0.945 ± 0.037	0.756CysLys: 0.756 ± 0.031	1.165CysLeu: 1.165 ± 0.042	0.346CysMet: 0.346 ± 0.023	0.591CysAsn: 0.591 ± 0.028	0.569CysPro: 0.569 ± 0.029	0.347CysGln: 0.347 ± 0.021	0.862CysArg: 0.862 ± 0.033	0.783CysSer: 0.783 ± 0.035	0.85CysThr: 0.85 ± 0.035	0.763CysVal: 0.763 ± 0.037	0.161CysTrp: 0.161 ± 0.016	0.546CysTyr: 0.546 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.346AspAla: 4.346 ± 0.075	0.706AspCys: 0.706 ± 0.035	3.004AspAsp: 3.004 ± 0.075	3.878AspGlu: 3.878 ± 0.077	2.945AspPhe: 2.945 ± 0.064	4.137AspGly: 4.137 ± 0.08	0.96AspHis: 0.96 ± 0.036	4.095AspIle: 4.095 ± 0.083	3.711AspLys: 3.711 ± 0.08	4.472AspLeu: 4.472 ± 0.096	1.643AspMet: 1.643 ± 0.046	2.84AspAsn: 2.84 ± 0.063	1.744AspPro: 1.744 ± 0.052	0.958AspGln: 0.958 ± 0.038	2.923AspArg: 2.923 ± 0.06	2.776AspSer: 2.776 ± 0.068	3.282AspThr: 3.282 ± 0.073	3.671AspVal: 3.671 ± 0.071	0.68AspTrp: 0.68 ± 0.031	2.731AspTyr: 2.731 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.9GluAla: 4.9 ± 0.097	0.628GluCys: 0.628 ± 0.031	2.989GluAsp: 2.989 ± 0.079	4.658GluGlu: 4.658 ± 0.115	1.97GluPhe: 1.97 ± 0.049	3.749GluGly: 3.749 ± 0.079	1.364GluHis: 1.364 ± 0.046	3.94GluIle: 3.94 ± 0.086	4.502GluLys: 4.502 ± 0.08	5.298GluLeu: 5.298 ± 0.103	1.949GluMet: 1.949 ± 0.055	2.932GluAsn: 2.932 ± 0.068	1.695GluPro: 1.695 ± 0.054	2.696GluGln: 2.696 ± 0.076	3.854GluArg: 3.854 ± 0.077	2.752GluSer: 2.752 ± 0.056	3.647GluThr: 3.647 ± 0.083	3.73GluVal: 3.73 ± 0.082	0.736GluTrp: 0.736 ± 0.037	2.317GluTyr: 2.317 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.331PheAla: 3.331 ± 0.075	0.785PheCys: 0.785 ± 0.033	2.617PheAsp: 2.617 ± 0.058	2.088PheGlu: 2.088 ± 0.052	2.14PhePhe: 2.14 ± 0.072	3.075PheGly: 3.075 ± 0.067	1.045PheHis: 1.045 ± 0.04	3.002PheIle: 3.002 ± 0.082	2.212PheLys: 2.212 ± 0.057	3.99PheLeu: 3.99 ± 0.088	1.187PheMet: 1.187 ± 0.045	2.196PheAsn: 2.196 ± 0.064	1.625PhePro: 1.625 ± 0.055	1.136PheGln: 1.136 ± 0.039	2.321PheArg: 2.321 ± 0.062	3.222PheSer: 3.222 ± 0.071	2.87PheThr: 2.87 ± 0.063	2.862PheVal: 2.862 ± 0.061	0.466PheTrp: 0.466 ± 0.027	1.899PheTyr: 1.899 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.594GlyAla: 4.594 ± 0.093	1.005GlyCys: 1.005 ± 0.036	3.417GlyAsp: 3.417 ± 0.082	3.836GlyGlu: 3.836 ± 0.081	3.05GlyPhe: 3.05 ± 0.071	4.686GlyGly: 4.686 ± 0.11	1.586GlyHis: 1.586 ± 0.048	5.207GlyIle: 5.207 ± 0.111	5.031GlyLys: 5.031 ± 0.081	5.817GlyLeu: 5.817 ± 0.111	2.124GlyMet: 2.124 ± 0.057	3.374GlyAsn: 3.374 ± 0.079	1.018GlyPro: 1.018 ± 0.036	2.154GlyGln: 2.154 ± 0.054	3.445GlyArg: 3.445 ± 0.072	3.914GlySer: 3.914 ± 0.082	4.67GlyThr: 4.67 ± 0.1	4.313GlyVal: 4.313 ± 0.072	0.854GlyTrp: 0.854 ± 0.037	3.017GlyTyr: 3.017 ± 0.081	0.0GlyXaa: 0.0 ± 0.0
His	1.725HisAla: 1.725 ± 0.053	0.362HisCys: 0.362 ± 0.023	1.098HisAsp: 1.098 ± 0.038	1.184HisGlu: 1.184 ± 0.041	1.143HisPhe: 1.143 ± 0.041	1.441HisGly: 1.441 ± 0.047	0.703HisHis: 0.703 ± 0.031	1.734HisIle: 1.734 ± 0.051	1.12HisLys: 1.12 ± 0.037	2.274HisLeu: 2.274 ± 0.057	0.432HisMet: 0.432 ± 0.029	1.007HisAsn: 1.007 ± 0.037	1.232HisPro: 1.232 ± 0.043	0.771HisGln: 0.771 ± 0.032	1.424HisArg: 1.424 ± 0.045	1.236HisSer: 1.236 ± 0.039	1.473HisThr: 1.473 ± 0.05	1.342HisVal: 1.342 ± 0.045	0.232HisTrp: 0.232 ± 0.018	0.981HisTyr: 0.981 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	5.534IleAla: 5.534 ± 0.091	0.965IleCys: 0.965 ± 0.035	4.703IleAsp: 4.703 ± 0.091	4.254IleGlu: 4.254 ± 0.079	2.452IlePhe: 2.452 ± 0.059	4.596IleGly: 4.596 ± 0.101	1.477IleHis: 1.477 ± 0.052	4.241IleIle: 4.241 ± 0.093	3.749IleLys: 3.749 ± 0.085	5.337IleLeu: 5.337 ± 0.119	1.434IleMet: 1.434 ± 0.048	3.107IleAsn: 3.107 ± 0.063	2.994IlePro: 2.994 ± 0.066	2.028IleGln: 2.028 ± 0.055	3.577IleArg: 3.577 ± 0.08	4.046IleSer: 4.046 ± 0.071	4.115IleThr: 4.115 ± 0.075	4.576IleVal: 4.576 ± 0.098	0.531IleTrp: 0.531 ± 0.029	2.534IleTyr: 2.534 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.125LysAla: 5.125 ± 0.108	0.579LysCys: 0.579 ± 0.027	3.718LysAsp: 3.718 ± 0.075	4.768LysGlu: 4.768 ± 0.108	1.885LysPhe: 1.885 ± 0.054	4.442LysGly: 4.442 ± 0.091	1.3LysHis: 1.3 ± 0.046	3.819LysIle: 3.819 ± 0.085	4.557LysLys: 4.557 ± 0.115	4.945LysLeu: 4.945 ± 0.091	2.001LysMet: 2.001 ± 0.052	3.079LysAsn: 3.079 ± 0.073	2.308LysPro: 2.308 ± 0.067	2.682LysGln: 2.682 ± 0.066	3.554LysArg: 3.554 ± 0.073	3.249LysSer: 3.249 ± 0.071	4.02LysThr: 4.02 ± 0.073	3.942LysVal: 3.942 ± 0.08	0.687LysTrp: 0.687 ± 0.033	2.483LysTyr: 2.483 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.45LeuAla: 6.45 ± 0.107	1.511LeuCys: 1.511 ± 0.048	4.498LeuAsp: 4.498 ± 0.091	4.237LeuGlu: 4.237 ± 0.095	4.463LeuPhe: 4.463 ± 0.106	5.43LeuGly: 5.43 ± 0.096	2.362LeuHis: 2.362 ± 0.063	5.242LeuIle: 5.242 ± 0.1	5.634LeuLys: 5.634 ± 0.086	9.141LeuLeu: 9.141 ± 0.176	2.609LeuMet: 2.609 ± 0.063	4.259LeuAsn: 4.259 ± 0.094	4.31LeuPro: 4.31 ± 0.085	3.596LeuGln: 3.596 ± 0.063	5.055LeuArg: 5.055 ± 0.085	7.266LeuSer: 7.266 ± 0.126	5.711LeuThr: 5.711 ± 0.113	4.96LeuVal: 4.96 ± 0.1	1.022LeuTrp: 1.022 ± 0.04	3.648LeuTyr: 3.648 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.444MetAla: 2.444 ± 0.058	0.259MetCys: 0.259 ± 0.018	1.279MetAsp: 1.279 ± 0.039	1.809MetGlu: 1.809 ± 0.052	1.018MetPhe: 1.018 ± 0.046	1.899MetGly: 1.899 ± 0.055	0.512MetHis: 0.512 ± 0.031	1.565MetIle: 1.565 ± 0.05	2.67MetLys: 2.67 ± 0.052	2.606MetLeu: 2.606 ± 0.071	0.97MetMet: 0.97 ± 0.037	1.533MetAsn: 1.533 ± 0.046	1.315MetPro: 1.315 ± 0.047	1.251MetGln: 1.251 ± 0.044	1.47MetArg: 1.47 ± 0.042	1.61MetSer: 1.61 ± 0.049	1.711MetThr: 1.711 ± 0.05	1.722MetVal: 1.722 ± 0.053	0.196MetTrp: 0.196 ± 0.017	0.73MetTyr: 0.73 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.681AsnAla: 3.681 ± 0.074	0.455AsnCys: 0.455 ± 0.026	2.637AsnAsp: 2.637 ± 0.058	2.772AsnGlu: 2.772 ± 0.063	1.868AsnPhe: 1.868 ± 0.053	3.617AsnGly: 3.617 ± 0.072	1.024AsnHis: 1.024 ± 0.037	3.475AsnIle: 3.475 ± 0.069	2.894AsnLys: 2.894 ± 0.073	3.904AsnLeu: 3.904 ± 0.088	1.291AsnMet: 1.291 ± 0.039	2.229AsnAsn: 2.229 ± 0.08	2.287AsnPro: 2.287 ± 0.059	1.354AsnGln: 1.354 ± 0.046	2.601AsnArg: 2.601 ± 0.068	2.334AsnSer: 2.334 ± 0.064	2.75AsnThr: 2.75 ± 0.069	2.998AsnVal: 2.998 ± 0.068	0.44AsnTrp: 0.44 ± 0.024	2.004AsnTyr: 2.004 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	3.114ProAla: 3.114 ± 0.084	0.436ProCys: 0.436 ± 0.024	2.481ProAsp: 2.481 ± 0.055	2.716ProGlu: 2.716 ± 0.068	1.876ProPhe: 1.876 ± 0.056	1.866ProGly: 1.866 ± 0.063	1.014ProHis: 1.014 ± 0.037	2.33ProIle: 2.33 ± 0.049	2.102ProLys: 2.102 ± 0.054	3.404ProLeu: 3.404 ± 0.068	1.064ProMet: 1.064 ± 0.037	1.61ProAsn: 1.61 ± 0.053	0.945ProPro: 0.945 ± 0.039	1.543ProGln: 1.543 ± 0.048	1.545ProArg: 1.545 ± 0.051	2.255ProSer: 2.255 ± 0.056	2.354ProThr: 2.354 ± 0.055	2.839ProVal: 2.839 ± 0.071	0.411ProTrp: 0.411 ± 0.024	1.689ProTyr: 1.689 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.605GlnAla: 2.605 ± 0.064	0.36GlnCys: 0.36 ± 0.024	1.428GlnAsp: 1.428 ± 0.045	2.173GlnGlu: 2.173 ± 0.056	1.296GlnPhe: 1.296 ± 0.038	2.285GlnGly: 2.285 ± 0.055	0.808GlnHis: 0.808 ± 0.034	2.32GlnIle: 2.32 ± 0.052	2.387GlnLys: 2.387 ± 0.068	3.658GlnLeu: 3.658 ± 0.081	1.116GlnMet: 1.116 ± 0.039	1.564GlnAsn: 1.564 ± 0.051	1.426GlnPro: 1.426 ± 0.048	1.89GlnGln: 1.89 ± 0.065	2.124GlnArg: 2.124 ± 0.057	2.007GlnSer: 2.007 ± 0.047	2.488GlnThr: 2.488 ± 0.055	1.973GlnVal: 1.973 ± 0.053	0.519GlnTrp: 0.519 ± 0.03	1.414GlnTyr: 1.414 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	3.215ArgAla: 3.215 ± 0.075	0.662ArgCys: 0.662 ± 0.029	2.434ArgAsp: 2.434 ± 0.06	3.286ArgGlu: 3.286 ± 0.076	2.598ArgPhe: 2.598 ± 0.063	2.793ArgGly: 2.793 ± 0.062	1.464ArgHis: 1.464 ± 0.041	3.903ArgIle: 3.903 ± 0.08	3.865ArgLys: 3.865 ± 0.067	5.591ArgLeu: 5.591 ± 0.102	1.872ArgMet: 1.872 ± 0.057	2.658ArgAsn: 2.658 ± 0.066	1.924ArgPro: 1.924 ± 0.056	2.503ArgGln: 2.503 ± 0.052	3.181ArgArg: 3.181 ± 0.08	2.689ArgSer: 2.689 ± 0.066	2.817ArgThr: 2.817 ± 0.072	2.885ArgVal: 2.885 ± 0.061	0.695ArgTrp: 0.695 ± 0.031	2.606ArgTyr: 2.606 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	4.5SerAla: 4.5 ± 0.093	0.82SerCys: 0.82 ± 0.032	3.216SerAsp: 3.216 ± 0.071	3.122SerGlu: 3.122 ± 0.064	3.012SerPhe: 3.012 ± 0.076	4.282SerGly: 4.282 ± 0.089	1.335SerHis: 1.335 ± 0.042	4.205SerIle: 4.205 ± 0.082	3.2SerLys: 3.2 ± 0.061	5.763SerLeu: 5.763 ± 0.106	1.666SerMet: 1.666 ± 0.048	2.552SerAsn: 2.552 ± 0.062	2.347SerPro: 2.347 ± 0.056	1.875SerGln: 1.875 ± 0.045	2.859SerArg: 2.859 ± 0.069	3.625SerSer: 3.625 ± 0.084	3.309SerThr: 3.309 ± 0.079	3.922SerVal: 3.922 ± 0.079	0.662SerTrp: 0.662 ± 0.029	2.577SerTyr: 2.577 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	5.109ThrAla: 5.109 ± 0.089	0.673ThrCys: 0.673 ± 0.029	3.968ThrAsp: 3.968 ± 0.079	3.504ThrGlu: 3.504 ± 0.078	2.933ThrPhe: 2.933 ± 0.061	4.562ThrGly: 4.562 ± 0.091	1.444ThrHis: 1.444 ± 0.046	3.891ThrIle: 3.891 ± 0.078	2.955ThrLys: 2.955 ± 0.072	6.249ThrLeu: 6.249 ± 0.116	1.433ThrMet: 1.433 ± 0.048	2.422ThrAsn: 2.422 ± 0.06	2.971ThrPro: 2.971 ± 0.068	2.003ThrGln: 2.003 ± 0.047	2.661ThrArg: 2.661 ± 0.063	3.463ThrSer: 3.463 ± 0.076	3.888ThrThr: 3.888 ± 0.093	4.376ThrVal: 4.376 ± 0.082	0.638ThrTrp: 0.638 ± 0.031	2.531ThrTyr: 2.531 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.88ValAla: 4.88 ± 0.075	1.076ValCys: 1.076 ± 0.041	3.264ValAsp: 3.264 ± 0.06	3.846ValGlu: 3.846 ± 0.08	2.808ValPhe: 2.808 ± 0.07	4.118ValGly: 4.118 ± 0.083	1.191ValHis: 1.191 ± 0.043	3.966ValIle: 3.966 ± 0.085	4.237ValLys: 4.237 ± 0.083	5.579ValLeu: 5.579 ± 0.102	1.781ValMet: 1.781 ± 0.053	2.746ValAsn: 2.746 ± 0.069	2.486ValPro: 2.486 ± 0.062	2.063ValGln: 2.063 ± 0.058	3.321ValArg: 3.321 ± 0.076	4.547ValSer: 4.547 ± 0.09	3.735ValThr: 3.735 ± 0.088	4.588ValVal: 4.588 ± 0.097	0.732ValTrp: 0.732 ± 0.035	2.659ValTyr: 2.659 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.747TrpAla: 0.747 ± 0.032	0.157TrpCys: 0.157 ± 0.015	0.613TrpAsp: 0.613 ± 0.032	0.609TrpGlu: 0.609 ± 0.032	0.507TrpPhe: 0.507 ± 0.029	0.797TrpGly: 0.797 ± 0.035	0.293TrpHis: 0.293 ± 0.024	0.674TrpIle: 0.674 ± 0.034	0.782TrpLys: 0.782 ± 0.033	1.153TrpLeu: 1.153 ± 0.042	0.424TrpMet: 0.424 ± 0.026	0.67TrpAsn: 0.67 ± 0.033	0.211TrpPro: 0.211 ± 0.019	0.529TrpGln: 0.529 ± 0.026	0.541TrpArg: 0.541 ± 0.025	0.582TrpSer: 0.582 ± 0.036	0.665TrpThr: 0.665 ± 0.029	0.608TrpVal: 0.608 ± 0.034	0.147TrpTrp: 0.147 ± 0.016	0.439TrpTyr: 0.439 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.096TyrAla: 3.096 ± 0.065	0.545TyrCys: 0.545 ± 0.028	2.553TyrAsp: 2.553 ± 0.064	2.157TyrGlu: 2.157 ± 0.052	1.854TyrPhe: 1.854 ± 0.056	2.898TyrGly: 2.898 ± 0.068	1.003TyrHis: 1.003 ± 0.039	2.791TyrIle: 2.791 ± 0.06	2.301TyrLys: 2.301 ± 0.059	3.75TyrLeu: 3.75 ± 0.074	1.067TyrMet: 1.067 ± 0.042	2.127TyrAsn: 2.127 ± 0.059	1.637TyrPro: 1.637 ± 0.048	1.477TyrGln: 1.477 ± 0.049	2.637TyrArg: 2.637 ± 0.062	2.372TyrSer: 2.372 ± 0.064	2.682TyrThr: 2.682 ± 0.068	2.41TyrVal: 2.41 ± 0.054	0.524TyrTrp: 0.524 ± 0.029	1.973TyrTyr: 1.973 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2334 proteins (734057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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