Amino acid dipepetide frequency for Tannerella sp. CAG:118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.609AlaAla: 4.609 ± 0.087	0.829AlaCys: 0.829 ± 0.03	3.551AlaAsp: 3.551 ± 0.056	4.04AlaGlu: 4.04 ± 0.079	2.955AlaPhe: 2.955 ± 0.057	4.644AlaGly: 4.644 ± 0.071	1.11AlaHis: 1.11 ± 0.036	4.951AlaIle: 4.951 ± 0.074	3.736AlaLys: 3.736 ± 0.071	6.019AlaLeu: 6.019 ± 0.087	1.584AlaMet: 1.584 ± 0.039	2.951AlaAsn: 2.951 ± 0.053	2.158AlaPro: 2.158 ± 0.049	2.48AlaGln: 2.48 ± 0.044	2.679AlaArg: 2.679 ± 0.047	4.154AlaSer: 4.154 ± 0.064	3.427AlaThr: 3.427 ± 0.062	4.01AlaVal: 4.01 ± 0.076	0.739AlaTrp: 0.739 ± 0.027	2.739AlaTyr: 2.739 ± 0.054	0.001AlaXaa: 0.001 ± 0.001
Cys	0.66CysAla: 0.66 ± 0.026	0.201CysCys: 0.201 ± 0.015	0.604CysAsp: 0.604 ± 0.026	0.625CysGlu: 0.625 ± 0.027	0.635CysPhe: 0.635 ± 0.025	0.931CysGly: 0.931 ± 0.029	0.275CysHis: 0.275 ± 0.015	1.094CysIle: 1.094 ± 0.033	0.667CysLys: 0.667 ± 0.025	1.038CysLeu: 1.038 ± 0.029	0.28CysMet: 0.28 ± 0.017	0.647CysAsn: 0.647 ± 0.027	0.524CysPro: 0.524 ± 0.025	0.334CysGln: 0.334 ± 0.018	0.587CysArg: 0.587 ± 0.024	0.784CysSer: 0.784 ± 0.026	0.662CysThr: 0.662 ± 0.026	0.648CysVal: 0.648 ± 0.028	0.153CysTrp: 0.153 ± 0.012	0.53CysTyr: 0.53 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.505AspAla: 3.505 ± 0.066	0.629AspCys: 0.629 ± 0.029	2.715AspAsp: 2.715 ± 0.067	3.705AspGlu: 3.705 ± 0.067	3.097AspPhe: 3.097 ± 0.057	3.89AspGly: 3.89 ± 0.075	0.761AspHis: 0.761 ± 0.026	5.02AspIle: 5.02 ± 0.075	4.147AspLys: 4.147 ± 0.069	4.45AspLeu: 4.45 ± 0.062	1.604AspMet: 1.604 ± 0.04	3.411AspAsn: 3.411 ± 0.069	1.823AspPro: 1.823 ± 0.046	1.172AspGln: 1.172 ± 0.036	2.258AspArg: 2.258 ± 0.045	3.102AspSer: 3.102 ± 0.052	2.833AspThr: 2.833 ± 0.05	3.264AspVal: 3.264 ± 0.064	0.856AspTrp: 0.856 ± 0.03	2.962AspTyr: 2.962 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.994GluAla: 3.994 ± 0.071	0.63GluCys: 0.63 ± 0.026	3.011GluAsp: 3.011 ± 0.054	4.301GluGlu: 4.301 ± 0.085	2.285GluPhe: 2.285 ± 0.045	3.725GluGly: 3.725 ± 0.059	1.106GluHis: 1.106 ± 0.033	5.25GluIle: 5.25 ± 0.072	5.411GluLys: 5.411 ± 0.079	5.534GluLeu: 5.534 ± 0.085	1.856GluMet: 1.856 ± 0.039	4.191GluAsn: 4.191 ± 0.067	1.696GluPro: 1.696 ± 0.038	2.235GluGln: 2.235 ± 0.054	2.841GluArg: 2.841 ± 0.055	3.392GluSer: 3.392 ± 0.058	3.246GluThr: 3.246 ± 0.059	3.638GluVal: 3.638 ± 0.06	0.8GluTrp: 0.8 ± 0.029	2.76GluTyr: 2.76 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.895PheAla: 2.895 ± 0.053	0.696PheCys: 0.696 ± 0.025	3.032PheAsp: 3.032 ± 0.06	2.552PheGlu: 2.552 ± 0.049	2.397PhePhe: 2.397 ± 0.057	3.287PheGly: 3.287 ± 0.057	0.797PheHis: 0.797 ± 0.033	3.802PheIle: 3.802 ± 0.065	2.61PheLys: 2.61 ± 0.047	4.142PheLeu: 4.142 ± 0.069	1.211PheMet: 1.211 ± 0.033	2.474PheAsn: 2.474 ± 0.056	1.892PhePro: 1.892 ± 0.041	1.13PheGln: 1.13 ± 0.028	2.008PheArg: 2.008 ± 0.045	3.947PheSer: 3.947 ± 0.069	2.716PheThr: 2.716 ± 0.049	2.832PheVal: 2.832 ± 0.054	0.62PheTrp: 0.62 ± 0.026	2.11PheTyr: 2.11 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.204GlyAla: 4.204 ± 0.078	0.889GlyCys: 0.889 ± 0.035	3.448GlyAsp: 3.448 ± 0.061	3.999GlyGlu: 3.999 ± 0.062	3.283GlyPhe: 3.283 ± 0.053	4.603GlyGly: 4.603 ± 0.085	1.234GlyHis: 1.234 ± 0.036	6.124GlyIle: 6.124 ± 0.096	5.269GlyLys: 5.269 ± 0.075	5.682GlyLeu: 5.682 ± 0.089	1.898GlyMet: 1.898 ± 0.04	3.904GlyAsn: 3.904 ± 0.071	1.371GlyPro: 1.371 ± 0.037	1.961GlyGln: 1.961 ± 0.038	2.81GlyArg: 2.81 ± 0.047	3.849GlySer: 3.849 ± 0.069	4.127GlyThr: 4.127 ± 0.073	4.405GlyVal: 4.405 ± 0.07	1.037GlyTrp: 1.037 ± 0.032	3.506GlyTyr: 3.506 ± 0.071	0.001GlyXaa: 0.001 ± 0.001
His	0.986HisAla: 0.986 ± 0.029	0.24HisCys: 0.24 ± 0.017	0.797HisAsp: 0.797 ± 0.029	0.888HisGlu: 0.888 ± 0.029	1.108HisPhe: 1.108 ± 0.033	1.086HisGly: 1.086 ± 0.035	0.479HisHis: 0.479 ± 0.023	1.662HisIle: 1.662 ± 0.045	1.056HisLys: 1.056 ± 0.031	1.7HisLeu: 1.7 ± 0.038	0.357HisMet: 0.357 ± 0.017	1.025HisAsn: 1.025 ± 0.031	1.041HisPro: 1.041 ± 0.037	0.588HisGln: 0.588 ± 0.023	0.832HisArg: 0.832 ± 0.028	1.146HisSer: 1.146 ± 0.034	1.027HisThr: 1.027 ± 0.029	0.906HisVal: 0.906 ± 0.031	0.254HisTrp: 0.254 ± 0.017	0.924HisTyr: 0.924 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.47IleAla: 5.47 ± 0.086	1.093IleCys: 1.093 ± 0.037	4.999IleAsp: 4.999 ± 0.066	5.147IleGlu: 5.147 ± 0.076	3.585IlePhe: 3.585 ± 0.064	5.225IleGly: 5.225 ± 0.081	1.455IleHis: 1.455 ± 0.038	6.264IleIle: 6.264 ± 0.087	5.19IleLys: 5.19 ± 0.078	7.053IleLeu: 7.053 ± 0.104	1.691IleMet: 1.691 ± 0.043	4.178IleAsn: 4.178 ± 0.075	3.697IlePro: 3.697 ± 0.061	2.564IleGln: 2.564 ± 0.049	3.518IleArg: 3.518 ± 0.069	6.024IleSer: 6.024 ± 0.087	4.534IleThr: 4.534 ± 0.081	4.717IleVal: 4.717 ± 0.075	0.902IleTrp: 0.902 ± 0.034	3.511IleTyr: 3.511 ± 0.068	0.001IleXaa: 0.001 ± 0.001
Lys	4.322LysAla: 4.322 ± 0.073	0.566LysCys: 0.566 ± 0.024	3.976LysAsp: 3.976 ± 0.063	5.393LysGlu: 5.393 ± 0.085	2.367LysPhe: 2.367 ± 0.048	4.442LysGly: 4.442 ± 0.068	1.148LysHis: 1.148 ± 0.037	5.536LysIle: 5.536 ± 0.076	5.493LysLys: 5.493 ± 0.087	5.201LysLeu: 5.201 ± 0.079	2.13LysMet: 2.13 ± 0.045	4.732LysAsn: 4.732 ± 0.076	2.078LysPro: 2.078 ± 0.045	2.436LysGln: 2.436 ± 0.05	2.88LysArg: 2.88 ± 0.057	3.97LysSer: 3.97 ± 0.055	3.489LysThr: 3.489 ± 0.064	4.105LysVal: 4.105 ± 0.06	0.804LysTrp: 0.804 ± 0.029	3.295LysTyr: 3.295 ± 0.068	0.001LysXaa: 0.001 ± 0.001
Leu	5.517LeuAla: 5.517 ± 0.08	1.217LeuCys: 1.217 ± 0.035	4.555LeuAsp: 4.555 ± 0.075	4.622LeuGlu: 4.622 ± 0.074	4.505LeuPhe: 4.505 ± 0.081	5.541LeuGly: 5.541 ± 0.092	1.655LeuHis: 1.655 ± 0.036	6.211LeuIle: 6.211 ± 0.098	6.291LeuLys: 6.291 ± 0.085	8.635LeuLeu: 8.635 ± 0.132	2.248LeuMet: 2.248 ± 0.055	4.799LeuAsn: 4.799 ± 0.084	3.99LeuPro: 3.99 ± 0.066	3.21LeuGln: 3.21 ± 0.065	3.792LeuArg: 3.792 ± 0.058	7.308LeuSer: 7.308 ± 0.098	4.784LeuThr: 4.784 ± 0.072	4.785LeuVal: 4.785 ± 0.083	1.059LeuTrp: 1.059 ± 0.037	3.97LeuTyr: 3.97 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.809MetAla: 1.809 ± 0.049	0.226MetCys: 0.226 ± 0.015	1.318MetAsp: 1.318 ± 0.037	1.512MetGlu: 1.512 ± 0.038	1.039MetPhe: 1.039 ± 0.034	1.751MetGly: 1.751 ± 0.04	0.461MetHis: 0.461 ± 0.018	1.743MetIle: 1.743 ± 0.039	2.292MetLys: 2.292 ± 0.044	2.215MetLeu: 2.215 ± 0.051	0.711MetMet: 0.711 ± 0.028	1.544MetAsn: 1.544 ± 0.033	1.121MetPro: 1.121 ± 0.03	1.022MetGln: 1.022 ± 0.029	1.187MetArg: 1.187 ± 0.031	1.584MetSer: 1.584 ± 0.039	1.416MetThr: 1.416 ± 0.038	1.528MetVal: 1.528 ± 0.039	0.262MetTrp: 0.262 ± 0.015	0.944MetTyr: 0.944 ± 0.032	0.001MetXaa: 0.001 ± 0.001
Asn	3.357AsnAla: 3.357 ± 0.06	0.617AsnCys: 0.617 ± 0.029	2.95AsnAsp: 2.95 ± 0.058	3.159AsnGlu: 3.159 ± 0.055	2.42AsnPhe: 2.42 ± 0.05	4.148AsnGly: 4.148 ± 0.07	1.02AsnHis: 1.02 ± 0.034	5.14AsnIle: 5.14 ± 0.078	3.916AsnLys: 3.916 ± 0.071	4.664AsnLeu: 4.664 ± 0.085	1.506AsnMet: 1.506 ± 0.037	3.536AsnAsn: 3.536 ± 0.069	2.624AsnPro: 2.624 ± 0.043	1.763AsnGln: 1.763 ± 0.044	2.657AsnArg: 2.657 ± 0.046	3.294AsnSer: 3.294 ± 0.062	3.173AsnThr: 3.173 ± 0.067	3.284AsnVal: 3.284 ± 0.054	0.705AsnTrp: 0.705 ± 0.03	2.704AsnTyr: 2.704 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.397ProAla: 2.397 ± 0.051	0.362ProCys: 0.362 ± 0.019	2.68ProAsp: 2.68 ± 0.047	3.312ProGlu: 3.312 ± 0.052	1.901ProPhe: 1.901 ± 0.048	2.585ProGly: 2.585 ± 0.057	0.709ProHis: 0.709 ± 0.025	2.681ProIle: 2.681 ± 0.058	1.968ProLys: 1.968 ± 0.047	3.283ProLeu: 3.283 ± 0.057	0.864ProMet: 0.864 ± 0.034	1.869ProAsn: 1.869 ± 0.043	0.868ProPro: 0.868 ± 0.029	1.491ProGln: 1.491 ± 0.046	1.304ProArg: 1.304 ± 0.04	2.367ProSer: 2.367 ± 0.044	1.883ProThr: 1.883 ± 0.041	3.014ProVal: 3.014 ± 0.056	0.46ProTrp: 0.46 ± 0.023	1.833ProTyr: 1.833 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.05GlnAla: 2.05 ± 0.055	0.289GlnCys: 0.289 ± 0.015	1.575GlnAsp: 1.575 ± 0.037	2.146GlnGlu: 2.146 ± 0.04	1.321GlnPhe: 1.321 ± 0.037	2.041GlnGly: 2.041 ± 0.044	0.606GlnHis: 0.606 ± 0.027	2.76GlnIle: 2.76 ± 0.056	2.589GlnLys: 2.589 ± 0.053	3.091GlnLeu: 3.091 ± 0.046	0.991GlnMet: 0.991 ± 0.034	2.006GlnAsn: 2.006 ± 0.048	1.161GlnPro: 1.161 ± 0.034	1.367GlnGln: 1.367 ± 0.045	1.383GlnArg: 1.383 ± 0.037	2.018GlnSer: 2.018 ± 0.047	1.867GlnThr: 1.867 ± 0.042	1.859GlnVal: 1.859 ± 0.048	0.44GlnTrp: 0.44 ± 0.019	1.539GlnTyr: 1.539 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.411ArgAla: 2.411 ± 0.045	0.424ArgCys: 0.424 ± 0.022	2.061ArgAsp: 2.061 ± 0.047	2.6ArgGlu: 2.6 ± 0.052	2.266ArgPhe: 2.266 ± 0.05	2.337ArgGly: 2.337 ± 0.052	0.837ArgHis: 0.837 ± 0.028	3.807ArgIle: 3.807 ± 0.06	3.178ArgLys: 3.178 ± 0.052	4.06ArgLeu: 4.06 ± 0.065	1.295ArgMet: 1.295 ± 0.038	2.56ArgAsn: 2.56 ± 0.049	1.602ArgPro: 1.602 ± 0.041	1.587ArgGln: 1.587 ± 0.038	1.919ArgArg: 1.919 ± 0.053	2.277ArgSer: 2.277 ± 0.042	2.266ArgThr: 2.266 ± 0.043	2.453ArgVal: 2.453 ± 0.056	0.662ArgTrp: 0.662 ± 0.026	2.277ArgTyr: 2.277 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.056SerAla: 4.056 ± 0.057	0.834SerCys: 0.834 ± 0.027	3.703SerAsp: 3.703 ± 0.07	3.824SerGlu: 3.824 ± 0.065	3.508SerPhe: 3.508 ± 0.065	5.078SerGly: 5.078 ± 0.079	1.249SerHis: 1.249 ± 0.034	5.267SerIle: 5.267 ± 0.074	3.688SerLys: 3.688 ± 0.062	6.24SerLeu: 6.24 ± 0.089	1.452SerMet: 1.452 ± 0.035	3.197SerAsn: 3.197 ± 0.059	2.457SerPro: 2.457 ± 0.05	2.178SerGln: 2.178 ± 0.047	2.636SerArg: 2.636 ± 0.049	4.415SerSer: 4.415 ± 0.086	3.434SerThr: 3.434 ± 0.065	4.402SerVal: 4.402 ± 0.071	0.889SerTrp: 0.889 ± 0.029	3.067SerTyr: 3.067 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	3.575ThrAla: 3.575 ± 0.061	0.536ThrCys: 0.536 ± 0.024	3.304ThrAsp: 3.304 ± 0.054	3.222ThrGlu: 3.222 ± 0.057	2.807ThrPhe: 2.807 ± 0.053	4.309ThrGly: 4.309 ± 0.074	1.072ThrHis: 1.072 ± 0.03	4.289ThrIle: 4.289 ± 0.078	2.748ThrLys: 2.748 ± 0.052	5.161ThrLeu: 5.161 ± 0.066	1.099ThrMet: 1.099 ± 0.033	2.624ThrAsn: 2.624 ± 0.054	2.803ThrPro: 2.803 ± 0.047	1.866ThrGln: 1.866 ± 0.047	2.138ThrArg: 2.138 ± 0.051	3.494ThrSer: 3.494 ± 0.066	3.176ThrThr: 3.176 ± 0.066	3.757ThrVal: 3.757 ± 0.06	0.652ThrTrp: 0.652 ± 0.03	2.48ThrTyr: 2.48 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.009ValAla: 4.009 ± 0.075	0.845ValCys: 0.845 ± 0.034	3.449ValAsp: 3.449 ± 0.057	3.58ValGlu: 3.58 ± 0.062	2.681ValPhe: 2.681 ± 0.05	3.891ValGly: 3.891 ± 0.072	0.949ValHis: 0.949 ± 0.031	4.685ValIle: 4.685 ± 0.072	4.194ValLys: 4.194 ± 0.06	5.307ValLeu: 5.307 ± 0.073	1.452ValMet: 1.452 ± 0.037	3.246ValAsn: 3.246 ± 0.058	2.553ValPro: 2.553 ± 0.043	1.78ValGln: 1.78 ± 0.042	2.647ValArg: 2.647 ± 0.056	4.64ValSer: 4.64 ± 0.064	3.549ValThr: 3.549 ± 0.057	3.913ValVal: 3.913 ± 0.078	0.759ValTrp: 0.759 ± 0.027	2.579ValTyr: 2.579 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.789TrpAla: 0.789 ± 0.03	0.17TrpCys: 0.17 ± 0.014	0.783TrpAsp: 0.783 ± 0.032	0.78TrpGlu: 0.78 ± 0.022	0.578TrpPhe: 0.578 ± 0.024	1.011TrpGly: 1.011 ± 0.028	0.225TrpHis: 0.225 ± 0.014	0.974TrpIle: 0.974 ± 0.036	0.896TrpLys: 0.896 ± 0.03	1.148TrpLeu: 1.148 ± 0.034	0.394TrpMet: 0.394 ± 0.019	0.863TrpAsn: 0.863 ± 0.03	0.285TrpPro: 0.285 ± 0.019	0.441TrpGln: 0.441 ± 0.019	0.556TrpArg: 0.556 ± 0.024	0.767TrpSer: 0.767 ± 0.028	0.684TrpThr: 0.684 ± 0.026	0.745TrpVal: 0.745 ± 0.024	0.187TrpTrp: 0.187 ± 0.014	0.557TrpTyr: 0.557 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.749TyrAla: 2.749 ± 0.048	0.587TyrCys: 0.587 ± 0.025	2.693TyrAsp: 2.693 ± 0.06	2.496TyrGlu: 2.496 ± 0.053	2.411TyrPhe: 2.411 ± 0.053	3.075TyrGly: 3.075 ± 0.068	0.954TyrHis: 0.954 ± 0.031	3.558TyrIle: 3.558 ± 0.058	3.024TyrLys: 3.024 ± 0.053	4.07TyrLeu: 4.07 ± 0.058	1.065TyrMet: 1.065 ± 0.029	2.879TyrAsn: 2.879 ± 0.069	2.085TyrPro: 2.085 ± 0.047	1.498TyrGln: 1.498 ± 0.047	2.248TyrArg: 2.248 ± 0.049	3.039TyrSer: 3.039 ± 0.052	2.819TyrThr: 2.819 ± 0.052	2.445TyrVal: 2.445 ± 0.05	0.592TyrTrp: 0.592 ± 0.027	2.249TyrTyr: 2.249 ± 0.051	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.004

Statistics based on 2920 proteins (1083655 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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