Amino acid dipepetide frequency for Mikania micrantha

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.107AlaAla: 5.107 ± 0.025	1.173AlaCys: 1.173 ± 0.009	3.043AlaAsp: 3.043 ± 0.012	3.488AlaGlu: 3.488 ± 0.017	2.548AlaPhe: 2.548 ± 0.012	3.701AlaGly: 3.701 ± 0.019	1.349AlaHis: 1.349 ± 0.01	3.635AlaIle: 3.635 ± 0.015	3.693AlaLys: 3.693 ± 0.017	5.758AlaLeu: 5.758 ± 0.021	1.693AlaMet: 1.693 ± 0.01	2.606AlaAsn: 2.606 ± 0.013	2.795AlaPro: 2.795 ± 0.013	2.012AlaGln: 2.012 ± 0.012	3.178AlaArg: 3.178 ± 0.015	5.181AlaSer: 5.181 ± 0.019	3.579AlaThr: 3.579 ± 0.016	4.234AlaVal: 4.234 ± 0.018	0.739AlaTrp: 0.739 ± 0.006	1.953AlaTyr: 1.953 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.007	0.455CysCys: 0.455 ± 0.006	1.009CysAsp: 1.009 ± 0.008	0.907CysGlu: 0.907 ± 0.008	0.883CysPhe: 0.883 ± 0.007	1.337CysGly: 1.337 ± 0.01	0.488CysHis: 0.488 ± 0.005	1.017CysIle: 1.017 ± 0.008	1.193CysLys: 1.193 ± 0.01	1.909CysLeu: 1.909 ± 0.01	0.463CysMet: 0.463 ± 0.005	0.905CysAsn: 0.905 ± 0.007	0.905CysPro: 0.905 ± 0.008	0.602CysGln: 0.602 ± 0.006	1.036CysArg: 1.036 ± 0.008	1.574CysSer: 1.574 ± 0.01	0.859CysThr: 0.859 ± 0.008	1.165CysVal: 1.165 ± 0.009	0.302CysTrp: 0.302 ± 0.004	0.642CysTyr: 0.642 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.289AspAla: 3.289 ± 0.013	0.997AspCys: 0.997 ± 0.007	4.25AspAsp: 4.25 ± 0.021	4.31AspGlu: 4.31 ± 0.019	2.461AspPhe: 2.461 ± 0.011	3.723AspGly: 3.723 ± 0.016	1.48AspHis: 1.48 ± 0.01	3.15AspIle: 3.15 ± 0.013	2.951AspLys: 2.951 ± 0.014	5.296AspLeu: 5.296 ± 0.02	1.517AspMet: 1.517 ± 0.01	2.299AspAsn: 2.299 ± 0.011	2.585AspPro: 2.585 ± 0.014	2.006AspGln: 2.006 ± 0.01	2.587AspArg: 2.587 ± 0.015	4.045AspSer: 4.045 ± 0.017	2.35AspThr: 2.35 ± 0.012	3.761AspVal: 3.761 ± 0.015	0.749AspTrp: 0.749 ± 0.006	1.709AspTyr: 1.709 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.321GluAla: 4.321 ± 0.016	0.91GluCys: 0.91 ± 0.008	4.043GluAsp: 4.043 ± 0.017	5.507GluGlu: 5.507 ± 0.025	2.597GluPhe: 2.597 ± 0.012	3.346GluGly: 3.346 ± 0.012	1.395GluHis: 1.395 ± 0.009	3.995GluIle: 3.995 ± 0.015	4.528GluLys: 4.528 ± 0.02	5.846GluLeu: 5.846 ± 0.021	1.793GluMet: 1.793 ± 0.01	3.11GluAsn: 3.11 ± 0.015	2.188GluPro: 2.188 ± 0.01	2.094GluGln: 2.094 ± 0.012	3.124GluArg: 3.124 ± 0.015	4.366GluSer: 4.366 ± 0.019	3.258GluThr: 3.258 ± 0.015	4.114GluVal: 4.114 ± 0.017	0.697GluTrp: 0.697 ± 0.007	1.635GluTyr: 1.635 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	2.359PheAla: 2.359 ± 0.014	0.849PheCys: 0.849 ± 0.008	2.578PheAsp: 2.578 ± 0.012	2.484PheGlu: 2.484 ± 0.012	1.786PhePhe: 1.786 ± 0.012	3.045PheGly: 3.045 ± 0.011	1.161PheHis: 1.161 ± 0.009	2.362PheIle: 2.362 ± 0.012	2.322PheLys: 2.322 ± 0.012	4.097PheLeu: 4.097 ± 0.019	1.073PheMet: 1.073 ± 0.007	1.871PheAsn: 1.871 ± 0.011	1.934PhePro: 1.934 ± 0.012	1.617PheGln: 1.617 ± 0.009	2.0PheArg: 2.0 ± 0.01	3.787PheSer: 3.787 ± 0.015	2.215PheThr: 2.215 ± 0.012	2.87PheVal: 2.87 ± 0.014	0.664PheTrp: 0.664 ± 0.006	1.213PheTyr: 1.213 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	3.458GlyAla: 3.458 ± 0.016	1.406GlyCys: 1.406 ± 0.011	3.378GlyAsp: 3.378 ± 0.013	3.366GlyGlu: 3.366 ± 0.016	3.049GlyPhe: 3.049 ± 0.014	5.112GlyGly: 5.112 ± 0.03	1.649GlyHis: 1.649 ± 0.01	3.398GlyIle: 3.398 ± 0.015	3.975GlyLys: 3.975 ± 0.018	5.672GlyLeu: 5.672 ± 0.02	1.544GlyMet: 1.544 ± 0.01	2.978GlyAsn: 2.978 ± 0.015	2.469GlyPro: 2.469 ± 0.012	1.998GlyGln: 1.998 ± 0.011	3.402GlyArg: 3.402 ± 0.016	5.599GlySer: 5.599 ± 0.019	3.151GlyThr: 3.151 ± 0.013	4.167GlyVal: 4.167 ± 0.018	0.88GlyTrp: 0.88 ± 0.006	2.149GlyTyr: 2.149 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	1.38HisAla: 1.38 ± 0.009	0.478HisCys: 0.478 ± 0.005	1.379HisAsp: 1.379 ± 0.009	1.517HisGlu: 1.517 ± 0.009	1.143HisPhe: 1.143 ± 0.009	1.738HisGly: 1.738 ± 0.011	1.111HisHis: 1.111 ± 0.01	1.335HisIle: 1.335 ± 0.008	1.442HisLys: 1.442 ± 0.01	2.58HisLeu: 2.58 ± 0.013	0.663HisMet: 0.663 ± 0.007	1.14HisAsn: 1.14 ± 0.008	1.486HisPro: 1.486 ± 0.01	1.176HisGln: 1.176 ± 0.008	1.429HisArg: 1.429 ± 0.01	1.825HisSer: 1.825 ± 0.009	1.155HisThr: 1.155 ± 0.009	1.778HisVal: 1.778 ± 0.01	0.305HisTrp: 0.305 ± 0.004	0.763HisTyr: 0.763 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.52IleAla: 3.52 ± 0.016	1.089IleCys: 1.089 ± 0.008	3.348IleAsp: 3.348 ± 0.014	3.473IleGlu: 3.473 ± 0.015	2.245IlePhe: 2.245 ± 0.012	3.483IleGly: 3.483 ± 0.015	1.493IleHis: 1.493 ± 0.009	3.098IleIle: 3.098 ± 0.018	3.373IleLys: 3.373 ± 0.014	5.271IleLeu: 5.271 ± 0.019	1.24IleMet: 1.24 ± 0.007	2.482IleAsn: 2.482 ± 0.012	3.11IlePro: 3.11 ± 0.017	2.239IleGln: 2.239 ± 0.011	2.895IleArg: 2.895 ± 0.013	4.84IleSer: 4.84 ± 0.017	2.916IleThr: 2.916 ± 0.013	3.558IleVal: 3.558 ± 0.015	0.834IleTrp: 0.834 ± 0.007	1.597IleTyr: 1.597 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.935LysAla: 3.935 ± 0.018	1.234LysCys: 1.234 ± 0.011	3.478LysAsp: 3.478 ± 0.017	4.524LysGlu: 4.524 ± 0.021	2.309LysPhe: 2.309 ± 0.012	3.671LysGly: 3.671 ± 0.015	1.548LysHis: 1.548 ± 0.009	3.644LysIle: 3.644 ± 0.013	5.212LysLys: 5.212 ± 0.026	6.169LysLeu: 6.169 ± 0.021	1.67LysMet: 1.67 ± 0.011	3.071LysAsn: 3.071 ± 0.015	2.856LysPro: 2.856 ± 0.013	2.511LysGln: 2.511 ± 0.014	3.628LysArg: 3.628 ± 0.015	4.803LysSer: 4.803 ± 0.019	3.332LysThr: 3.332 ± 0.014	4.031LysVal: 4.031 ± 0.016	0.955LysTrp: 0.955 ± 0.007	1.753LysTyr: 1.753 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	5.887LeuAla: 5.887 ± 0.022	1.676LeuCys: 1.676 ± 0.01	5.075LeuAsp: 5.075 ± 0.018	6.116LeuGlu: 6.116 ± 0.026	3.61LeuPhe: 3.61 ± 0.016	5.481LeuGly: 5.481 ± 0.02	2.53LeuHis: 2.53 ± 0.013	4.839LeuIle: 4.839 ± 0.02	6.681LeuLys: 6.681 ± 0.025	8.984LeuLeu: 8.984 ± 0.036	2.252LeuMet: 2.252 ± 0.01	4.186LeuAsn: 4.186 ± 0.018	4.997LeuPro: 4.997 ± 0.02	4.109LeuGln: 4.109 ± 0.015	5.046LeuArg: 5.046 ± 0.02	7.84LeuSer: 7.84 ± 0.028	4.895LeuThr: 4.895 ± 0.02	6.078LeuVal: 6.078 ± 0.019	1.147LeuTrp: 1.147 ± 0.008	2.549LeuTyr: 2.549 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	1.997MetAla: 1.997 ± 0.011	0.403MetCys: 0.403 ± 0.004	1.603MetAsp: 1.603 ± 0.01	1.895MetGlu: 1.895 ± 0.01	0.915MetPhe: 0.915 ± 0.007	1.555MetGly: 1.555 ± 0.01	0.566MetHis: 0.566 ± 0.006	1.418MetIle: 1.418 ± 0.01	1.893MetLys: 1.893 ± 0.011	2.282MetLeu: 2.282 ± 0.011	0.802MetMet: 0.802 ± 0.007	1.209MetAsn: 1.209 ± 0.009	1.048MetPro: 1.048 ± 0.008	0.947MetGln: 0.947 ± 0.008	1.221MetArg: 1.221 ± 0.009	1.812MetSer: 1.812 ± 0.01	1.223MetThr: 1.223 ± 0.008	1.809MetVal: 1.809 ± 0.01	0.311MetTrp: 0.311 ± 0.004	0.68MetTyr: 0.68 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.486AsnAla: 2.486 ± 0.014	0.874AsnCys: 0.874 ± 0.007	2.417AsnAsp: 2.417 ± 0.012	2.845AsnGlu: 2.845 ± 0.014	1.938AsnPhe: 1.938 ± 0.01	3.189AsnGly: 3.189 ± 0.015	1.379AsnHis: 1.379 ± 0.011	2.619AsnIle: 2.619 ± 0.012	2.788AsnLys: 2.788 ± 0.016	4.822AsnLeu: 4.822 ± 0.021	1.286AsnMet: 1.286 ± 0.01	2.711AsnAsn: 2.711 ± 0.021	2.458AsnPro: 2.458 ± 0.013	2.017AsnGln: 2.017 ± 0.012	2.344AsnArg: 2.344 ± 0.012	3.78AsnSer: 3.78 ± 0.014	2.247AsnThr: 2.247 ± 0.014	2.809AsnVal: 2.809 ± 0.013	0.635AsnTrp: 0.635 ± 0.006	1.396AsnTyr: 1.396 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	2.819ProAla: 2.819 ± 0.015	0.713ProCys: 0.713 ± 0.007	2.457ProAsp: 2.457 ± 0.012	3.074ProGlu: 3.074 ± 0.013	2.099ProPhe: 2.099 ± 0.013	2.452ProGly: 2.452 ± 0.012	1.174ProHis: 1.174 ± 0.008	2.691ProIle: 2.691 ± 0.013	2.759ProLys: 2.759 ± 0.014	4.167ProLeu: 4.167 ± 0.019	1.056ProMet: 1.056 ± 0.007	2.365ProAsn: 2.365 ± 0.013	3.983ProPro: 3.983 ± 0.045	1.823ProGln: 1.823 ± 0.011	2.369ProArg: 2.369 ± 0.011	4.62ProSer: 4.62 ± 0.021	2.8ProThr: 2.8 ± 0.015	3.314ProVal: 3.314 ± 0.015	0.648ProTrp: 0.648 ± 0.006	1.443ProTyr: 1.443 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	2.266GlnAla: 2.266 ± 0.013	0.558GlnCys: 0.558 ± 0.006	1.759GlnAsp: 1.759 ± 0.011	2.502GlnGlu: 2.502 ± 0.014	1.479GlnPhe: 1.479 ± 0.01	2.016GlnGly: 2.016 ± 0.012	1.058GlnHis: 1.058 ± 0.009	2.208GlnIle: 2.208 ± 0.011	2.533GlnLys: 2.533 ± 0.016	3.674GlnLeu: 3.674 ± 0.016	1.038GlnMet: 1.038 ± 0.007	1.913GlnAsn: 1.913 ± 0.011	1.875GlnPro: 1.875 ± 0.012	2.065GlnGln: 2.065 ± 0.021	2.017GlnArg: 2.017 ± 0.01	2.751GlnSer: 2.751 ± 0.014	2.035GlnThr: 2.035 ± 0.011	2.349GlnVal: 2.349 ± 0.012	0.504GlnTrp: 0.504 ± 0.005	0.9GlnTyr: 0.9 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	2.89ArgAla: 2.89 ± 0.012	1.022ArgCys: 1.022 ± 0.008	2.571ArgAsp: 2.571 ± 0.014	2.955ArgGlu: 2.955 ± 0.014	2.479ArgPhe: 2.479 ± 0.013	3.097ArgGly: 3.097 ± 0.017	1.345ArgHis: 1.345 ± 0.008	3.0ArgIle: 3.0 ± 0.013	3.78ArgLys: 3.78 ± 0.018	5.108ArgLeu: 5.108 ± 0.021	1.347ArgMet: 1.347 ± 0.009	2.436ArgAsn: 2.436 ± 0.012	2.232ArgPro: 2.232 ± 0.012	1.849ArgGln: 1.849 ± 0.012	3.913ArgArg: 3.913 ± 0.019	4.282ArgSer: 4.282 ± 0.017	2.514ArgThr: 2.514 ± 0.011	3.268ArgVal: 3.268 ± 0.013	0.894ArgTrp: 0.894 ± 0.008	1.677ArgTyr: 1.677 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	4.398SerAla: 4.398 ± 0.018	1.605SerCys: 1.605 ± 0.009	4.335SerAsp: 4.335 ± 0.02	4.276SerGlu: 4.276 ± 0.02	3.866SerPhe: 3.866 ± 0.018	5.481SerGly: 5.481 ± 0.021	1.978SerHis: 1.978 ± 0.011	4.592SerIle: 4.592 ± 0.016	5.07SerLys: 5.07 ± 0.018	7.724SerLeu: 7.724 ± 0.028	2.082SerMet: 2.082 ± 0.011	4.167SerAsn: 4.167 ± 0.019	4.188SerPro: 4.188 ± 0.023	2.952SerGln: 2.952 ± 0.015	4.414SerArg: 4.414 ± 0.017	9.705SerSer: 9.705 ± 0.041	4.682SerThr: 4.682 ± 0.018	4.783SerVal: 4.783 ± 0.019	1.19SerTrp: 1.19 ± 0.009	2.46SerTyr: 2.46 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.212ThrAla: 3.212 ± 0.016	1.028ThrCys: 1.028 ± 0.007	2.513ThrAsp: 2.513 ± 0.013	2.803ThrGlu: 2.803 ± 0.011	2.132ThrPhe: 2.132 ± 0.012	3.322ThrGly: 3.322 ± 0.015	1.31ThrHis: 1.31 ± 0.009	3.112ThrIle: 3.112 ± 0.013	3.147ThrLys: 3.147 ± 0.015	4.687ThrLeu: 4.687 ± 0.018	1.268ThrMet: 1.268 ± 0.01	2.503ThrAsn: 2.503 ± 0.014	2.865ThrPro: 2.865 ± 0.015	1.777ThrGln: 1.777 ± 0.011	2.674ThrArg: 2.674 ± 0.013	4.77ThrSer: 4.77 ± 0.017	3.582ThrThr: 3.582 ± 0.02	3.266ThrVal: 3.266 ± 0.015	0.76ThrTrp: 0.76 ± 0.007	1.434ThrTyr: 1.434 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.563ValAla: 4.563 ± 0.019	1.198ValCys: 1.198 ± 0.009	3.909ValAsp: 3.909 ± 0.016	4.278ValGlu: 4.278 ± 0.015	2.923ValPhe: 2.923 ± 0.014	4.097ValGly: 4.097 ± 0.018	1.54ValHis: 1.54 ± 0.008	3.654ValIle: 3.654 ± 0.015	4.232ValLys: 4.232 ± 0.018	5.909ValLeu: 5.909 ± 0.02	1.656ValMet: 1.656 ± 0.009	2.893ValAsn: 2.893 ± 0.012	3.02ValPro: 3.02 ± 0.014	2.229ValGln: 2.229 ± 0.012	2.955ValArg: 2.955 ± 0.014	5.16ValSer: 5.16 ± 0.018	3.325ValThr: 3.325 ± 0.014	5.11ValVal: 5.11 ± 0.022	0.818ValTrp: 0.818 ± 0.007	1.996ValTyr: 1.996 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.795TrpAla: 0.795 ± 0.007	0.255TrpCys: 0.255 ± 0.004	0.751TrpAsp: 0.751 ± 0.006	0.89TrpGlu: 0.89 ± 0.008	0.577TrpPhe: 0.577 ± 0.006	0.788TrpGly: 0.788 ± 0.006	0.317TrpHis: 0.317 ± 0.004	0.772TrpIle: 0.772 ± 0.006	1.096TrpLys: 1.096 ± 0.008	1.283TrpLeu: 1.283 ± 0.008	0.366TrpMet: 0.366 ± 0.004	0.754TrpAsn: 0.754 ± 0.007	0.522TrpPro: 0.522 ± 0.005	0.465TrpGln: 0.465 ± 0.005	0.836TrpArg: 0.836 ± 0.007	1.0TrpSer: 1.0 ± 0.009	0.617TrpThr: 0.617 ± 0.006	1.015TrpVal: 1.015 ± 0.007	0.343TrpTrp: 0.343 ± 0.005	0.372TrpTyr: 0.372 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.9TyrAla: 1.9 ± 0.013	0.612TyrCys: 0.612 ± 0.006	1.619TyrAsp: 1.619 ± 0.01	1.661TyrGlu: 1.661 ± 0.01	1.245TyrPhe: 1.245 ± 0.008	2.163TyrGly: 2.163 ± 0.013	0.951TyrHis: 0.951 ± 0.009	1.563TyrIle: 1.563 ± 0.009	1.668TyrLys: 1.668 ± 0.01	2.74TyrLeu: 2.74 ± 0.013	0.778TyrMet: 0.778 ± 0.006	1.445TyrAsn: 1.445 ± 0.009	1.314TyrPro: 1.314 ± 0.01	1.013TyrGln: 1.013 ± 0.007	1.589TyrArg: 1.589 ± 0.009	2.206TyrSer: 2.206 ± 0.012	1.429TyrThr: 1.429 ± 0.009	1.984TyrVal: 1.984 ± 0.012	0.441TyrTrp: 0.441 ± 0.004	0.965TyrTyr: 0.965 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 45070 proteins (18775044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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