Amino acid dipepetide frequency for Escherichia phage EC6098

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.634AlaAla: 5.634 ± 2.183
1.408AlaCys: 1.408 ± 1.243
5.634AlaAsp: 5.634 ± 2.328
2.113AlaGlu: 2.113 ± 1.4
3.521AlaPhe: 3.521 ± 1.932
5.634AlaGly: 5.634 ± 2.123
3.521AlaHis: 3.521 ± 1.392
3.521AlaIle: 3.521 ± 1.219
7.042AlaLys: 7.042 ± 1.74
7.042AlaLeu: 7.042 ± 1.608
2.113AlaMet: 2.113 ± 1.311
4.225AlaAsn: 4.225 ± 1.742
3.521AlaPro: 3.521 ± 1.739
7.746AlaGln: 7.746 ± 3.504
7.746AlaArg: 7.746 ± 1.984
4.225AlaSer: 4.225 ± 1.604
2.817AlaThr: 2.817 ± 1.116
5.634AlaVal: 5.634 ± 3.186
0.0AlaTrp: 0.0 ± 0.0
4.93AlaTyr: 4.93 ± 2.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.408CysAsp: 1.408 ± 0.829
0.704CysGlu: 0.704 ± 1.082
1.408CysPhe: 1.408 ± 0.576
1.408CysGly: 1.408 ± 1.243
0.0CysHis: 0.0 ± 0.0
1.408CysIle: 1.408 ± 1.243
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.704CysAsn: 0.704 ± 1.082
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.704CysArg: 0.704 ± 0.621
0.0CysSer: 0.0 ± 0.0
0.704CysThr: 0.704 ± 0.621
3.521CysVal: 3.521 ± 2.295
0.704CysTrp: 0.704 ± 0.621
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
9.859AspAla: 9.859 ± 2.089
0.0AspCys: 0.0 ± 0.0
4.225AspAsp: 4.225 ± 1.321
4.93AspGlu: 4.93 ± 2.016
6.338AspPhe: 6.338 ± 2.959
0.704AspGly: 0.704 ± 1.082
1.408AspHis: 1.408 ± 0.576
4.225AspIle: 4.225 ± 1.202
4.225AspLys: 4.225 ± 2.428
3.521AspLeu: 3.521 ± 0.966
0.0AspMet: 0.0 ± 0.0
2.817AspAsn: 2.817 ± 1.241
2.113AspPro: 2.113 ± 0.861
0.704AspGln: 0.704 ± 1.082
0.704AspArg: 0.704 ± 1.082
2.817AspSer: 2.817 ± 1.353
1.408AspThr: 1.408 ± 0.752
3.521AspVal: 3.521 ± 1.022
0.704AspTrp: 0.704 ± 0.621
3.521AspTyr: 3.521 ± 1.198
0.0AspXaa: 0.0 ± 0.0
Glu
4.225GluAla: 4.225 ± 2.269
0.704GluCys: 0.704 ± 0.728
0.704GluAsp: 0.704 ± 1.082
2.817GluGlu: 2.817 ± 1.423
2.113GluPhe: 2.113 ± 0.661
4.225GluGly: 4.225 ± 1.386
1.408GluHis: 1.408 ± 0.576
2.113GluIle: 2.113 ± 1.444
0.704GluLys: 0.704 ± 0.621
0.704GluLeu: 0.704 ± 0.728
0.704GluMet: 0.704 ± 0.728
4.225GluAsn: 4.225 ± 1.722
3.521GluPro: 3.521 ± 2.816
1.408GluGln: 1.408 ± 0.963
4.93GluArg: 4.93 ± 1.627
2.113GluSer: 2.113 ± 0.975
0.704GluThr: 0.704 ± 0.481
2.817GluVal: 2.817 ± 0.898
1.408GluTrp: 1.408 ± 0.752
3.521GluTyr: 3.521 ± 1.384
0.0GluXaa: 0.0 ± 0.0
Phe
0.704PheAla: 0.704 ± 1.082
0.704PheCys: 0.704 ± 1.082
4.93PheAsp: 4.93 ± 2.606
2.113PheGlu: 2.113 ± 1.271
3.521PhePhe: 3.521 ± 1.589
7.042PheGly: 7.042 ± 0.989
1.408PheHis: 1.408 ± 0.752
3.521PheIle: 3.521 ± 1.384
1.408PheLys: 1.408 ± 1.426
2.113PheLeu: 2.113 ± 1.027
4.225PheMet: 4.225 ± 2.164
2.817PheAsn: 2.817 ± 1.153
3.521PhePro: 3.521 ± 1.718
2.113PheGln: 2.113 ± 0.553
2.113PheArg: 2.113 ± 1.298
6.338PheSer: 6.338 ± 1.407
2.817PheThr: 2.817 ± 1.039
1.408PheVal: 1.408 ± 0.963
0.704PheTrp: 0.704 ± 0.621
1.408PheTyr: 1.408 ± 0.752
0.0PheXaa: 0.0 ± 0.0
Gly
4.93GlyAla: 4.93 ± 2.372
2.113GlyCys: 2.113 ± 1.864
4.225GlyAsp: 4.225 ± 1.589
4.225GlyGlu: 4.225 ± 1.569
3.521GlyPhe: 3.521 ± 1.681
8.451GlyGly: 8.451 ± 1.193
1.408GlyHis: 1.408 ± 1.288
5.634GlyIle: 5.634 ± 1.633
2.113GlyLys: 2.113 ± 0.553
7.042GlyLeu: 7.042 ± 2.405
1.408GlyMet: 1.408 ± 0.595
4.225GlyAsn: 4.225 ± 1.589
0.0GlyPro: 0.0 ± 0.0
0.704GlyGln: 0.704 ± 0.621
4.93GlyArg: 4.93 ± 1.413
8.451GlySer: 8.451 ± 2.486
1.408GlyThr: 1.408 ± 0.576
5.634GlyVal: 5.634 ± 3.077
0.704GlyTrp: 0.704 ± 0.621
3.521GlyTyr: 3.521 ± 1.384
0.0GlyXaa: 0.0 ± 0.0
His
1.408HisAla: 1.408 ± 1.288
0.704HisCys: 0.704 ± 0.481
4.225HisAsp: 4.225 ± 2.082
0.704HisGlu: 0.704 ± 0.621
2.817HisPhe: 2.817 ± 0.805
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.408HisLys: 1.408 ± 1.202
2.817HisLeu: 2.817 ± 1.353
0.704HisMet: 0.704 ± 0.621
1.408HisAsn: 1.408 ± 0.576
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.408HisArg: 1.408 ± 1.288
2.817HisSer: 2.817 ± 1.053
0.704HisThr: 0.704 ± 0.728
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.408HisTyr: 1.408 ± 1.243
0.0HisXaa: 0.0 ± 0.0
Ile
3.521IleAla: 3.521 ± 2.012
0.704IleCys: 0.704 ± 0.621
2.113IleAsp: 2.113 ± 1.127
2.817IleGlu: 2.817 ± 0.971
2.113IlePhe: 2.113 ± 1.305
4.93IleGly: 4.93 ± 1.938
1.408IleHis: 1.408 ± 1.277
1.408IleIle: 1.408 ± 0.576
1.408IleLys: 1.408 ± 0.576
1.408IleLeu: 1.408 ± 0.595
1.408IleMet: 1.408 ± 0.595
6.338IleAsn: 6.338 ± 1.598
3.521IlePro: 3.521 ± 1.718
3.521IleGln: 3.521 ± 0.966
4.225IleArg: 4.225 ± 1.735
2.817IleSer: 2.817 ± 1.27
2.113IleThr: 2.113 ± 0.661
2.113IleVal: 2.113 ± 1.432
0.0IleTrp: 0.0 ± 0.0
1.408IleTyr: 1.408 ± 0.963
0.0IleXaa: 0.0 ± 0.0
Lys
5.634LysAla: 5.634 ± 2.114
0.704LysCys: 0.704 ± 0.481
1.408LysAsp: 1.408 ± 0.963
3.521LysGlu: 3.521 ± 0.959
4.225LysPhe: 4.225 ± 1.462
2.113LysGly: 2.113 ± 1.027
0.704LysHis: 0.704 ± 0.621
1.408LysIle: 1.408 ± 0.829
1.408LysLys: 1.408 ± 0.576
5.634LysLeu: 5.634 ± 2.52
0.704LysMet: 0.704 ± 0.728
1.408LysAsn: 1.408 ± 0.595
1.408LysPro: 1.408 ± 0.829
0.704LysGln: 0.704 ± 0.728
4.225LysArg: 4.225 ± 1.928
2.817LysSer: 2.817 ± 1.278
3.521LysThr: 3.521 ± 1.144
3.521LysVal: 3.521 ± 0.927
0.0LysTrp: 0.0 ± 0.0
0.704LysTyr: 0.704 ± 1.066
0.0LysXaa: 0.0 ± 0.0
Leu
7.746LeuAla: 7.746 ± 2.335
0.0LeuCys: 0.0 ± 0.0
3.521LeuAsp: 3.521 ± 1.384
4.225LeuGlu: 4.225 ± 1.729
0.0LeuPhe: 0.0 ± 0.0
6.338LeuGly: 6.338 ± 2.075
2.113LeuHis: 2.113 ± 2.296
6.338LeuIle: 6.338 ± 1.598
3.521LeuLys: 3.521 ± 1.137
3.521LeuLeu: 3.521 ± 0.927
0.704LeuMet: 0.704 ± 1.08
4.225LeuAsn: 4.225 ± 1.105
7.042LeuPro: 7.042 ± 1.169
4.225LeuGln: 4.225 ± 1.105
4.225LeuArg: 4.225 ± 1.386
2.817LeuSer: 2.817 ± 0.604
4.225LeuThr: 4.225 ± 1.549
3.521LeuVal: 3.521 ± 1.326
0.0LeuTrp: 0.0 ± 0.0
0.704LeuTyr: 0.704 ± 0.621
0.0LeuXaa: 0.0 ± 0.0
Met
3.521MetAla: 3.521 ± 2.893
0.0MetCys: 0.0 ± 0.0
2.113MetAsp: 2.113 ± 0.846
0.704MetGlu: 0.704 ± 0.621
2.113MetPhe: 2.113 ± 1.127
1.408MetGly: 1.408 ± 0.595
0.704MetHis: 0.704 ± 0.621
0.0MetIle: 0.0 ± 0.0
2.113MetLys: 2.113 ± 0.661
0.0MetLeu: 0.0 ± 0.0
0.704MetMet: 0.704 ± 0.621
0.704MetAsn: 0.704 ± 0.728
1.408MetPro: 1.408 ± 0.576
2.113MetGln: 2.113 ± 1.734
3.521MetArg: 3.521 ± 1.786
3.521MetSer: 3.521 ± 1.234
0.704MetThr: 0.704 ± 0.728
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
5.634AsnAla: 5.634 ± 1.129
0.704AsnCys: 0.704 ± 0.621
0.0AsnAsp: 0.0 ± 0.0
0.704AsnGlu: 0.704 ± 0.481
2.817AsnPhe: 2.817 ± 1.441
2.817AsnGly: 2.817 ± 0.617
0.0AsnHis: 0.0 ± 0.0
4.225AsnIle: 4.225 ± 2.14
3.521AsnLys: 3.521 ± 1.219
6.338AsnLeu: 6.338 ± 1.823
0.704AsnMet: 0.704 ± 0.676
1.408AsnAsn: 1.408 ± 0.971
4.225AsnPro: 4.225 ± 1.546
3.521AsnGln: 3.521 ± 1.881
2.817AsnArg: 2.817 ± 1.033
4.93AsnSer: 4.93 ± 1.507
0.704AsnThr: 0.704 ± 0.481
0.704AsnVal: 0.704 ± 0.728
1.408AsnTrp: 1.408 ± 0.752
2.113AsnTyr: 2.113 ± 1.179
0.0AsnXaa: 0.0 ± 0.0
Pro
7.746ProAla: 7.746 ± 2.676
0.704ProCys: 0.704 ± 0.621
2.113ProAsp: 2.113 ± 0.661
2.817ProGlu: 2.817 ± 1.688
1.408ProPhe: 1.408 ± 0.963
3.521ProGly: 3.521 ± 1.151
0.704ProHis: 0.704 ± 0.621
0.704ProIle: 0.704 ± 0.676
1.408ProLys: 1.408 ± 1.457
2.817ProLeu: 2.817 ± 1.27
1.408ProMet: 1.408 ± 0.963
2.113ProAsn: 2.113 ± 0.846
4.93ProPro: 4.93 ± 1.145
3.521ProGln: 3.521 ± 2.406
2.113ProArg: 2.113 ± 0.661
5.634ProSer: 5.634 ± 1.611
2.113ProThr: 2.113 ± 1.031
4.93ProVal: 4.93 ± 2.581
1.408ProTrp: 1.408 ± 0.576
1.408ProTyr: 1.408 ± 0.963
0.0ProXaa: 0.0 ± 0.0
Gln
4.93GlnAla: 4.93 ± 2.349
0.704GlnCys: 0.704 ± 0.621
2.817GlnAsp: 2.817 ± 1.092
2.113GlnGlu: 2.113 ± 0.846
1.408GlnPhe: 1.408 ± 0.595
2.113GlnGly: 2.113 ± 1.444
2.113GlnHis: 2.113 ± 1.127
3.521GlnIle: 3.521 ± 0.966
2.113GlnLys: 2.113 ± 1.444
3.521GlnLeu: 3.521 ± 1.392
0.704GlnMet: 0.704 ± 0.621
2.113GlnAsn: 2.113 ± 0.553
0.704GlnPro: 0.704 ± 0.676
7.042GlnGln: 7.042 ± 3.813
6.338GlnArg: 6.338 ± 0.792
2.113GlnSer: 2.113 ± 1.179
2.817GlnThr: 2.817 ± 1.827
1.408GlnVal: 1.408 ± 0.832
0.0GlnTrp: 0.0 ± 0.0
2.817GlnTyr: 2.817 ± 1.278
0.0GlnXaa: 0.0 ± 0.0
Arg
4.93ArgAla: 4.93 ± 1.145
2.113ArgCys: 2.113 ± 1.864
2.817ArgAsp: 2.817 ± 0.805
2.817ArgGlu: 2.817 ± 2.258
3.521ArgPhe: 3.521 ± 0.905
4.225ArgGly: 4.225 ± 1.324
0.704ArgHis: 0.704 ± 0.481
2.113ArgIle: 2.113 ± 1.305
4.93ArgLys: 4.93 ± 1.512
6.338ArgLeu: 6.338 ± 1.386
3.521ArgMet: 3.521 ± 1.633
1.408ArgAsn: 1.408 ± 1.308
4.225ArgPro: 4.225 ± 1.729
3.521ArgGln: 3.521 ± 0.905
4.93ArgArg: 4.93 ± 3.885
9.155ArgSer: 9.155 ± 4.077
4.225ArgThr: 4.225 ± 1.52
3.521ArgVal: 3.521 ± 1.873
0.0ArgTrp: 0.0 ± 0.0
4.93ArgTyr: 4.93 ± 1.5
0.0ArgXaa: 0.0 ± 0.0
Ser
11.972SerAla: 11.972 ± 3.547
0.0SerCys: 0.0 ± 0.0
1.408SerAsp: 1.408 ± 1.288
2.817SerGlu: 2.817 ± 1.635
2.817SerPhe: 2.817 ± 1.018
8.451SerGly: 8.451 ± 1.733
1.408SerHis: 1.408 ± 0.963
1.408SerIle: 1.408 ± 0.832
3.521SerLys: 3.521 ± 1.234
6.338SerLeu: 6.338 ± 0.723
1.408SerMet: 1.408 ± 1.426
4.225SerAsn: 4.225 ± 0.765
3.521SerPro: 3.521 ± 1.271
3.521SerGln: 3.521 ± 1.741
4.93SerArg: 4.93 ± 2.464
7.746SerSer: 7.746 ± 2.097
3.521SerThr: 3.521 ± 1.198
7.746SerVal: 7.746 ± 3.019
0.0SerTrp: 0.0 ± 0.0
1.408SerTyr: 1.408 ± 0.595
0.0SerXaa: 0.0 ± 0.0
Thr
0.704ThrAla: 0.704 ± 1.082
0.0ThrCys: 0.0 ± 0.0
4.93ThrAsp: 4.93 ± 0.672
1.408ThrGlu: 1.408 ± 0.971
2.817ThrPhe: 2.817 ± 1.27
4.93ThrGly: 4.93 ± 0.871
0.704ThrHis: 0.704 ± 1.066
1.408ThrIle: 1.408 ± 0.752
0.704ThrLys: 0.704 ± 0.621
3.521ThrLeu: 3.521 ± 1.64
2.817ThrMet: 2.817 ± 1.911
0.0ThrAsn: 0.0 ± 0.0
2.817ThrPro: 2.817 ± 1.033
1.408ThrGln: 1.408 ± 0.971
4.225ThrArg: 4.225 ± 0.672
2.817ThrSer: 2.817 ± 1.503
2.113ThrThr: 2.113 ± 1.031
1.408ThrVal: 1.408 ± 0.971
0.0ThrTrp: 0.0 ± 0.0
2.113ThrTyr: 2.113 ± 0.861
0.0ThrXaa: 0.0 ± 0.0
Val
2.113ValAla: 2.113 ± 1.305
0.704ValCys: 0.704 ± 1.082
2.817ValAsp: 2.817 ± 1.116
3.521ValGlu: 3.521 ± 1.739
5.634ValPhe: 5.634 ± 1.09
3.521ValGly: 3.521 ± 1.741
1.408ValHis: 1.408 ± 0.829
3.521ValIle: 3.521 ± 1.137
2.817ValLys: 2.817 ± 1.315
4.225ValLeu: 4.225 ± 1.386
0.704ValMet: 0.704 ± 0.621
2.113ValAsn: 2.113 ± 0.553
4.93ValPro: 4.93 ± 2.581
2.113ValGln: 2.113 ± 0.846
3.521ValArg: 3.521 ± 1.003
4.93ValSer: 4.93 ± 1.731
2.817ValThr: 2.817 ± 1.053
2.817ValVal: 2.817 ± 0.617
1.408ValTrp: 1.408 ± 0.963
2.113ValTyr: 2.113 ± 1.991
0.0ValXaa: 0.0 ± 0.0
Trp
0.704TrpAla: 0.704 ± 0.621
0.0TrpCys: 0.0 ± 0.0
0.704TrpAsp: 0.704 ± 0.481
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.704TrpHis: 0.704 ± 0.481
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.704TrpMet: 0.704 ± 0.728
0.704TrpAsn: 0.704 ± 0.728
1.408TrpPro: 1.408 ± 0.963
0.704TrpGln: 0.704 ± 0.481
1.408TrpArg: 1.408 ± 1.243
0.704TrpSer: 0.704 ± 0.621
0.704TrpThr: 0.704 ± 0.621
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.704TrpTyr: 0.704 ± 0.481
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.113TyrAla: 2.113 ± 1.14
0.704TyrCys: 0.704 ± 0.621
5.634TyrAsp: 5.634 ± 2.3
0.0TyrGlu: 0.0 ± 0.0
2.817TyrPhe: 2.817 ± 1.925
2.817TyrGly: 2.817 ± 1.153
0.704TyrHis: 0.704 ± 0.621
2.817TyrIle: 2.817 ± 0.971
1.408TyrLys: 1.408 ± 0.963
2.817TyrLeu: 2.817 ± 1.241
0.0TyrMet: 0.0 ± 0.0
2.113TyrAsn: 2.113 ± 1.031
0.704TyrPro: 0.704 ± 0.481
2.817TyrGln: 2.817 ± 0.617
4.93TyrArg: 4.93 ± 1.344
1.408TyrSer: 1.408 ± 0.576
0.704TyrThr: 0.704 ± 0.481
3.521TyrVal: 3.521 ± 2.641
0.704TyrTrp: 0.704 ± 0.481
2.113TyrTyr: 2.113 ± 1.098
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski