Amino acid dipepetide frequency for Human metapneumovirus (strain CAN97-83) (HMPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.313AlaAla: 5.313 ± 2.025
1.207AlaCys: 1.207 ± 0.538
2.656AlaAsp: 2.656 ± 0.671
5.554AlaGlu: 5.554 ± 1.681
1.207AlaPhe: 1.207 ± 0.45
3.381AlaGly: 3.381 ± 1.544
0.241AlaHis: 0.241 ± 0.152
5.071AlaIle: 5.071 ± 0.994
4.105AlaLys: 4.105 ± 1.302
7.003AlaLeu: 7.003 ± 2.254
1.207AlaMet: 1.207 ± 0.398
1.69AlaAsn: 1.69 ± 0.605
1.449AlaPro: 1.449 ± 0.666
0.724AlaGln: 0.724 ± 0.338
2.898AlaArg: 2.898 ± 1.454
4.105AlaSer: 4.105 ± 1.778
3.139AlaThr: 3.139 ± 0.563
3.864AlaVal: 3.864 ± 1.206
0.241AlaTrp: 0.241 ± 0.398
1.69AlaTyr: 1.69 ± 0.691
0.0AlaXaa: 0.0 ± 0.0
Cys
0.483CysAla: 0.483 ± 0.305
0.483CysCys: 0.483 ± 0.305
1.69CysAsp: 1.69 ± 0.503
0.966CysGlu: 0.966 ± 0.347
0.483CysPhe: 0.483 ± 0.505
0.724CysGly: 0.724 ± 0.319
0.724CysHis: 0.724 ± 0.36
1.449CysIle: 1.449 ± 0.686
1.69CysLys: 1.69 ± 0.833
0.724CysLeu: 0.724 ± 0.295
0.241CysMet: 0.241 ± 0.152
1.207CysAsn: 1.207 ± 0.453
0.241CysPro: 0.241 ± 0.375
1.449CysGln: 1.449 ± 0.48
0.724CysArg: 0.724 ± 0.36
1.69CysSer: 1.69 ± 1.197
0.724CysThr: 0.724 ± 0.68
0.724CysVal: 0.724 ± 0.319
0.724CysTrp: 0.724 ± 0.351
1.207CysTyr: 1.207 ± 0.698
0.0CysXaa: 0.0 ± 0.0
Asp
2.898AspAla: 2.898 ± 0.893
0.483AspCys: 0.483 ± 0.222
1.932AspAsp: 1.932 ± 0.358
2.173AspGlu: 2.173 ± 0.557
2.173AspPhe: 2.173 ± 0.768
1.69AspGly: 1.69 ± 1.092
1.207AspHis: 1.207 ± 0.637
4.105AspIle: 4.105 ± 0.908
2.415AspLys: 2.415 ± 0.545
5.796AspLeu: 5.796 ± 1.135
0.966AspMet: 0.966 ± 0.401
3.622AspAsn: 3.622 ± 0.992
1.449AspPro: 1.449 ± 0.457
2.656AspGln: 2.656 ± 1.138
2.173AspArg: 2.173 ± 0.885
3.622AspSer: 3.622 ± 1.333
3.139AspThr: 3.139 ± 0.82
2.415AspVal: 2.415 ± 0.695
0.724AspTrp: 0.724 ± 0.457
1.69AspTyr: 1.69 ± 0.696
0.0AspXaa: 0.0 ± 0.0
Glu
4.347GluAla: 4.347 ± 2.028
0.966GluCys: 0.966 ± 0.454
2.898GluAsp: 2.898 ± 1.301
6.037GluGlu: 6.037 ± 5.232
2.173GluPhe: 2.173 ± 0.88
3.139GluGly: 3.139 ± 1.204
1.69GluHis: 1.69 ± 0.527
4.347GluIle: 4.347 ± 1.575
4.588GluLys: 4.588 ± 2.111
6.52GluLeu: 6.52 ± 1.07
1.69GluMet: 1.69 ± 1.24
4.83GluAsn: 4.83 ± 1.066
1.207GluPro: 1.207 ± 0.738
2.898GluGln: 2.898 ± 0.917
1.932GluArg: 1.932 ± 0.637
7.486GluSer: 7.486 ± 2.272
3.864GluThr: 3.864 ± 1.083
4.105GluVal: 4.105 ± 1.33
0.241GluTrp: 0.241 ± 0.366
1.69GluTyr: 1.69 ± 0.581
0.0GluXaa: 0.0 ± 0.0
Phe
0.724PheAla: 0.724 ± 0.319
0.724PheCys: 0.724 ± 0.295
0.966PheAsp: 0.966 ± 0.347
2.415PheGlu: 2.415 ± 0.429
1.932PhePhe: 1.932 ± 0.964
1.207PheGly: 1.207 ± 0.5
0.483PheHis: 0.483 ± 0.305
3.864PheIle: 3.864 ± 0.941
3.139PheLys: 3.139 ± 1.155
2.656PheLeu: 2.656 ± 0.828
1.207PheMet: 1.207 ± 0.457
1.69PheAsn: 1.69 ± 0.617
1.449PhePro: 1.449 ± 0.392
0.966PheGln: 0.966 ± 0.418
1.449PheArg: 1.449 ± 0.708
3.622PheSer: 3.622 ± 1.049
1.449PheThr: 1.449 ± 0.933
2.173PheVal: 2.173 ± 0.479
0.483PheTrp: 0.483 ± 0.305
0.966PheTyr: 0.966 ± 0.39
0.0PheXaa: 0.0 ± 0.0
Gly
3.139GlyAla: 3.139 ± 1.4
0.724GlyCys: 0.724 ± 0.295
1.932GlyAsp: 1.932 ± 0.828
3.381GlyGlu: 3.381 ± 0.817
1.932GlyPhe: 1.932 ± 0.79
1.207GlyGly: 1.207 ± 0.535
0.966GlyHis: 0.966 ± 0.39
4.588GlyIle: 4.588 ± 1.161
5.071GlyLys: 5.071 ± 1.097
4.588GlyLeu: 4.588 ± 1.255
0.724GlyMet: 0.724 ± 0.394
2.656GlyAsn: 2.656 ± 0.858
1.69GlyPro: 1.69 ± 0.659
0.966GlyGln: 0.966 ± 0.3
1.69GlyArg: 1.69 ± 0.487
5.554GlySer: 5.554 ± 0.965
1.69GlyThr: 1.69 ± 0.616
2.898GlyVal: 2.898 ± 1.565
0.724GlyTrp: 0.724 ± 0.436
0.966GlyTyr: 0.966 ± 0.39
0.0GlyXaa: 0.0 ± 0.0
His
1.69HisAla: 1.69 ± 0.696
0.241HisCys: 0.241 ± 0.366
0.483HisAsp: 0.483 ± 0.511
0.966HisGlu: 0.966 ± 0.436
0.483HisPhe: 0.483 ± 0.313
1.69HisGly: 1.69 ± 0.455
0.966HisHis: 0.966 ± 0.435
0.724HisIle: 0.724 ± 0.457
0.724HisLys: 0.724 ± 0.36
1.207HisLeu: 1.207 ± 0.734
0.483HisMet: 0.483 ± 0.399
0.966HisAsn: 0.966 ± 0.898
1.207HisPro: 1.207 ± 0.412
0.241HisGln: 0.241 ± 0.303
0.483HisArg: 0.483 ± 0.305
1.449HisSer: 1.449 ± 0.627
0.966HisThr: 0.966 ± 0.936
1.932HisVal: 1.932 ± 0.49
0.483HisTrp: 0.483 ± 0.305
0.483HisTyr: 0.483 ± 0.305
0.0HisXaa: 0.0 ± 0.0
Ile
3.381IleAla: 3.381 ± 1.2
1.932IleCys: 1.932 ± 0.799
4.83IleAsp: 4.83 ± 1.112
5.554IleGlu: 5.554 ± 1.06
2.656IlePhe: 2.656 ± 0.65
3.864IleGly: 3.864 ± 0.877
0.966IleHis: 0.966 ± 0.626
5.796IleIle: 5.796 ± 1.414
8.935IleLys: 8.935 ± 1.199
8.211IleLeu: 8.211 ± 0.893
2.656IleMet: 2.656 ± 0.75
4.347IleAsn: 4.347 ± 1.11
2.656IlePro: 2.656 ± 0.681
1.69IleGln: 1.69 ± 0.506
2.173IleArg: 2.173 ± 0.859
6.279IleSer: 6.279 ± 1.257
5.554IleThr: 5.554 ± 1.668
3.622IleVal: 3.622 ± 0.992
0.966IleTrp: 0.966 ± 0.505
1.932IleTyr: 1.932 ± 1.092
0.0IleXaa: 0.0 ± 0.0
Lys
4.347LysAla: 4.347 ± 1.453
1.449LysCys: 1.449 ± 0.79
4.105LysAsp: 4.105 ± 1.007
5.071LysGlu: 5.071 ± 1.862
2.656LysPhe: 2.656 ± 0.779
4.347LysGly: 4.347 ± 1.052
0.966LysHis: 0.966 ± 0.713
5.313LysIle: 5.313 ± 1.282
4.83LysLys: 4.83 ± 1.126
9.66LysLeu: 9.66 ± 2.438
1.932LysMet: 1.932 ± 0.97
5.554LysAsn: 5.554 ± 1.75
2.415LysPro: 2.415 ± 1.321
2.656LysGln: 2.656 ± 0.572
3.622LysArg: 3.622 ± 0.723
5.071LysSer: 5.071 ± 1.13
7.003LysThr: 7.003 ± 1.516
6.037LysVal: 6.037 ± 0.724
0.241LysTrp: 0.241 ± 0.152
1.207LysTyr: 1.207 ± 0.468
0.0LysXaa: 0.0 ± 0.0
Leu
3.622LeuAla: 3.622 ± 0.704
2.656LeuCys: 2.656 ± 0.873
4.105LeuAsp: 4.105 ± 0.659
6.52LeuGlu: 6.52 ± 1.221
2.656LeuPhe: 2.656 ± 1.196
6.037LeuGly: 6.037 ± 1.992
1.932LeuHis: 1.932 ± 0.706
8.211LeuIle: 8.211 ± 1.346
9.901LeuLys: 9.901 ± 0.668
9.177LeuLeu: 9.177 ± 1.597
1.449LeuMet: 1.449 ± 0.591
5.796LeuAsn: 5.796 ± 1.47
3.139LeuPro: 3.139 ± 0.861
3.139LeuGln: 3.139 ± 0.936
6.037LeuArg: 6.037 ± 1.238
10.867LeuSer: 10.867 ± 1.419
8.694LeuThr: 8.694 ± 1.89
3.622LeuVal: 3.622 ± 0.954
0.724LeuTrp: 0.724 ± 0.457
2.656LeuTyr: 2.656 ± 1.123
0.0LeuXaa: 0.0 ± 0.0
Met
0.966MetAla: 0.966 ± 0.3
0.241MetCys: 0.241 ± 0.152
1.69MetAsp: 1.69 ± 0.422
2.173MetGlu: 2.173 ± 0.56
0.724MetPhe: 0.724 ± 0.457
0.724MetGly: 0.724 ± 0.477
0.483MetHis: 0.483 ± 0.305
2.656MetIle: 2.656 ± 0.774
1.207MetLys: 1.207 ± 0.593
3.381MetLeu: 3.381 ± 0.991
0.483MetMet: 0.483 ± 0.722
0.724MetAsn: 0.724 ± 0.44
0.966MetPro: 0.966 ± 0.405
1.449MetGln: 1.449 ± 0.462
0.483MetArg: 0.483 ± 0.305
2.415MetSer: 2.415 ± 0.687
1.207MetThr: 1.207 ± 0.494
1.932MetVal: 1.932 ± 0.694
0.0MetTrp: 0.0 ± 0.0
0.724MetTyr: 0.724 ± 0.319
0.0MetXaa: 0.0 ± 0.0
Asn
3.864AsnAla: 3.864 ± 0.863
0.724AsnCys: 0.724 ± 0.553
1.932AsnAsp: 1.932 ± 0.699
3.381AsnGlu: 3.381 ± 1.128
1.449AsnPhe: 1.449 ± 0.638
1.69AsnGly: 1.69 ± 0.497
0.724AsnHis: 0.724 ± 0.364
5.071AsnIle: 5.071 ± 1.174
5.313AsnLys: 5.313 ± 0.889
4.105AsnLeu: 4.105 ± 1.443
1.69AsnMet: 1.69 ± 0.635
3.622AsnAsn: 3.622 ± 0.363
2.415AsnPro: 2.415 ± 1.537
3.381AsnGln: 3.381 ± 0.9
3.139AsnArg: 3.139 ± 0.926
2.173AsnSer: 2.173 ± 0.468
3.381AsnThr: 3.381 ± 0.757
2.173AsnVal: 2.173 ± 0.885
0.966AsnTrp: 0.966 ± 0.609
4.105AsnTyr: 4.105 ± 1.243
0.0AsnXaa: 0.0 ± 0.0
Pro
2.415ProAla: 2.415 ± 1.052
1.207ProCys: 1.207 ± 0.698
1.932ProAsp: 1.932 ± 0.542
2.173ProGlu: 2.173 ± 0.384
0.724ProPhe: 0.724 ± 0.457
0.724ProGly: 0.724 ± 0.36
0.483ProHis: 0.483 ± 0.222
2.656ProIle: 2.656 ± 0.475
3.381ProLys: 3.381 ± 0.888
1.449ProLeu: 1.449 ± 0.529
1.449ProMet: 1.449 ± 0.914
1.69ProAsn: 1.69 ± 0.741
1.932ProPro: 1.932 ± 0.575
1.207ProGln: 1.207 ± 0.364
1.207ProArg: 1.207 ± 0.529
3.381ProSer: 3.381 ± 1.586
3.381ProThr: 3.381 ± 2.001
2.656ProVal: 2.656 ± 0.91
0.966ProTrp: 0.966 ± 0.609
0.966ProTyr: 0.966 ± 0.874
0.0ProXaa: 0.0 ± 0.0
Gln
3.139GlnAla: 3.139 ± 1.139
0.483GlnCys: 0.483 ± 0.329
0.966GlnAsp: 0.966 ± 0.659
2.173GlnGlu: 2.173 ± 0.676
2.173GlnPhe: 2.173 ± 0.886
2.415GlnGly: 2.415 ± 0.836
1.69GlnHis: 1.69 ± 0.577
1.932GlnIle: 1.932 ± 0.43
1.932GlnLys: 1.932 ± 0.55
5.313GlnLeu: 5.313 ± 1.586
0.724GlnMet: 0.724 ± 0.392
1.69GlnAsn: 1.69 ± 0.795
0.483GlnPro: 0.483 ± 0.255
0.966GlnGln: 0.966 ± 0.724
2.656GlnArg: 2.656 ± 0.795
4.105GlnSer: 4.105 ± 0.812
0.483GlnThr: 0.483 ± 0.576
1.69GlnVal: 1.69 ± 0.934
0.0GlnTrp: 0.0 ± 0.0
0.724GlnTyr: 0.724 ± 0.898
0.0GlnXaa: 0.0 ± 0.0
Arg
2.656ArgAla: 2.656 ± 1.012
0.483ArgCys: 0.483 ± 0.305
2.415ArgAsp: 2.415 ± 0.998
3.381ArgGlu: 3.381 ± 0.887
1.69ArgPhe: 1.69 ± 0.703
1.932ArgGly: 1.932 ± 0.602
0.483ArgHis: 0.483 ± 0.222
2.898ArgIle: 2.898 ± 1.586
1.449ArgLys: 1.449 ± 0.477
4.105ArgLeu: 4.105 ± 1.079
1.207ArgMet: 1.207 ± 0.383
2.656ArgAsn: 2.656 ± 0.726
1.449ArgPro: 1.449 ± 0.467
2.173ArgGln: 2.173 ± 0.537
2.415ArgArg: 2.415 ± 0.599
3.622ArgSer: 3.622 ± 0.856
3.381ArgThr: 3.381 ± 0.655
3.622ArgVal: 3.622 ± 0.806
0.966ArgTrp: 0.966 ± 0.39
1.932ArgTyr: 1.932 ± 0.48
0.0ArgXaa: 0.0 ± 0.0
Ser
4.347SerAla: 4.347 ± 1.022
1.932SerCys: 1.932 ± 0.645
4.588SerAsp: 4.588 ± 1.177
5.796SerGlu: 5.796 ± 1.277
2.415SerPhe: 2.415 ± 0.592
3.622SerGly: 3.622 ± 1.197
1.207SerHis: 1.207 ± 0.595
7.003SerIle: 7.003 ± 1.564
7.486SerLys: 7.486 ± 1.581
9.418SerLeu: 9.418 ± 1.905
1.69SerMet: 1.69 ± 0.687
3.864SerAsn: 3.864 ± 0.639
3.622SerPro: 3.622 ± 1.002
2.173SerGln: 2.173 ± 0.815
3.139SerArg: 3.139 ± 0.572
7.969SerSer: 7.969 ± 2.441
7.245SerThr: 7.245 ± 2.679
6.037SerVal: 6.037 ± 0.997
1.449SerTrp: 1.449 ± 0.369
2.898SerTyr: 2.898 ± 0.724
0.0SerXaa: 0.0 ± 0.0
Thr
3.864ThrAla: 3.864 ± 1.287
1.207ThrCys: 1.207 ± 0.637
3.381ThrAsp: 3.381 ± 0.566
3.622ThrGlu: 3.622 ± 1.47
1.69ThrPhe: 1.69 ± 0.531
2.898ThrGly: 2.898 ± 0.897
0.724ThrHis: 0.724 ± 0.456
5.313ThrIle: 5.313 ± 2.418
4.588ThrLys: 4.588 ± 1.428
6.279ThrLeu: 6.279 ± 0.758
1.932ThrMet: 1.932 ± 0.727
3.864ThrAsn: 3.864 ± 1.037
3.864ThrPro: 3.864 ± 0.892
3.381ThrGln: 3.381 ± 1.071
3.139ThrArg: 3.139 ± 0.729
5.071ThrSer: 5.071 ± 1.517
6.762ThrThr: 6.762 ± 2.533
4.347ThrVal: 4.347 ± 1.349
0.483ThrTrp: 0.483 ± 0.295
1.69ThrTyr: 1.69 ± 0.502
0.0ThrXaa: 0.0 ± 0.0
Val
3.139ValAla: 3.139 ± 1.362
0.483ValCys: 0.483 ± 0.295
3.139ValAsp: 3.139 ± 0.937
3.864ValGlu: 3.864 ± 1.246
2.415ValPhe: 2.415 ± 0.793
3.381ValGly: 3.381 ± 0.838
0.724ValHis: 0.724 ± 0.323
4.105ValIle: 4.105 ± 0.958
4.83ValLys: 4.83 ± 1.208
5.796ValLeu: 5.796 ± 0.732
0.966ValMet: 0.966 ± 0.429
2.898ValAsn: 2.898 ± 0.854
1.449ValPro: 1.449 ± 0.626
2.415ValGln: 2.415 ± 1.368
2.656ValArg: 2.656 ± 1.13
7.728ValSer: 7.728 ± 1.467
3.139ValThr: 3.139 ± 0.802
3.622ValVal: 3.622 ± 0.988
0.0ValTrp: 0.0 ± 0.0
2.898ValTyr: 2.898 ± 0.651
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.483TrpCys: 0.483 ± 0.305
0.241TrpAsp: 0.241 ± 0.152
0.0TrpGlu: 0.0 ± 0.0
0.724TrpPhe: 0.724 ± 0.359
0.724TrpGly: 0.724 ± 0.319
0.0TrpHis: 0.0 ± 0.0
0.724TrpIle: 0.724 ± 0.295
0.966TrpLys: 0.966 ± 0.682
1.207TrpLeu: 1.207 ± 0.761
0.483TrpMet: 0.483 ± 0.305
0.241TrpAsn: 0.241 ± 0.152
0.483TrpPro: 0.483 ± 0.3
0.241TrpGln: 0.241 ± 0.152
0.483TrpArg: 0.483 ± 0.305
0.724TrpSer: 0.724 ± 0.42
0.966TrpThr: 0.966 ± 0.511
1.207TrpVal: 1.207 ± 0.498
0.0TrpTrp: 0.0 ± 0.0
0.724TrpTyr: 0.724 ± 0.436
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.415TyrAla: 2.415 ± 1.019
0.241TyrCys: 0.241 ± 0.24
1.449TyrAsp: 1.449 ± 0.638
1.449TyrGlu: 1.449 ± 0.466
1.207TyrPhe: 1.207 ± 0.557
1.69TyrGly: 1.69 ± 0.565
1.207TyrHis: 1.207 ± 0.673
2.173TyrIle: 2.173 ± 0.416
1.932TyrLys: 1.932 ± 0.603
4.347TyrLeu: 4.347 ± 1.178
1.449TyrMet: 1.449 ± 0.553
1.69TyrAsn: 1.69 ± 0.827
2.415TyrPro: 2.415 ± 0.77
0.966TyrGln: 0.966 ± 0.457
2.415TyrArg: 2.415 ± 0.997
0.966TyrSer: 0.966 ± 0.487
1.932TyrThr: 1.932 ± 1.069
0.966TyrVal: 0.966 ± 0.751
0.241TyrTrp: 0.241 ± 0.312
0.966TyrTyr: 0.966 ± 0.3
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski