Amino acid dipepetide frequency for Rhodohalobacter barkolensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.09AlaAla: 5.09 ± 0.093	0.45AlaCys: 0.45 ± 0.021	4.206AlaAsp: 4.206 ± 0.074	5.237AlaGlu: 5.237 ± 0.077	3.007AlaPhe: 3.007 ± 0.057	5.36AlaGly: 5.36 ± 0.096	1.185AlaHis: 1.185 ± 0.036	4.876AlaIle: 4.876 ± 0.087	3.246AlaLys: 3.246 ± 0.06	6.135AlaLeu: 6.135 ± 0.075	1.689AlaMet: 1.689 ± 0.042	2.745AlaAsn: 2.745 ± 0.057	2.059AlaPro: 2.059 ± 0.049	2.36AlaGln: 2.36 ± 0.053	2.833AlaArg: 2.833 ± 0.059	4.107AlaSer: 4.107 ± 0.07	3.309AlaThr: 3.309 ± 0.074	4.731AlaVal: 4.731 ± 0.079	0.811AlaTrp: 0.811 ± 0.029	2.209AlaTyr: 2.209 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.353CysAla: 0.353 ± 0.022	0.075CysCys: 0.075 ± 0.009	0.368CysAsp: 0.368 ± 0.021	0.387CysGlu: 0.387 ± 0.023	0.24CysPhe: 0.24 ± 0.016	0.539CysGly: 0.539 ± 0.023	0.151CysHis: 0.151 ± 0.013	0.377CysIle: 0.377 ± 0.019	0.316CysLys: 0.316 ± 0.017	0.428CysLeu: 0.428 ± 0.022	0.13CysMet: 0.13 ± 0.011	0.254CysAsn: 0.254 ± 0.017	0.28CysPro: 0.28 ± 0.018	0.128CysGln: 0.128 ± 0.012	0.278CysArg: 0.278 ± 0.017	0.505CysSer: 0.505 ± 0.022	0.363CysThr: 0.363 ± 0.018	0.353CysVal: 0.353 ± 0.019	0.058CysTrp: 0.058 ± 0.008	0.176CysTyr: 0.176 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.697AspAla: 3.697 ± 0.065	0.256AspCys: 0.256 ± 0.018	3.943AspAsp: 3.943 ± 0.074	5.457AspGlu: 5.457 ± 0.077	3.195AspPhe: 3.195 ± 0.06	4.386AspGly: 4.386 ± 0.088	1.388AspHis: 1.388 ± 0.042	4.173AspIle: 4.173 ± 0.069	3.032AspLys: 3.032 ± 0.069	6.143AspLeu: 6.143 ± 0.098	1.398AspMet: 1.398 ± 0.036	2.472AspAsn: 2.472 ± 0.048	2.732AspPro: 2.732 ± 0.055	2.812AspGln: 2.812 ± 0.061	3.316AspArg: 3.316 ± 0.06	3.837AspSer: 3.837 ± 0.067	2.614AspThr: 2.614 ± 0.058	4.117AspVal: 4.117 ± 0.068	0.912AspTrp: 0.912 ± 0.032	2.426AspTyr: 2.426 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.969GluAla: 4.969 ± 0.079	0.335GluCys: 0.335 ± 0.02	4.296GluAsp: 4.296 ± 0.073	6.724GluGlu: 6.724 ± 0.124	3.438GluPhe: 3.438 ± 0.054	4.465GluGly: 4.465 ± 0.073	1.373GluHis: 1.373 ± 0.038	5.905GluIle: 5.905 ± 0.074	5.317GluLys: 5.317 ± 0.101	7.388GluLeu: 7.388 ± 0.085	2.254GluMet: 2.254 ± 0.053	4.411GluAsn: 4.411 ± 0.062	2.474GluPro: 2.474 ± 0.055	3.048GluGln: 3.048 ± 0.065	3.755GluArg: 3.755 ± 0.064	4.912GluSer: 4.912 ± 0.074	3.887GluThr: 3.887 ± 0.064	4.767GluVal: 4.767 ± 0.074	0.97GluTrp: 0.97 ± 0.032	2.563GluTyr: 2.563 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.948PheAla: 2.948 ± 0.055	0.3PheCys: 0.3 ± 0.02	3.406PheAsp: 3.406 ± 0.065	3.778PheGlu: 3.778 ± 0.065	2.32PhePhe: 2.32 ± 0.056	3.606PheGly: 3.606 ± 0.072	0.832PheHis: 0.832 ± 0.031	3.29PheIle: 3.29 ± 0.056	2.393PheLys: 2.393 ± 0.054	4.291PheLeu: 4.291 ± 0.081	1.109PheMet: 1.109 ± 0.034	2.492PheAsn: 2.492 ± 0.057	1.653PhePro: 1.653 ± 0.046	1.523PheGln: 1.523 ± 0.037	2.18PheArg: 2.18 ± 0.048	3.854PheSer: 3.854 ± 0.063	2.963PheThr: 2.963 ± 0.067	2.823PheVal: 2.823 ± 0.058	0.654PheTrp: 0.654 ± 0.027	1.709PheTyr: 1.709 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.448GlyAla: 4.448 ± 0.072	0.509GlyCys: 0.509 ± 0.023	4.078GlyAsp: 4.078 ± 0.076	4.898GlyGlu: 4.898 ± 0.08	3.583GlyPhe: 3.583 ± 0.073	5.084GlyGly: 5.084 ± 0.108	1.292GlyHis: 1.292 ± 0.04	5.233GlyIle: 5.233 ± 0.083	3.785GlyLys: 3.785 ± 0.067	6.415GlyLeu: 6.415 ± 0.093	1.968GlyMet: 1.968 ± 0.052	3.276GlyAsn: 3.276 ± 0.08	1.801GlyPro: 1.801 ± 0.045	2.116GlyGln: 2.116 ± 0.055	2.983GlyArg: 2.983 ± 0.059	4.871GlySer: 4.871 ± 0.092	4.025GlyThr: 4.025 ± 0.083	4.934GlyVal: 4.934 ± 0.071	1.01GlyTrp: 1.01 ± 0.032	2.892GlyTyr: 2.892 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.198HisAla: 1.198 ± 0.033	0.152HisCys: 0.152 ± 0.013	1.044HisAsp: 1.044 ± 0.035	1.204HisGlu: 1.204 ± 0.034	1.094HisPhe: 1.094 ± 0.032	1.299HisGly: 1.299 ± 0.039	0.552HisHis: 0.552 ± 0.023	1.332HisIle: 1.332 ± 0.037	0.931HisLys: 0.931 ± 0.027	1.86HisLeu: 1.86 ± 0.047	0.371HisMet: 0.371 ± 0.02	0.78HisAsn: 0.78 ± 0.028	1.166HisPro: 1.166 ± 0.035	0.773HisGln: 0.773 ± 0.028	0.986HisArg: 0.986 ± 0.031	1.31HisSer: 1.31 ± 0.036	1.036HisThr: 1.036 ± 0.031	1.061HisVal: 1.061 ± 0.034	0.259HisTrp: 0.259 ± 0.016	0.808HisTyr: 0.808 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.089IleAla: 5.089 ± 0.076	0.475IleCys: 0.475 ± 0.02	4.64IleAsp: 4.64 ± 0.071	5.634IleGlu: 5.634 ± 0.08	3.273IlePhe: 3.273 ± 0.073	4.968IleGly: 4.968 ± 0.081	1.497IleHis: 1.497 ± 0.042	4.789IleIle: 4.789 ± 0.084	3.547IleLys: 3.547 ± 0.068	6.515IleLeu: 6.515 ± 0.113	1.376IleMet: 1.376 ± 0.034	3.321IleAsn: 3.321 ± 0.06	3.277IlePro: 3.277 ± 0.054	2.821IleGln: 2.821 ± 0.061	3.559IleArg: 3.559 ± 0.057	5.409IleSer: 5.409 ± 0.07	4.355IleThr: 4.355 ± 0.089	4.298IleVal: 4.298 ± 0.079	0.763IleTrp: 0.763 ± 0.038	2.449IleTyr: 2.449 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	3.669LysAla: 3.669 ± 0.059	0.254LysCys: 0.254 ± 0.018	2.949LysAsp: 2.949 ± 0.061	4.821LysGlu: 4.821 ± 0.098	1.904LysPhe: 1.904 ± 0.044	3.226LysGly: 3.226 ± 0.073	1.076LysHis: 1.076 ± 0.033	3.933LysIle: 3.933 ± 0.066	4.659LysLys: 4.659 ± 0.101	5.012LysLeu: 5.012 ± 0.081	1.628LysMet: 1.628 ± 0.04	3.005LysAsn: 3.005 ± 0.062	2.236LysPro: 2.236 ± 0.056	1.93LysGln: 1.93 ± 0.052	2.764LysArg: 2.764 ± 0.061	3.832LysSer: 3.832 ± 0.077	2.971LysThr: 2.971 ± 0.06	3.37LysVal: 3.37 ± 0.065	0.671LysTrp: 0.671 ± 0.025	1.952LysTyr: 1.952 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	6.162LeuAla: 6.162 ± 0.092	0.505LeuCys: 0.505 ± 0.022	5.601LeuAsp: 5.601 ± 0.089	6.473LeuGlu: 6.473 ± 0.084	5.039LeuPhe: 5.039 ± 0.085	5.83LeuGly: 5.83 ± 0.091	1.726LeuHis: 1.726 ± 0.038	6.91LeuIle: 6.91 ± 0.095	5.874LeuLys: 5.874 ± 0.099	8.742LeuLeu: 8.742 ± 0.154	2.344LeuMet: 2.344 ± 0.046	5.196LeuAsn: 5.196 ± 0.071	3.947LeuPro: 3.947 ± 0.061	3.374LeuGln: 3.374 ± 0.059	4.091LeuArg: 4.091 ± 0.073	6.942LeuSer: 6.942 ± 0.087	5.279LeuThr: 5.279 ± 0.072	5.207LeuVal: 5.207 ± 0.086	0.859LeuTrp: 0.859 ± 0.029	2.912LeuTyr: 2.912 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.046	0.102MetCys: 0.102 ± 0.01	1.566MetAsp: 1.566 ± 0.037	1.814MetGlu: 1.814 ± 0.047	0.956MetPhe: 0.956 ± 0.04	1.741MetGly: 1.741 ± 0.045	0.444MetHis: 0.444 ± 0.02	1.863MetIle: 1.863 ± 0.045	1.836MetLys: 1.836 ± 0.046	2.139MetLeu: 2.139 ± 0.044	0.76MetMet: 0.76 ± 0.028	1.533MetAsn: 1.533 ± 0.042	0.995MetPro: 0.995 ± 0.033	0.896MetGln: 0.896 ± 0.031	1.032MetArg: 1.032 ± 0.035	1.68MetSer: 1.68 ± 0.041	1.25MetThr: 1.25 ± 0.038	1.516MetVal: 1.516 ± 0.045	0.198MetTrp: 0.198 ± 0.013	0.628MetTyr: 0.628 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.809AsnAla: 2.809 ± 0.05	0.303AsnCys: 0.303 ± 0.018	2.466AsnAsp: 2.466 ± 0.057	3.442AsnGlu: 3.442 ± 0.063	2.178AsnPhe: 2.178 ± 0.05	3.484AsnGly: 3.484 ± 0.063	1.039AsnHis: 1.039 ± 0.032	3.47AsnIle: 3.47 ± 0.066	2.191AsnLys: 2.191 ± 0.05	4.742AsnLeu: 4.742 ± 0.075	1.292AsnMet: 1.292 ± 0.037	2.272AsnAsn: 2.272 ± 0.06	2.775AsnPro: 2.775 ± 0.063	2.102AsnGln: 2.102 ± 0.051	3.071AsnArg: 3.071 ± 0.061	3.487AsnSer: 3.487 ± 0.086	2.445AsnThr: 2.445 ± 0.048	3.039AsnVal: 3.039 ± 0.057	0.679AsnTrp: 0.679 ± 0.031	1.903AsnTyr: 1.903 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.547ProAla: 2.547 ± 0.052	0.17ProCys: 0.17 ± 0.013	3.371ProAsp: 3.371 ± 0.06	3.911ProGlu: 3.911 ± 0.065	2.041ProPhe: 2.041 ± 0.037	2.916ProGly: 2.916 ± 0.063	0.698ProHis: 0.698 ± 0.028	2.654ProIle: 2.654 ± 0.058	1.925ProLys: 1.925 ± 0.048	3.27ProLeu: 3.27 ± 0.068	0.772ProMet: 0.772 ± 0.033	1.867ProAsn: 1.867 ± 0.046	1.197ProPro: 1.197 ± 0.043	1.199ProGln: 1.199 ± 0.037	1.295ProArg: 1.295 ± 0.04	2.347ProSer: 2.347 ± 0.051	1.857ProThr: 1.857 ± 0.037	3.147ProVal: 3.147 ± 0.068	0.435ProTrp: 0.435 ± 0.018	1.362ProTyr: 1.362 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.311GlnAla: 2.311 ± 0.052	0.138GlnCys: 0.138 ± 0.012	1.864GlnAsp: 1.864 ± 0.043	2.496GlnGlu: 2.496 ± 0.051	1.891GlnPhe: 1.891 ± 0.043	1.795GlnGly: 1.795 ± 0.04	0.648GlnHis: 0.648 ± 0.025	2.863GlnIle: 2.863 ± 0.058	2.438GlnLys: 2.438 ± 0.059	3.573GlnLeu: 3.573 ± 0.061	0.928GlnMet: 0.928 ± 0.029	2.122GlnAsn: 2.122 ± 0.054	1.448GlnPro: 1.448 ± 0.043	1.657GlnGln: 1.657 ± 0.048	1.72GlnArg: 1.72 ± 0.045	2.599GlnSer: 2.599 ± 0.051	2.197GlnThr: 2.197 ± 0.052	2.101GlnVal: 2.101 ± 0.048	0.419GlnTrp: 0.419 ± 0.023	1.298GlnTyr: 1.298 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.814ArgAla: 2.814 ± 0.056	0.233ArgCys: 0.233 ± 0.014	2.892ArgAsp: 2.892 ± 0.05	3.693ArgGlu: 3.693 ± 0.071	2.588ArgPhe: 2.588 ± 0.057	2.677ArgGly: 2.677 ± 0.046	0.821ArgHis: 0.821 ± 0.026	3.525ArgIle: 3.525 ± 0.063	2.829ArgLys: 2.829 ± 0.06	4.322ArgLeu: 4.322 ± 0.071	1.271ArgMet: 1.271 ± 0.034	2.442ArgAsn: 2.442 ± 0.05	1.582ArgPro: 1.582 ± 0.046	1.638ArgGln: 1.638 ± 0.039	2.222ArgArg: 2.222 ± 0.047	3.202ArgSer: 3.202 ± 0.059	2.367ArgThr: 2.367 ± 0.049	3.145ArgVal: 3.145 ± 0.057	0.583ArgTrp: 0.583 ± 0.023	1.987ArgTyr: 1.987 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.48SerAla: 4.48 ± 0.069	0.424SerCys: 0.424 ± 0.021	4.745SerAsp: 4.745 ± 0.089	5.355SerGlu: 5.355 ± 0.087	3.462SerPhe: 3.462 ± 0.067	5.703SerGly: 5.703 ± 0.101	1.187SerHis: 1.187 ± 0.034	5.021SerIle: 5.021 ± 0.075	3.474SerLys: 3.474 ± 0.063	6.318SerLeu: 6.318 ± 0.084	1.636SerMet: 1.636 ± 0.041	3.237SerAsn: 3.237 ± 0.071	2.542SerPro: 2.542 ± 0.051	2.159SerGln: 2.159 ± 0.049	3.03SerArg: 3.03 ± 0.056	4.871SerSer: 4.871 ± 0.084	3.596SerThr: 3.596 ± 0.068	4.844SerVal: 4.844 ± 0.085	0.73SerTrp: 0.73 ± 0.031	2.489SerTyr: 2.489 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.884ThrAla: 3.884 ± 0.082	0.295ThrCys: 0.295 ± 0.018	3.594ThrAsp: 3.594 ± 0.072	3.832ThrGlu: 3.832 ± 0.064	2.685ThrPhe: 2.685 ± 0.061	4.745ThrGly: 4.745 ± 0.078	1.012ThrHis: 1.012 ± 0.033	3.956ThrIle: 3.956 ± 0.079	2.275ThrLys: 2.275 ± 0.049	5.097ThrLeu: 5.097 ± 0.081	1.115ThrMet: 1.115 ± 0.037	2.262ThrAsn: 2.262 ± 0.052	2.408ThrPro: 2.408 ± 0.057	1.662ThrGln: 1.662 ± 0.041	2.104ThrArg: 2.104 ± 0.047	3.36ThrSer: 3.36 ± 0.067	2.912ThrThr: 2.912 ± 0.075	4.045ThrVal: 4.045 ± 0.086	0.588ThrTrp: 0.588 ± 0.026	1.884ThrTyr: 1.884 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.408ValAla: 4.408 ± 0.08	0.426ValCys: 0.426 ± 0.019	4.26ValAsp: 4.26 ± 0.069	4.947ValGlu: 4.947 ± 0.075	2.801ValPhe: 2.801 ± 0.056	4.032ValGly: 4.032 ± 0.071	1.246ValHis: 1.246 ± 0.035	4.816ValIle: 4.816 ± 0.076	3.376ValLys: 3.376 ± 0.061	5.93ValLeu: 5.93 ± 0.082	1.623ValMet: 1.623 ± 0.043	3.136ValAsn: 3.136 ± 0.058	2.52ValPro: 2.52 ± 0.052	2.4ValGln: 2.4 ± 0.048	2.976ValArg: 2.976 ± 0.061	4.561ValSer: 4.561 ± 0.094	3.784ValThr: 3.784 ± 0.09	4.339ValVal: 4.339 ± 0.081	0.767ValTrp: 0.767 ± 0.026	2.175ValTyr: 2.175 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.711TrpAla: 0.711 ± 0.027	0.088TrpCys: 0.088 ± 0.009	0.771TrpAsp: 0.771 ± 0.033	0.778TrpGlu: 0.778 ± 0.029	0.627TrpPhe: 0.627 ± 0.027	0.812TrpGly: 0.812 ± 0.035	0.255TrpHis: 0.255 ± 0.015	0.895TrpIle: 0.895 ± 0.032	0.665TrpLys: 0.665 ± 0.027	1.164TrpLeu: 1.164 ± 0.037	0.432TrpMet: 0.432 ± 0.02	0.639TrpAsn: 0.639 ± 0.023	0.345TrpPro: 0.345 ± 0.019	0.449TrpGln: 0.449 ± 0.022	0.521TrpArg: 0.521 ± 0.02	0.826TrpSer: 0.826 ± 0.028	0.621TrpThr: 0.621 ± 0.026	0.767TrpVal: 0.767 ± 0.03	0.19TrpTrp: 0.19 ± 0.016	0.434TrpTyr: 0.434 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.156TyrAla: 2.156 ± 0.05	0.269TyrCys: 0.269 ± 0.018	2.248TyrAsp: 2.248 ± 0.049	2.37TyrGlu: 2.37 ± 0.043	1.805TyrPhe: 1.805 ± 0.051	2.533TyrGly: 2.533 ± 0.054	0.794TyrHis: 0.794 ± 0.028	2.174TyrIle: 2.174 ± 0.044	1.749TyrLys: 1.749 ± 0.042	3.531TyrLeu: 3.531 ± 0.062	0.75TyrMet: 0.75 ± 0.027	1.726TyrAsn: 1.726 ± 0.049	1.546TyrPro: 1.546 ± 0.041	1.458TyrGln: 1.458 ± 0.036	2.117TyrArg: 2.117 ± 0.044	2.79TyrSer: 2.79 ± 0.05	1.887TyrThr: 1.887 ± 0.044	1.919TyrVal: 1.919 ± 0.042	0.433TyrTrp: 0.433 ± 0.022	1.428TyrTyr: 1.428 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3017 proteins (1043729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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