Amino acid dipepetide frequency for Hymenobacter jejuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.502AlaAla: 11.502 ± 0.125	0.775AlaCys: 0.775 ± 0.024	5.363AlaAsp: 5.363 ± 0.058	5.629AlaGlu: 5.629 ± 0.065	3.846AlaPhe: 3.846 ± 0.054	7.786AlaGly: 7.786 ± 0.088	1.979AlaHis: 1.979 ± 0.038	4.342AlaIle: 4.342 ± 0.065	4.063AlaLys: 4.063 ± 0.058	10.386AlaLeu: 10.386 ± 0.109	1.878AlaMet: 1.878 ± 0.042	3.474AlaAsn: 3.474 ± 0.05	4.694AlaPro: 4.694 ± 0.078	4.788AlaGln: 4.788 ± 0.063	5.05AlaArg: 5.05 ± 0.075	5.677AlaSer: 5.677 ± 0.065	6.327AlaThr: 6.327 ± 0.096	6.936AlaVal: 6.936 ± 0.071	1.139AlaTrp: 1.139 ± 0.03	3.183AlaTyr: 3.183 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.607CysAla: 0.607 ± 0.02	0.117CysCys: 0.117 ± 0.009	0.375CysAsp: 0.375 ± 0.017	0.377CysGlu: 0.377 ± 0.02	0.311CysPhe: 0.311 ± 0.015	0.625CysGly: 0.625 ± 0.023	0.212CysHis: 0.212 ± 0.012	0.394CysIle: 0.394 ± 0.015	0.233CysLys: 0.233 ± 0.013	0.791CysLeu: 0.791 ± 0.025	0.127CysMet: 0.127 ± 0.01	0.255CysAsn: 0.255 ± 0.014	0.379CysPro: 0.379 ± 0.019	0.3CysGln: 0.3 ± 0.015	0.383CysArg: 0.383 ± 0.02	0.436CysSer: 0.436 ± 0.017	0.444CysThr: 0.444 ± 0.019	0.486CysVal: 0.486 ± 0.018	0.1CysTrp: 0.1 ± 0.009	0.263CysTyr: 0.263 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.904AspAla: 4.904 ± 0.065	0.341AspCys: 0.341 ± 0.017	2.325AspAsp: 2.325 ± 0.044	3.086AspGlu: 3.086 ± 0.053	2.626AspPhe: 2.626 ± 0.046	3.689AspGly: 3.689 ± 0.063	0.903AspHis: 0.903 ± 0.025	2.639AspIle: 2.639 ± 0.044	2.503AspLys: 2.503 ± 0.048	5.144AspLeu: 5.144 ± 0.068	0.946AspMet: 0.946 ± 0.029	2.168AspAsn: 2.168 ± 0.048	2.489AspPro: 2.489 ± 0.042	2.078AspGln: 2.078 ± 0.034	2.68AspArg: 2.68 ± 0.05	2.662AspSer: 2.662 ± 0.048	2.512AspThr: 2.512 ± 0.044	3.701AspVal: 3.701 ± 0.057	0.762AspTrp: 0.762 ± 0.025	2.186AspTyr: 2.186 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.555GluAla: 5.555 ± 0.068	0.319GluCys: 0.319 ± 0.015	2.223GluAsp: 2.223 ± 0.046	3.263GluGlu: 3.263 ± 0.062	2.149GluPhe: 2.149 ± 0.042	3.466GluGly: 3.466 ± 0.05	1.276GluHis: 1.276 ± 0.032	2.883GluIle: 2.883 ± 0.052	2.997GluLys: 2.997 ± 0.048	5.815GluLeu: 5.815 ± 0.073	1.242GluMet: 1.242 ± 0.031	2.11GluAsn: 2.11 ± 0.037	2.272GluPro: 2.272 ± 0.041	2.888GluGln: 2.888 ± 0.049	3.238GluArg: 3.238 ± 0.057	2.472GluSer: 2.472 ± 0.045	2.785GluThr: 2.785 ± 0.049	3.937GluVal: 3.937 ± 0.058	0.635GluTrp: 0.635 ± 0.024	1.839GluTyr: 1.839 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.846PheAla: 3.846 ± 0.057	0.377PheCys: 0.377 ± 0.016	2.497PheAsp: 2.497 ± 0.043	2.301PheGlu: 2.301 ± 0.039	2.035PhePhe: 2.035 ± 0.043	3.448PheGly: 3.448 ± 0.047	0.811PheHis: 0.811 ± 0.025	1.906PheIle: 1.906 ± 0.041	1.642PheLys: 1.642 ± 0.033	4.117PheLeu: 4.117 ± 0.066	0.824PheMet: 0.824 ± 0.022	1.784PheAsn: 1.784 ± 0.041	1.829PhePro: 1.829 ± 0.034	1.638PheGln: 1.638 ± 0.032	2.564PheArg: 2.564 ± 0.046	2.813PheSer: 2.813 ± 0.051	2.809PheThr: 2.809 ± 0.055	3.066PheVal: 3.066 ± 0.048	0.603PheTrp: 0.603 ± 0.024	1.644PheTyr: 1.644 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.429GlyAla: 6.429 ± 0.078	0.63GlyCys: 0.63 ± 0.026	3.231GlyAsp: 3.231 ± 0.055	3.411GlyGlu: 3.411 ± 0.05	3.467GlyPhe: 3.467 ± 0.054	5.653GlyGly: 5.653 ± 0.084	1.638GlyHis: 1.638 ± 0.037	4.114GlyIle: 4.114 ± 0.068	3.936GlyLys: 3.936 ± 0.057	7.696GlyLeu: 7.696 ± 0.084	1.534GlyMet: 1.534 ± 0.036	2.97GlyAsn: 2.97 ± 0.055	2.767GlyPro: 2.767 ± 0.048	3.438GlyGln: 3.438 ± 0.052	4.2GlyArg: 4.2 ± 0.063	4.547GlySer: 4.547 ± 0.076	4.93GlyThr: 4.93 ± 0.086	5.189GlyVal: 5.189 ± 0.072	1.094GlyTrp: 1.094 ± 0.027	2.984GlyTyr: 2.984 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.749HisAla: 1.749 ± 0.041	0.184HisCys: 0.184 ± 0.011	1.161HisAsp: 1.161 ± 0.031	1.104HisGlu: 1.104 ± 0.031	1.123HisPhe: 1.123 ± 0.029	1.535HisGly: 1.535 ± 0.035	0.605HisHis: 0.605 ± 0.022	1.05HisIle: 1.05 ± 0.026	0.746HisLys: 0.746 ± 0.025	2.372HisLeu: 2.372 ± 0.045	0.386HisMet: 0.386 ± 0.019	0.847HisAsn: 0.847 ± 0.023	1.284HisPro: 1.284 ± 0.035	0.918HisGln: 0.918 ± 0.028	1.178HisArg: 1.178 ± 0.029	1.043HisSer: 1.043 ± 0.028	1.229HisThr: 1.229 ± 0.029	1.32HisVal: 1.32 ± 0.033	0.301HisTrp: 0.301 ± 0.015	0.95HisTyr: 0.95 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.596IleAla: 4.596 ± 0.069	0.444IleCys: 0.444 ± 0.019	2.81IleAsp: 2.81 ± 0.052	2.737IleGlu: 2.737 ± 0.052	1.886IlePhe: 1.886 ± 0.036	3.908IleGly: 3.908 ± 0.058	0.885IleHis: 0.885 ± 0.022	2.528IleIle: 2.528 ± 0.054	2.179IleLys: 2.179 ± 0.043	4.299IleLeu: 4.299 ± 0.063	0.871IleMet: 0.871 ± 0.027	2.105IleAsn: 2.105 ± 0.043	2.382IlePro: 2.382 ± 0.039	1.838IleGln: 1.838 ± 0.034	2.941IleArg: 2.941 ± 0.045	3.104IleSer: 3.104 ± 0.05	3.394IleThr: 3.394 ± 0.045	3.405IleVal: 3.405 ± 0.049	0.581IleTrp: 0.581 ± 0.019	1.542IleTyr: 1.542 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.38LysAla: 4.38 ± 0.066	0.189LysCys: 0.189 ± 0.013	2.318LysAsp: 2.318 ± 0.04	2.568LysGlu: 2.568 ± 0.047	1.532LysPhe: 1.532 ± 0.032	3.145LysGly: 3.145 ± 0.048	0.849LysHis: 0.849 ± 0.026	2.251LysIle: 2.251 ± 0.04	2.481LysLys: 2.481 ± 0.053	4.498LysLeu: 4.498 ± 0.055	1.184LysMet: 1.184 ± 0.029	1.868LysAsn: 1.868 ± 0.035	2.482LysPro: 2.482 ± 0.045	2.164LysGln: 2.164 ± 0.039	2.335LysArg: 2.335 ± 0.043	2.408LysSer: 2.408 ± 0.041	2.636LysThr: 2.636 ± 0.049	3.191LysVal: 3.191 ± 0.049	0.537LysTrp: 0.537 ± 0.019	1.591LysTyr: 1.591 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	10.609LeuAla: 10.609 ± 0.099	0.787LeuCys: 0.787 ± 0.026	5.295LeuAsp: 5.295 ± 0.06	5.029LeuGlu: 5.029 ± 0.069	4.147LeuPhe: 4.147 ± 0.056	7.454LeuGly: 7.454 ± 0.085	2.379LeuHis: 2.379 ± 0.048	4.657LeuIle: 4.657 ± 0.064	4.324LeuLys: 4.324 ± 0.062	12.601LeuLeu: 12.601 ± 0.148	2.061LeuMet: 2.061 ± 0.036	4.324LeuAsn: 4.324 ± 0.069	5.865LeuPro: 5.865 ± 0.076	4.599LeuGln: 4.599 ± 0.064	6.857LeuArg: 6.857 ± 0.08	6.377LeuSer: 6.377 ± 0.068	6.876LeuThr: 6.876 ± 0.073	7.207LeuVal: 7.207 ± 0.085	1.124LeuTrp: 1.124 ± 0.029	3.362LeuTyr: 3.362 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.999MetAla: 1.999 ± 0.04	0.111MetCys: 0.111 ± 0.008	0.808MetAsp: 0.808 ± 0.025	0.959MetGlu: 0.959 ± 0.03	0.617MetPhe: 0.617 ± 0.02	1.415MetGly: 1.415 ± 0.032	0.466MetHis: 0.466 ± 0.018	0.888MetIle: 0.888 ± 0.031	1.206MetLys: 1.206 ± 0.031	2.167MetLeu: 2.167 ± 0.041	0.449MetMet: 0.449 ± 0.019	0.839MetAsn: 0.839 ± 0.025	1.23MetPro: 1.23 ± 0.029	1.021MetGln: 1.021 ± 0.027	1.268MetArg: 1.268 ± 0.027	1.201MetSer: 1.201 ± 0.032	1.088MetThr: 1.088 ± 0.028	1.266MetVal: 1.266 ± 0.031	0.19MetTrp: 0.19 ± 0.012	0.491MetTyr: 0.491 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.642AsnAla: 3.642 ± 0.06	0.295AsnCys: 0.295 ± 0.015	1.935AsnAsp: 1.935 ± 0.045	1.919AsnGlu: 1.919 ± 0.032	1.76AsnPhe: 1.76 ± 0.034	3.309AsnGly: 3.309 ± 0.063	0.783AsnHis: 0.783 ± 0.024	2.087AsnIle: 2.087 ± 0.037	1.706AsnLys: 1.706 ± 0.04	4.119AsnLeu: 4.119 ± 0.054	0.748AsnMet: 0.748 ± 0.024	1.749AsnAsn: 1.749 ± 0.046	2.59AsnPro: 2.59 ± 0.046	1.84AsnGln: 1.84 ± 0.036	2.282AsnArg: 2.282 ± 0.046	2.336AsnSer: 2.336 ± 0.047	2.495AsnThr: 2.495 ± 0.049	2.716AsnVal: 2.716 ± 0.051	0.594AsnTrp: 0.594 ± 0.018	1.642AsnTyr: 1.642 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	5.935ProAla: 5.935 ± 0.086	0.253ProCys: 0.253 ± 0.013	3.25ProAsp: 3.25 ± 0.051	3.394ProGlu: 3.394 ± 0.048	1.971ProPhe: 1.971 ± 0.038	3.649ProGly: 3.649 ± 0.056	1.001ProHis: 1.001 ± 0.026	2.266ProIle: 2.266 ± 0.035	2.027ProLys: 2.027 ± 0.036	4.674ProLeu: 4.674 ± 0.06	0.846ProMet: 0.846 ± 0.025	2.175ProAsn: 2.175 ± 0.041	1.901ProPro: 1.901 ± 0.048	2.075ProGln: 2.075 ± 0.036	2.259ProArg: 2.259 ± 0.037	2.706ProSer: 2.706 ± 0.053	3.313ProThr: 3.313 ± 0.06	4.11ProVal: 4.11 ± 0.067	0.58ProTrp: 0.58 ± 0.021	1.61ProTyr: 1.61 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.644GlnAla: 4.644 ± 0.066	0.227GlnCys: 0.227 ± 0.014	1.871GlnAsp: 1.871 ± 0.038	2.486GlnGlu: 2.486 ± 0.046	1.721GlnPhe: 1.721 ± 0.039	2.887GlnGly: 2.887 ± 0.045	1.241GlnHis: 1.241 ± 0.034	2.099GlnIle: 2.099 ± 0.042	2.08GlnLys: 2.08 ± 0.041	5.094GlnLeu: 5.094 ± 0.065	0.956GlnMet: 0.956 ± 0.027	1.906GlnAsn: 1.906 ± 0.044	2.72GlnPro: 2.72 ± 0.05	3.083GlnGln: 3.083 ± 0.06	3.012GlnArg: 3.012 ± 0.052	2.112GlnSer: 2.112 ± 0.036	2.586GlnThr: 2.586 ± 0.045	3.308GlnVal: 3.308 ± 0.048	0.585GlnTrp: 0.585 ± 0.022	1.619GlnTyr: 1.619 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.885ArgAla: 4.885 ± 0.069	0.351ArgCys: 0.351 ± 0.018	2.761ArgAsp: 2.761 ± 0.04	3.219ArgGlu: 3.219 ± 0.061	2.666ArgPhe: 2.666 ± 0.041	3.364ArgGly: 3.364 ± 0.058	1.345ArgHis: 1.345 ± 0.035	3.055ArgIle: 3.055 ± 0.051	2.487ArgLys: 2.487 ± 0.042	6.427ArgLeu: 6.427 ± 0.069	1.293ArgMet: 1.293 ± 0.029	2.402ArgAsn: 2.402 ± 0.045	2.777ArgPro: 2.777 ± 0.051	3.098ArgGln: 3.098 ± 0.05	3.941ArgArg: 3.941 ± 0.062	2.828ArgSer: 2.828 ± 0.045	3.401ArgThr: 3.401 ± 0.049	4.108ArgVal: 4.108 ± 0.057	0.804ArgTrp: 0.804 ± 0.026	2.458ArgTyr: 2.458 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.435SerAla: 5.435 ± 0.077	0.491SerCys: 0.491 ± 0.018	2.836SerAsp: 2.836 ± 0.043	2.744SerGlu: 2.744 ± 0.047	2.826SerPhe: 2.826 ± 0.038	4.72SerGly: 4.72 ± 0.079	1.087SerHis: 1.087 ± 0.028	2.954SerIle: 2.954 ± 0.047	2.424SerLys: 2.424 ± 0.046	6.044SerLeu: 6.044 ± 0.065	1.141SerMet: 1.141 ± 0.028	2.243SerAsn: 2.243 ± 0.041	2.834SerPro: 2.834 ± 0.051	2.27SerGln: 2.27 ± 0.041	3.077SerArg: 3.077 ± 0.052	3.641SerSer: 3.641 ± 0.064	3.534SerThr: 3.534 ± 0.065	4.189SerVal: 4.189 ± 0.055	0.718SerTrp: 0.718 ± 0.021	2.164SerTyr: 2.164 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.234ThrAla: 6.234 ± 0.096	0.379ThrCys: 0.379 ± 0.016	3.371ThrAsp: 3.371 ± 0.051	3.018ThrGlu: 3.018 ± 0.046	2.622ThrPhe: 2.622 ± 0.048	5.205ThrGly: 5.205 ± 0.075	1.143ThrHis: 1.143 ± 0.031	2.938ThrIle: 2.938 ± 0.048	2.462ThrLys: 2.462 ± 0.044	6.386ThrLeu: 6.386 ± 0.074	0.994ThrMet: 0.994 ± 0.028	2.457ThrAsn: 2.457 ± 0.06	3.686ThrPro: 3.686 ± 0.054	2.407ThrGln: 2.407 ± 0.042	2.837ThrArg: 2.837 ± 0.042	3.687ThrSer: 3.687 ± 0.063	4.08ThrThr: 4.08 ± 0.087	4.608ThrVal: 4.608 ± 0.069	0.792ThrTrp: 0.792 ± 0.023	2.336ThrTyr: 2.336 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	7.512ValAla: 7.512 ± 0.088	0.552ValCys: 0.552 ± 0.021	3.278ValAsp: 3.278 ± 0.05	3.699ValGlu: 3.699 ± 0.063	2.938ValPhe: 2.938 ± 0.047	5.089ValGly: 5.089 ± 0.063	1.32ValHis: 1.32 ± 0.034	3.412ValIle: 3.412 ± 0.052	3.054ValLys: 3.054 ± 0.055	7.897ValLeu: 7.897 ± 0.079	1.339ValMet: 1.339 ± 0.031	2.687ValAsn: 2.687 ± 0.053	3.684ValPro: 3.684 ± 0.051	3.18ValGln: 3.18 ± 0.047	4.415ValArg: 4.415 ± 0.064	4.344ValSer: 4.344 ± 0.063	4.393ValThr: 4.393 ± 0.073	5.896ValVal: 5.896 ± 0.071	0.818ValTrp: 0.818 ± 0.026	2.306ValTyr: 2.306 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.113TrpAla: 1.113 ± 0.029	0.095TrpCys: 0.095 ± 0.008	0.576TrpAsp: 0.576 ± 0.019	0.643TrpGlu: 0.643 ± 0.023	0.546TrpPhe: 0.546 ± 0.023	0.822TrpGly: 0.822 ± 0.029	0.345TrpHis: 0.345 ± 0.017	0.519TrpIle: 0.519 ± 0.021	0.535TrpLys: 0.535 ± 0.02	1.63TrpLeu: 1.63 ± 0.044	0.303TrpMet: 0.303 ± 0.014	0.549TrpAsn: 0.549 ± 0.019	0.493TrpPro: 0.493 ± 0.017	0.813TrpGln: 0.813 ± 0.028	0.816TrpArg: 0.816 ± 0.026	0.716TrpSer: 0.716 ± 0.023	0.667TrpThr: 0.667 ± 0.026	0.861TrpVal: 0.861 ± 0.026	0.214TrpTrp: 0.214 ± 0.014	0.411TrpTyr: 0.411 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.242TyrAla: 3.242 ± 0.049	0.298TyrCys: 0.298 ± 0.015	2.061TyrAsp: 2.061 ± 0.04	1.777TyrGlu: 1.777 ± 0.035	1.767TyrPhe: 1.767 ± 0.036	2.69TyrGly: 2.69 ± 0.052	0.816TyrHis: 0.816 ± 0.028	1.451TyrIle: 1.451 ± 0.027	1.526TyrLys: 1.526 ± 0.032	3.777TyrLeu: 3.777 ± 0.05	0.555TyrMet: 0.555 ± 0.016	1.633TyrAsn: 1.633 ± 0.04	1.636TyrPro: 1.636 ± 0.039	1.802TyrGln: 1.802 ± 0.037	2.335TyrArg: 2.335 ± 0.047	2.262TyrSer: 2.262 ± 0.04	2.143TyrThr: 2.143 ± 0.04	2.316TyrVal: 2.316 ± 0.04	0.493TyrTrp: 0.493 ± 0.02	1.586TyrTyr: 1.586 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4100 proteins (1465612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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