Amino acid dipepetide frequency for Rhodothalassium salexigens DSM 2132

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.204AlaAla: 22.204 ± 0.313	1.063AlaCys: 1.063 ± 0.038	9.753AlaAsp: 9.753 ± 0.113	8.919AlaGlu: 8.919 ± 0.121	4.42AlaPhe: 4.42 ± 0.071	13.586AlaGly: 13.586 ± 0.18	2.915AlaHis: 2.915 ± 0.057	5.142AlaIle: 5.142 ± 0.095	3.175AlaLys: 3.175 ± 0.072	15.971AlaLeu: 15.971 ± 0.184	3.496AlaMet: 3.496 ± 0.069	2.54AlaAsn: 2.54 ± 0.058	7.592AlaPro: 7.592 ± 0.115	4.781AlaGln: 4.781 ± 0.072	11.949AlaArg: 11.949 ± 0.162	5.329AlaSer: 5.329 ± 0.075	6.699AlaThr: 6.699 ± 0.096	10.14AlaVal: 10.14 ± 0.133	1.814AlaTrp: 1.814 ± 0.045	2.627AlaTyr: 2.627 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.04	0.093CysCys: 0.093 ± 0.009	0.52CysAsp: 0.52 ± 0.022	0.319CysGlu: 0.319 ± 0.017	0.235CysPhe: 0.235 ± 0.016	0.824CysGly: 0.824 ± 0.033	0.212CysHis: 0.212 ± 0.017	0.258CysIle: 0.258 ± 0.017	0.118CysLys: 0.118 ± 0.012	0.798CysLeu: 0.798 ± 0.028	0.093CysMet: 0.093 ± 0.009	0.167CysAsn: 0.167 ± 0.013	0.484CysPro: 0.484 ± 0.027	0.231CysGln: 0.231 ± 0.017	0.648CysArg: 0.648 ± 0.027	0.306CysSer: 0.306 ± 0.021	0.377CysThr: 0.377 ± 0.019	0.502CysVal: 0.502 ± 0.024	0.083CysTrp: 0.083 ± 0.01	0.158CysTyr: 0.158 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.845AspAla: 9.845 ± 0.131	0.38AspCys: 0.38 ± 0.022	4.704AspAsp: 4.704 ± 0.096	3.346AspGlu: 3.346 ± 0.068	2.104AspPhe: 2.104 ± 0.055	6.485AspGly: 6.485 ± 0.126	1.62AspHis: 1.62 ± 0.042	2.498AspIle: 2.498 ± 0.049	1.559AspLys: 1.559 ± 0.046	7.406AspLeu: 7.406 ± 0.094	1.336AspMet: 1.336 ± 0.04	1.37AspAsn: 1.37 ± 0.04	4.423AspPro: 4.423 ± 0.078	2.381AspGln: 2.381 ± 0.05	6.698AspArg: 6.698 ± 0.097	2.203AspSer: 2.203 ± 0.048	3.559AspThr: 3.559 ± 0.076	4.137AspVal: 4.137 ± 0.069	1.101AspTrp: 1.101 ± 0.033	1.561AspTyr: 1.561 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.425GluAla: 8.425 ± 0.114	0.283GluCys: 0.283 ± 0.018	2.952GluAsp: 2.952 ± 0.064	2.556GluGlu: 2.556 ± 0.067	1.284GluPhe: 1.284 ± 0.039	3.797GluGly: 3.797 ± 0.076	0.92GluHis: 0.92 ± 0.029	2.649GluIle: 2.649 ± 0.065	1.427GluLys: 1.427 ± 0.048	4.117GluLeu: 4.117 ± 0.076	1.3GluMet: 1.3 ± 0.038	1.059GluAsn: 1.059 ± 0.038	3.047GluPro: 3.047 ± 0.06	1.955GluGln: 1.955 ± 0.053	5.641GluArg: 5.641 ± 0.08	1.704GluSer: 1.704 ± 0.047	4.031GluThr: 4.031 ± 0.064	3.76GluVal: 3.76 ± 0.068	0.462GluTrp: 0.462 ± 0.02	0.827GluTyr: 0.827 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.427PheAla: 4.427 ± 0.07	0.336PheCys: 0.336 ± 0.02	2.902PheAsp: 2.902 ± 0.06	2.043PheGlu: 2.043 ± 0.049	1.286PhePhe: 1.286 ± 0.041	3.02PheGly: 3.02 ± 0.067	0.676PheHis: 0.676 ± 0.023	1.233PheIle: 1.233 ± 0.041	0.831PheLys: 0.831 ± 0.03	3.022PheLeu: 3.022 ± 0.063	0.712PheMet: 0.712 ± 0.029	0.945PheAsn: 0.945 ± 0.038	1.303PhePro: 1.303 ± 0.036	0.939PheGln: 0.939 ± 0.034	2.146PheArg: 2.146 ± 0.045	1.664PheSer: 1.664 ± 0.046	1.875PheThr: 1.875 ± 0.045	2.476PheVal: 2.476 ± 0.053	0.424PheTrp: 0.424 ± 0.025	0.882PheTyr: 0.882 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.438GlyAla: 11.438 ± 0.135	0.765GlyCys: 0.765 ± 0.032	5.696GlyAsp: 5.696 ± 0.11	4.562GlyGlu: 4.562 ± 0.08	3.433GlyPhe: 3.433 ± 0.059	8.032GlyGly: 8.032 ± 0.119	1.938GlyHis: 1.938 ± 0.044	3.192GlyIle: 3.192 ± 0.059	2.063GlyLys: 2.063 ± 0.05	9.956GlyLeu: 9.956 ± 0.121	1.787GlyMet: 1.787 ± 0.046	1.696GlyAsn: 1.696 ± 0.056	4.6GlyPro: 4.6 ± 0.079	3.215GlyGln: 3.215 ± 0.063	7.842GlyArg: 7.842 ± 0.087	3.854GlySer: 3.854 ± 0.068	4.486GlyThr: 4.486 ± 0.08	6.614GlyVal: 6.614 ± 0.088	1.372GlyTrp: 1.372 ± 0.04	2.153GlyTyr: 2.153 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.509HisAla: 2.509 ± 0.052	0.203HisCys: 0.203 ± 0.015	1.292HisAsp: 1.292 ± 0.036	0.939HisGlu: 0.939 ± 0.031	0.683HisPhe: 0.683 ± 0.027	2.003HisGly: 2.003 ± 0.049	0.549HisHis: 0.549 ± 0.027	0.823HisIle: 0.823 ± 0.028	0.511HisLys: 0.511 ± 0.024	2.266HisLeu: 2.266 ± 0.049	0.511HisMet: 0.511 ± 0.022	0.433HisAsn: 0.433 ± 0.019	1.232HisPro: 1.232 ± 0.035	0.563HisGln: 0.563 ± 0.023	1.73HisArg: 1.73 ± 0.047	0.796HisSer: 0.796 ± 0.029	0.893HisThr: 0.893 ± 0.031	1.479HisVal: 1.479 ± 0.039	0.363HisTrp: 0.363 ± 0.016	0.56HisTyr: 0.56 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.004IleAla: 6.004 ± 0.086	0.332IleCys: 0.332 ± 0.018	3.45IleAsp: 3.45 ± 0.073	2.745IleGlu: 2.745 ± 0.053	1.077IlePhe: 1.077 ± 0.037	3.672IleGly: 3.672 ± 0.064	0.762IleHis: 0.762 ± 0.024	1.268IleIle: 1.268 ± 0.044	1.084IleLys: 1.084 ± 0.035	3.343IleLeu: 3.343 ± 0.067	0.715IleMet: 0.715 ± 0.029	1.098IleAsn: 1.098 ± 0.037	1.737IlePro: 1.737 ± 0.045	1.154IleGln: 1.154 ± 0.039	2.728IleArg: 2.728 ± 0.052	1.78IleSer: 1.78 ± 0.046	2.179IleThr: 2.179 ± 0.055	3.205IleVal: 3.205 ± 0.066	0.438IleTrp: 0.438 ± 0.024	0.806IleTyr: 0.806 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.552LysAla: 3.552 ± 0.071	0.096LysCys: 0.096 ± 0.011	1.361LysAsp: 1.361 ± 0.041	1.052LysGlu: 1.052 ± 0.038	0.535LysPhe: 0.535 ± 0.026	1.92LysGly: 1.92 ± 0.053	0.435LysHis: 0.435 ± 0.021	1.003LysIle: 1.003 ± 0.032	0.856LysLys: 0.856 ± 0.032	2.384LysLeu: 2.384 ± 0.055	0.497LysMet: 0.497 ± 0.027	0.533LysAsn: 0.533 ± 0.022	1.634LysPro: 1.634 ± 0.043	0.748LysGln: 0.748 ± 0.03	2.071LysArg: 2.071 ± 0.053	1.201LysSer: 1.201 ± 0.031	1.586LysThr: 1.586 ± 0.041	1.724LysVal: 1.724 ± 0.049	0.241LysTrp: 0.241 ± 0.017	0.418LysTyr: 0.418 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.073LeuAla: 16.073 ± 0.195	0.875LeuCys: 0.875 ± 0.032	8.237LeuAsp: 8.237 ± 0.106	4.535LeuGlu: 4.535 ± 0.074	3.579LeuPhe: 3.579 ± 0.074	8.766LeuGly: 8.766 ± 0.102	1.831LeuHis: 1.831 ± 0.041	4.357LeuIle: 4.357 ± 0.076	2.84LeuLys: 2.84 ± 0.064	8.771LeuLeu: 8.771 ± 0.13	2.14LeuMet: 2.14 ± 0.046	2.175LeuAsn: 2.175 ± 0.05	5.377LeuPro: 5.377 ± 0.079	2.243LeuGln: 2.243 ± 0.056	6.819LeuArg: 6.819 ± 0.084	5.966LeuSer: 5.966 ± 0.081	5.986LeuThr: 5.986 ± 0.086	8.279LeuVal: 8.279 ± 0.115	1.269LeuTrp: 1.269 ± 0.04	2.133LeuTyr: 2.133 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.565MetAla: 3.565 ± 0.061	0.106MetCys: 0.106 ± 0.012	1.205MetAsp: 1.205 ± 0.042	0.913MetGlu: 0.913 ± 0.032	0.496MetPhe: 0.496 ± 0.022	1.773MetGly: 1.773 ± 0.049	0.364MetHis: 0.364 ± 0.019	1.006MetIle: 1.006 ± 0.033	0.582MetLys: 0.582 ± 0.026	1.955MetLeu: 1.955 ± 0.051	0.482MetMet: 0.482 ± 0.027	0.506MetAsn: 0.506 ± 0.021	1.258MetPro: 1.258 ± 0.038	0.531MetGln: 0.531 ± 0.024	1.473MetArg: 1.473 ± 0.045	1.228MetSer: 1.228 ± 0.034	1.946MetThr: 1.946 ± 0.042	1.737MetVal: 1.737 ± 0.045	0.18MetTrp: 0.18 ± 0.016	0.206MetTyr: 0.206 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.746AsnAla: 2.746 ± 0.053	0.17AsnCys: 0.17 ± 0.013	1.232AsnAsp: 1.232 ± 0.05	0.943AsnGlu: 0.943 ± 0.036	0.717AsnPhe: 0.717 ± 0.034	1.723AsnGly: 1.723 ± 0.046	0.419AsnHis: 0.419 ± 0.019	0.949AsnIle: 0.949 ± 0.031	0.532AsnLys: 0.532 ± 0.025	2.155AsnLeu: 2.155 ± 0.049	0.462AsnMet: 0.462 ± 0.02	0.589AsnAsn: 0.589 ± 0.032	1.625AsnPro: 1.625 ± 0.044	0.743AsnGln: 0.743 ± 0.028	1.822AsnArg: 1.822 ± 0.051	0.803AsnSer: 0.803 ± 0.033	1.171AsnThr: 1.171 ± 0.037	1.511AsnVal: 1.511 ± 0.038	0.278AsnTrp: 0.278 ± 0.016	0.491AsnTyr: 0.491 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.382ProAla: 8.382 ± 0.128	0.351ProCys: 0.351 ± 0.017	4.572ProAsp: 4.572 ± 0.078	3.587ProGlu: 3.587 ± 0.059	1.852ProPhe: 1.852 ± 0.038	5.833ProGly: 5.833 ± 0.097	1.098ProHis: 1.098 ± 0.032	1.876ProIle: 1.876 ± 0.046	1.382ProLys: 1.382 ± 0.042	4.994ProLeu: 4.994 ± 0.081	1.131ProMet: 1.131 ± 0.037	1.082ProAsn: 1.082 ± 0.037	3.189ProPro: 3.189 ± 0.075	1.67ProGln: 1.67 ± 0.042	3.493ProArg: 3.493 ± 0.069	2.527ProSer: 2.527 ± 0.053	2.682ProThr: 2.682 ± 0.058	4.951ProVal: 4.951 ± 0.084	0.737ProTrp: 0.737 ± 0.027	1.025ProTyr: 1.025 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.767GlnAla: 4.767 ± 0.075	0.192GlnCys: 0.192 ± 0.014	1.688GlnAsp: 1.688 ± 0.045	1.409GlnGlu: 1.409 ± 0.039	0.94GlnPhe: 0.94 ± 0.031	2.86GlnGly: 2.86 ± 0.054	0.543GlnHis: 0.543 ± 0.024	1.556GlnIle: 1.556 ± 0.046	0.724GlnLys: 0.724 ± 0.033	2.487GlnLeu: 2.487 ± 0.051	0.827GlnMet: 0.827 ± 0.028	0.685GlnAsn: 0.685 ± 0.027	1.886GlnPro: 1.886 ± 0.04	1.087GlnGln: 1.087 ± 0.042	2.595GlnArg: 2.595 ± 0.057	1.589GlnSer: 1.589 ± 0.037	2.015GlnThr: 2.015 ± 0.055	2.629GlnVal: 2.629 ± 0.052	0.413GlnTrp: 0.413 ± 0.018	0.523GlnTyr: 0.523 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.997ArgAla: 10.997 ± 0.149	0.587ArgCys: 0.587 ± 0.025	4.944ArgAsp: 4.944 ± 0.064	3.464ArgGlu: 3.464 ± 0.075	3.279ArgPhe: 3.279 ± 0.069	5.559ArgGly: 5.559 ± 0.077	1.925ArgHis: 1.925 ± 0.045	3.368ArgIle: 3.368 ± 0.055	1.578ArgLys: 1.578 ± 0.051	10.324ArgLeu: 10.324 ± 0.129	1.639ArgMet: 1.639 ± 0.042	1.535ArgAsn: 1.535 ± 0.044	4.894ArgPro: 4.894 ± 0.093	2.888ArgGln: 2.888 ± 0.059	7.687ArgArg: 7.687 ± 0.102	3.384ArgSer: 3.384 ± 0.053	3.974ArgThr: 3.974 ± 0.064	6.055ArgVal: 6.055 ± 0.088	1.204ArgTrp: 1.204 ± 0.04	1.877ArgTyr: 1.877 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.815SerAla: 5.815 ± 0.089	0.27SerCys: 0.27 ± 0.021	2.83SerAsp: 2.83 ± 0.055	2.089SerGlu: 2.089 ± 0.05	1.686SerPhe: 1.686 ± 0.041	4.395SerGly: 4.395 ± 0.065	0.913SerHis: 0.913 ± 0.031	1.723SerIle: 1.723 ± 0.044	1.0SerLys: 1.0 ± 0.036	4.76SerLeu: 4.76 ± 0.059	0.988SerMet: 0.988 ± 0.029	0.974SerAsn: 0.974 ± 0.029	2.597SerPro: 2.597 ± 0.057	1.454SerGln: 1.454 ± 0.043	3.094SerArg: 3.094 ± 0.059	1.965SerSer: 1.965 ± 0.045	2.152SerThr: 2.152 ± 0.047	3.563SerVal: 3.563 ± 0.06	0.531SerTrp: 0.531 ± 0.024	0.987SerTyr: 0.987 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.334ThrAla: 7.334 ± 0.108	0.363ThrCys: 0.363 ± 0.02	3.688ThrAsp: 3.688 ± 0.079	2.626ThrGlu: 2.626 ± 0.061	1.649ThrPhe: 1.649 ± 0.047	5.747ThrGly: 5.747 ± 0.092	0.987ThrHis: 0.987 ± 0.031	2.217ThrIle: 2.217 ± 0.05	1.114ThrLys: 1.114 ± 0.035	6.435ThrLeu: 6.435 ± 0.086	1.021ThrMet: 1.021 ± 0.032	1.159ThrAsn: 1.159 ± 0.041	3.797ThrPro: 3.797 ± 0.065	1.481ThrGln: 1.481 ± 0.041	3.622ThrArg: 3.622 ± 0.061	2.094ThrSer: 2.094 ± 0.052	2.526ThrThr: 2.526 ± 0.064	4.962ThrVal: 4.962 ± 0.086	0.612ThrTrp: 0.612 ± 0.029	1.111ThrTyr: 1.111 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.938ValAla: 10.938 ± 0.143	0.659ValCys: 0.659 ± 0.026	5.386ValAsp: 5.386 ± 0.071	4.501ValGlu: 4.501 ± 0.078	2.673ValPhe: 2.673 ± 0.05	5.696ValGly: 5.696 ± 0.071	1.407ValHis: 1.407 ± 0.036	3.272ValIle: 3.272 ± 0.061	1.741ValLys: 1.741 ± 0.044	7.379ValLeu: 7.379 ± 0.104	1.693ValMet: 1.693 ± 0.049	1.826ValAsn: 1.826 ± 0.046	4.051ValPro: 4.051 ± 0.076	1.996ValGln: 1.996 ± 0.045	5.792ValArg: 5.792 ± 0.086	3.862ValSer: 3.862 ± 0.074	4.623ValThr: 4.623 ± 0.078	5.946ValVal: 5.946 ± 0.104	0.987ValTrp: 0.987 ± 0.028	1.61ValTyr: 1.61 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.607TrpAla: 1.607 ± 0.047	0.111TrpCys: 0.111 ± 0.008	0.724TrpAsp: 0.724 ± 0.03	0.445TrpGlu: 0.445 ± 0.02	0.442TrpPhe: 0.442 ± 0.024	0.925TrpGly: 0.925 ± 0.033	0.35TrpHis: 0.35 ± 0.018	0.524TrpIle: 0.524 ± 0.023	0.245TrpLys: 0.245 ± 0.017	1.611TrpLeu: 1.611 ± 0.05	0.287TrpMet: 0.287 ± 0.018	0.228TrpAsn: 0.228 ± 0.015	0.723TrpPro: 0.723 ± 0.025	0.644TrpGln: 0.644 ± 0.026	1.366TrpArg: 1.366 ± 0.038	0.684TrpSer: 0.684 ± 0.025	0.758TrpThr: 0.758 ± 0.032	0.909TrpVal: 0.909 ± 0.029	0.204TrpTrp: 0.204 ± 0.015	0.244TrpTyr: 0.244 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.49TyrAla: 2.49 ± 0.047	0.181TyrCys: 0.181 ± 0.013	1.58TyrAsp: 1.58 ± 0.045	1.203TyrGlu: 1.203 ± 0.037	0.774TyrPhe: 0.774 ± 0.029	2.078TyrGly: 2.078 ± 0.052	0.475TyrHis: 0.475 ± 0.023	0.664TyrIle: 0.664 ± 0.028	0.486TyrLys: 0.486 ± 0.025	2.117TyrLeu: 2.117 ± 0.045	0.394TyrMet: 0.394 ± 0.019	0.482TyrAsn: 0.482 ± 0.022	0.962TyrPro: 0.962 ± 0.03	0.713TyrGln: 0.713 ± 0.027	1.948TyrArg: 1.948 ± 0.05	0.847TyrSer: 0.847 ± 0.031	1.027TyrThr: 1.027 ± 0.04	1.461TyrVal: 1.461 ± 0.036	0.318TyrTrp: 0.318 ± 0.019	0.52TyrTyr: 0.52 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2870 proteins (988374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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