Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA261D19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.763AlaAla: 4.763 ± 0.236
0.822AlaCys: 0.822 ± 0.081
3.277AlaAsp: 3.277 ± 0.158
6.033AlaGlu: 6.033 ± 0.247
2.615AlaPhe: 2.615 ± 0.14
4.996AlaGly: 4.996 ± 0.23
1.007AlaHis: 1.007 ± 0.076
4.634AlaIle: 4.634 ± 0.192
5.223AlaLys: 5.223 ± 0.194
6.653AlaLeu: 6.653 ± 0.247
1.792AlaMet: 1.792 ± 0.134
1.964AlaAsn: 1.964 ± 0.115
2.246AlaPro: 2.246 ± 0.116
1.712AlaGln: 1.712 ± 0.113
4.118AlaArg: 4.118 ± 0.167
4.278AlaSer: 4.278 ± 0.189
3.093AlaThr: 3.093 ± 0.147
4.947AlaVal: 4.947 ± 0.207
0.546AlaTrp: 0.546 ± 0.056
1.571AlaTyr: 1.571 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.663CysAla: 0.663 ± 0.076
0.147CysCys: 0.147 ± 0.034
0.614CysAsp: 0.614 ± 0.077
0.816CysGlu: 0.816 ± 0.084
0.393CysPhe: 0.393 ± 0.049
1.338CysGly: 1.338 ± 0.114
0.288CysHis: 0.288 ± 0.055
0.571CysIle: 0.571 ± 0.068
0.651CysLys: 0.651 ± 0.072
0.792CysLeu: 0.792 ± 0.072
0.19CysMet: 0.19 ± 0.036
0.325CysAsn: 0.325 ± 0.047
0.749CysPro: 0.749 ± 0.083
0.233CysGln: 0.233 ± 0.033
0.626CysArg: 0.626 ± 0.076
0.706CysSer: 0.706 ± 0.072
0.509CysThr: 0.509 ± 0.057
0.571CysVal: 0.571 ± 0.058
0.123CysTrp: 0.123 ± 0.027
0.344CysTyr: 0.344 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
3.241AspAla: 3.241 ± 0.16
0.534AspCys: 0.534 ± 0.06
2.228AspAsp: 2.228 ± 0.132
4.935AspGlu: 4.935 ± 0.2
2.639AspPhe: 2.639 ± 0.123
3.511AspGly: 3.511 ± 0.154
0.872AspHis: 0.872 ± 0.073
3.897AspIle: 3.897 ± 0.152
3.222AspLys: 3.222 ± 0.162
6.635AspLeu: 6.635 ± 0.227
1.16AspMet: 1.16 ± 0.089
1.498AspAsn: 1.498 ± 0.101
2.719AspPro: 2.719 ± 0.141
1.221AspGln: 1.221 ± 0.073
3.29AspArg: 3.29 ± 0.122
2.67AspSer: 2.67 ± 0.13
1.927AspThr: 1.927 ± 0.117
4.235AspVal: 4.235 ± 0.184
0.681AspTrp: 0.681 ± 0.071
2.05AspTyr: 2.05 ± 0.126
0.0AspXaa: 0.0 ± 0.0
Glu
5.653GluAla: 5.653 ± 0.188
0.694GluCys: 0.694 ± 0.075
4.726GluAsp: 4.726 ± 0.172
10.759GluGlu: 10.759 ± 0.4
3.173GluPhe: 3.173 ± 0.14
6.598GluGly: 6.598 ± 0.22
1.289GluHis: 1.289 ± 0.088
7.678GluIle: 7.678 ± 0.227
8.826GluLys: 8.826 ± 0.286
9.274GluLeu: 9.274 ± 0.266
2.124GluMet: 2.124 ± 0.116
4.155GluAsn: 4.155 ± 0.21
2.664GluPro: 2.664 ± 0.135
1.663GluGln: 1.663 ± 0.102
6.125GluArg: 6.125 ± 0.21
4.615GluSer: 4.615 ± 0.169
3.664GluThr: 3.664 ± 0.156
6.42GluVal: 6.42 ± 0.187
0.884GluTrp: 0.884 ± 0.066
2.271GluTyr: 2.271 ± 0.105
0.0GluXaa: 0.0 ± 0.0
Phe
2.418PheAla: 2.418 ± 0.151
0.528PheCys: 0.528 ± 0.062
2.424PheAsp: 2.424 ± 0.118
3.37PheGlu: 3.37 ± 0.146
1.731PhePhe: 1.731 ± 0.135
3.069PheGly: 3.069 ± 0.155
0.669PheHis: 0.669 ± 0.068
2.068PheIle: 2.068 ± 0.121
2.498PheLys: 2.498 ± 0.13
3.959PheLeu: 3.959 ± 0.212
0.847PheMet: 0.847 ± 0.077
0.994PheAsn: 0.994 ± 0.078
1.59PhePro: 1.59 ± 0.103
1.099PheGln: 1.099 ± 0.073
2.179PheArg: 2.179 ± 0.138
2.713PheSer: 2.713 ± 0.144
1.669PheThr: 1.669 ± 0.092
2.596PheVal: 2.596 ± 0.15
0.417PheTrp: 0.417 ± 0.057
1.172PheTyr: 1.172 ± 0.098
0.0PheXaa: 0.0 ± 0.0
Gly
5.18GlyAla: 5.18 ± 0.211
0.927GlyCys: 0.927 ± 0.092
3.584GlyAsp: 3.584 ± 0.168
6.665GlyGlu: 6.665 ± 0.209
3.063GlyPhe: 3.063 ± 0.14
6.193GlyGly: 6.193 ± 0.262
1.277GlyHis: 1.277 ± 0.086
5.548GlyIle: 5.548 ± 0.21
6.512GlyLys: 6.512 ± 0.213
6.629GlyLeu: 6.629 ± 0.251
1.817GlyMet: 1.817 ± 0.122
2.338GlyAsn: 2.338 ± 0.104
2.486GlyPro: 2.486 ± 0.114
1.442GlyGln: 1.442 ± 0.102
4.886GlyArg: 4.886 ± 0.18
4.695GlySer: 4.695 ± 0.18
3.584GlyThr: 3.584 ± 0.166
5.886GlyVal: 5.886 ± 0.229
0.908GlyTrp: 0.908 ± 0.076
2.363GlyTyr: 2.363 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
1.074HisAla: 1.074 ± 0.088
0.196HisCys: 0.196 ± 0.033
0.97HisAsp: 0.97 ± 0.091
1.356HisGlu: 1.356 ± 0.099
0.663HisPhe: 0.663 ± 0.059
1.32HisGly: 1.32 ± 0.107
0.35HisHis: 0.35 ± 0.046
1.086HisIle: 1.086 ± 0.076
1.099HisLys: 1.099 ± 0.084
1.712HisLeu: 1.712 ± 0.087
0.35HisMet: 0.35 ± 0.04
0.497HisAsn: 0.497 ± 0.056
1.264HisPro: 1.264 ± 0.088
0.442HisGln: 0.442 ± 0.047
1.08HisArg: 1.08 ± 0.083
1.105HisSer: 1.105 ± 0.085
0.675HisThr: 0.675 ± 0.062
1.068HisVal: 1.068 ± 0.077
0.184HisTrp: 0.184 ± 0.028
0.528HisTyr: 0.528 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
4.996IleAla: 4.996 ± 0.183
0.816IleCys: 0.816 ± 0.068
4.045IleAsp: 4.045 ± 0.19
6.481IleGlu: 6.481 ± 0.24
2.566IlePhe: 2.566 ± 0.122
5.334IleGly: 5.334 ± 0.229
1.191IleHis: 1.191 ± 0.074
4.241IleIle: 4.241 ± 0.192
5.272IleLys: 5.272 ± 0.197
6.641IleLeu: 6.641 ± 0.238
1.301IleMet: 1.301 ± 0.093
2.338IleAsn: 2.338 ± 0.122
3.198IlePro: 3.198 ± 0.139
1.719IleGln: 1.719 ± 0.114
3.965IleArg: 3.965 ± 0.143
5.37IleSer: 5.37 ± 0.2
3.149IleThr: 3.149 ± 0.167
4.886IleVal: 4.886 ± 0.18
0.601IleTrp: 0.601 ± 0.063
2.087IleTyr: 2.087 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
5.321LysAla: 5.321 ± 0.194
0.73LysCys: 0.73 ± 0.085
3.707LysAsp: 3.707 ± 0.16
7.813LysGlu: 7.813 ± 0.239
2.688LysPhe: 2.688 ± 0.134
5.395LysGly: 5.395 ± 0.224
1.32LysHis: 1.32 ± 0.089
6.494LysIle: 6.494 ± 0.223
7.193LysLys: 7.193 ± 0.247
7.519LysLeu: 7.519 ± 0.214
1.829LysMet: 1.829 ± 0.109
3.173LysAsn: 3.173 ± 0.172
2.977LysPro: 2.977 ± 0.142
1.633LysGln: 1.633 ± 0.102
5.027LysArg: 5.027 ± 0.17
4.474LysSer: 4.474 ± 0.18
3.382LysThr: 3.382 ± 0.164
5.315LysVal: 5.315 ± 0.187
0.62LysTrp: 0.62 ± 0.072
2.283LysTyr: 2.283 ± 0.123
0.0LysXaa: 0.0 ± 0.0
Leu
6.856LeuAla: 6.856 ± 0.216
0.939LeuCys: 0.939 ± 0.098
5.868LeuAsp: 5.868 ± 0.187
8.998LeuGlu: 8.998 ± 0.264
3.179LeuPhe: 3.179 ± 0.198
7.69LeuGly: 7.69 ± 0.231
1.626LeuHis: 1.626 ± 0.111
5.88LeuIle: 5.88 ± 0.198
7.954LeuLys: 7.954 ± 0.225
8.126LeuLeu: 8.126 ± 0.287
1.909LeuMet: 1.909 ± 0.113
3.719LeuAsn: 3.719 ± 0.134
4.204LeuPro: 4.204 ± 0.153
2.369LeuGln: 2.369 ± 0.129
6.42LeuArg: 6.42 ± 0.233
6.647LeuSer: 6.647 ± 0.242
4.284LeuThr: 4.284 ± 0.149
6.211LeuVal: 6.211 ± 0.224
0.804LeuTrp: 0.804 ± 0.09
2.203LeuTyr: 2.203 ± 0.143
0.0LeuXaa: 0.0 ± 0.0
Met
1.755MetAla: 1.755 ± 0.106
0.172MetCys: 0.172 ± 0.035
1.32MetAsp: 1.32 ± 0.086
1.854MetGlu: 1.854 ± 0.115
0.62MetPhe: 0.62 ± 0.076
1.872MetGly: 1.872 ± 0.11
0.319MetHis: 0.319 ± 0.043
1.498MetIle: 1.498 ± 0.1
2.038MetLys: 2.038 ± 0.122
1.86MetLeu: 1.86 ± 0.108
0.509MetMet: 0.509 ± 0.059
0.915MetAsn: 0.915 ± 0.077
0.988MetPro: 0.988 ± 0.074
0.356MetGln: 0.356 ± 0.057
1.522MetArg: 1.522 ± 0.101
1.547MetSer: 1.547 ± 0.093
1.154MetThr: 1.154 ± 0.081
1.522MetVal: 1.522 ± 0.093
0.209MetTrp: 0.209 ± 0.034
0.344MetTyr: 0.344 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
2.093AsnAla: 2.093 ± 0.129
0.534AsnCys: 0.534 ± 0.066
1.51AsnAsp: 1.51 ± 0.1
2.572AsnGlu: 2.572 ± 0.146
1.7AsnPhe: 1.7 ± 0.101
2.167AsnGly: 2.167 ± 0.127
0.571AsnHis: 0.571 ± 0.058
2.302AsnIle: 2.302 ± 0.126
2.05AsnLys: 2.05 ± 0.125
4.235AsnLeu: 4.235 ± 0.173
0.706AsnMet: 0.706 ± 0.073
0.933AsnAsn: 0.933 ± 0.079
2.203AsnPro: 2.203 ± 0.121
1.0AsnGln: 1.0 ± 0.076
2.148AsnArg: 2.148 ± 0.101
1.964AsnSer: 1.964 ± 0.115
1.455AsnThr: 1.455 ± 0.106
2.725AsnVal: 2.725 ± 0.145
0.485AsnTrp: 0.485 ± 0.06
1.185AsnTyr: 1.185 ± 0.09
0.0AsnXaa: 0.0 ± 0.0
Pro
2.32ProAla: 2.32 ± 0.115
0.405ProCys: 0.405 ± 0.049
2.51ProAsp: 2.51 ± 0.118
4.364ProGlu: 4.364 ± 0.183
1.688ProPhe: 1.688 ± 0.107
3.007ProGly: 3.007 ± 0.141
0.976ProHis: 0.976 ± 0.087
3.02ProIle: 3.02 ± 0.127
2.842ProLys: 2.842 ± 0.13
3.523ProLeu: 3.523 ± 0.15
0.773ProMet: 0.773 ± 0.067
1.547ProAsn: 1.547 ± 0.112
2.001ProPro: 2.001 ± 0.129
1.142ProGln: 1.142 ± 0.085
2.461ProArg: 2.461 ± 0.126
2.995ProSer: 2.995 ± 0.119
2.068ProThr: 2.068 ± 0.111
2.627ProVal: 2.627 ± 0.112
0.362ProTrp: 0.362 ± 0.048
1.381ProTyr: 1.381 ± 0.096
0.0ProXaa: 0.0 ± 0.0
Gln
1.626GlnAla: 1.626 ± 0.105
0.172GlnCys: 0.172 ± 0.034
1.332GlnAsp: 1.332 ± 0.079
1.995GlnGlu: 1.995 ± 0.109
0.835GlnPhe: 0.835 ± 0.072
1.436GlnGly: 1.436 ± 0.099
0.374GlnHis: 0.374 ± 0.048
1.921GlnIle: 1.921 ± 0.098
2.111GlnLys: 2.111 ± 0.126
2.234GlnLeu: 2.234 ± 0.107
0.552GlnMet: 0.552 ± 0.055
0.921GlnAsn: 0.921 ± 0.079
0.829GlnPro: 0.829 ± 0.074
0.552GlnGln: 0.552 ± 0.062
1.633GlnArg: 1.633 ± 0.096
1.338GlnSer: 1.338 ± 0.096
1.062GlnThr: 1.062 ± 0.084
1.633GlnVal: 1.633 ± 0.091
0.141GlnTrp: 0.141 ± 0.031
0.675GlnTyr: 0.675 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
4.161ArgAla: 4.161 ± 0.174
0.601ArgCys: 0.601 ± 0.066
3.093ArgAsp: 3.093 ± 0.127
6.033ArgGlu: 6.033 ± 0.203
2.277ArgPhe: 2.277 ± 0.121
4.744ArgGly: 4.744 ± 0.161
0.884ArgHis: 0.884 ± 0.077
4.658ArgIle: 4.658 ± 0.174
5.923ArgLys: 5.923 ± 0.21
5.383ArgLeu: 5.383 ± 0.167
1.534ArgMet: 1.534 ± 0.1
2.277ArgAsn: 2.277 ± 0.106
2.148ArgPro: 2.148 ± 0.11
1.332ArgGln: 1.332 ± 0.087
4.364ArgArg: 4.364 ± 0.204
3.64ArgSer: 3.64 ± 0.159
2.891ArgThr: 2.891 ± 0.126
4.358ArgVal: 4.358 ± 0.167
0.601ArgTrp: 0.601 ± 0.058
1.682ArgTyr: 1.682 ± 0.123
0.0ArgXaa: 0.0 ± 0.0
Ser
3.861SerAla: 3.861 ± 0.158
0.626SerCys: 0.626 ± 0.067
3.271SerAsp: 3.271 ± 0.15
6.131SerGlu: 6.131 ± 0.231
2.658SerPhe: 2.658 ± 0.132
5.057SerGly: 5.057 ± 0.188
1.197SerHis: 1.197 ± 0.082
4.358SerIle: 4.358 ± 0.178
4.683SerLys: 4.683 ± 0.172
6.033SerLeu: 6.033 ± 0.221
1.657SerMet: 1.657 ± 0.104
2.038SerAsn: 2.038 ± 0.123
2.786SerPro: 2.786 ± 0.118
1.657SerGln: 1.657 ± 0.107
3.652SerArg: 3.652 ± 0.155
4.382SerSer: 4.382 ± 0.163
2.971SerThr: 2.971 ± 0.119
4.204SerVal: 4.204 ± 0.165
0.687SerTrp: 0.687 ± 0.063
1.614SerTyr: 1.614 ± 0.102
0.0SerXaa: 0.0 ± 0.0
Thr
3.192ThrAla: 3.192 ± 0.16
0.479ThrCys: 0.479 ± 0.057
2.265ThrAsp: 2.265 ± 0.126
3.057ThrGlu: 3.057 ± 0.137
1.424ThrPhe: 1.424 ± 0.109
3.787ThrGly: 3.787 ± 0.158
0.841ThrHis: 0.841 ± 0.072
3.376ThrIle: 3.376 ± 0.149
2.94ThrLys: 2.94 ± 0.141
4.493ThrLeu: 4.493 ± 0.172
1.019ThrMet: 1.019 ± 0.082
1.289ThrAsn: 1.289 ± 0.092
2.314ThrPro: 2.314 ± 0.132
1.025ThrGln: 1.025 ± 0.073
2.234ThrArg: 2.234 ± 0.118
3.29ThrSer: 3.29 ± 0.129
2.203ThrThr: 2.203 ± 0.131
3.431ThrVal: 3.431 ± 0.144
0.387ThrTrp: 0.387 ± 0.056
1.356ThrTyr: 1.356 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
4.953ValAla: 4.953 ± 0.205
0.798ValCys: 0.798 ± 0.078
4.247ValAsp: 4.247 ± 0.173
6.85ValGlu: 6.85 ± 0.193
2.461ValPhe: 2.461 ± 0.133
5.42ValGly: 5.42 ± 0.204
1.215ValHis: 1.215 ± 0.088
4.566ValIle: 4.566 ± 0.181
5.291ValLys: 5.291 ± 0.21
6.285ValLeu: 6.285 ± 0.206
1.498ValMet: 1.498 ± 0.102
2.357ValAsn: 2.357 ± 0.116
2.952ValPro: 2.952 ± 0.139
1.694ValGln: 1.694 ± 0.108
4.149ValArg: 4.149 ± 0.169
4.53ValSer: 4.53 ± 0.18
3.32ValThr: 3.32 ± 0.142
5.088ValVal: 5.088 ± 0.231
0.632ValTrp: 0.632 ± 0.062
1.774ValTyr: 1.774 ± 0.122
0.0ValXaa: 0.0 ± 0.0
Trp
0.54TrpAla: 0.54 ± 0.056
0.141TrpCys: 0.141 ± 0.027
0.485TrpAsp: 0.485 ± 0.051
0.773TrpGlu: 0.773 ± 0.063
0.411TrpPhe: 0.411 ± 0.058
0.669TrpGly: 0.669 ± 0.059
0.16TrpHis: 0.16 ± 0.025
0.724TrpIle: 0.724 ± 0.073
0.939TrpLys: 0.939 ± 0.083
0.939TrpLeu: 0.939 ± 0.076
0.282TrpMet: 0.282 ± 0.037
0.436TrpAsn: 0.436 ± 0.057
0.319TrpPro: 0.319 ± 0.04
0.252TrpGln: 0.252 ± 0.039
0.822TrpArg: 0.822 ± 0.073
0.54TrpSer: 0.54 ± 0.055
0.27TrpThr: 0.27 ± 0.038
0.614TrpVal: 0.614 ± 0.064
0.153TrpTrp: 0.153 ± 0.031
0.264TrpTyr: 0.264 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.626TyrAla: 1.626 ± 0.102
0.387TyrCys: 0.387 ± 0.051
1.688TyrAsp: 1.688 ± 0.105
2.4TyrGlu: 2.4 ± 0.137
1.234TyrPhe: 1.234 ± 0.09
2.381TyrGly: 2.381 ± 0.133
0.595TyrHis: 0.595 ± 0.055
1.676TyrIle: 1.676 ± 0.115
1.626TyrLys: 1.626 ± 0.1
2.964TyrLeu: 2.964 ± 0.138
0.516TyrMet: 0.516 ± 0.051
0.822TyrAsn: 0.822 ± 0.077
1.375TyrPro: 1.375 ± 0.097
0.829TyrGln: 0.829 ± 0.079
1.884TyrArg: 1.884 ± 0.122
2.025TyrSer: 2.025 ± 0.1
1.068TyrThr: 1.068 ± 0.078
1.743TyrVal: 1.743 ± 0.115
0.307TyrTrp: 0.307 ± 0.052
0.89TyrTyr: 0.89 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 687 proteins (162931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski