Amino acid dipepetide frequency for Circovirus-like genome DCCV-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.631AlaAla: 8.631 ± 5.613
2.466AlaCys: 2.466 ± 1.593
7.398AlaAsp: 7.398 ± 2.382
3.699AlaGlu: 3.699 ± 1.325
3.699AlaPhe: 3.699 ± 1.839
7.398AlaGly: 7.398 ± 4.601
3.699AlaHis: 3.699 ± 1.191
4.932AlaIle: 4.932 ± 1.874
0.0AlaLys: 0.0 ± 0.0
4.932AlaLeu: 4.932 ± 2.595
4.932AlaMet: 4.932 ± 0.987
2.466AlaAsn: 2.466 ± 0.77
2.466AlaPro: 2.466 ± 2.037
6.165AlaGln: 6.165 ± 2.325
4.932AlaArg: 4.932 ± 1.541
6.165AlaSer: 6.165 ± 1.841
7.398AlaThr: 7.398 ± 3.241
6.165AlaVal: 6.165 ± 3.594
0.0AlaTrp: 0.0 ± 0.0
1.233AlaTyr: 1.233 ± 1.018
0.0AlaXaa: 0.0 ± 0.0
Cys
1.233CysAla: 1.233 ± 0.797
0.0CysCys: 0.0 ± 0.0
1.233CysAsp: 1.233 ± 0.797
1.233CysGlu: 1.233 ± 1.018
0.0CysPhe: 0.0 ± 0.0
4.932CysGly: 4.932 ± 1.541
0.0CysHis: 0.0 ± 0.0
1.233CysIle: 1.233 ± 0.797
1.233CysLys: 1.233 ± 0.797
2.466CysLeu: 2.466 ± 0.77
1.233CysMet: 1.233 ± 1.018
0.0CysAsn: 0.0 ± 0.0
1.233CysPro: 1.233 ± 0.797
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.233CysSer: 1.233 ± 2.015
2.466CysThr: 2.466 ± 0.77
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.233CysTyr: 1.233 ± 1.018
0.0CysXaa: 0.0 ± 0.0
Asp
9.864AspAla: 9.864 ± 1.858
2.466AspCys: 2.466 ± 0.77
1.233AspAsp: 1.233 ± 0.797
0.0AspGlu: 0.0 ± 0.0
1.233AspPhe: 1.233 ± 2.015
7.398AspGly: 7.398 ± 4.779
0.0AspHis: 0.0 ± 0.0
2.466AspIle: 2.466 ± 0.77
3.699AspLys: 3.699 ± 1.325
4.932AspLeu: 4.932 ± 3.186
2.466AspMet: 2.466 ± 1.437
2.466AspAsn: 2.466 ± 1.951
7.398AspPro: 7.398 ± 5.158
0.0AspGln: 0.0 ± 0.0
3.699AspArg: 3.699 ± 1.191
3.699AspSer: 3.699 ± 1.191
2.466AspThr: 2.466 ± 0.77
3.699AspVal: 3.699 ± 2.39
0.0AspTrp: 0.0 ± 0.0
2.466AspTyr: 2.466 ± 1.757
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
0.0GluCys: 0.0 ± 0.0
4.932GluAsp: 4.932 ± 1.874
8.631GluGlu: 8.631 ± 6.954
1.233GluPhe: 1.233 ± 2.015
1.233GluGly: 1.233 ± 0.797
0.0GluHis: 0.0 ± 0.0
1.233GluIle: 1.233 ± 2.015
1.233GluLys: 1.233 ± 1.018
3.699GluLeu: 3.699 ± 1.839
3.699GluMet: 3.699 ± 2.756
1.233GluAsn: 1.233 ± 2.015
2.466GluPro: 2.466 ± 1.757
0.0GluGln: 0.0 ± 0.0
6.165GluArg: 6.165 ± 2.622
4.932GluSer: 4.932 ± 2.224
4.932GluThr: 4.932 ± 3.322
2.466GluVal: 2.466 ± 1.757
0.0GluTrp: 0.0 ± 0.0
4.932GluTyr: 4.932 ± 2.224
0.0GluXaa: 0.0 ± 0.0
Phe
2.466PheAla: 2.466 ± 1.951
0.0PheCys: 0.0 ± 0.0
3.699PheAsp: 3.699 ± 1.325
1.233PheGlu: 1.233 ± 2.015
0.0PhePhe: 0.0 ± 0.0
2.466PheGly: 2.466 ± 0.77
0.0PheHis: 0.0 ± 0.0
1.233PheIle: 1.233 ± 0.797
3.699PheLys: 3.699 ± 1.621
2.466PheLeu: 2.466 ± 4.03
0.0PheMet: 0.0 ± 0.0
3.699PheAsn: 3.699 ± 3.055
0.0PhePro: 0.0 ± 0.0
2.466PheGln: 2.466 ± 1.951
4.932PheArg: 4.932 ± 0.987
6.165PheSer: 6.165 ± 2.622
3.699PheThr: 3.699 ± 2.39
3.699PheVal: 3.699 ± 2.39
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
8.631GlyAla: 8.631 ± 3.061
3.699GlyCys: 3.699 ± 1.621
3.699GlyAsp: 3.699 ± 1.621
1.233GlyGlu: 1.233 ± 1.018
2.466GlyPhe: 2.466 ± 1.593
4.932GlyGly: 4.932 ± 1.541
2.466GlyHis: 2.466 ± 1.593
0.0GlyIle: 0.0 ± 0.0
3.699GlyLys: 3.699 ± 2.39
4.932GlyLeu: 4.932 ± 3.186
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
0.0GlyPro: 0.0 ± 0.0
2.466GlyGln: 2.466 ± 1.593
4.932GlyArg: 4.932 ± 2.595
4.932GlySer: 4.932 ± 1.874
8.631GlyThr: 8.631 ± 2.559
3.699GlyVal: 3.699 ± 1.191
0.0GlyTrp: 0.0 ± 0.0
3.699GlyTyr: 3.699 ± 1.191
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.233HisCys: 1.233 ± 0.797
1.233HisAsp: 1.233 ± 0.797
1.233HisGlu: 1.233 ± 0.797
1.233HisPhe: 1.233 ± 0.797
2.466HisGly: 2.466 ± 1.593
0.0HisHis: 0.0 ± 0.0
4.932HisIle: 4.932 ± 1.874
0.0HisLys: 0.0 ± 0.0
1.233HisLeu: 1.233 ± 0.797
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.233HisPro: 1.233 ± 2.015
1.233HisGln: 1.233 ± 2.015
1.233HisArg: 1.233 ± 2.015
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.233HisVal: 1.233 ± 1.018
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.165IleAla: 6.165 ± 1.841
0.0IleCys: 0.0 ± 0.0
2.466IleAsp: 2.466 ± 1.951
1.233IleGlu: 1.233 ± 0.797
1.233IlePhe: 1.233 ± 0.797
1.233IleGly: 1.233 ± 1.018
0.0IleHis: 0.0 ± 0.0
3.699IleIle: 3.699 ± 1.191
1.233IleLys: 1.233 ± 1.018
4.932IleLeu: 4.932 ± 3.186
0.0IleMet: 0.0 ± 0.0
3.699IleAsn: 3.699 ± 1.621
3.699IlePro: 3.699 ± 1.325
2.466IleGln: 2.466 ± 1.593
3.699IleArg: 3.699 ± 1.621
3.699IleSer: 3.699 ± 1.325
3.699IleThr: 3.699 ± 1.191
1.233IleVal: 1.233 ± 1.018
1.233IleTrp: 1.233 ± 2.015
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.233LysAla: 1.233 ± 1.018
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
6.165LysGlu: 6.165 ± 1.841
1.233LysPhe: 1.233 ± 0.797
3.699LysGly: 3.699 ± 2.39
1.233LysHis: 1.233 ± 0.797
1.233LysIle: 1.233 ± 1.018
0.0LysLys: 0.0 ± 0.0
1.233LysLeu: 1.233 ± 1.018
1.233LysMet: 1.233 ± 1.018
1.233LysAsn: 1.233 ± 0.797
0.0LysPro: 0.0 ± 0.0
3.699LysGln: 3.699 ± 1.621
3.699LysArg: 3.699 ± 1.621
3.699LysSer: 3.699 ± 3.695
3.699LysThr: 3.699 ± 1.839
2.466LysVal: 2.466 ± 2.037
1.233LysTrp: 1.233 ± 0.797
2.466LysTyr: 2.466 ± 2.037
0.0LysXaa: 0.0 ± 0.0
Leu
6.165LeuAla: 6.165 ± 1.841
1.233LeuCys: 1.233 ± 1.018
6.165LeuAsp: 6.165 ± 2.941
3.699LeuGlu: 3.699 ± 1.839
4.932LeuPhe: 4.932 ± 1.582
3.699LeuGly: 3.699 ± 1.191
2.466LeuHis: 2.466 ± 0.77
3.699LeuIle: 3.699 ± 1.839
4.932LeuLys: 4.932 ± 1.874
2.466LeuLeu: 2.466 ± 1.593
0.0LeuMet: 0.0 ± 0.0
2.466LeuAsn: 2.466 ± 1.951
3.699LeuPro: 3.699 ± 1.191
3.699LeuGln: 3.699 ± 1.839
6.165LeuArg: 6.165 ± 3.983
6.165LeuSer: 6.165 ± 3.507
6.165LeuThr: 6.165 ± 3.507
2.466LeuVal: 2.466 ± 2.037
3.699LeuTrp: 3.699 ± 1.839
3.699LeuTyr: 3.699 ± 3.834
0.0LeuXaa: 0.0 ± 0.0
Met
2.466MetAla: 2.466 ± 0.77
0.0MetCys: 0.0 ± 0.0
1.233MetAsp: 1.233 ± 0.797
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
4.932MetLys: 4.932 ± 1.582
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
3.699MetPro: 3.699 ± 1.839
1.233MetGln: 1.233 ± 1.018
2.466MetArg: 2.466 ± 0.77
1.233MetSer: 1.233 ± 1.018
2.466MetThr: 2.466 ± 1.951
1.233MetVal: 1.233 ± 1.018
1.233MetTrp: 1.233 ± 0.797
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.699AsnAla: 3.699 ± 1.621
0.0AsnCys: 0.0 ± 0.0
3.699AsnAsp: 3.699 ± 1.621
1.233AsnGlu: 1.233 ± 0.797
3.699AsnPhe: 3.699 ± 3.055
3.699AsnGly: 3.699 ± 1.621
1.233AsnHis: 1.233 ± 0.797
0.0AsnIle: 0.0 ± 0.0
0.0AsnLys: 0.0 ± 0.0
4.932AsnLeu: 4.932 ± 2.595
1.233AsnMet: 1.233 ± 1.274
1.233AsnAsn: 1.233 ± 1.018
2.466AsnPro: 2.466 ± 1.951
1.233AsnGln: 1.233 ± 0.797
1.233AsnArg: 1.233 ± 1.018
3.699AsnSer: 3.699 ± 1.191
0.0AsnThr: 0.0 ± 0.0
2.466AsnVal: 2.466 ± 1.951
0.0AsnTrp: 0.0 ± 0.0
1.233AsnTyr: 1.233 ± 1.018
0.0AsnXaa: 0.0 ± 0.0
Pro
4.932ProAla: 4.932 ± 1.541
0.0ProCys: 0.0 ± 0.0
3.699ProAsp: 3.699 ± 3.695
0.0ProGlu: 0.0 ± 0.0
3.699ProPhe: 3.699 ± 1.839
1.233ProGly: 1.233 ± 0.797
2.466ProHis: 2.466 ± 1.757
1.233ProIle: 1.233 ± 2.015
4.932ProLys: 4.932 ± 1.874
8.631ProLeu: 8.631 ± 9.359
0.0ProMet: 0.0 ± 0.0
2.466ProAsn: 2.466 ± 2.037
1.233ProPro: 1.233 ± 1.018
3.699ProGln: 3.699 ± 1.325
1.233ProArg: 1.233 ± 1.018
0.0ProSer: 0.0 ± 0.0
8.631ProThr: 8.631 ± 2.735
3.699ProVal: 3.699 ± 1.621
1.233ProTrp: 1.233 ± 2.015
1.233ProTyr: 1.233 ± 0.797
0.0ProXaa: 0.0 ± 0.0
Gln
1.233GlnAla: 1.233 ± 0.797
1.233GlnCys: 1.233 ± 1.018
2.466GlnAsp: 2.466 ± 0.77
1.233GlnGlu: 1.233 ± 2.015
1.233GlnPhe: 1.233 ± 1.018
4.932GlnGly: 4.932 ± 1.874
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.233GlnLys: 1.233 ± 2.015
3.699GlnLeu: 3.699 ± 1.839
1.233GlnMet: 1.233 ± 1.018
1.233GlnAsn: 1.233 ± 1.018
4.932GlnPro: 4.932 ± 0.987
4.932GlnGln: 4.932 ± 2.224
6.165GlnArg: 6.165 ± 1.209
3.699GlnSer: 3.699 ± 1.325
3.699GlnThr: 3.699 ± 3.834
4.932GlnVal: 4.932 ± 1.874
1.233GlnTrp: 1.233 ± 0.797
1.233GlnTyr: 1.233 ± 2.015
0.0GlnXaa: 0.0 ± 0.0
Arg
6.165ArgAla: 6.165 ± 2.325
1.233ArgCys: 1.233 ± 0.797
6.165ArgAsp: 6.165 ± 2.622
7.398ArgGlu: 7.398 ± 1.793
4.932ArgPhe: 4.932 ± 1.874
4.932ArgGly: 4.932 ± 1.541
1.233ArgHis: 1.233 ± 2.015
4.932ArgIle: 4.932 ± 2.595
3.699ArgLys: 3.699 ± 1.621
2.466ArgLeu: 2.466 ± 0.77
2.466ArgMet: 2.466 ± 1.951
2.466ArgAsn: 2.466 ± 1.593
3.699ArgPro: 3.699 ± 2.373
1.233ArgGln: 1.233 ± 0.797
3.699ArgArg: 3.699 ± 1.191
1.233ArgSer: 1.233 ± 0.797
4.932ArgThr: 4.932 ± 1.874
4.932ArgVal: 4.932 ± 1.541
0.0ArgTrp: 0.0 ± 0.0
2.466ArgTyr: 2.466 ± 1.593
0.0ArgXaa: 0.0 ± 0.0
Ser
7.398SerAla: 7.398 ± 2.382
0.0SerCys: 0.0 ± 0.0
3.699SerAsp: 3.699 ± 2.39
8.631SerGlu: 8.631 ± 7.167
2.466SerPhe: 2.466 ± 2.037
3.699SerGly: 3.699 ± 1.191
2.466SerHis: 2.466 ± 1.593
2.466SerIle: 2.466 ± 1.593
0.0SerLys: 0.0 ± 0.0
6.165SerLeu: 6.165 ± 2.941
0.0SerMet: 0.0 ± 0.0
4.932SerAsn: 4.932 ± 1.541
3.699SerPro: 3.699 ± 1.325
3.699SerGln: 3.699 ± 3.695
3.699SerArg: 3.699 ± 1.191
6.165SerSer: 6.165 ± 3.507
3.699SerThr: 3.699 ± 1.191
7.398SerVal: 7.398 ± 2.311
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
9.864ThrAla: 9.864 ± 3.477
2.466ThrCys: 2.466 ± 1.757
0.0ThrAsp: 0.0 ± 0.0
2.466ThrGlu: 2.466 ± 1.757
1.233ThrPhe: 1.233 ± 1.018
2.466ThrGly: 2.466 ± 0.77
0.0ThrHis: 0.0 ± 0.0
9.864ThrIle: 9.864 ± 3.933
1.233ThrLys: 1.233 ± 0.797
8.631ThrLeu: 8.631 ± 4.66
1.233ThrMet: 1.233 ± 0.797
3.699ThrAsn: 3.699 ± 1.191
6.165ThrPro: 6.165 ± 1.209
3.699ThrGln: 3.699 ± 1.839
4.932ThrArg: 4.932 ± 0.987
4.932ThrSer: 4.932 ± 1.541
8.631ThrThr: 8.631 ± 2.559
3.699ThrVal: 3.699 ± 1.325
1.233ThrTrp: 1.233 ± 1.018
2.466ThrTyr: 2.466 ± 1.757
0.0ThrXaa: 0.0 ± 0.0
Val
8.631ValAla: 8.631 ± 3.061
3.699ValCys: 3.699 ± 1.621
4.932ValAsp: 4.932 ± 0.987
1.233ValGlu: 1.233 ± 0.797
3.699ValPhe: 3.699 ± 1.839
1.233ValGly: 1.233 ± 0.797
0.0ValHis: 0.0 ± 0.0
2.466ValIle: 2.466 ± 1.951
0.0ValLys: 0.0 ± 0.0
6.165ValLeu: 6.165 ± 1.841
1.233ValMet: 1.233 ± 0.797
3.699ValAsn: 3.699 ± 3.055
2.466ValPro: 2.466 ± 0.77
3.699ValGln: 3.699 ± 1.621
3.699ValArg: 3.699 ± 1.191
6.165ValSer: 6.165 ± 1.841
2.466ValThr: 2.466 ± 2.037
0.0ValVal: 0.0 ± 0.0
1.233ValTrp: 1.233 ± 0.797
2.466ValTyr: 2.466 ± 2.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
1.233TrpPhe: 1.233 ± 0.797
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.466TrpLeu: 2.466 ± 1.593
0.0TrpMet: 0.0 ± 0.0
1.233TrpAsn: 1.233 ± 0.797
1.233TrpPro: 1.233 ± 2.015
2.466TrpGln: 2.466 ± 1.757
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
1.233TrpThr: 1.233 ± 2.015
2.466TrpVal: 2.466 ± 0.77
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.233TyrCys: 1.233 ± 0.797
3.699TyrAsp: 3.699 ± 1.839
2.466TyrGlu: 2.466 ± 0.77
2.466TyrPhe: 2.466 ± 1.951
2.466TyrGly: 2.466 ± 0.77
1.233TyrHis: 1.233 ± 2.015
0.0TyrIle: 0.0 ± 0.0
3.699TyrLys: 3.699 ± 3.055
1.233TyrLeu: 1.233 ± 0.797
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
2.466TyrPro: 2.466 ± 1.757
2.466TyrGln: 2.466 ± 1.951
3.699TyrArg: 3.699 ± 1.191
2.466TyrSer: 2.466 ± 1.951
0.0TyrThr: 0.0 ± 0.0
1.233TyrVal: 1.233 ± 0.797
0.0TyrTrp: 0.0 ± 0.0
2.466TyrTyr: 2.466 ± 2.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski