Amino acid dipepetide frequency for Mycobacterium virus Mutaforma13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.208AlaAla: 14.208 ± 2.065
0.874AlaCys: 0.874 ± 0.259
7.377AlaAsp: 7.377 ± 0.649
7.268AlaGlu: 7.268 ± 0.787
2.732AlaPhe: 2.732 ± 0.354
9.836AlaGly: 9.836 ± 1.344
2.24AlaHis: 2.24 ± 0.374
4.481AlaIle: 4.481 ± 0.455
4.208AlaLys: 4.208 ± 0.455
8.197AlaLeu: 8.197 ± 0.794
2.678AlaMet: 2.678 ± 0.403
2.678AlaAsn: 2.678 ± 0.4
4.973AlaPro: 4.973 ± 0.588
3.169AlaGln: 3.169 ± 0.448
7.814AlaArg: 7.814 ± 0.741
5.027AlaSer: 5.027 ± 0.588
5.956AlaThr: 5.956 ± 0.554
6.721AlaVal: 6.721 ± 0.548
3.169AlaTrp: 3.169 ± 0.641
2.077AlaTyr: 2.077 ± 0.316
0.0AlaXaa: 0.0 ± 0.0
Cys
0.929CysAla: 0.929 ± 0.268
0.109CysCys: 0.109 ± 0.079
0.929CysAsp: 0.929 ± 0.259
0.929CysGlu: 0.929 ± 0.273
0.273CysPhe: 0.273 ± 0.123
1.311CysGly: 1.311 ± 0.318
0.273CysHis: 0.273 ± 0.102
0.219CysIle: 0.219 ± 0.118
0.492CysLys: 0.492 ± 0.169
0.82CysLeu: 0.82 ± 0.296
0.055CysMet: 0.055 ± 0.056
0.437CysAsn: 0.437 ± 0.162
1.038CysPro: 1.038 ± 0.257
0.219CysGln: 0.219 ± 0.108
1.038CysArg: 1.038 ± 0.256
0.656CysSer: 0.656 ± 0.218
0.71CysThr: 0.71 ± 0.216
0.765CysVal: 0.765 ± 0.17
0.328CysTrp: 0.328 ± 0.144
0.273CysTyr: 0.273 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
7.104AspAla: 7.104 ± 0.57
0.765AspCys: 0.765 ± 0.209
4.426AspAsp: 4.426 ± 0.594
3.279AspGlu: 3.279 ± 0.442
1.749AspPhe: 1.749 ± 0.261
6.393AspGly: 6.393 ± 0.607
1.475AspHis: 1.475 ± 0.299
2.131AspIle: 2.131 ± 0.305
1.639AspLys: 1.639 ± 0.292
5.956AspLeu: 5.956 ± 0.657
0.929AspMet: 0.929 ± 0.244
1.803AspAsn: 1.803 ± 0.38
4.645AspPro: 4.645 ± 0.651
2.295AspGln: 2.295 ± 0.326
5.027AspArg: 5.027 ± 0.571
3.77AspSer: 3.77 ± 0.447
3.934AspThr: 3.934 ± 0.525
4.317AspVal: 4.317 ± 0.654
1.366AspTrp: 1.366 ± 0.338
1.749AspTyr: 1.749 ± 0.331
0.0AspXaa: 0.0 ± 0.0
Glu
5.738GluAla: 5.738 ± 0.563
0.874GluCys: 0.874 ± 0.297
2.951GluAsp: 2.951 ± 0.338
2.623GluGlu: 2.623 ± 0.485
2.35GluPhe: 2.35 ± 0.371
3.224GluGly: 3.224 ± 0.438
0.82GluHis: 0.82 ± 0.25
2.35GluIle: 2.35 ± 0.351
1.858GluLys: 1.858 ± 0.27
5.355GluLeu: 5.355 ± 0.687
1.639GluMet: 1.639 ± 0.359
2.35GluAsn: 2.35 ± 0.331
3.005GluPro: 3.005 ± 0.505
2.842GluGln: 2.842 ± 0.397
5.191GluArg: 5.191 ± 0.56
3.115GluSer: 3.115 ± 0.642
3.716GluThr: 3.716 ± 0.522
3.989GluVal: 3.989 ± 0.451
1.475GluTrp: 1.475 ± 0.274
2.459GluTyr: 2.459 ± 0.4
0.0GluXaa: 0.0 ± 0.0
Phe
3.169PheAla: 3.169 ± 0.424
0.273PheCys: 0.273 ± 0.115
2.295PheAsp: 2.295 ± 0.393
1.694PheGlu: 1.694 ± 0.291
0.984PhePhe: 0.984 ± 0.283
2.842PheGly: 2.842 ± 0.646
0.437PheHis: 0.437 ± 0.155
1.202PheIle: 1.202 ± 0.342
0.874PheLys: 0.874 ± 0.231
1.858PheLeu: 1.858 ± 0.286
0.71PheMet: 0.71 ± 0.222
1.421PheAsn: 1.421 ± 0.328
1.639PhePro: 1.639 ± 0.333
1.038PheGln: 1.038 ± 0.298
1.366PheArg: 1.366 ± 0.264
1.421PheSer: 1.421 ± 0.253
2.459PheThr: 2.459 ± 0.365
1.967PheVal: 1.967 ± 0.284
0.71PheTrp: 0.71 ± 0.157
0.929PheTyr: 0.929 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
9.29GlyAla: 9.29 ± 1.387
1.093GlyCys: 1.093 ± 0.265
5.956GlyAsp: 5.956 ± 0.523
3.825GlyGlu: 3.825 ± 0.51
2.35GlyPhe: 2.35 ± 0.391
10.328GlyGly: 10.328 ± 2.267
2.131GlyHis: 2.131 ± 0.359
4.372GlyIle: 4.372 ± 0.659
2.35GlyLys: 2.35 ± 0.352
6.339GlyLeu: 6.339 ± 0.564
2.186GlyMet: 2.186 ± 0.461
3.169GlyAsn: 3.169 ± 0.325
4.59GlyPro: 4.59 ± 0.631
2.568GlyGln: 2.568 ± 0.608
5.519GlyArg: 5.519 ± 0.7
6.23GlySer: 6.23 ± 0.881
6.23GlyThr: 6.23 ± 0.797
5.574GlyVal: 5.574 ± 0.481
2.295GlyTrp: 2.295 ± 0.424
1.967GlyTyr: 1.967 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
1.803HisAla: 1.803 ± 0.42
0.492HisCys: 0.492 ± 0.202
0.929HisAsp: 0.929 ± 0.208
1.585HisGlu: 1.585 ± 0.437
0.601HisPhe: 0.601 ± 0.186
1.475HisGly: 1.475 ± 0.285
0.929HisHis: 0.929 ± 0.235
1.257HisIle: 1.257 ± 0.29
0.82HisLys: 0.82 ± 0.234
1.53HisLeu: 1.53 ± 0.33
0.601HisMet: 0.601 ± 0.149
0.71HisAsn: 0.71 ± 0.19
1.53HisPro: 1.53 ± 0.264
0.929HisGln: 0.929 ± 0.239
1.913HisArg: 1.913 ± 0.375
0.82HisSer: 0.82 ± 0.194
1.53HisThr: 1.53 ± 0.327
1.475HisVal: 1.475 ± 0.293
0.328HisTrp: 0.328 ± 0.125
0.71HisTyr: 0.71 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
5.082IleAla: 5.082 ± 0.564
0.492IleCys: 0.492 ± 0.2
3.934IleAsp: 3.934 ± 0.604
3.825IleGlu: 3.825 ± 0.4
0.601IlePhe: 0.601 ± 0.22
3.934IleGly: 3.934 ± 0.522
1.421IleHis: 1.421 ± 0.313
1.366IleIle: 1.366 ± 0.28
1.093IleLys: 1.093 ± 0.241
1.967IleLeu: 1.967 ± 0.38
0.328IleMet: 0.328 ± 0.136
2.022IleAsn: 2.022 ± 0.316
2.842IlePro: 2.842 ± 0.366
1.694IleGln: 1.694 ± 0.276
2.787IleArg: 2.787 ± 0.384
2.24IleSer: 2.24 ± 0.451
3.661IleThr: 3.661 ± 0.432
2.732IleVal: 2.732 ± 0.317
0.874IleTrp: 0.874 ± 0.228
0.601IleTyr: 0.601 ± 0.18
0.0IleXaa: 0.0 ± 0.0
Lys
3.716LysAla: 3.716 ± 0.487
0.383LysCys: 0.383 ± 0.156
1.858LysAsp: 1.858 ± 0.299
1.421LysGlu: 1.421 ± 0.271
1.53LysPhe: 1.53 ± 0.22
2.678LysGly: 2.678 ± 0.35
1.202LysHis: 1.202 ± 0.299
1.148LysIle: 1.148 ± 0.269
1.366LysLys: 1.366 ± 0.348
2.404LysLeu: 2.404 ± 0.469
0.492LysMet: 0.492 ± 0.179
0.984LysAsn: 0.984 ± 0.225
2.24LysPro: 2.24 ± 0.396
1.858LysGln: 1.858 ± 0.321
2.077LysArg: 2.077 ± 0.383
2.295LysSer: 2.295 ± 0.412
2.022LysThr: 2.022 ± 0.367
2.514LysVal: 2.514 ± 0.316
0.765LysTrp: 0.765 ± 0.285
0.874LysTyr: 0.874 ± 0.217
0.0LysXaa: 0.0 ± 0.0
Leu
7.541LeuAla: 7.541 ± 0.777
0.82LeuCys: 0.82 ± 0.292
4.863LeuAsp: 4.863 ± 0.628
3.88LeuGlu: 3.88 ± 0.447
2.459LeuPhe: 2.459 ± 0.295
4.918LeuGly: 4.918 ± 0.486
0.984LeuHis: 0.984 ± 0.278
3.06LeuIle: 3.06 ± 0.353
2.131LeuLys: 2.131 ± 0.329
4.973LeuLeu: 4.973 ± 0.62
2.077LeuMet: 2.077 ± 0.314
2.787LeuAsn: 2.787 ± 0.415
5.137LeuPro: 5.137 ± 0.683
2.787LeuGln: 2.787 ± 0.376
5.301LeuArg: 5.301 ± 0.678
5.464LeuSer: 5.464 ± 0.571
6.23LeuThr: 6.23 ± 0.548
4.481LeuVal: 4.481 ± 0.472
1.366LeuTrp: 1.366 ± 0.327
2.077LeuTyr: 2.077 ± 0.384
0.0LeuXaa: 0.0 ± 0.0
Met
2.295MetAla: 2.295 ± 0.394
0.109MetCys: 0.109 ± 0.081
1.311MetAsp: 1.311 ± 0.29
0.874MetGlu: 0.874 ± 0.174
0.601MetPhe: 0.601 ± 0.202
1.694MetGly: 1.694 ± 0.317
0.109MetHis: 0.109 ± 0.069
0.765MetIle: 0.765 ± 0.218
0.765MetLys: 0.765 ± 0.228
1.803MetLeu: 1.803 ± 0.251
0.656MetMet: 0.656 ± 0.231
0.984MetAsn: 0.984 ± 0.237
1.421MetPro: 1.421 ± 0.307
0.437MetGln: 0.437 ± 0.127
1.475MetArg: 1.475 ± 0.304
2.842MetSer: 2.842 ± 0.457
2.24MetThr: 2.24 ± 0.351
1.475MetVal: 1.475 ± 0.316
0.492MetTrp: 0.492 ± 0.156
0.492MetTyr: 0.492 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
3.443AsnAla: 3.443 ± 0.434
0.492AsnCys: 0.492 ± 0.19
1.803AsnAsp: 1.803 ± 0.256
1.53AsnGlu: 1.53 ± 0.29
0.929AsnPhe: 0.929 ± 0.291
4.372AsnGly: 4.372 ± 0.501
0.984AsnHis: 0.984 ± 0.177
1.639AsnIle: 1.639 ± 0.476
1.093AsnLys: 1.093 ± 0.248
2.568AsnLeu: 2.568 ± 0.348
0.656AsnMet: 0.656 ± 0.171
1.803AsnAsn: 1.803 ± 0.381
2.787AsnPro: 2.787 ± 0.378
0.984AsnGln: 0.984 ± 0.318
2.295AsnArg: 2.295 ± 0.369
1.803AsnSer: 1.803 ± 0.26
2.514AsnThr: 2.514 ± 0.318
1.803AsnVal: 1.803 ± 0.365
0.765AsnTrp: 0.765 ± 0.195
0.929AsnTyr: 0.929 ± 0.196
0.0AsnXaa: 0.0 ± 0.0
Pro
5.847ProAla: 5.847 ± 0.621
0.546ProCys: 0.546 ± 0.172
4.044ProAsp: 4.044 ± 0.548
4.372ProGlu: 4.372 ± 0.465
1.475ProPhe: 1.475 ± 0.346
6.393ProGly: 6.393 ± 0.776
1.694ProHis: 1.694 ± 0.3
2.24ProIle: 2.24 ± 0.344
2.568ProLys: 2.568 ± 0.461
4.481ProLeu: 4.481 ± 0.493
1.311ProMet: 1.311 ± 0.271
2.24ProAsn: 2.24 ± 0.369
3.77ProPro: 3.77 ± 0.587
2.35ProGln: 2.35 ± 0.456
3.661ProArg: 3.661 ± 0.557
3.005ProSer: 3.005 ± 0.419
3.005ProThr: 3.005 ± 0.39
4.863ProVal: 4.863 ± 0.527
1.257ProTrp: 1.257 ± 0.273
1.585ProTyr: 1.585 ± 0.252
0.0ProXaa: 0.0 ± 0.0
Gln
4.59GlnAla: 4.59 ± 0.575
0.273GlnCys: 0.273 ± 0.195
1.421GlnAsp: 1.421 ± 0.242
1.749GlnGlu: 1.749 ± 0.38
1.093GlnPhe: 1.093 ± 0.19
2.514GlnGly: 2.514 ± 0.509
0.929GlnHis: 0.929 ± 0.275
1.913GlnIle: 1.913 ± 0.297
1.148GlnLys: 1.148 ± 0.227
2.623GlnLeu: 2.623 ± 0.419
0.874GlnMet: 0.874 ± 0.216
1.202GlnAsn: 1.202 ± 0.294
2.842GlnPro: 2.842 ± 0.431
1.093GlnGln: 1.093 ± 0.275
2.404GlnArg: 2.404 ± 0.383
2.24GlnSer: 2.24 ± 0.39
1.53GlnThr: 1.53 ± 0.309
2.678GlnVal: 2.678 ± 0.449
0.82GlnTrp: 0.82 ± 0.219
0.929GlnTyr: 0.929 ± 0.274
0.0GlnXaa: 0.0 ± 0.0
Arg
5.902ArgAla: 5.902 ± 0.604
1.421ArgCys: 1.421 ± 0.375
3.825ArgAsp: 3.825 ± 0.494
4.59ArgGlu: 4.59 ± 0.601
2.186ArgPhe: 2.186 ± 0.431
4.645ArgGly: 4.645 ± 0.61
1.202ArgHis: 1.202 ± 0.317
3.88ArgIle: 3.88 ± 0.577
2.842ArgLys: 2.842 ± 0.452
5.027ArgLeu: 5.027 ± 0.568
2.131ArgMet: 2.131 ± 0.38
2.514ArgAsn: 2.514 ± 0.432
3.934ArgPro: 3.934 ± 0.411
1.967ArgGln: 1.967 ± 0.361
5.847ArgArg: 5.847 ± 0.808
4.59ArgSer: 4.59 ± 0.519
3.115ArgThr: 3.115 ± 0.489
5.628ArgVal: 5.628 ± 0.647
1.803ArgTrp: 1.803 ± 0.275
2.24ArgTyr: 2.24 ± 0.326
0.0ArgXaa: 0.0 ± 0.0
Ser
7.268SerAla: 7.268 ± 1.725
0.492SerCys: 0.492 ± 0.198
4.481SerAsp: 4.481 ± 0.422
3.169SerGlu: 3.169 ± 0.501
2.131SerPhe: 2.131 ± 0.451
6.667SerGly: 6.667 ± 0.75
0.984SerHis: 0.984 ± 0.245
2.842SerIle: 2.842 ± 0.37
2.623SerLys: 2.623 ± 0.376
3.825SerLeu: 3.825 ± 0.491
1.858SerMet: 1.858 ± 0.311
2.186SerAsn: 2.186 ± 0.341
3.279SerPro: 3.279 ± 0.382
1.639SerGln: 1.639 ± 0.316
3.607SerArg: 3.607 ± 0.407
3.661SerSer: 3.661 ± 0.665
3.224SerThr: 3.224 ± 0.442
4.481SerVal: 4.481 ± 0.491
1.257SerTrp: 1.257 ± 0.258
1.421SerTyr: 1.421 ± 0.202
0.0SerXaa: 0.0 ± 0.0
Thr
6.23ThrAla: 6.23 ± 0.566
0.765ThrCys: 0.765 ± 0.263
3.607ThrAsp: 3.607 ± 0.601
3.661ThrGlu: 3.661 ± 0.453
1.858ThrPhe: 1.858 ± 0.299
6.339ThrGly: 6.339 ± 0.697
1.858ThrHis: 1.858 ± 0.324
3.825ThrIle: 3.825 ± 0.455
1.858ThrLys: 1.858 ± 0.369
4.317ThrLeu: 4.317 ± 0.455
1.366ThrMet: 1.366 ± 0.262
2.459ThrAsn: 2.459 ± 0.387
4.481ThrPro: 4.481 ± 0.465
2.24ThrGln: 2.24 ± 0.316
3.552ThrArg: 3.552 ± 0.471
3.661ThrSer: 3.661 ± 0.456
4.809ThrThr: 4.809 ± 0.716
5.574ThrVal: 5.574 ± 0.626
0.984ThrTrp: 0.984 ± 0.254
1.749ThrTyr: 1.749 ± 0.298
0.0ThrXaa: 0.0 ± 0.0
Val
7.432ValAla: 7.432 ± 0.603
0.984ValCys: 0.984 ± 0.207
5.355ValAsp: 5.355 ± 0.567
4.645ValGlu: 4.645 ± 0.537
1.967ValPhe: 1.967 ± 0.319
5.628ValGly: 5.628 ± 0.601
1.475ValHis: 1.475 ± 0.291
2.514ValIle: 2.514 ± 0.402
2.514ValLys: 2.514 ± 0.401
5.082ValLeu: 5.082 ± 0.522
1.311ValMet: 1.311 ± 0.281
2.186ValAsn: 2.186 ± 0.353
3.934ValPro: 3.934 ± 0.407
2.896ValGln: 2.896 ± 0.349
4.426ValArg: 4.426 ± 0.642
5.191ValSer: 5.191 ± 0.649
5.027ValThr: 5.027 ± 0.478
6.448ValVal: 6.448 ± 0.694
1.53ValTrp: 1.53 ± 0.352
1.202ValTyr: 1.202 ± 0.257
0.0ValXaa: 0.0 ± 0.0
Trp
1.803TrpAla: 1.803 ± 0.305
0.273TrpCys: 0.273 ± 0.122
1.475TrpAsp: 1.475 ± 0.317
1.202TrpGlu: 1.202 ± 0.324
0.765TrpPhe: 0.765 ± 0.254
1.257TrpGly: 1.257 ± 0.264
0.383TrpHis: 0.383 ± 0.173
1.202TrpIle: 1.202 ± 0.264
0.874TrpLys: 0.874 ± 0.199
1.967TrpLeu: 1.967 ± 0.323
0.82TrpMet: 0.82 ± 0.228
0.546TrpAsn: 0.546 ± 0.206
0.82TrpPro: 0.82 ± 0.246
1.038TrpGln: 1.038 ± 0.274
2.077TrpArg: 2.077 ± 0.403
1.913TrpSer: 1.913 ± 0.573
1.421TrpThr: 1.421 ± 0.29
1.913TrpVal: 1.913 ± 0.463
1.148TrpTrp: 1.148 ± 0.229
0.437TrpTyr: 0.437 ± 0.164
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.295TyrAla: 2.295 ± 0.383
0.273TyrCys: 0.273 ± 0.107
1.913TyrAsp: 1.913 ± 0.405
1.803TyrGlu: 1.803 ± 0.333
0.656TyrPhe: 0.656 ± 0.219
1.913TyrGly: 1.913 ± 0.383
0.437TyrHis: 0.437 ± 0.146
1.093TyrIle: 1.093 ± 0.214
0.765TyrLys: 0.765 ± 0.201
2.24TyrLeu: 2.24 ± 0.346
0.109TyrMet: 0.109 ± 0.075
0.71TyrAsn: 0.71 ± 0.207
1.803TyrPro: 1.803 ± 0.288
0.82TyrGln: 0.82 ± 0.259
1.913TyrArg: 1.913 ± 0.284
1.148TyrSer: 1.148 ± 0.229
1.858TyrThr: 1.858 ± 0.392
2.35TyrVal: 2.35 ± 0.332
0.601TyrTrp: 0.601 ± 0.19
0.601TyrTyr: 0.601 ± 0.169
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 106 proteins (18301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski