Amino acid dipepetide frequency for Nocardia seriolae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.672AlaAla: 21.672 ± 0.169
0.955AlaCys: 0.955 ± 0.025
8.586AlaAsp: 8.586 ± 0.065
8.494AlaGlu: 8.494 ± 0.074
3.429AlaPhe: 3.429 ± 0.047
12.015AlaGly: 12.015 ± 0.095
2.773AlaHis: 2.773 ± 0.039
5.195AlaIle: 5.195 ± 0.058
2.921AlaLys: 2.921 ± 0.043
13.495AlaLeu: 13.495 ± 0.092
2.84AlaMet: 2.84 ± 0.038
2.45AlaAsn: 2.45 ± 0.033
6.496AlaPro: 6.496 ± 0.078
3.948AlaGln: 3.948 ± 0.05
9.367AlaArg: 9.367 ± 0.085
5.288AlaSer: 5.288 ± 0.058
7.58AlaThr: 7.58 ± 0.066
11.748AlaVal: 11.748 ± 0.101
1.733AlaTrp: 1.733 ± 0.029
2.378AlaTyr: 2.378 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.055CysAla: 1.055 ± 0.023
0.105CysCys: 0.105 ± 0.009
0.459CysAsp: 0.459 ± 0.016
0.403CysGlu: 0.403 ± 0.014
0.232CysPhe: 0.232 ± 0.01
0.955CysGly: 0.955 ± 0.022
0.182CysHis: 0.182 ± 0.009
0.206CysIle: 0.206 ± 0.01
0.13CysLys: 0.13 ± 0.008
0.661CysLeu: 0.661 ± 0.018
0.11CysMet: 0.11 ± 0.007
0.158CysAsn: 0.158 ± 0.009
0.509CysPro: 0.509 ± 0.015
0.166CysGln: 0.166 ± 0.008
0.56CysArg: 0.56 ± 0.016
0.473CysSer: 0.473 ± 0.015
0.499CysThr: 0.499 ± 0.014
0.609CysVal: 0.609 ± 0.017
0.118CysTrp: 0.118 ± 0.007
0.168CysTyr: 0.168 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.385AspAla: 7.385 ± 0.062
0.464AspCys: 0.464 ± 0.016
3.273AspAsp: 3.273 ± 0.037
3.504AspGlu: 3.504 ± 0.044
1.777AspPhe: 1.777 ± 0.029
5.501AspGly: 5.501 ± 0.052
1.483AspHis: 1.483 ± 0.03
2.525AspIle: 2.525 ± 0.038
1.268AspLys: 1.268 ± 0.026
6.186AspLeu: 6.186 ± 0.063
0.958AspMet: 0.958 ± 0.02
1.213AspAsn: 1.213 ± 0.025
4.687AspPro: 4.687 ± 0.055
1.718AspGln: 1.718 ± 0.031
5.094AspArg: 5.094 ± 0.055
3.062AspSer: 3.062 ± 0.038
3.335AspThr: 3.335 ± 0.041
4.118AspVal: 4.118 ± 0.049
1.002AspTrp: 1.002 ± 0.022
1.387AspTyr: 1.387 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
5.991GluAla: 5.991 ± 0.064
0.371GluCys: 0.371 ± 0.014
2.301GluAsp: 2.301 ± 0.035
2.387GluGlu: 2.387 ± 0.039
2.053GluPhe: 2.053 ± 0.034
3.338GluGly: 3.338 ± 0.046
1.591GluHis: 1.591 ± 0.027
2.835GluIle: 2.835 ± 0.04
1.279GluLys: 1.279 ± 0.024
7.195GluLeu: 7.195 ± 0.077
0.994GluMet: 0.994 ± 0.021
1.208GluAsn: 1.208 ± 0.026
3.228GluPro: 3.228 ± 0.047
2.275GluGln: 2.275 ± 0.037
4.808GluArg: 4.808 ± 0.053
3.02GluSer: 3.02 ± 0.037
2.948GluThr: 2.948 ± 0.036
4.332GluVal: 4.332 ± 0.052
0.805GluTrp: 0.805 ± 0.02
1.189GluTyr: 1.189 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.174PheAla: 4.174 ± 0.05
0.26PheCys: 0.26 ± 0.01
2.4PheAsp: 2.4 ± 0.033
1.676PheGlu: 1.676 ± 0.029
0.9PhePhe: 0.9 ± 0.024
3.525PheGly: 3.525 ± 0.04
0.645PheHis: 0.645 ± 0.017
0.923PheIle: 0.923 ± 0.021
0.457PheLys: 0.457 ± 0.017
2.588PheLeu: 2.588 ± 0.04
0.469PheMet: 0.469 ± 0.016
0.609PheAsn: 0.609 ± 0.017
1.469PhePro: 1.469 ± 0.027
0.732PheGln: 0.732 ± 0.022
1.882PheArg: 1.882 ± 0.031
1.54PheSer: 1.54 ± 0.031
2.141PheThr: 2.141 ± 0.031
2.426PheVal: 2.426 ± 0.036
0.426PheTrp: 0.426 ± 0.014
0.643PheTyr: 0.643 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
10.29GlyAla: 10.29 ± 0.083
0.865GlyCys: 0.865 ± 0.023
4.86GlyAsp: 4.86 ± 0.057
4.626GlyGlu: 4.626 ± 0.051
3.166GlyPhe: 3.166 ± 0.035
8.102GlyGly: 8.102 ± 0.082
2.158GlyHis: 2.158 ± 0.039
4.364GlyIle: 4.364 ± 0.049
2.469GlyLys: 2.469 ± 0.039
8.89GlyLeu: 8.89 ± 0.08
2.113GlyMet: 2.113 ± 0.032
2.052GlyAsn: 2.052 ± 0.036
4.77GlyPro: 4.77 ± 0.046
2.661GlyGln: 2.661 ± 0.047
6.631GlyArg: 6.631 ± 0.061
5.263GlySer: 5.263 ± 0.051
5.626GlyThr: 5.626 ± 0.051
7.333GlyVal: 7.333 ± 0.083
1.615GlyTrp: 1.615 ± 0.031
2.439GlyTyr: 2.439 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.576HisAla: 2.576 ± 0.033
0.213HisCys: 0.213 ± 0.009
1.34HisAsp: 1.34 ± 0.03
1.152HisGlu: 1.152 ± 0.03
0.665HisPhe: 0.665 ± 0.018
2.232HisGly: 2.232 ± 0.032
0.687HisHis: 0.687 ± 0.019
0.835HisIle: 0.835 ± 0.018
0.339HisLys: 0.339 ± 0.012
2.236HisLeu: 2.236 ± 0.035
0.391HisMet: 0.391 ± 0.011
0.479HisAsn: 0.479 ± 0.015
1.818HisPro: 1.818 ± 0.034
0.599HisGln: 0.599 ± 0.015
2.065HisArg: 2.065 ± 0.034
1.102HisSer: 1.102 ± 0.023
1.294HisThr: 1.294 ± 0.025
1.492HisVal: 1.492 ± 0.028
0.381HisTrp: 0.381 ± 0.013
0.539HisTyr: 0.539 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.498IleAla: 6.498 ± 0.06
0.321IleCys: 0.321 ± 0.012
3.227IleAsp: 3.227 ± 0.037
2.566IleGlu: 2.566 ± 0.035
0.991IlePhe: 0.991 ± 0.021
4.57IleGly: 4.57 ± 0.047
0.795IleHis: 0.795 ± 0.018
1.344IleIle: 1.344 ± 0.024
0.762IleLys: 0.762 ± 0.025
3.283IleLeu: 3.283 ± 0.046
0.655IleMet: 0.655 ± 0.017
0.9IleAsn: 0.9 ± 0.024
2.541IlePro: 2.541 ± 0.034
0.909IleGln: 0.909 ± 0.019
2.836IleArg: 2.836 ± 0.04
2.203IleSer: 2.203 ± 0.036
2.862IleThr: 2.862 ± 0.04
3.534IleVal: 3.534 ± 0.041
0.457IleTrp: 0.457 ± 0.016
0.747IleTyr: 0.747 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
2.562LysAla: 2.562 ± 0.044
0.125LysCys: 0.125 ± 0.009
1.077LysAsp: 1.077 ± 0.028
0.913LysGlu: 0.913 ± 0.023
0.619LysPhe: 0.619 ± 0.017
1.527LysGly: 1.527 ± 0.035
0.463LysHis: 0.463 ± 0.016
0.995LysIle: 0.995 ± 0.02
0.635LysLys: 0.635 ± 0.025
2.273LysLeu: 2.273 ± 0.037
0.466LysMet: 0.466 ± 0.014
0.515LysAsn: 0.515 ± 0.016
1.438LysPro: 1.438 ± 0.026
0.761LysGln: 0.761 ± 0.022
1.446LysArg: 1.446 ± 0.03
1.242LysSer: 1.242 ± 0.029
1.324LysThr: 1.324 ± 0.027
1.817LysVal: 1.817 ± 0.03
0.3LysTrp: 0.3 ± 0.012
0.477LysTyr: 0.477 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
14.492LeuAla: 14.492 ± 0.098
0.782LeuCys: 0.782 ± 0.016
6.774LeuAsp: 6.774 ± 0.077
4.909LeuGlu: 4.909 ± 0.047
2.737LeuPhe: 2.737 ± 0.041
9.265LeuGly: 9.265 ± 0.083
2.113LeuHis: 2.113 ± 0.032
4.182LeuIle: 4.182 ± 0.054
1.641LeuLys: 1.641 ± 0.028
10.296LeuLeu: 10.296 ± 0.096
1.638LeuMet: 1.638 ± 0.032
1.922LeuAsn: 1.922 ± 0.031
6.251LeuPro: 6.251 ± 0.06
2.219LeuGln: 2.219 ± 0.032
8.37LeuArg: 8.37 ± 0.06
5.615LeuSer: 5.615 ± 0.055
6.734LeuThr: 6.734 ± 0.064
8.375LeuVal: 8.375 ± 0.071
1.257LeuTrp: 1.257 ± 0.026
1.694LeuTyr: 1.694 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.428MetAla: 2.428 ± 0.034
0.154MetCys: 0.154 ± 0.008
0.885MetAsp: 0.885 ± 0.019
0.707MetGlu: 0.707 ± 0.017
0.622MetPhe: 0.622 ± 0.018
1.41MetGly: 1.41 ± 0.03
0.426MetHis: 0.426 ± 0.014
0.911MetIle: 0.911 ± 0.022
0.413MetLys: 0.413 ± 0.014
2.114MetLeu: 2.114 ± 0.036
0.361MetMet: 0.361 ± 0.013
0.541MetAsn: 0.541 ± 0.016
1.225MetPro: 1.225 ± 0.025
0.51MetGln: 0.51 ± 0.016
1.547MetArg: 1.547 ± 0.024
1.481MetSer: 1.481 ± 0.026
1.647MetThr: 1.647 ± 0.028
1.57MetVal: 1.57 ± 0.025
0.232MetTrp: 0.232 ± 0.011
0.355MetTyr: 0.355 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.536AsnAla: 2.536 ± 0.037
0.17AsnCys: 0.17 ± 0.01
1.096AsnAsp: 1.096 ± 0.023
0.861AsnGlu: 0.861 ± 0.021
0.636AsnPhe: 0.636 ± 0.018
2.143AsnGly: 2.143 ± 0.042
0.455AsnHis: 0.455 ± 0.014
0.875AsnIle: 0.875 ± 0.019
0.452AsnLys: 0.452 ± 0.017
2.057AsnLeu: 2.057 ± 0.036
0.434AsnMet: 0.434 ± 0.014
0.491AsnAsn: 0.491 ± 0.016
1.833AsnPro: 1.833 ± 0.03
0.623AsnGln: 0.623 ± 0.02
1.545AsnArg: 1.545 ± 0.031
1.19AsnSer: 1.19 ± 0.025
1.291AsnThr: 1.291 ± 0.025
1.506AsnVal: 1.506 ± 0.029
0.384AsnTrp: 0.384 ± 0.015
0.497AsnTyr: 0.497 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
8.205ProAla: 8.205 ± 0.087
0.296ProCys: 0.296 ± 0.012
4.458ProAsp: 4.458 ± 0.054
4.347ProGlu: 4.347 ± 0.053
1.608ProPhe: 1.608 ± 0.024
6.343ProGly: 6.343 ± 0.058
1.264ProHis: 1.264 ± 0.026
2.312ProIle: 2.312 ± 0.033
1.31ProLys: 1.31 ± 0.023
4.986ProLeu: 4.986 ± 0.053
1.175ProMet: 1.175 ± 0.022
1.347ProAsn: 1.347 ± 0.031
3.305ProPro: 3.305 ± 0.064
1.827ProGln: 1.827 ± 0.042
3.74ProArg: 3.74 ± 0.048
2.879ProSer: 2.879 ± 0.039
3.479ProThr: 3.479 ± 0.044
5.362ProVal: 5.362 ± 0.056
0.799ProTrp: 0.799 ± 0.02
1.111ProTyr: 1.111 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.487GlnAla: 3.487 ± 0.044
0.192GlnCys: 0.192 ± 0.008
1.162GlnAsp: 1.162 ± 0.025
1.068GlnGlu: 1.068 ± 0.025
0.868GlnPhe: 0.868 ± 0.019
1.988GlnGly: 1.988 ± 0.034
0.717GlnHis: 0.717 ± 0.022
1.308GlnIle: 1.308 ± 0.023
0.524GlnLys: 0.524 ± 0.017
3.505GlnLeu: 3.505 ± 0.044
0.535GlnMet: 0.535 ± 0.018
0.554GlnAsn: 0.554 ± 0.019
2.051GlnPro: 2.051 ± 0.04
1.322GlnGln: 1.322 ± 0.032
2.734GlnArg: 2.734 ± 0.047
1.356GlnSer: 1.356 ± 0.03
1.391GlnThr: 1.391 ± 0.029
2.605GlnVal: 2.605 ± 0.041
0.51GlnTrp: 0.51 ± 0.014
0.628GlnTyr: 0.628 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.233ArgAla: 9.233 ± 0.085
0.576ArgCys: 0.576 ± 0.019
4.238ArgAsp: 4.238 ± 0.05
4.36ArgGlu: 4.36 ± 0.05
2.472ArgPhe: 2.472 ± 0.037
5.427ArgGly: 5.427 ± 0.056
1.87ArgHis: 1.87 ± 0.03
3.786ArgIle: 3.786 ± 0.045
1.752ArgLys: 1.752 ± 0.033
7.895ArgLeu: 7.895 ± 0.073
1.972ArgMet: 1.972 ± 0.027
1.7ArgAsn: 1.7 ± 0.031
4.395ArgPro: 4.395 ± 0.054
2.196ArgGln: 2.196 ± 0.034
6.729ArgArg: 6.729 ± 0.074
3.916ArgSer: 3.916 ± 0.044
4.893ArgThr: 4.893 ± 0.048
5.748ArgVal: 5.748 ± 0.053
1.384ArgTrp: 1.384 ± 0.025
1.859ArgTyr: 1.859 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.917SerAla: 6.917 ± 0.065
0.426SerCys: 0.426 ± 0.015
3.028SerAsp: 3.028 ± 0.036
2.634SerGlu: 2.634 ± 0.038
1.571SerPhe: 1.571 ± 0.028
5.916SerGly: 5.916 ± 0.057
0.976SerHis: 0.976 ± 0.022
2.119SerIle: 2.119 ± 0.03
1.197SerLys: 1.197 ± 0.026
4.559SerLeu: 4.559 ± 0.043
1.283SerMet: 1.283 ± 0.022
1.122SerAsn: 1.122 ± 0.023
3.023SerPro: 3.023 ± 0.041
1.319SerGln: 1.319 ± 0.029
3.541SerArg: 3.541 ± 0.038
2.744SerSer: 2.744 ± 0.038
3.21SerThr: 3.21 ± 0.042
4.118SerVal: 4.118 ± 0.043
0.88SerTrp: 0.88 ± 0.018
1.167SerTyr: 1.167 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
8.77ThrAla: 8.77 ± 0.073
0.419ThrCys: 0.419 ± 0.013
3.771ThrAsp: 3.771 ± 0.04
3.362ThrGlu: 3.362 ± 0.045
1.702ThrPhe: 1.702 ± 0.029
6.381ThrGly: 6.381 ± 0.061
1.188ThrHis: 1.188 ± 0.023
2.367ThrIle: 2.367 ± 0.033
1.185ThrLys: 1.185 ± 0.027
5.913ThrLeu: 5.913 ± 0.051
1.068ThrMet: 1.068 ± 0.025
1.118ThrAsn: 1.118 ± 0.021
4.13ThrPro: 4.13 ± 0.058
1.435ThrGln: 1.435 ± 0.025
3.963ThrArg: 3.963 ± 0.044
2.882ThrSer: 2.882 ± 0.036
3.935ThrThr: 3.935 ± 0.056
6.179ThrVal: 6.179 ± 0.052
0.792ThrTrp: 0.792 ± 0.02
1.218ThrTyr: 1.218 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
11.13ValAla: 11.13 ± 0.095
0.713ValCys: 0.713 ± 0.018
4.936ValAsp: 4.936 ± 0.054
4.477ValGlu: 4.477 ± 0.052
2.576ValPhe: 2.576 ± 0.038
6.605ValGly: 6.605 ± 0.072
1.841ValHis: 1.841 ± 0.031
3.61ValIle: 3.61 ± 0.042
1.548ValLys: 1.548 ± 0.029
9.068ValLeu: 9.068 ± 0.073
1.427ValMet: 1.427 ± 0.027
1.834ValAsn: 1.834 ± 0.032
4.949ValPro: 4.949 ± 0.056
2.04ValGln: 2.04 ± 0.033
6.268ValArg: 6.268 ± 0.05
4.446ValSer: 4.446 ± 0.049
5.413ValThr: 5.413 ± 0.056
7.62ValVal: 7.62 ± 0.085
1.04ValTrp: 1.04 ± 0.02
1.535ValTyr: 1.535 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.543TrpAla: 1.543 ± 0.03
0.139TrpCys: 0.139 ± 0.008
0.759TrpAsp: 0.759 ± 0.02
0.689TrpGlu: 0.689 ± 0.017
0.527TrpPhe: 0.527 ± 0.016
1.006TrpGly: 1.006 ± 0.02
0.366TrpHis: 0.366 ± 0.014
0.662TrpIle: 0.662 ± 0.017
0.352TrpLys: 0.352 ± 0.014
1.717TrpLeu: 1.717 ± 0.032
0.351TrpMet: 0.351 ± 0.013
0.44TrpAsn: 0.44 ± 0.015
0.783TrpPro: 0.783 ± 0.021
0.594TrpGln: 0.594 ± 0.016
1.312TrpArg: 1.312 ± 0.025
0.912TrpSer: 0.912 ± 0.022
0.968TrpThr: 0.968 ± 0.017
1.037TrpVal: 1.037 ± 0.024
0.34TrpTrp: 0.34 ± 0.014
0.334TrpTyr: 0.334 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.417TyrAla: 2.417 ± 0.033
0.212TyrCys: 0.212 ± 0.009
1.305TyrAsp: 1.305 ± 0.028
1.017TyrGlu: 1.017 ± 0.025
0.73TyrPhe: 0.73 ± 0.021
2.044TyrGly: 2.044 ± 0.031
0.442TyrHis: 0.442 ± 0.014
0.646TyrIle: 0.646 ± 0.018
0.34TyrLys: 0.34 ± 0.016
2.349TyrLeu: 2.349 ± 0.034
0.302TyrMet: 0.302 ± 0.012
0.423TyrAsn: 0.423 ± 0.013
1.251TyrPro: 1.251 ± 0.026
0.651TyrGln: 0.651 ± 0.017
1.965TyrArg: 1.965 ± 0.034
1.137TyrSer: 1.137 ± 0.024
1.207TyrThr: 1.207 ± 0.021
1.549TyrVal: 1.549 ± 0.032
0.375TyrTrp: 0.375 ± 0.014
0.466TyrTyr: 0.466 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7386 proteins (2267378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski