Amino acid dipepetide frequency for Myxococcus xanthus (strain DK1622)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.264AlaAla: 15.264 ± 0.124	1.349AlaCys: 1.349 ± 0.023	5.261AlaAsp: 5.261 ± 0.048	7.589AlaGlu: 7.589 ± 0.09	3.987AlaPhe: 3.987 ± 0.04	9.849AlaGly: 9.849 ± 0.069	2.576AlaHis: 2.576 ± 0.034	3.315AlaIle: 3.315 ± 0.042	3.249AlaLys: 3.249 ± 0.048	15.004AlaLeu: 15.004 ± 0.118	2.638AlaMet: 2.638 ± 0.032	2.314AlaAsn: 2.314 ± 0.034	7.654AlaPro: 7.654 ± 0.07	4.603AlaGln: 4.603 ± 0.055	10.91AlaArg: 10.91 ± 0.1	7.288AlaSer: 7.288 ± 0.061	6.107AlaThr: 6.107 ± 0.051	9.215AlaVal: 9.215 ± 0.07	1.798AlaTrp: 1.798 ± 0.033	2.314AlaTyr: 2.314 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.145CysAla: 1.145 ± 0.025	0.121CysCys: 0.121 ± 0.008	0.525CysAsp: 0.525 ± 0.018	0.552CysGlu: 0.552 ± 0.018	0.327CysPhe: 0.327 ± 0.011	1.014CysGly: 1.014 ± 0.027	0.27CysHis: 0.27 ± 0.013	0.299CysIle: 0.299 ± 0.01	0.211CysLys: 0.211 ± 0.01	0.848CysLeu: 0.848 ± 0.018	0.164CysMet: 0.164 ± 0.007	0.242CysAsn: 0.242 ± 0.011	0.595CysPro: 0.595 ± 0.018	0.299CysGln: 0.299 ± 0.011	0.716CysArg: 0.716 ± 0.016	0.582CysSer: 0.582 ± 0.016	0.527CysThr: 0.527 ± 0.016	0.759CysVal: 0.759 ± 0.017	0.114CysTrp: 0.114 ± 0.007	0.186CysTyr: 0.186 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.848AspAla: 7.848 ± 0.064	0.477AspCys: 0.477 ± 0.015	2.633AspAsp: 2.633 ± 0.038	3.261AspGlu: 3.261 ± 0.042	1.985AspPhe: 1.985 ± 0.026	5.131AspGly: 5.131 ± 0.052	0.828AspHis: 0.828 ± 0.019	1.853AspIle: 1.853 ± 0.031	1.185AspLys: 1.185 ± 0.023	5.065AspLeu: 5.065 ± 0.043	0.905AspMet: 0.905 ± 0.02	0.943AspAsn: 0.943 ± 0.021	2.772AspPro: 2.772 ± 0.037	1.118AspGln: 1.118 ± 0.022	3.143AspArg: 3.143 ± 0.037	2.486AspSer: 2.486 ± 0.034	2.742AspThr: 2.742 ± 0.036	4.953AspVal: 4.953 ± 0.047	0.771AspTrp: 0.771 ± 0.017	1.087AspTyr: 1.087 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	8.723GluAla: 8.723 ± 0.09	0.416GluCys: 0.416 ± 0.013	3.334GluAsp: 3.334 ± 0.036	3.981GluGlu: 3.981 ± 0.047	1.49GluPhe: 1.49 ± 0.025	5.349GluGly: 5.349 ± 0.045	1.468GluHis: 1.468 ± 0.026	1.551GluIle: 1.551 ± 0.029	2.033GluLys: 2.033 ± 0.039	7.202GluLeu: 7.202 ± 0.063	1.132GluMet: 1.132 ± 0.024	1.147GluAsn: 1.147 ± 0.021	3.605GluPro: 3.605 ± 0.042	2.551GluGln: 2.551 ± 0.034	6.295GluArg: 6.295 ± 0.057	3.281GluSer: 3.281 ± 0.039	2.714GluThr: 2.714 ± 0.032	5.33GluVal: 5.33 ± 0.056	0.722GluTrp: 0.722 ± 0.026	1.069GluTyr: 1.069 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.488PheAla: 3.488 ± 0.039	0.326PheCys: 0.326 ± 0.012	2.088PheAsp: 2.088 ± 0.03	2.127PheGlu: 2.127 ± 0.033	1.396PhePhe: 1.396 ± 0.029	2.896PheGly: 2.896 ± 0.034	0.792PheHis: 0.792 ± 0.019	1.266PheIle: 1.266 ± 0.022	0.831PheLys: 0.831 ± 0.018	3.278PheLeu: 3.278 ± 0.036	0.622PheMet: 0.622 ± 0.015	0.893PheAsn: 0.893 ± 0.019	1.668PhePro: 1.668 ± 0.024	1.201PheGln: 1.201 ± 0.019	2.332PheArg: 2.332 ± 0.032	2.106PheSer: 2.106 ± 0.028	2.116PheThr: 2.116 ± 0.026	2.501PheVal: 2.501 ± 0.029	0.415PheTrp: 0.415 ± 0.013	0.707PheTyr: 0.707 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.0GlyAla: 10.0 ± 0.085	1.005GlyCys: 1.005 ± 0.025	4.277GlyAsp: 4.277 ± 0.048	5.045GlyGlu: 5.045 ± 0.051	3.038GlyPhe: 3.038 ± 0.037	8.024GlyGly: 8.024 ± 0.081	1.927GlyHis: 1.927 ± 0.028	2.957GlyIle: 2.957 ± 0.028	2.78GlyLys: 2.78 ± 0.034	8.972GlyLeu: 8.972 ± 0.069	2.087GlyMet: 2.087 ± 0.027	2.011GlyAsn: 2.011 ± 0.035	4.392GlyPro: 4.392 ± 0.049	3.121GlyGln: 3.121 ± 0.04	6.915GlyArg: 6.915 ± 0.053	4.695GlySer: 4.695 ± 0.049	5.588GlyThr: 5.588 ± 0.065	6.989GlyVal: 6.989 ± 0.06	1.322GlyTrp: 1.322 ± 0.026	1.966GlyTyr: 1.966 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.715HisAla: 2.715 ± 0.034	0.235HisCys: 0.235 ± 0.011	0.986HisAsp: 0.986 ± 0.02	1.255HisGlu: 1.255 ± 0.021	0.834HisPhe: 0.834 ± 0.021	2.116HisGly: 2.116 ± 0.033	0.66HisHis: 0.66 ± 0.019	0.642HisIle: 0.642 ± 0.015	0.4HisLys: 0.4 ± 0.013	2.431HisLeu: 2.431 ± 0.033	0.362HisMet: 0.362 ± 0.012	0.371HisAsn: 0.371 ± 0.012	1.658HisPro: 1.658 ± 0.026	0.719HisGln: 0.719 ± 0.017	1.783HisArg: 1.783 ± 0.027	1.013HisSer: 1.013 ± 0.019	1.009HisThr: 1.009 ± 0.025	1.77HisVal: 1.77 ± 0.029	0.319HisTrp: 0.319 ± 0.011	0.502HisTyr: 0.502 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.485IleAla: 3.485 ± 0.043	0.28IleCys: 0.28 ± 0.011	1.752IleAsp: 1.752 ± 0.029	1.932IleGlu: 1.932 ± 0.031	0.933IlePhe: 0.933 ± 0.017	2.322IleGly: 2.322 ± 0.031	0.821IleHis: 0.821 ± 0.018	1.177IleIle: 1.177 ± 0.026	0.707IleLys: 0.707 ± 0.02	2.618IleLeu: 2.618 ± 0.038	0.377IleMet: 0.377 ± 0.013	0.848IleAsn: 0.848 ± 0.022	1.953IlePro: 1.953 ± 0.031	1.153IleGln: 1.153 ± 0.021	2.24IleArg: 2.24 ± 0.032	1.696IleSer: 1.696 ± 0.028	1.69IleThr: 1.69 ± 0.026	2.183IleVal: 2.183 ± 0.03	0.316IleTrp: 0.316 ± 0.012	0.656IleTyr: 0.656 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.534LysAla: 3.534 ± 0.053	0.182LysCys: 0.182 ± 0.01	1.716LysAsp: 1.716 ± 0.032	1.732LysGlu: 1.732 ± 0.03	0.613LysPhe: 0.613 ± 0.016	2.375LysGly: 2.375 ± 0.036	0.581LysHis: 0.581 ± 0.016	0.666LysIle: 0.666 ± 0.019	1.265LysLys: 1.265 ± 0.033	3.007LysLeu: 3.007 ± 0.037	0.584LysMet: 0.584 ± 0.015	0.635LysAsn: 0.635 ± 0.018	1.817LysPro: 1.817 ± 0.03	1.024LysGln: 1.024 ± 0.022	2.16LysArg: 2.16 ± 0.031	1.438LysSer: 1.438 ± 0.027	1.455LysThr: 1.455 ± 0.031	2.487LysVal: 2.487 ± 0.037	0.295LysTrp: 0.295 ± 0.01	0.535LysTyr: 0.535 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.721LeuAla: 13.721 ± 0.106	1.004LeuCys: 1.004 ± 0.021	5.844LeuAsp: 5.844 ± 0.052	7.358LeuGlu: 7.358 ± 0.068	3.462LeuPhe: 3.462 ± 0.044	9.329LeuGly: 9.329 ± 0.075	2.372LeuHis: 2.372 ± 0.03	2.78LeuIle: 2.78 ± 0.035	3.404LeuLys: 3.404 ± 0.042	11.504LeuLeu: 11.504 ± 0.097	2.09LeuMet: 2.09 ± 0.031	2.177LeuAsn: 2.177 ± 0.031	6.658LeuPro: 6.658 ± 0.06	3.403LeuGln: 3.403 ± 0.036	9.13LeuArg: 9.13 ± 0.068	6.856LeuSer: 6.856 ± 0.054	6.046LeuThr: 6.046 ± 0.052	8.492LeuVal: 8.492 ± 0.08	1.324LeuTrp: 1.324 ± 0.03	2.151LeuTyr: 2.151 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.502MetAla: 2.502 ± 0.039	0.148MetCys: 0.148 ± 0.007	1.063MetAsp: 1.063 ± 0.02	1.249MetGlu: 1.249 ± 0.022	0.476MetPhe: 0.476 ± 0.014	1.86MetGly: 1.86 ± 0.03	0.402MetHis: 0.402 ± 0.012	0.376MetIle: 0.376 ± 0.011	0.831MetLys: 0.831 ± 0.02	2.102MetLeu: 2.102 ± 0.03	0.497MetMet: 0.497 ± 0.015	0.537MetAsn: 0.537 ± 0.014	1.295MetPro: 1.295 ± 0.025	0.643MetGln: 0.643 ± 0.015	1.723MetArg: 1.723 ± 0.024	1.448MetSer: 1.448 ± 0.024	1.17MetThr: 1.17 ± 0.021	1.463MetVal: 1.463 ± 0.025	0.19MetTrp: 0.19 ± 0.009	0.281MetTyr: 0.281 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.627AsnAla: 2.627 ± 0.034	0.23AsnCys: 0.23 ± 0.011	1.015AsnAsp: 1.015 ± 0.023	1.057AsnGlu: 1.057 ± 0.022	0.706AsnPhe: 0.706 ± 0.017	1.966AsnGly: 1.966 ± 0.038	0.467AsnHis: 0.467 ± 0.014	0.805AsnIle: 0.805 ± 0.017	0.468AsnLys: 0.468 ± 0.014	2.205AsnLeu: 2.205 ± 0.036	0.359AsnMet: 0.359 ± 0.011	0.565AsnAsn: 0.565 ± 0.018	1.636AsnPro: 1.636 ± 0.029	0.676AsnGln: 0.676 ± 0.02	1.449AsnArg: 1.449 ± 0.025	0.952AsnSer: 0.952 ± 0.025	1.204AsnThr: 1.204 ± 0.024	1.827AsnVal: 1.827 ± 0.031	0.277AsnTrp: 0.277 ± 0.011	0.487AsnTyr: 0.487 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.248ProAla: 7.248 ± 0.071	0.44ProCys: 0.44 ± 0.015	3.604ProAsp: 3.604 ± 0.047	4.884ProGlu: 4.884 ± 0.046	1.927ProPhe: 1.927 ± 0.03	5.874ProGly: 5.874 ± 0.059	1.237ProHis: 1.237 ± 0.026	1.501ProIle: 1.501 ± 0.027	1.502ProLys: 1.502 ± 0.027	5.995ProLeu: 5.995 ± 0.066	1.318ProMet: 1.318 ± 0.022	1.142ProAsn: 1.142 ± 0.021	4.717ProPro: 4.717 ± 0.082	1.882ProGln: 1.882 ± 0.025	4.453ProArg: 4.453 ± 0.055	3.822ProSer: 3.822 ± 0.048	3.159ProThr: 3.159 ± 0.036	5.058ProVal: 5.058 ± 0.047	0.86ProTrp: 0.86 ± 0.018	1.103ProTyr: 1.103 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	4.478GlnAla: 4.478 ± 0.05	0.274GlnCys: 0.274 ± 0.011	1.641GlnAsp: 1.641 ± 0.025	2.037GlnGlu: 2.037 ± 0.031	0.872GlnPhe: 0.872 ± 0.019	3.149GlnGly: 3.149 ± 0.038	0.731GlnHis: 0.731 ± 0.019	0.738GlnIle: 0.738 ± 0.018	1.033GlnLys: 1.033 ± 0.024	3.63GlnLeu: 3.63 ± 0.043	0.634GlnMet: 0.634 ± 0.015	0.62GlnAsn: 0.62 ± 0.017	2.151GlnPro: 2.151 ± 0.028	1.455GlnGln: 1.455 ± 0.028	3.202GlnArg: 3.202 ± 0.039	1.675GlnSer: 1.675 ± 0.03	1.555GlnThr: 1.555 ± 0.025	3.3GlnVal: 3.3 ± 0.045	0.474GlnTrp: 0.474 ± 0.015	0.616GlnTyr: 0.616 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.538ArgAla: 9.538 ± 0.084	0.793ArgCys: 0.793 ± 0.019	3.812ArgAsp: 3.812 ± 0.039	5.724ArgGlu: 5.724 ± 0.056	3.204ArgPhe: 3.204 ± 0.037	6.098ArgGly: 6.098 ± 0.054	1.855ArgHis: 1.855 ± 0.03	2.969ArgIle: 2.969 ± 0.033	2.36ArgLys: 2.36 ± 0.034	9.184ArgLeu: 9.184 ± 0.077	2.098ArgMet: 2.098 ± 0.031	1.649ArgAsn: 1.649 ± 0.027	4.635ArgPro: 4.635 ± 0.049	2.849ArgGln: 2.849 ± 0.032	6.815ArgArg: 6.815 ± 0.078	3.916ArgSer: 3.916 ± 0.04	4.18ArgThr: 4.18 ± 0.047	6.726ArgVal: 6.726 ± 0.054	1.298ArgTrp: 1.298 ± 0.025	1.982ArgTyr: 1.982 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.725SerAla: 6.725 ± 0.063	0.538SerCys: 0.538 ± 0.015	2.615SerAsp: 2.615 ± 0.037	3.222SerGlu: 3.222 ± 0.042	2.019SerPhe: 2.019 ± 0.031	5.575SerGly: 5.575 ± 0.06	1.202SerHis: 1.202 ± 0.023	1.733SerIle: 1.733 ± 0.027	1.375SerLys: 1.375 ± 0.026	6.414SerLeu: 6.414 ± 0.054	1.197SerMet: 1.197 ± 0.024	1.233SerAsn: 1.233 ± 0.024	3.776SerPro: 3.776 ± 0.044	1.853SerGln: 1.853 ± 0.027	4.525SerArg: 4.525 ± 0.044	3.587SerSer: 3.587 ± 0.045	3.094SerThr: 3.094 ± 0.04	4.386SerVal: 4.386 ± 0.046	0.759SerTrp: 0.759 ± 0.017	1.048SerTyr: 1.048 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.945ThrAla: 5.945 ± 0.055	0.556ThrCys: 0.556 ± 0.018	2.517ThrAsp: 2.517 ± 0.037	2.934ThrGlu: 2.934 ± 0.034	2.01ThrPhe: 2.01 ± 0.031	4.959ThrGly: 4.959 ± 0.051	1.201ThrHis: 1.201 ± 0.02	1.265ThrIle: 1.265 ± 0.027	1.109ThrLys: 1.109 ± 0.021	6.449ThrLeu: 6.449 ± 0.055	0.866ThrMet: 0.866 ± 0.019	1.062ThrAsn: 1.062 ± 0.024	4.096ThrPro: 4.096 ± 0.044	1.967ThrGln: 1.967 ± 0.031	4.093ThrArg: 4.093 ± 0.044	3.146ThrSer: 3.146 ± 0.042	2.74ThrThr: 2.74 ± 0.038	4.634ThrVal: 4.634 ± 0.052	0.852ThrTrp: 0.852 ± 0.02	1.269ThrTyr: 1.269 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.626ValAla: 9.626 ± 0.082	0.777ValCys: 0.777 ± 0.018	4.749ValAsp: 4.749 ± 0.045	5.526ValGlu: 5.526 ± 0.057	2.465ValPhe: 2.465 ± 0.029	6.385ValGly: 6.385 ± 0.057	1.684ValHis: 1.684 ± 0.028	2.404ValIle: 2.404 ± 0.036	2.431ValLys: 2.431 ± 0.038	9.318ValLeu: 9.318 ± 0.097	1.588ValMet: 1.588 ± 0.027	1.712ValAsn: 1.712 ± 0.025	4.945ValPro: 4.945 ± 0.053	2.589ValGln: 2.589 ± 0.035	6.754ValArg: 6.754 ± 0.061	4.921ValSer: 4.921 ± 0.056	4.638ValThr: 4.638 ± 0.049	7.121ValVal: 7.121 ± 0.065	0.953ValTrp: 0.953 ± 0.023	1.508ValTyr: 1.508 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.361TrpAla: 1.361 ± 0.027	0.152TrpCys: 0.152 ± 0.007	0.653TrpAsp: 0.653 ± 0.018	0.722TrpGlu: 0.722 ± 0.018	0.437TrpPhe: 0.437 ± 0.013	1.071TrpGly: 1.071 ± 0.027	0.296TrpHis: 0.296 ± 0.012	0.298TrpIle: 0.298 ± 0.009	0.484TrpLys: 0.484 ± 0.018	1.669TrpLeu: 1.669 ± 0.027	0.397TrpMet: 0.397 ± 0.013	0.4TrpAsn: 0.4 ± 0.012	0.66TrpPro: 0.66 ± 0.016	0.448TrpGln: 0.448 ± 0.015	1.294TrpArg: 1.294 ± 0.024	0.859TrpSer: 0.859 ± 0.022	0.826TrpThr: 0.826 ± 0.019	1.121TrpVal: 1.121 ± 0.024	0.231TrpTrp: 0.231 ± 0.009	0.243TrpTyr: 0.243 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.313TyrAla: 2.313 ± 0.035	0.194TyrCys: 0.194 ± 0.009	1.103TyrAsp: 1.103 ± 0.024	1.204TyrGlu: 1.204 ± 0.025	0.868TyrPhe: 0.868 ± 0.02	1.765TyrGly: 1.765 ± 0.03	0.409TyrHis: 0.409 ± 0.014	0.546TyrIle: 0.546 ± 0.014	0.44TyrLys: 0.44 ± 0.016	2.211TyrLeu: 2.211 ± 0.03	0.339TyrMet: 0.339 ± 0.013	0.476TyrAsn: 0.476 ± 0.015	1.045TyrPro: 1.045 ± 0.02	0.713TyrGln: 0.713 ± 0.017	1.753TyrArg: 1.753 ± 0.026	1.111TyrSer: 1.111 ± 0.02	1.11TyrThr: 1.11 ± 0.022	1.779TyrVal: 1.779 ± 0.035	0.332TyrTrp: 0.332 ± 0.012	0.479TyrTyr: 0.479 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7314 proteins (2775111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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