Amino acid dipepetide frequency for Aspergillus ibericus CBS 121593

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.729AlaAla: 8.729 ± 0.058	1.144AlaCys: 1.144 ± 0.016	4.172AlaAsp: 4.172 ± 0.027	4.981AlaGlu: 4.981 ± 0.038	3.167AlaPhe: 3.167 ± 0.028	5.798AlaGly: 5.798 ± 0.039	1.825AlaHis: 1.825 ± 0.017	4.293AlaIle: 4.293 ± 0.033	3.598AlaLys: 3.598 ± 0.031	7.923AlaLeu: 7.923 ± 0.038	1.98AlaMet: 1.98 ± 0.021	2.715AlaAsn: 2.715 ± 0.022	4.722AlaPro: 4.722 ± 0.039	3.343AlaGln: 3.343 ± 0.029	5.006AlaArg: 5.006 ± 0.031	7.227AlaSer: 7.227 ± 0.046	5.355AlaThr: 5.355 ± 0.033	5.482AlaVal: 5.482 ± 0.033	1.209AlaTrp: 1.209 ± 0.016	2.263AlaTyr: 2.263 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.015	0.285CysCys: 0.285 ± 0.008	0.695CysAsp: 0.695 ± 0.012	0.632CysGlu: 0.632 ± 0.01	0.559CysPhe: 0.559 ± 0.011	0.958CysGly: 0.958 ± 0.013	0.383CysHis: 0.383 ± 0.008	0.749CysIle: 0.749 ± 0.012	0.453CysLys: 0.453 ± 0.011	1.426CysLeu: 1.426 ± 0.017	0.286CysMet: 0.286 ± 0.007	0.449CysAsn: 0.449 ± 0.009	0.7CysPro: 0.7 ± 0.013	0.492CysGln: 0.492 ± 0.011	0.868CysArg: 0.868 ± 0.015	1.027CysSer: 1.027 ± 0.015	0.747CysThr: 0.747 ± 0.013	0.849CysVal: 0.849 ± 0.013	0.216CysTrp: 0.216 ± 0.006	0.385CysTyr: 0.385 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.623AspAla: 4.623 ± 0.032	0.643AspCys: 0.643 ± 0.012	3.877AspAsp: 3.877 ± 0.042	4.179AspGlu: 4.179 ± 0.034	2.099AspPhe: 2.099 ± 0.021	3.945AspGly: 3.945 ± 0.034	1.286AspHis: 1.286 ± 0.014	3.009AspIle: 3.009 ± 0.02	2.049AspLys: 2.049 ± 0.023	5.245AspLeu: 5.245 ± 0.029	1.223AspMet: 1.223 ± 0.016	1.752AspAsn: 1.752 ± 0.02	3.475AspPro: 3.475 ± 0.025	1.971AspGln: 1.971 ± 0.02	3.203AspArg: 3.203 ± 0.028	3.982AspSer: 3.982 ± 0.032	3.001AspThr: 3.001 ± 0.027	3.582AspVal: 3.582 ± 0.029	0.899AspTrp: 0.899 ± 0.013	1.66AspTyr: 1.66 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.159GluAla: 5.159 ± 0.042	0.638GluCys: 0.638 ± 0.01	3.975GluAsp: 3.975 ± 0.034	5.401GluGlu: 5.401 ± 0.056	1.923GluPhe: 1.923 ± 0.021	3.832GluGly: 3.832 ± 0.029	1.358GluHis: 1.358 ± 0.017	2.969GluIle: 2.969 ± 0.025	3.335GluLys: 3.335 ± 0.034	5.063GluLeu: 5.063 ± 0.034	1.463GluMet: 1.463 ± 0.017	2.11GluAsn: 2.11 ± 0.019	2.836GluPro: 2.836 ± 0.043	2.433GluGln: 2.433 ± 0.028	3.937GluArg: 3.937 ± 0.033	4.257GluSer: 4.257 ± 0.031	3.49GluThr: 3.49 ± 0.028	3.606GluVal: 3.606 ± 0.028	0.908GluTrp: 0.908 ± 0.013	1.746GluTyr: 1.746 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.002PheAla: 3.002 ± 0.025	0.597PheCys: 0.597 ± 0.011	2.23PheAsp: 2.23 ± 0.02	2.038PheGlu: 2.038 ± 0.022	1.681PhePhe: 1.681 ± 0.022	2.773PheGly: 2.773 ± 0.026	0.992PheHis: 0.992 ± 0.014	1.835PheIle: 1.835 ± 0.021	1.304PheLys: 1.304 ± 0.015	3.73PheLeu: 3.73 ± 0.029	0.766PheMet: 0.766 ± 0.014	1.359PheAsn: 1.359 ± 0.017	2.078PhePro: 2.078 ± 0.02	1.453PheGln: 1.453 ± 0.017	2.066PheArg: 2.066 ± 0.02	3.031PheSer: 3.031 ± 0.027	2.207PheThr: 2.207 ± 0.022	2.39PheVal: 2.39 ± 0.024	0.658PheTrp: 0.658 ± 0.012	1.168PheTyr: 1.168 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.242GlyAla: 5.242 ± 0.043	0.961GlyCys: 0.961 ± 0.015	3.597GlyAsp: 3.597 ± 0.027	3.685GlyGlu: 3.685 ± 0.03	2.805GlyPhe: 2.805 ± 0.023	5.52GlyGly: 5.52 ± 0.049	1.686GlyHis: 1.686 ± 0.019	3.552GlyIle: 3.552 ± 0.027	3.104GlyLys: 3.104 ± 0.027	6.346GlyLeu: 6.346 ± 0.037	1.592GlyMet: 1.592 ± 0.018	2.389GlyAsn: 2.389 ± 0.023	3.446GlyPro: 3.446 ± 0.03	2.593GlyGln: 2.593 ± 0.025	4.191GlyArg: 4.191 ± 0.034	5.689GlySer: 5.689 ± 0.043	4.024GlyThr: 4.024 ± 0.034	4.586GlyVal: 4.586 ± 0.033	1.249GlyTrp: 1.249 ± 0.017	2.232GlyTyr: 2.232 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.94HisAla: 1.94 ± 0.02	0.37HisCys: 0.37 ± 0.009	1.353HisAsp: 1.353 ± 0.017	1.327HisGlu: 1.327 ± 0.015	0.927HisPhe: 0.927 ± 0.012	1.754HisGly: 1.754 ± 0.021	0.948HisHis: 0.948 ± 0.018	1.244HisIle: 1.244 ± 0.017	0.784HisLys: 0.784 ± 0.013	2.455HisLeu: 2.455 ± 0.021	0.509HisMet: 0.509 ± 0.01	0.828HisAsn: 0.828 ± 0.012	1.909HisPro: 1.909 ± 0.02	1.019HisGln: 1.019 ± 0.013	1.663HisArg: 1.663 ± 0.017	1.849HisSer: 1.849 ± 0.021	1.382HisThr: 1.382 ± 0.018	1.443HisVal: 1.443 ± 0.017	0.377HisTrp: 0.377 ± 0.008	0.741HisTyr: 0.741 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.148IleAla: 4.148 ± 0.027	0.813IleCys: 0.813 ± 0.012	2.76IleAsp: 2.76 ± 0.025	2.711IleGlu: 2.711 ± 0.022	2.037IlePhe: 2.037 ± 0.023	3.209IleGly: 3.209 ± 0.029	1.299IleHis: 1.299 ± 0.017	2.57IleIle: 2.57 ± 0.027	1.919IleLys: 1.919 ± 0.021	4.846IleLeu: 4.846 ± 0.034	1.019IleMet: 1.019 ± 0.015	1.718IleAsn: 1.718 ± 0.017	3.281IlePro: 3.281 ± 0.025	1.957IleGln: 1.957 ± 0.022	2.882IleArg: 2.882 ± 0.023	3.854IleSer: 3.854 ± 0.027	2.888IleThr: 2.888 ± 0.025	3.142IleVal: 3.142 ± 0.025	0.732IleTrp: 0.732 ± 0.011	1.514IleTyr: 1.514 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.727LysAla: 3.727 ± 0.031	0.475LysCys: 0.475 ± 0.008	2.404LysAsp: 2.404 ± 0.022	3.03LysGlu: 3.03 ± 0.029	1.255LysPhe: 1.255 ± 0.017	2.699LysGly: 2.699 ± 0.024	1.014LysHis: 1.014 ± 0.014	2.042LysIle: 2.042 ± 0.021	2.715LysLys: 2.715 ± 0.037	3.659LysLeu: 3.659 ± 0.027	0.899LysMet: 0.899 ± 0.014	1.485LysAsn: 1.485 ± 0.02	2.503LysPro: 2.503 ± 0.027	1.685LysGln: 1.685 ± 0.021	3.157LysArg: 3.157 ± 0.029	3.071LysSer: 3.071 ± 0.028	2.448LysThr: 2.448 ± 0.023	2.609LysVal: 2.609 ± 0.024	0.599LysTrp: 0.599 ± 0.009	1.286LysTyr: 1.286 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.056LeuAla: 8.056 ± 0.045	1.303LeuCys: 1.303 ± 0.016	5.272LeuAsp: 5.272 ± 0.035	5.541LeuGlu: 5.541 ± 0.037	3.519LeuPhe: 3.519 ± 0.031	6.241LeuGly: 6.241 ± 0.04	2.439LeuHis: 2.439 ± 0.025	4.158LeuIle: 4.158 ± 0.032	3.794LeuLys: 3.794 ± 0.031	8.988LeuLeu: 8.988 ± 0.057	1.835LeuMet: 1.835 ± 0.019	3.118LeuAsn: 3.118 ± 0.025	5.722LeuPro: 5.722 ± 0.036	3.976LeuGln: 3.976 ± 0.029	6.039LeuArg: 6.039 ± 0.037	7.699LeuSer: 7.699 ± 0.043	5.119LeuThr: 5.119 ± 0.029	5.73LeuVal: 5.73 ± 0.037	1.285LeuTrp: 1.285 ± 0.02	2.582LeuTyr: 2.582 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.021	0.25MetCys: 0.25 ± 0.007	1.218MetAsp: 1.218 ± 0.015	1.297MetGlu: 1.297 ± 0.016	0.762MetPhe: 0.762 ± 0.013	1.505MetGly: 1.505 ± 0.017	0.501MetHis: 0.501 ± 0.01	1.018MetIle: 1.018 ± 0.015	0.919MetLys: 0.919 ± 0.013	1.886MetLeu: 1.886 ± 0.019	0.577MetMet: 0.577 ± 0.01	0.792MetAsn: 0.792 ± 0.012	1.229MetPro: 1.229 ± 0.015	0.856MetGln: 0.856 ± 0.012	1.276MetArg: 1.276 ± 0.014	1.848MetSer: 1.848 ± 0.019	1.32MetThr: 1.32 ± 0.016	1.398MetVal: 1.398 ± 0.016	0.261MetTrp: 0.261 ± 0.006	0.549MetTyr: 0.549 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.945AsnAla: 2.945 ± 0.022	0.457AsnCys: 0.457 ± 0.01	1.79AsnAsp: 1.79 ± 0.018	1.856AsnGlu: 1.856 ± 0.019	1.28AsnPhe: 1.28 ± 0.016	2.727AsnGly: 2.727 ± 0.025	0.861AsnHis: 0.861 ± 0.012	1.931AsnIle: 1.931 ± 0.018	1.318AsnLys: 1.318 ± 0.016	3.192AsnLeu: 3.192 ± 0.028	0.782AsnMet: 0.782 ± 0.011	1.326AsnAsn: 1.326 ± 0.017	2.505AsnPro: 2.505 ± 0.023	1.28AsnGln: 1.28 ± 0.016	1.931AsnArg: 1.931 ± 0.019	2.497AsnSer: 2.497 ± 0.024	2.116AsnThr: 2.116 ± 0.023	2.192AsnVal: 2.192 ± 0.021	0.556AsnTrp: 0.556 ± 0.01	1.07AsnTyr: 1.07 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.358ProAla: 5.358 ± 0.044	0.598ProCys: 0.598 ± 0.011	3.359ProAsp: 3.359 ± 0.028	3.957ProGlu: 3.957 ± 0.039	2.165ProPhe: 2.165 ± 0.02	4.01ProGly: 4.01 ± 0.032	1.426ProHis: 1.426 ± 0.022	2.602ProIle: 2.602 ± 0.025	2.397ProLys: 2.397 ± 0.024	4.932ProLeu: 4.932 ± 0.032	1.097ProMet: 1.097 ± 0.015	2.138ProAsn: 2.138 ± 0.022	5.049ProPro: 5.049 ± 0.064	2.462ProGln: 2.462 ± 0.029	3.559ProArg: 3.559 ± 0.025	6.347ProSer: 6.347 ± 0.046	4.182ProThr: 4.182 ± 0.033	3.835ProVal: 3.835 ± 0.032	0.819ProTrp: 0.819 ± 0.013	1.604ProTyr: 1.604 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.434GlnAla: 3.434 ± 0.03	0.491GlnCys: 0.491 ± 0.01	2.024GlnAsp: 2.024 ± 0.022	2.362GlnGlu: 2.362 ± 0.024	1.304GlnPhe: 1.304 ± 0.015	2.439GlnGly: 2.439 ± 0.021	1.06GlnHis: 1.06 ± 0.016	1.893GlnIle: 1.893 ± 0.019	1.822GlnLys: 1.822 ± 0.023	3.591GlnLeu: 3.591 ± 0.028	0.877GlnMet: 0.877 ± 0.011	1.448GlnAsn: 1.448 ± 0.018	2.657GlnPro: 2.657 ± 0.031	2.232GlnGln: 2.232 ± 0.041	2.689GlnArg: 2.689 ± 0.023	3.204GlnSer: 3.204 ± 0.024	2.414GlnThr: 2.414 ± 0.022	2.218GlnVal: 2.218 ± 0.023	0.599GlnTrp: 0.599 ± 0.011	1.192GlnTyr: 1.192 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.749ArgAla: 4.749 ± 0.033	0.799ArgCys: 0.799 ± 0.014	3.382ArgAsp: 3.382 ± 0.028	3.851ArgGlu: 3.851 ± 0.034	2.243ArgPhe: 2.243 ± 0.02	3.823ArgGly: 3.823 ± 0.029	1.629ArgHis: 1.629 ± 0.018	2.928ArgIle: 2.928 ± 0.024	3.257ArgLys: 3.257 ± 0.029	5.851ArgLeu: 5.851 ± 0.041	1.375ArgMet: 1.375 ± 0.017	2.159ArgAsn: 2.159 ± 0.02	3.662ArgPro: 3.662 ± 0.033	2.646ArgGln: 2.646 ± 0.025	5.211ArgArg: 5.211 ± 0.044	4.888ArgSer: 4.888 ± 0.039	3.386ArgThr: 3.386 ± 0.027	3.657ArgVal: 3.657 ± 0.028	1.009ArgTrp: 1.009 ± 0.014	1.793ArgTyr: 1.793 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.668SerAla: 6.668 ± 0.045	0.948SerCys: 0.948 ± 0.016	4.246SerAsp: 4.246 ± 0.034	4.121SerGlu: 4.121 ± 0.031	3.056SerPhe: 3.056 ± 0.026	5.571SerGly: 5.571 ± 0.042	2.045SerHis: 2.045 ± 0.022	3.988SerIle: 3.988 ± 0.033	3.27SerLys: 3.27 ± 0.03	7.564SerLeu: 7.564 ± 0.044	1.694SerMet: 1.694 ± 0.018	2.818SerAsn: 2.818 ± 0.025	5.64SerPro: 5.64 ± 0.046	3.271SerGln: 3.271 ± 0.028	5.064SerArg: 5.064 ± 0.045	8.805SerSer: 8.805 ± 0.074	5.702SerThr: 5.702 ± 0.045	4.786SerVal: 4.786 ± 0.035	1.177SerTrp: 1.177 ± 0.016	2.166SerTyr: 2.166 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.284ThrAla: 5.284 ± 0.034	0.816ThrCys: 0.816 ± 0.014	2.992ThrAsp: 2.992 ± 0.028	3.159ThrGlu: 3.159 ± 0.029	2.254ThrPhe: 2.254 ± 0.023	4.37ThrGly: 4.37 ± 0.033	1.397ThrHis: 1.397 ± 0.015	3.158ThrIle: 3.158 ± 0.025	2.335ThrLys: 2.335 ± 0.022	5.526ThrLeu: 5.526 ± 0.033	1.233ThrMet: 1.233 ± 0.016	2.056ThrAsn: 2.056 ± 0.02	4.386ThrPro: 4.386 ± 0.038	2.09ThrGln: 2.09 ± 0.022	3.164ThrArg: 3.164 ± 0.024	5.281ThrSer: 5.281 ± 0.04	4.656ThrThr: 4.656 ± 0.048	3.975ThrVal: 3.975 ± 0.032	0.91ThrTrp: 0.91 ± 0.014	1.759ThrTyr: 1.759 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.312ValAla: 5.312 ± 0.034	0.896ValCys: 0.896 ± 0.013	3.749ValAsp: 3.749 ± 0.028	3.872ValGlu: 3.872 ± 0.032	2.521ValPhe: 2.521 ± 0.025	4.152ValGly: 4.152 ± 0.034	1.479ValHis: 1.479 ± 0.018	3.052ValIle: 3.052 ± 0.025	2.629ValLys: 2.629 ± 0.024	5.895ValLeu: 5.895 ± 0.043	1.373ValMet: 1.373 ± 0.018	2.176ValAsn: 2.176 ± 0.021	3.769ValPro: 3.769 ± 0.03	2.452ValGln: 2.452 ± 0.023	3.636ValArg: 3.636 ± 0.028	4.826ValSer: 4.826 ± 0.031	3.633ValThr: 3.633 ± 0.03	4.431ValVal: 4.431 ± 0.034	0.917ValTrp: 0.917 ± 0.013	1.864ValTyr: 1.864 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.151TrpAla: 1.151 ± 0.017	0.211TrpCys: 0.211 ± 0.007	0.922TrpAsp: 0.922 ± 0.014	0.883TrpGlu: 0.883 ± 0.013	0.568TrpPhe: 0.568 ± 0.01	0.97TrpGly: 0.97 ± 0.016	0.37TrpHis: 0.37 ± 0.008	0.793TrpIle: 0.793 ± 0.012	0.774TrpLys: 0.774 ± 0.012	1.417TrpLeu: 1.417 ± 0.016	0.401TrpMet: 0.401 ± 0.008	0.645TrpAsn: 0.645 ± 0.01	0.652TrpPro: 0.652 ± 0.011	0.587TrpGln: 0.587 ± 0.009	1.009TrpArg: 1.009 ± 0.015	1.107TrpSer: 1.107 ± 0.015	0.977TrpThr: 0.977 ± 0.013	0.968TrpVal: 0.968 ± 0.014	0.299TrpTrp: 0.299 ± 0.009	0.453TrpTyr: 0.453 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.257TyrAla: 2.257 ± 0.02	0.444TyrCys: 0.444 ± 0.009	1.685TyrAsp: 1.685 ± 0.018	1.557TyrGlu: 1.557 ± 0.02	1.234TyrPhe: 1.234 ± 0.014	2.193TyrGly: 2.193 ± 0.024	0.825TyrHis: 0.825 ± 0.012	1.514TyrIle: 1.514 ± 0.018	0.985TyrLys: 0.985 ± 0.015	2.882TyrLeu: 2.882 ± 0.023	0.651TyrMet: 0.651 ± 0.012	1.133TyrAsn: 1.133 ± 0.016	1.675TyrPro: 1.675 ± 0.021	1.15TyrGln: 1.15 ± 0.017	1.746TyrArg: 1.746 ± 0.019	2.109TyrSer: 2.109 ± 0.021	1.752TyrThr: 1.752 ± 0.019	1.757TyrVal: 1.757 ± 0.02	0.478TyrTrp: 0.478 ± 0.009	1.038TyrTyr: 1.038 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11680 proteins (5453369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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