Amino acid dipepetide frequency for Firmicutes bacterium CAG:552

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.494AlaAla: 7.494 ± 0.205
1.233AlaCys: 1.233 ± 0.059
4.849AlaAsp: 4.849 ± 0.119
5.291AlaGlu: 5.291 ± 0.118
3.976AlaPhe: 3.976 ± 0.232
4.59AlaGly: 4.59 ± 0.127
1.032AlaHis: 1.032 ± 0.053
6.084AlaIle: 6.084 ± 0.145
6.338AlaLys: 6.338 ± 0.125
8.081AlaLeu: 8.081 ± 0.161
2.182AlaMet: 2.182 ± 0.081
3.042AlaAsn: 3.042 ± 0.097
2.055AlaPro: 2.055 ± 0.072
2.013AlaGln: 2.013 ± 0.08
2.83AlaArg: 2.83 ± 0.085
4.515AlaSer: 4.515 ± 0.114
3.992AlaThr: 3.992 ± 0.123
6.991AlaVal: 6.991 ± 0.176
0.325AlaTrp: 0.325 ± 0.029
2.952AlaTyr: 2.952 ± 0.101
0.0AlaXaa: 0.0 ± 0.0
Cys
1.452CysAla: 1.452 ± 0.075
0.365CysCys: 0.365 ± 0.037
1.399CysAsp: 1.399 ± 0.068
1.175CysGlu: 1.175 ± 0.066
0.749CysPhe: 0.749 ± 0.045
1.987CysGly: 1.987 ± 0.084
0.241CysHis: 0.241 ± 0.025
1.214CysIle: 1.214 ± 0.059
1.167CysLys: 1.167 ± 0.061
1.304CysLeu: 1.304 ± 0.064
0.376CysMet: 0.376 ± 0.032
0.712CysAsn: 0.712 ± 0.041
0.645CysPro: 0.645 ± 0.044
0.291CysGln: 0.291 ± 0.028
0.643CysArg: 0.643 ± 0.042
1.312CysSer: 1.312 ± 0.072
0.833CysThr: 0.833 ± 0.091
1.585CysVal: 1.585 ± 0.073
0.056CysTrp: 0.056 ± 0.013
0.574CysTyr: 0.574 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
4.325AspAla: 4.325 ± 0.127
1.272AspCys: 1.272 ± 0.076
3.505AspAsp: 3.505 ± 0.115
4.91AspGlu: 4.91 ± 0.15
2.897AspPhe: 2.897 ± 0.099
5.386AspGly: 5.386 ± 0.143
0.545AspHis: 0.545 ± 0.039
4.743AspIle: 4.743 ± 0.108
5.1AspLys: 5.1 ± 0.117
4.24AspLeu: 4.24 ± 0.11
1.64AspMet: 1.64 ± 0.074
2.701AspAsn: 2.701 ± 0.104
1.386AspPro: 1.386 ± 0.066
0.754AspGln: 0.754 ± 0.052
2.304AspArg: 2.304 ± 0.084
3.219AspSer: 3.219 ± 0.095
2.637AspThr: 2.637 ± 0.076
4.825AspVal: 4.825 ± 0.137
0.373AspTrp: 0.373 ± 0.029
2.936AspTyr: 2.936 ± 0.098
0.0AspXaa: 0.0 ± 0.0
Glu
4.484GluAla: 4.484 ± 0.132
0.976GluCys: 0.976 ± 0.052
3.455GluAsp: 3.455 ± 0.104
4.574GluGlu: 4.574 ± 0.146
2.756GluPhe: 2.756 ± 0.08
3.886GluGly: 3.886 ± 0.11
0.894GluHis: 0.894 ± 0.053
5.724GluIle: 5.724 ± 0.145
5.611GluLys: 5.611 ± 0.142
5.949GluLeu: 5.949 ± 0.127
1.722GluMet: 1.722 ± 0.073
3.754GluAsn: 3.754 ± 0.116
1.505GluPro: 1.505 ± 0.064
2.222GluGln: 2.222 ± 0.071
3.248GluArg: 3.248 ± 0.102
3.777GluSer: 3.777 ± 0.117
3.256GluThr: 3.256 ± 0.089
4.418GluVal: 4.418 ± 0.114
0.381GluTrp: 0.381 ± 0.034
2.883GluTyr: 2.883 ± 0.09
0.0GluXaa: 0.0 ± 0.0
Phe
3.931PheAla: 3.931 ± 0.108
0.91PheCys: 0.91 ± 0.053
3.386PheAsp: 3.386 ± 0.09
2.637PheGlu: 2.637 ± 0.087
2.135PhePhe: 2.135 ± 0.099
3.444PheGly: 3.444 ± 0.104
0.46PheHis: 0.46 ± 0.039
2.651PheIle: 2.651 ± 0.095
2.465PheLys: 2.465 ± 0.091
3.561PheLeu: 3.561 ± 0.12
1.026PheMet: 1.026 ± 0.053
1.952PheAsn: 1.952 ± 0.069
1.275PhePro: 1.275 ± 0.057
0.563PheGln: 0.563 ± 0.039
1.458PheArg: 1.458 ± 0.068
3.357PheSer: 3.357 ± 0.117
2.5PheThr: 2.5 ± 0.077
3.949PheVal: 3.949 ± 0.12
0.212PheTrp: 0.212 ± 0.023
1.844PheTyr: 1.844 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
5.325GlyAla: 5.325 ± 0.137
1.608GlyCys: 1.608 ± 0.127
4.349GlyAsp: 4.349 ± 0.121
5.14GlyGlu: 5.14 ± 0.117
2.923GlyPhe: 2.923 ± 0.095
5.542GlyGly: 5.542 ± 0.157
1.005GlyHis: 1.005 ± 0.053
5.521GlyIle: 5.521 ± 0.148
6.333GlyLys: 6.333 ± 0.131
5.42GlyLeu: 5.42 ± 0.128
1.934GlyMet: 1.934 ± 0.079
3.254GlyAsn: 3.254 ± 0.13
1.066GlyPro: 1.066 ± 0.067
1.479GlyGln: 1.479 ± 0.07
2.738GlyArg: 2.738 ± 0.087
4.505GlySer: 4.505 ± 0.119
3.428GlyThr: 3.428 ± 0.116
5.788GlyVal: 5.788 ± 0.138
0.497GlyTrp: 0.497 ± 0.042
3.275GlyTyr: 3.275 ± 0.091
0.003GlyXaa: 0.003 ± 0.002
His
0.936HisAla: 0.936 ± 0.055
0.278HisCys: 0.278 ± 0.026
0.696HisAsp: 0.696 ± 0.037
0.725HisGlu: 0.725 ± 0.042
0.6HisPhe: 0.6 ± 0.045
1.034HisGly: 1.034 ± 0.053
0.217HisHis: 0.217 ± 0.025
1.082HisIle: 1.082 ± 0.059
0.778HisLys: 0.778 ± 0.048
1.058HisLeu: 1.058 ± 0.066
0.233HisMet: 0.233 ± 0.022
0.598HisAsn: 0.598 ± 0.043
0.571HisPro: 0.571 ± 0.041
0.272HisGln: 0.272 ± 0.027
0.667HisArg: 0.667 ± 0.044
0.857HisSer: 0.857 ± 0.043
0.712HisThr: 0.712 ± 0.041
0.868HisVal: 0.868 ± 0.05
0.09HisTrp: 0.09 ± 0.016
0.497HisTyr: 0.497 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.827IleAla: 6.827 ± 0.164
1.487IleCys: 1.487 ± 0.066
4.849IleAsp: 4.849 ± 0.133
4.963IleGlu: 4.963 ± 0.132
2.875IlePhe: 2.875 ± 0.1
5.592IleGly: 5.592 ± 0.164
0.751IleHis: 0.751 ± 0.044
5.716IleIle: 5.716 ± 0.136
5.968IleLys: 5.968 ± 0.13
5.759IleLeu: 5.759 ± 0.157
1.96IleMet: 1.96 ± 0.086
3.632IleAsn: 3.632 ± 0.099
2.5IlePro: 2.5 ± 0.09
1.283IleGln: 1.283 ± 0.06
2.976IleArg: 2.976 ± 0.093
5.383IleSer: 5.383 ± 0.133
4.74IleThr: 4.74 ± 0.139
6.015IleVal: 6.015 ± 0.121
0.384IleTrp: 0.384 ± 0.026
2.426IleTyr: 2.426 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.87LysAla: 5.87 ± 0.127
1.119LysCys: 1.119 ± 0.057
4.267LysAsp: 4.267 ± 0.117
5.621LysGlu: 5.621 ± 0.14
2.854LysPhe: 2.854 ± 0.082
4.592LysGly: 4.592 ± 0.112
0.981LysHis: 0.981 ± 0.05
5.955LysIle: 5.955 ± 0.134
6.333LysLys: 6.333 ± 0.163
6.571LysLeu: 6.571 ± 0.145
2.061LysMet: 2.061 ± 0.064
4.124LysAsn: 4.124 ± 0.112
2.114LysPro: 2.114 ± 0.08
2.206LysGln: 2.206 ± 0.085
3.783LysArg: 3.783 ± 0.115
4.616LysSer: 4.616 ± 0.109
4.56LysThr: 4.56 ± 0.113
5.148LysVal: 5.148 ± 0.142
0.516LysTrp: 0.516 ± 0.038
3.307LysTyr: 3.307 ± 0.088
0.0LysXaa: 0.0 ± 0.0
Leu
6.526LeuAla: 6.526 ± 0.141
1.828LeuCys: 1.828 ± 0.087
4.584LeuAsp: 4.584 ± 0.124
4.23LeuGlu: 4.23 ± 0.115
3.598LeuPhe: 3.598 ± 0.121
5.746LeuGly: 5.746 ± 0.122
1.095LeuHis: 1.095 ± 0.062
6.544LeuIle: 6.544 ± 0.182
6.991LeuLys: 6.991 ± 0.153
7.407LeuLeu: 7.407 ± 0.187
2.188LeuMet: 2.188 ± 0.091
4.01LeuAsn: 4.01 ± 0.111
3.59LeuPro: 3.59 ± 0.124
1.841LeuGln: 1.841 ± 0.074
3.881LeuArg: 3.881 ± 0.113
7.552LeuSer: 7.552 ± 0.162
5.492LeuThr: 5.492 ± 0.146
5.484LeuVal: 5.484 ± 0.121
0.569LeuTrp: 0.569 ± 0.045
3.135LeuTyr: 3.135 ± 0.097
0.0LeuXaa: 0.0 ± 0.0
Met
1.894MetAla: 1.894 ± 0.075
0.368MetCys: 0.368 ± 0.033
1.389MetAsp: 1.389 ± 0.069
1.537MetGlu: 1.537 ± 0.073
1.082MetPhe: 1.082 ± 0.061
1.571MetGly: 1.571 ± 0.069
0.354MetHis: 0.354 ± 0.031
1.651MetIle: 1.651 ± 0.072
1.852MetLys: 1.852 ± 0.069
2.648MetLeu: 2.648 ± 0.098
0.624MetMet: 0.624 ± 0.042
1.164MetAsn: 1.164 ± 0.064
1.222MetPro: 1.222 ± 0.058
0.921MetGln: 0.921 ± 0.05
1.518MetArg: 1.518 ± 0.068
1.767MetSer: 1.767 ± 0.078
1.426MetThr: 1.426 ± 0.054
1.484MetVal: 1.484 ± 0.058
0.143MetTrp: 0.143 ± 0.021
0.857MetTyr: 0.857 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.793AsnAla: 3.793 ± 0.12
0.897AsnCys: 0.897 ± 0.074
2.487AsnAsp: 2.487 ± 0.101
3.034AsnGlu: 3.034 ± 0.103
1.878AsnPhe: 1.878 ± 0.072
3.907AsnGly: 3.907 ± 0.105
0.571AsnHis: 0.571 ± 0.039
3.537AsnIle: 3.537 ± 0.099
3.288AsnLys: 3.288 ± 0.097
3.473AsnLeu: 3.473 ± 0.097
1.243AsnMet: 1.243 ± 0.068
2.077AsnAsn: 2.077 ± 0.092
1.667AsnPro: 1.667 ± 0.064
0.91AsnGln: 0.91 ± 0.046
1.738AsnArg: 1.738 ± 0.076
2.571AsnSer: 2.571 ± 0.091
1.958AsnThr: 1.958 ± 0.082
3.83AsnVal: 3.83 ± 0.107
0.299AsnTrp: 0.299 ± 0.029
1.878AsnTyr: 1.878 ± 0.089
0.0AsnXaa: 0.0 ± 0.0
Pro
2.002ProAla: 2.002 ± 0.086
0.571ProCys: 0.571 ± 0.039
1.976ProAsp: 1.976 ± 0.081
2.074ProGlu: 2.074 ± 0.086
1.571ProPhe: 1.571 ± 0.064
1.5ProGly: 1.5 ± 0.059
0.585ProHis: 0.585 ± 0.039
2.177ProIle: 2.177 ± 0.073
1.931ProLys: 1.931 ± 0.076
2.907ProLeu: 2.907 ± 0.081
0.696ProMet: 0.696 ± 0.04
1.095ProAsn: 1.095 ± 0.049
0.878ProPro: 0.878 ± 0.053
1.09ProGln: 1.09 ± 0.058
0.799ProArg: 0.799 ± 0.041
2.537ProSer: 2.537 ± 0.096
1.778ProThr: 1.778 ± 0.067
2.45ProVal: 2.45 ± 0.077
0.164ProTrp: 0.164 ± 0.021
1.368ProTyr: 1.368 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
1.735GlnAla: 1.735 ± 0.077
0.267GlnCys: 0.267 ± 0.026
0.942GlnAsp: 0.942 ± 0.046
1.201GlnGlu: 1.201 ± 0.058
0.865GlnPhe: 0.865 ± 0.049
1.418GlnGly: 1.418 ± 0.065
0.28GlnHis: 0.28 ± 0.029
1.849GlnIle: 1.849 ± 0.073
2.177GlnLys: 2.177 ± 0.085
2.127GlnLeu: 2.127 ± 0.08
0.696GlnMet: 0.696 ± 0.042
1.339GlnAsn: 1.339 ± 0.064
0.783GlnPro: 0.783 ± 0.048
0.598GlnGln: 0.598 ± 0.054
1.196GlnArg: 1.196 ± 0.057
1.672GlnSer: 1.672 ± 0.067
1.352GlnThr: 1.352 ± 0.059
1.365GlnVal: 1.365 ± 0.066
0.18GlnTrp: 0.18 ± 0.024
0.807GlnTyr: 0.807 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.799ArgAla: 2.799 ± 0.09
0.664ArgCys: 0.664 ± 0.04
1.862ArgAsp: 1.862 ± 0.087
2.801ArgGlu: 2.801 ± 0.103
1.844ArgPhe: 1.844 ± 0.073
2.412ArgGly: 2.412 ± 0.084
0.622ArgHis: 0.622 ± 0.042
3.748ArgIle: 3.748 ± 0.114
3.489ArgLys: 3.489 ± 0.117
4.023ArgLeu: 4.023 ± 0.101
1.259ArgMet: 1.259 ± 0.061
2.024ArgAsn: 2.024 ± 0.08
1.185ArgPro: 1.185 ± 0.058
1.156ArgGln: 1.156 ± 0.062
2.325ArgArg: 2.325 ± 0.085
2.457ArgSer: 2.457 ± 0.073
2.153ArgThr: 2.153 ± 0.069
2.42ArgVal: 2.42 ± 0.091
0.262ArgTrp: 0.262 ± 0.029
1.857ArgTyr: 1.857 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
5.619SerAla: 5.619 ± 0.138
1.032SerCys: 1.032 ± 0.058
4.783SerAsp: 4.783 ± 0.132
4.574SerGlu: 4.574 ± 0.109
2.878SerPhe: 2.878 ± 0.081
5.716SerGly: 5.716 ± 0.128
0.913SerHis: 0.913 ± 0.051
4.595SerIle: 4.595 ± 0.145
4.161SerLys: 4.161 ± 0.113
6.499SerLeu: 6.499 ± 0.161
1.603SerMet: 1.603 ± 0.065
2.19SerAsn: 2.19 ± 0.088
2.01SerPro: 2.01 ± 0.078
1.622SerGln: 1.622 ± 0.068
2.373SerArg: 2.373 ± 0.086
4.288SerSer: 4.288 ± 0.144
2.992SerThr: 2.992 ± 0.108
6.187SerVal: 6.187 ± 0.164
0.291SerTrp: 0.291 ± 0.031
2.603SerTyr: 2.603 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
4.841ThrAla: 4.841 ± 0.132
0.714ThrCys: 0.714 ± 0.05
3.299ThrAsp: 3.299 ± 0.095
3.672ThrGlu: 3.672 ± 0.108
2.415ThrPhe: 2.415 ± 0.109
3.767ThrGly: 3.767 ± 0.106
0.857ThrHis: 0.857 ± 0.054
4.013ThrIle: 4.013 ± 0.147
3.322ThrLys: 3.322 ± 0.111
5.174ThrLeu: 5.174 ± 0.134
1.132ThrMet: 1.132 ± 0.052
1.749ThrAsn: 1.749 ± 0.075
1.939ThrPro: 1.939 ± 0.08
1.386ThrGln: 1.386 ± 0.065
1.672ThrArg: 1.672 ± 0.07
3.402ThrSer: 3.402 ± 0.152
2.764ThrThr: 2.764 ± 0.121
5.817ThrVal: 5.817 ± 0.171
0.214ThrTrp: 0.214 ± 0.027
2.127ThrTyr: 2.127 ± 0.092
0.003ThrXaa: 0.003 ± 0.003
Val
6.269ValAla: 6.269 ± 0.127
1.622ValCys: 1.622 ± 0.071
4.391ValAsp: 4.391 ± 0.126
4.489ValGlu: 4.489 ± 0.118
3.613ValPhe: 3.613 ± 0.108
5.32ValGly: 5.32 ± 0.139
0.857ValHis: 0.857 ± 0.051
6.182ValIle: 6.182 ± 0.129
6.129ValLys: 6.129 ± 0.148
6.354ValLeu: 6.354 ± 0.139
1.897ValMet: 1.897 ± 0.068
3.46ValAsn: 3.46 ± 0.098
2.426ValPro: 2.426 ± 0.08
1.283ValGln: 1.283 ± 0.063
3.124ValArg: 3.124 ± 0.101
6.018ValSer: 6.018 ± 0.144
5.134ValThr: 5.134 ± 0.162
5.857ValVal: 5.857 ± 0.149
0.45ValTrp: 0.45 ± 0.032
3.148ValTyr: 3.148 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.376TrpAla: 0.376 ± 0.033
0.111TrpCys: 0.111 ± 0.018
0.294TrpAsp: 0.294 ± 0.028
0.341TrpGlu: 0.341 ± 0.028
0.294TrpPhe: 0.294 ± 0.027
0.402TrpGly: 0.402 ± 0.032
0.09TrpHis: 0.09 ± 0.015
0.458TrpIle: 0.458 ± 0.038
0.389TrpLys: 0.389 ± 0.033
0.606TrpLeu: 0.606 ± 0.047
0.135TrpMet: 0.135 ± 0.019
0.233TrpAsn: 0.233 ± 0.025
0.093TrpPro: 0.093 ± 0.016
0.204TrpGln: 0.204 ± 0.023
0.23TrpArg: 0.23 ± 0.023
0.37TrpSer: 0.37 ± 0.034
0.307TrpThr: 0.307 ± 0.032
0.333TrpVal: 0.333 ± 0.026
0.071TrpTrp: 0.071 ± 0.012
0.317TrpTyr: 0.317 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.367TyrAla: 3.367 ± 0.113
0.757TyrCys: 0.757 ± 0.045
2.939TyrAsp: 2.939 ± 0.103
2.489TyrGlu: 2.489 ± 0.086
1.913TyrPhe: 1.913 ± 0.071
3.32TyrGly: 3.32 ± 0.08
0.418TyrHis: 0.418 ± 0.032
2.645TyrIle: 2.645 ± 0.085
2.775TyrLys: 2.775 ± 0.09
3.127TyrLeu: 3.127 ± 0.112
0.862TyrMet: 0.862 ± 0.044
1.928TyrAsn: 1.928 ± 0.075
1.238TyrPro: 1.238 ± 0.055
0.754TyrGln: 0.754 ± 0.04
1.86TyrArg: 1.86 ± 0.072
2.748TyrSer: 2.748 ± 0.112
2.264TyrThr: 2.264 ± 0.1
3.209TyrVal: 3.209 ± 0.095
0.177TyrTrp: 0.177 ± 0.02
1.741TyrTyr: 1.741 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.003XaaArg: 0.003 ± 0.003
0.003XaaSer: 0.003 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.006
Statistics based on 1175 proteins (378033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski