Amino acid dipepetide frequency for Tomato leaf curl New Delhi virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.637AlaAla: 1.637 ± 1.241
0.818AlaCys: 0.818 ± 0.647
2.455AlaAsp: 2.455 ± 0.837
1.637AlaGlu: 1.637 ± 0.851
2.455AlaPhe: 2.455 ± 1.925
1.637AlaGly: 1.637 ± 1.109
1.637AlaHis: 1.637 ± 0.851
0.818AlaIle: 0.818 ± 0.621
4.092AlaLys: 4.092 ± 1.114
7.365AlaLeu: 7.365 ± 1.912
2.455AlaMet: 2.455 ± 1.436
0.818AlaAsn: 0.818 ± 0.621
1.637AlaPro: 1.637 ± 1.134
2.455AlaGln: 2.455 ± 1.499
5.728AlaArg: 5.728 ± 1.421
4.092AlaSer: 4.092 ± 1.793
3.273AlaThr: 3.273 ± 1.726
2.455AlaVal: 2.455 ± 1.217
2.455AlaTrp: 2.455 ± 1.048
0.818AlaTyr: 0.818 ± 0.806
0.0AlaXaa: 0.0 ± 0.0
Cys
1.637CysAla: 1.637 ± 0.928
0.818CysCys: 0.818 ± 0.944
0.818CysAsp: 0.818 ± 0.944
0.818CysGlu: 0.818 ± 0.944
1.637CysPhe: 1.637 ± 1.146
2.455CysGly: 2.455 ± 1.503
0.818CysHis: 0.818 ± 0.774
0.0CysIle: 0.0 ± 0.0
0.818CysLys: 0.818 ± 0.621
1.637CysLeu: 1.637 ± 1.241
0.0CysMet: 0.0 ± 0.0
0.818CysAsn: 0.818 ± 0.621
0.818CysPro: 0.818 ± 0.806
2.455CysGln: 2.455 ± 1.229
1.637CysArg: 1.637 ± 0.928
2.455CysSer: 2.455 ± 1.127
1.637CysThr: 1.637 ± 1.109
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.637AspAla: 1.637 ± 1.302
0.0AspCys: 0.0 ± 0.0
0.818AspAsp: 0.818 ± 0.621
1.637AspGlu: 1.637 ± 0.643
4.092AspPhe: 4.092 ± 1.988
4.092AspGly: 4.092 ± 1.618
2.455AspHis: 2.455 ± 1.345
4.91AspIle: 4.91 ± 2.225
0.0AspLys: 0.0 ± 0.0
3.273AspLeu: 3.273 ± 1.351
0.818AspMet: 0.818 ± 0.819
1.637AspAsn: 1.637 ± 0.959
4.092AspPro: 4.092 ± 1.577
1.637AspGln: 1.637 ± 0.834
4.092AspArg: 4.092 ± 1.248
4.91AspSer: 4.91 ± 1.601
0.818AspThr: 0.818 ± 0.806
5.728AspVal: 5.728 ± 1.8
2.455AspTrp: 2.455 ± 1.272
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.092GluAla: 4.092 ± 1.673
0.818GluCys: 0.818 ± 0.806
0.818GluAsp: 0.818 ± 0.806
1.637GluGlu: 1.637 ± 0.834
0.0GluPhe: 0.0 ± 0.0
4.91GluGly: 4.91 ± 2.049
0.0GluHis: 0.0 ± 0.0
3.273GluIle: 3.273 ± 0.92
4.092GluLys: 4.092 ± 1.494
3.273GluLeu: 3.273 ± 1.457
0.818GluMet: 0.818 ± 0.806
2.455GluAsn: 2.455 ± 1.13
1.637GluPro: 1.637 ± 0.977
1.637GluGln: 1.637 ± 0.977
1.637GluArg: 1.637 ± 1.193
4.092GluSer: 4.092 ± 1.619
3.273GluThr: 3.273 ± 1.206
0.818GluVal: 0.818 ± 0.621
1.637GluTrp: 1.637 ± 0.851
1.637GluTyr: 1.637 ± 0.918
0.0GluXaa: 0.0 ± 0.0
Phe
0.818PheAla: 0.818 ± 0.944
0.818PheCys: 0.818 ± 0.944
3.273PheAsp: 3.273 ± 1.286
1.637PheGlu: 1.637 ± 0.851
0.818PhePhe: 0.818 ± 0.647
3.273PheGly: 3.273 ± 1.699
2.455PheHis: 2.455 ± 1.862
3.273PheIle: 3.273 ± 1.979
3.273PheLys: 3.273 ± 2.405
6.547PheLeu: 6.547 ± 2.327
0.818PheMet: 0.818 ± 0.936
2.455PheAsn: 2.455 ± 1.217
2.455PhePro: 2.455 ± 1.449
4.092PheGln: 4.092 ± 1.527
2.455PheArg: 2.455 ± 1.499
3.273PheSer: 3.273 ± 1.683
1.637PheThr: 1.637 ± 1.085
2.455PheVal: 2.455 ± 1.085
0.818PheTrp: 0.818 ± 0.944
0.818PheTyr: 0.818 ± 0.647
0.0PheXaa: 0.0 ± 0.0
Gly
3.273GlyAla: 3.273 ± 1.076
1.637GlyCys: 1.637 ± 0.851
4.092GlyAsp: 4.092 ± 1.509
1.637GlyGlu: 1.637 ± 0.918
4.91GlyPhe: 4.91 ± 2.643
2.455GlyGly: 2.455 ± 1.085
0.818GlyHis: 0.818 ± 0.621
4.092GlyIle: 4.092 ± 2.044
4.91GlyLys: 4.91 ± 1.928
5.728GlyLeu: 5.728 ± 2.256
0.0GlyMet: 0.0 ± 0.0
4.092GlyAsn: 4.092 ± 1.855
4.91GlyPro: 4.91 ± 1.493
2.455GlyGln: 2.455 ± 1.048
2.455GlyArg: 2.455 ± 1.085
2.455GlySer: 2.455 ± 0.942
4.092GlyThr: 4.092 ± 1.648
5.728GlyVal: 5.728 ± 1.757
0.0GlyTrp: 0.0 ± 0.0
0.818GlyTyr: 0.818 ± 0.806
0.0GlyXaa: 0.0 ± 0.0
His
1.637HisAla: 1.637 ± 1.294
3.273HisCys: 3.273 ± 1.086
2.455HisAsp: 2.455 ± 1.694
0.0HisGlu: 0.0 ± 0.0
2.455HisPhe: 2.455 ± 1.862
1.637HisGly: 1.637 ± 1.218
1.637HisHis: 1.637 ± 1.218
4.092HisIle: 4.092 ± 1.846
1.637HisLys: 1.637 ± 1.031
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
3.273HisAsn: 3.273 ± 1.287
1.637HisPro: 1.637 ± 0.928
0.0HisGln: 0.0 ± 0.0
4.91HisArg: 4.91 ± 2.196
2.455HisSer: 2.455 ± 1.433
1.637HisThr: 1.637 ± 1.294
4.91HisVal: 4.91 ± 2.547
0.0HisTrp: 0.0 ± 0.0
2.455HisTyr: 2.455 ± 0.957
0.0HisXaa: 0.0 ± 0.0
Ile
1.637IleAla: 1.637 ± 0.953
1.637IleCys: 1.637 ± 0.834
3.273IleAsp: 3.273 ± 0.92
2.455IleGlu: 2.455 ± 0.781
1.637IlePhe: 1.637 ± 0.918
2.455IleGly: 2.455 ± 1.662
1.637IleHis: 1.637 ± 1.109
2.455IleIle: 2.455 ± 1.416
7.365IleLys: 7.365 ± 1.836
3.273IleLeu: 3.273 ± 1.108
0.818IleMet: 0.818 ± 0.621
2.455IleAsn: 2.455 ± 1.034
0.0IlePro: 0.0 ± 0.0
6.547IleGln: 6.547 ± 2.392
4.092IleArg: 4.092 ± 2.044
4.91IleSer: 4.91 ± 1.963
1.637IleThr: 1.637 ± 1.257
1.637IleVal: 1.637 ± 0.928
0.818IleTrp: 0.818 ± 0.819
4.092IleTyr: 4.092 ± 1.532
0.0IleXaa: 0.0 ± 0.0
Lys
3.273LysAla: 3.273 ± 1.441
1.637LysCys: 1.637 ± 0.918
0.818LysAsp: 0.818 ± 0.621
2.455LysGlu: 2.455 ± 1.085
3.273LysPhe: 3.273 ± 1.286
5.728LysGly: 5.728 ± 1.417
4.092LysHis: 4.092 ± 2.621
4.092LysIle: 4.092 ± 2.587
4.092LysLys: 4.092 ± 1.42
2.455LysLeu: 2.455 ± 1.097
0.0LysMet: 0.0 ± 0.0
4.91LysAsn: 4.91 ± 1.484
4.91LysPro: 4.91 ± 1.712
0.0LysGln: 0.0 ± 0.0
1.637LysArg: 1.637 ± 1.294
5.728LysSer: 5.728 ± 1.818
4.092LysThr: 4.092 ± 1.578
2.455LysVal: 2.455 ± 0.802
0.818LysTrp: 0.818 ± 0.647
3.273LysTyr: 3.273 ± 1.119
0.0LysXaa: 0.0 ± 0.0
Leu
2.455LeuAla: 2.455 ± 1.345
3.273LeuCys: 3.273 ± 1.764
9.002LeuAsp: 9.002 ± 2.554
4.092LeuGlu: 4.092 ± 1.557
0.818LeuPhe: 0.818 ± 0.944
4.092LeuGly: 4.092 ± 1.495
3.273LeuHis: 3.273 ± 0.92
0.818LeuIle: 0.818 ± 0.806
4.91LeuLys: 4.91 ± 1.944
1.637LeuLeu: 1.637 ± 1.612
1.637LeuMet: 1.637 ± 1.06
1.637LeuAsn: 1.637 ± 1.241
2.455LeuPro: 2.455 ± 1.632
3.273LeuGln: 3.273 ± 1.351
7.365LeuArg: 7.365 ± 2.168
1.637LeuSer: 1.637 ± 1.11
5.728LeuThr: 5.728 ± 1.726
4.91LeuVal: 4.91 ± 1.562
0.0LeuTrp: 0.0 ± 0.0
2.455LeuTyr: 2.455 ± 0.837
0.0LeuXaa: 0.0 ± 0.0
Met
1.637MetAla: 1.637 ± 1.109
0.818MetCys: 0.818 ± 0.944
0.0MetAsp: 0.0 ± 0.0
2.455MetGlu: 2.455 ± 1.121
1.637MetPhe: 1.637 ± 1.294
1.637MetGly: 1.637 ± 1.11
1.637MetHis: 1.637 ± 1.109
0.0MetIle: 0.0 ± 0.0
0.818MetLys: 0.818 ± 0.647
2.455MetLeu: 2.455 ± 1.248
0.0MetMet: 0.0 ± 0.0
1.637MetAsn: 1.637 ± 1.109
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
2.455MetArg: 2.455 ± 1.345
0.818MetSer: 0.818 ± 0.994
0.818MetThr: 0.818 ± 0.819
0.818MetVal: 0.818 ± 0.621
0.818MetTrp: 0.818 ± 0.621
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.273AsnAla: 3.273 ± 1.018
0.0AsnCys: 0.0 ± 0.0
0.818AsnAsp: 0.818 ± 0.621
1.637AsnGlu: 1.637 ± 0.643
1.637AsnPhe: 1.637 ± 1.547
0.818AsnGly: 0.818 ± 0.944
1.637AsnHis: 1.637 ± 0.959
1.637AsnIle: 1.637 ± 0.834
0.0AsnLys: 0.0 ± 0.0
3.273AsnLeu: 3.273 ± 1.287
3.273AsnMet: 3.273 ± 2.051
3.273AsnAsn: 3.273 ± 0.92
4.91AsnPro: 4.91 ± 1.267
4.092AsnGln: 4.092 ± 1.357
4.91AsnArg: 4.91 ± 2.287
4.91AsnSer: 4.91 ± 2.344
4.092AsnThr: 4.092 ± 1.527
3.273AsnVal: 3.273 ± 1.836
0.818AsnTrp: 0.818 ± 0.994
2.455AsnTyr: 2.455 ± 0.781
0.0AsnXaa: 0.0 ± 0.0
Pro
2.455ProAla: 2.455 ± 0.802
0.818ProCys: 0.818 ± 0.774
2.455ProAsp: 2.455 ± 0.781
1.637ProGlu: 1.637 ± 1.134
2.455ProPhe: 2.455 ± 1.336
4.91ProGly: 4.91 ± 1.884
2.455ProHis: 2.455 ± 1.229
4.092ProIle: 4.092 ± 0.951
4.092ProLys: 4.092 ± 1.246
4.092ProLeu: 4.092 ± 1.639
0.818ProMet: 0.818 ± 0.904
1.637ProAsn: 1.637 ± 0.851
1.637ProPro: 1.637 ± 0.643
4.092ProGln: 4.092 ± 1.72
2.455ProArg: 2.455 ± 1.448
6.547ProSer: 6.547 ± 1.947
4.092ProThr: 4.092 ± 1.259
4.092ProVal: 4.092 ± 1.61
0.818ProTrp: 0.818 ± 0.944
1.637ProTyr: 1.637 ± 0.928
0.0ProXaa: 0.0 ± 0.0
Gln
4.91GlnAla: 4.91 ± 1.385
0.0GlnCys: 0.0 ± 0.0
1.637GlnAsp: 1.637 ± 0.953
2.455GlnGlu: 2.455 ± 0.781
3.273GlnPhe: 3.273 ± 1.263
1.637GlnGly: 1.637 ± 1.241
3.273GlnHis: 3.273 ± 1.499
3.273GlnIle: 3.273 ± 1.777
3.273GlnLys: 3.273 ± 1.086
0.818GlnLeu: 0.818 ± 0.621
0.0GlnMet: 0.0 ± 0.0
4.092GlnAsn: 4.092 ± 3.066
3.273GlnPro: 3.273 ± 1.744
2.455GlnGln: 2.455 ± 1.296
2.455GlnArg: 2.455 ± 0.781
2.455GlnSer: 2.455 ± 1.862
1.637GlnThr: 1.637 ± 1.241
6.547GlnVal: 6.547 ± 1.769
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.455ArgAla: 2.455 ± 1.53
2.455ArgCys: 2.455 ± 1.265
4.092ArgAsp: 4.092 ± 1.657
6.547ArgGlu: 6.547 ± 2.068
1.637ArgPhe: 1.637 ± 1.109
3.273ArgGly: 3.273 ± 1.183
2.455ArgHis: 2.455 ± 1.127
4.91ArgIle: 4.91 ± 1.367
3.273ArgLys: 3.273 ± 1.981
1.637ArgLeu: 1.637 ± 1.116
0.0ArgMet: 0.0 ± 0.0
0.818ArgAsn: 0.818 ± 0.819
8.183ArgPro: 8.183 ± 1.332
1.637ArgGln: 1.637 ± 1.218
3.273ArgArg: 3.273 ± 2.341
6.547ArgSer: 6.547 ± 2.206
6.547ArgThr: 6.547 ± 2.308
7.365ArgVal: 7.365 ± 1.102
0.818ArgTrp: 0.818 ± 0.944
2.455ArgTyr: 2.455 ± 1.448
0.0ArgXaa: 0.0 ± 0.0
Ser
4.092SerAla: 4.092 ± 2.24
0.818SerCys: 0.818 ± 0.944
2.455SerAsp: 2.455 ± 0.942
1.637SerGlu: 1.637 ± 0.834
1.637SerPhe: 1.637 ± 0.928
4.91SerGly: 4.91 ± 1.659
0.818SerHis: 0.818 ± 0.647
4.092SerIle: 4.092 ± 1.765
6.547SerLys: 6.547 ± 2.418
3.273SerLeu: 3.273 ± 1.683
3.273SerMet: 3.273 ± 1.788
6.547SerAsn: 6.547 ± 2.572
9.002SerPro: 9.002 ± 1.994
2.455SerGln: 2.455 ± 1.272
5.728SerArg: 5.728 ± 1.768
5.728SerSer: 5.728 ± 2.237
4.092SerThr: 4.092 ± 1.348
4.91SerVal: 4.91 ± 3.326
0.0SerTrp: 0.0 ± 0.0
3.273SerTyr: 3.273 ± 1.702
0.0SerXaa: 0.0 ± 0.0
Thr
4.91ThrAla: 4.91 ± 1.052
0.818ThrCys: 0.818 ± 0.774
2.455ThrAsp: 2.455 ± 1.269
3.273ThrGlu: 3.273 ± 1.609
4.092ThrPhe: 4.092 ± 2.239
4.91ThrGly: 4.91 ± 2.053
3.273ThrHis: 3.273 ± 2.009
2.455ThrIle: 2.455 ± 1.097
1.637ThrLys: 1.637 ± 1.241
2.455ThrLeu: 2.455 ± 0.899
0.818ThrMet: 0.818 ± 0.621
4.092ThrAsn: 4.092 ± 1.246
1.637ThrPro: 1.637 ± 0.953
4.092ThrGln: 4.092 ± 1.822
4.092ThrArg: 4.092 ± 1.357
4.91ThrSer: 4.91 ± 1.493
3.273ThrThr: 3.273 ± 1.619
3.273ThrVal: 3.273 ± 1.604
2.455ThrTrp: 2.455 ± 1.269
3.273ThrTyr: 3.273 ± 1.181
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.818ValCys: 0.818 ± 0.621
4.092ValAsp: 4.092 ± 2.392
1.637ValGlu: 1.637 ± 1.134
4.092ValPhe: 4.092 ± 1.395
3.273ValGly: 3.273 ± 1.47
2.455ValHis: 2.455 ± 1.345
4.91ValIle: 4.91 ± 1.944
3.273ValLys: 3.273 ± 1.262
6.547ValLeu: 6.547 ± 1.378
1.637ValMet: 1.637 ± 0.959
1.637ValAsn: 1.637 ± 1.294
4.092ValPro: 4.092 ± 1.184
2.455ValGln: 2.455 ± 0.942
4.092ValArg: 4.092 ± 1.657
4.092ValSer: 4.092 ± 1.509
5.728ValThr: 5.728 ± 2.202
3.273ValVal: 3.273 ± 1.286
1.637ValTrp: 1.637 ± 1.146
9.002ValTyr: 9.002 ± 2.886
0.0ValXaa: 0.0 ± 0.0
Trp
1.637TrpAla: 1.637 ± 1.241
0.0TrpCys: 0.0 ± 0.0
0.818TrpAsp: 0.818 ± 0.774
0.818TrpGlu: 0.818 ± 0.819
0.818TrpPhe: 0.818 ± 0.994
1.637TrpGly: 1.637 ± 0.928
1.637TrpHis: 1.637 ± 1.109
0.0TrpIle: 0.0 ± 0.0
0.818TrpLys: 0.818 ± 0.994
0.818TrpLeu: 0.818 ± 0.944
0.0TrpMet: 0.0 ± 0.0
0.818TrpAsn: 0.818 ± 0.994
0.0TrpPro: 0.0 ± 0.0
0.818TrpGln: 0.818 ± 0.621
0.818TrpArg: 0.818 ± 0.774
0.0TrpSer: 0.0 ± 0.0
3.273TrpThr: 3.273 ± 1.753
0.818TrpVal: 0.818 ± 0.621
0.0TrpTrp: 0.0 ± 0.0
0.818TrpTyr: 0.818 ± 0.621
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.273TyrAla: 3.273 ± 1.262
0.0TyrCys: 0.0 ± 0.0
2.455TyrAsp: 2.455 ± 1.248
2.455TyrGlu: 2.455 ± 1.67
4.092TyrPhe: 4.092 ± 1.008
0.818TyrGly: 0.818 ± 0.621
1.637TyrHis: 1.637 ± 1.193
1.637TyrIle: 1.637 ± 1.146
0.818TyrLys: 0.818 ± 0.621
4.91TyrLeu: 4.91 ± 1.481
2.455TyrMet: 2.455 ± 0.799
1.637TyrAsn: 1.637 ± 0.643
0.818TyrPro: 0.818 ± 0.944
0.818TyrGln: 0.818 ± 0.647
4.092TyrArg: 4.092 ± 2.618
3.273TyrSer: 3.273 ± 1.148
0.818TyrThr: 0.818 ± 0.819
3.273TyrVal: 3.273 ± 1.726
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski