Amino acid dipepetide frequency for archaeon HR02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.061AlaAla: 8.061 ± 0.16	0.868AlaCys: 0.868 ± 0.042	2.897AlaAsp: 2.897 ± 0.076	5.938AlaGlu: 5.938 ± 0.109	2.674AlaPhe: 2.674 ± 0.076	6.57AlaGly: 6.57 ± 0.12	1.249AlaHis: 1.249 ± 0.044	5.332AlaIle: 5.332 ± 0.102	3.724AlaLys: 3.724 ± 0.089	9.486AlaLeu: 9.486 ± 0.154	1.861AlaMet: 1.861 ± 0.064	1.593AlaAsn: 1.593 ± 0.061	2.972AlaPro: 2.972 ± 0.069	1.952AlaGln: 1.952 ± 0.067	5.784AlaArg: 5.784 ± 0.117	5.573AlaSer: 5.573 ± 0.105	3.698AlaThr: 3.698 ± 0.093	6.996AlaVal: 6.996 ± 0.125	0.971AlaTrp: 0.971 ± 0.043	2.721AlaTyr: 2.721 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.458CysAla: 0.458 ± 0.031	0.12CysCys: 0.12 ± 0.016	0.42CysAsp: 0.42 ± 0.031	0.572CysGlu: 0.572 ± 0.035	0.341CysPhe: 0.341 ± 0.025	1.225CysGly: 1.225 ± 0.051	0.182CysHis: 0.182 ± 0.022	0.639CysIle: 0.639 ± 0.041	0.359CysLys: 0.359 ± 0.027	0.914CysLeu: 0.914 ± 0.045	0.237CysMet: 0.237 ± 0.022	0.227CysAsn: 0.227 ± 0.023	0.63CysPro: 0.63 ± 0.04	0.182CysGln: 0.182 ± 0.018	0.813CysArg: 0.813 ± 0.038	0.616CysSer: 0.616 ± 0.037	0.385CysThr: 0.385 ± 0.03	0.708CysVal: 0.708 ± 0.043	0.124CysTrp: 0.124 ± 0.015	0.29CysTyr: 0.29 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.625AspAla: 3.625 ± 0.081	0.391AspCys: 0.391 ± 0.024	1.733AspAsp: 1.733 ± 0.062	3.416AspGlu: 3.416 ± 0.098	1.636AspPhe: 1.636 ± 0.063	3.556AspGly: 3.556 ± 0.08	0.665AspHis: 0.665 ± 0.04	3.298AspIle: 3.298 ± 0.084	1.904AspLys: 1.904 ± 0.069	4.493AspLeu: 4.493 ± 0.095	1.014AspMet: 1.014 ± 0.046	1.026AspAsn: 1.026 ± 0.049	2.676AspPro: 2.676 ± 0.075	0.75AspGln: 0.75 ± 0.037	2.859AspArg: 2.859 ± 0.075	2.502AspSer: 2.502 ± 0.081	1.835AspThr: 1.835 ± 0.064	4.04AspVal: 4.04 ± 0.096	0.614AspTrp: 0.614 ± 0.035	1.782AspTyr: 1.782 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	7.205GluAla: 7.205 ± 0.1	0.466GluCys: 0.466 ± 0.026	3.138GluAsp: 3.138 ± 0.07	6.439GluGlu: 6.439 ± 0.162	2.384GluPhe: 2.384 ± 0.059	4.999GluGly: 4.999 ± 0.103	1.022GluHis: 1.022 ± 0.05	4.784GluIle: 4.784 ± 0.1	4.549GluLys: 4.549 ± 0.122	7.864GluLeu: 7.864 ± 0.154	1.743GluMet: 1.743 ± 0.075	1.928GluAsn: 1.928 ± 0.068	2.648GluPro: 2.648 ± 0.075	1.464GluGln: 1.464 ± 0.053	5.76GluArg: 5.76 ± 0.113	3.552GluSer: 3.552 ± 0.085	3.077GluThr: 3.077 ± 0.08	6.491GluVal: 6.491 ± 0.117	0.819GluTrp: 0.819 ± 0.045	2.232GluTyr: 2.232 ± 0.076	0.0GluXaa: 0.0 ± 0.0
Phe	2.481PheAla: 2.481 ± 0.069	0.373PheCys: 0.373 ± 0.03	1.681PheAsp: 1.681 ± 0.059	2.165PheGlu: 2.165 ± 0.063	1.541PhePhe: 1.541 ± 0.057	2.66PheGly: 2.66 ± 0.078	0.626PheHis: 0.626 ± 0.035	2.534PheIle: 2.534 ± 0.083	1.837PheLys: 1.837 ± 0.066	3.751PheLeu: 3.751 ± 0.094	0.803PheMet: 0.803 ± 0.045	1.186PheAsn: 1.186 ± 0.056	1.498PhePro: 1.498 ± 0.061	0.856PheGln: 0.856 ± 0.043	2.619PheArg: 2.619 ± 0.076	2.678PheSer: 2.678 ± 0.078	2.194PheThr: 2.194 ± 0.076	2.412PheVal: 2.412 ± 0.076	0.505PheTrp: 0.505 ± 0.031	1.385PheTyr: 1.385 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	5.922GlyAla: 5.922 ± 0.119	0.914GlyCys: 0.914 ± 0.044	3.603GlyAsp: 3.603 ± 0.086	6.039GlyGlu: 6.039 ± 0.108	3.262GlyPhe: 3.262 ± 0.086	6.684GlyGly: 6.684 ± 0.158	1.316GlyHis: 1.316 ± 0.059	5.178GlyIle: 5.178 ± 0.102	3.596GlyLys: 3.596 ± 0.084	8.831GlyLeu: 8.831 ± 0.164	2.06GlyMet: 2.06 ± 0.064	1.593GlyAsn: 1.593 ± 0.055	2.83GlyPro: 2.83 ± 0.08	1.585GlyGln: 1.585 ± 0.049	5.93GlyArg: 5.93 ± 0.12	4.649GlySer: 4.649 ± 0.103	2.966GlyThr: 2.966 ± 0.087	8.091GlyVal: 8.091 ± 0.133	1.231GlyTrp: 1.231 ± 0.046	3.12GlyTyr: 3.12 ± 0.082	0.0GlyXaa: 0.0 ± 0.0
His	1.231HisAla: 1.231 ± 0.052	0.211HisCys: 0.211 ± 0.021	0.63HisAsp: 0.63 ± 0.035	0.991HisGlu: 0.991 ± 0.037	0.63HisPhe: 0.63 ± 0.034	1.46HisGly: 1.46 ± 0.053	0.43HisHis: 0.43 ± 0.029	1.287HisIle: 1.287 ± 0.052	0.56HisLys: 0.56 ± 0.032	1.938HisLeu: 1.938 ± 0.064	0.395HisMet: 0.395 ± 0.026	0.448HisAsn: 0.448 ± 0.031	1.139HisPro: 1.139 ± 0.045	0.377HisGln: 0.377 ± 0.025	1.22HisArg: 1.22 ± 0.052	1.034HisSer: 1.034 ± 0.04	0.813HisThr: 0.813 ± 0.041	1.531HisVal: 1.531 ± 0.053	0.203HisTrp: 0.203 ± 0.02	0.691HisTyr: 0.691 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.743IleAla: 5.743 ± 0.102	0.653IleCys: 0.653 ± 0.036	3.603IleAsp: 3.603 ± 0.081	4.811IleGlu: 4.811 ± 0.1	2.575IlePhe: 2.575 ± 0.079	5.387IleGly: 5.387 ± 0.112	1.362IleHis: 1.362 ± 0.053	4.588IleIle: 4.588 ± 0.107	2.794IleLys: 2.794 ± 0.081	7.576IleLeu: 7.576 ± 0.144	1.31IleMet: 1.31 ± 0.05	1.954IleAsn: 1.954 ± 0.063	3.592IlePro: 3.592 ± 0.08	1.525IleGln: 1.525 ± 0.05	4.304IleArg: 4.304 ± 0.097	4.503IleSer: 4.503 ± 0.102	3.232IleThr: 3.232 ± 0.084	6.031IleVal: 6.031 ± 0.105	0.669IleTrp: 0.669 ± 0.035	2.453IleTyr: 2.453 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	3.659LysAla: 3.659 ± 0.087	0.489LysCys: 0.489 ± 0.04	1.875LysAsp: 1.875 ± 0.061	3.177LysGlu: 3.177 ± 0.096	1.257LysPhe: 1.257 ± 0.058	3.371LysGly: 3.371 ± 0.079	0.805LysHis: 0.805 ± 0.039	3.777LysIle: 3.777 ± 0.088	2.642LysLys: 2.642 ± 0.089	4.693LysLeu: 4.693 ± 0.102	1.277LysMet: 1.277 ± 0.053	1.342LysAsn: 1.342 ± 0.055	2.41LysPro: 2.41 ± 0.075	0.955LysGln: 0.955 ± 0.039	3.659LysArg: 3.659 ± 0.074	2.881LysSer: 2.881 ± 0.085	2.585LysThr: 2.585 ± 0.068	3.7LysVal: 3.7 ± 0.088	0.568LysTrp: 0.568 ± 0.035	1.725LysTyr: 1.725 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	9.761LeuAla: 9.761 ± 0.171	0.868LeuCys: 0.868 ± 0.037	5.042LeuAsp: 5.042 ± 0.11	7.967LeuGlu: 7.967 ± 0.162	3.568LeuPhe: 3.568 ± 0.103	8.835LeuGly: 8.835 ± 0.158	1.652LeuHis: 1.652 ± 0.063	6.759LeuIle: 6.759 ± 0.123	5.599LeuLys: 5.599 ± 0.101	11.454LeuLeu: 11.454 ± 0.186	2.494LeuMet: 2.494 ± 0.073	3.069LeuAsn: 3.069 ± 0.081	4.49LeuPro: 4.49 ± 0.103	2.524LeuGln: 2.524 ± 0.073	8.35LeuArg: 8.35 ± 0.138	8.253LeuSer: 8.253 ± 0.143	5.498LeuThr: 5.498 ± 0.117	8.359LeuVal: 8.359 ± 0.131	1.119LeuTrp: 1.119 ± 0.047	3.511LeuTyr: 3.511 ± 0.103	0.0LeuXaa: 0.0 ± 0.0
Met	2.031MetAla: 2.031 ± 0.072	0.176MetCys: 0.176 ± 0.018	1.072MetAsp: 1.072 ± 0.042	1.433MetGlu: 1.433 ± 0.056	0.626MetPhe: 0.626 ± 0.039	2.044MetGly: 2.044 ± 0.067	0.42MetHis: 0.42 ± 0.029	1.545MetIle: 1.545 ± 0.056	1.113MetLys: 1.113 ± 0.044	2.603MetLeu: 2.603 ± 0.079	0.669MetMet: 0.669 ± 0.037	0.633MetAsn: 0.633 ± 0.036	1.097MetPro: 1.097 ± 0.046	0.444MetGln: 0.444 ± 0.028	1.993MetArg: 1.993 ± 0.068	1.66MetSer: 1.66 ± 0.06	1.154MetThr: 1.154 ± 0.045	1.993MetVal: 1.993 ± 0.064	0.272MetTrp: 0.272 ± 0.025	0.594MetTyr: 0.594 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	1.758AsnAla: 1.758 ± 0.061	0.266AsnCys: 0.266 ± 0.028	0.929AsnAsp: 0.929 ± 0.04	1.34AsnGlu: 1.34 ± 0.048	0.999AsnPhe: 0.999 ± 0.046	1.699AsnGly: 1.699 ± 0.058	0.478AsnHis: 0.478 ± 0.03	2.192AsnIle: 2.192 ± 0.067	1.052AsnLys: 1.052 ± 0.049	2.808AsnLeu: 2.808 ± 0.06	0.663AsnMet: 0.663 ± 0.039	0.835AsnAsn: 0.835 ± 0.046	1.938AsnPro: 1.938 ± 0.065	0.574AsnGln: 0.574 ± 0.034	1.772AsnArg: 1.772 ± 0.061	1.52AsnSer: 1.52 ± 0.059	1.397AsnThr: 1.397 ± 0.05	2.151AsnVal: 2.151 ± 0.071	0.377AsnTrp: 0.377 ± 0.031	1.006AsnTyr: 1.006 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.26ProAla: 3.26 ± 0.089	0.363ProCys: 0.363 ± 0.026	2.208ProAsp: 2.208 ± 0.065	3.596ProGlu: 3.596 ± 0.076	1.772ProPhe: 1.772 ± 0.058	3.452ProGly: 3.452 ± 0.091	1.04ProHis: 1.04 ± 0.048	3.009ProIle: 3.009 ± 0.086	1.762ProLys: 1.762 ± 0.06	4.949ProLeu: 4.949 ± 0.103	0.9ProMet: 0.9 ± 0.04	1.208ProAsn: 1.208 ± 0.046	2.893ProPro: 2.893 ± 0.078	1.273ProGln: 1.273 ± 0.055	3.229ProArg: 3.229 ± 0.091	3.28ProSer: 3.28 ± 0.078	2.402ProThr: 2.402 ± 0.073	3.532ProVal: 3.532 ± 0.078	0.669ProTrp: 0.669 ± 0.038	1.823ProTyr: 1.823 ± 0.059	0.0ProXaa: 0.0 ± 0.0
Gln	1.853GlnAla: 1.853 ± 0.064	0.13GlnCys: 0.13 ± 0.015	0.819GlnAsp: 0.819 ± 0.043	1.482GlnGlu: 1.482 ± 0.055	0.683GlnPhe: 0.683 ± 0.036	1.539GlnGly: 1.539 ± 0.061	0.482GlnHis: 0.482 ± 0.031	1.581GlnIle: 1.581 ± 0.052	0.991GlnLys: 0.991 ± 0.048	2.611GlnLeu: 2.611 ± 0.072	0.539GlnMet: 0.539 ± 0.031	0.576GlnAsn: 0.576 ± 0.033	1.076GlnPro: 1.076 ± 0.053	0.724GlnGln: 0.724 ± 0.043	1.772GlnArg: 1.772 ± 0.056	1.299GlnSer: 1.299 ± 0.056	1.083GlnThr: 1.083 ± 0.05	1.896GlnVal: 1.896 ± 0.065	0.245GlnTrp: 0.245 ± 0.023	0.722GlnTyr: 0.722 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.176ArgAla: 5.176 ± 0.105	0.87ArgCys: 0.87 ± 0.045	3.377ArgAsp: 3.377 ± 0.08	6.22ArgGlu: 6.22 ± 0.134	2.658ArgPhe: 2.658 ± 0.067	6.236ArgGly: 6.236 ± 0.121	1.297ArgHis: 1.297 ± 0.052	5.208ArgIle: 5.208 ± 0.113	3.14ArgLys: 3.14 ± 0.09	8.953ArgLeu: 8.953 ± 0.143	1.867ArgMet: 1.867 ± 0.054	1.788ArgAsn: 1.788 ± 0.06	3.229ArgPro: 3.229 ± 0.093	1.579ArgGln: 1.579 ± 0.055	6.696ArgArg: 6.696 ± 0.131	3.83ArgSer: 3.83 ± 0.086	2.496ArgThr: 2.496 ± 0.073	6.514ArgVal: 6.514 ± 0.133	0.902ArgTrp: 0.902 ± 0.044	2.644ArgTyr: 2.644 ± 0.081	0.0ArgXaa: 0.0 ± 0.0
Ser	4.314SerAla: 4.314 ± 0.091	0.57SerCys: 0.57 ± 0.033	2.781SerAsp: 2.781 ± 0.081	4.286SerGlu: 4.286 ± 0.102	2.339SerPhe: 2.339 ± 0.068	5.403SerGly: 5.403 ± 0.114	1.162SerHis: 1.162 ± 0.047	4.88SerIle: 4.88 ± 0.116	2.919SerLys: 2.919 ± 0.084	7.373SerLeu: 7.373 ± 0.145	1.602SerMet: 1.602 ± 0.054	1.555SerAsn: 1.555 ± 0.047	3.292SerPro: 3.292 ± 0.077	1.654SerGln: 1.654 ± 0.06	5.085SerArg: 5.085 ± 0.106	4.387SerSer: 4.387 ± 0.119	2.948SerThr: 2.948 ± 0.093	4.523SerVal: 4.523 ± 0.1	0.995SerTrp: 0.995 ± 0.049	2.254SerTyr: 2.254 ± 0.083	0.0SerXaa: 0.0 ± 0.0
Thr	3.706ThrAla: 3.706 ± 0.094	0.442ThrCys: 0.442 ± 0.032	1.827ThrAsp: 1.827 ± 0.06	2.352ThrGlu: 2.352 ± 0.069	1.658ThrPhe: 1.658 ± 0.065	4.046ThrGly: 4.046 ± 0.101	0.997ThrHis: 0.997 ± 0.042	3.53ThrIle: 3.53 ± 0.086	1.622ThrLys: 1.622 ± 0.068	5.401ThrLeu: 5.401 ± 0.106	1.07ThrMet: 1.07 ± 0.051	1.056ThrAsn: 1.056 ± 0.044	2.836ThrPro: 2.836 ± 0.083	1.07ThrGln: 1.07 ± 0.047	2.852ThrArg: 2.852 ± 0.075	3.081ThrSer: 3.081 ± 0.071	2.534ThrThr: 2.534 ± 0.119	4.026ThrVal: 4.026 ± 0.1	0.553ThrTrp: 0.553 ± 0.036	1.711ThrTyr: 1.711 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	7.209ValAla: 7.209 ± 0.122	0.734ValCys: 0.734 ± 0.039	4.128ValAsp: 4.128 ± 0.092	7.418ValGlu: 7.418 ± 0.138	3.307ValPhe: 3.307 ± 0.081	6.471ValGly: 6.471 ± 0.123	1.188ValHis: 1.188 ± 0.051	5.149ValIle: 5.149 ± 0.106	4.961ValLys: 4.961 ± 0.099	8.073ValLeu: 8.073 ± 0.139	1.863ValMet: 1.863 ± 0.062	2.356ValAsn: 2.356 ± 0.059	2.996ValPro: 2.996 ± 0.084	1.553ValGln: 1.553 ± 0.059	5.964ValArg: 5.964 ± 0.11	5.683ValSer: 5.683 ± 0.114	3.714ValThr: 3.714 ± 0.099	7.846ValVal: 7.846 ± 0.176	1.06ValTrp: 1.06 ± 0.045	3.041ValTyr: 3.041 ± 0.079	0.0ValXaa: 0.0 ± 0.0
Trp	0.811TrpAla: 0.811 ± 0.043	0.138TrpCys: 0.138 ± 0.015	0.48TrpAsp: 0.48 ± 0.031	0.776TrpGlu: 0.776 ± 0.04	0.485TrpPhe: 0.485 ± 0.032	1.093TrpGly: 1.093 ± 0.044	0.221TrpHis: 0.221 ± 0.02	0.937TrpIle: 0.937 ± 0.037	0.456TrpLys: 0.456 ± 0.032	1.512TrpLeu: 1.512 ± 0.059	0.379TrpMet: 0.379 ± 0.028	0.353TrpAsn: 0.353 ± 0.03	0.511TrpPro: 0.511 ± 0.03	0.29TrpGln: 0.29 ± 0.024	1.247TrpArg: 1.247 ± 0.054	0.819TrpSer: 0.819 ± 0.04	0.535TrpThr: 0.535 ± 0.038	1.03TrpVal: 1.03 ± 0.055	0.262TrpTrp: 0.262 ± 0.026	0.369TrpTyr: 0.369 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.656TyrAla: 2.656 ± 0.065	0.399TyrCys: 0.399 ± 0.029	1.573TyrAsp: 1.573 ± 0.068	2.145TyrGlu: 2.145 ± 0.079	1.391TyrPhe: 1.391 ± 0.053	2.67TyrGly: 2.67 ± 0.077	0.626TyrHis: 0.626 ± 0.038	2.459TyrIle: 2.459 ± 0.071	1.267TyrLys: 1.267 ± 0.051	3.886TyrLeu: 3.886 ± 0.085	0.825TyrMet: 0.825 ± 0.044	1.03TyrAsn: 1.03 ± 0.038	1.871TyrPro: 1.871 ± 0.063	0.772TyrGln: 0.772 ± 0.035	2.773TyrArg: 2.773 ± 0.074	2.522TyrSer: 2.522 ± 0.064	1.821TyrThr: 1.821 ± 0.069	2.844TyrVal: 2.844 ± 0.082	0.547TyrTrp: 0.547 ± 0.034	1.257TyrTyr: 1.257 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1939 proteins (506736 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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