Amino acid dipepetide frequency for Blueberry mosaic associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.715AlaAla: 1.715 ± 0.738
0.572AlaCys: 0.572 ± 0.405
2.572AlaAsp: 2.572 ± 1.155
5.144AlaGlu: 5.144 ± 1.165
1.715AlaPhe: 1.715 ± 0.209
4.001AlaGly: 4.001 ± 2.087
0.857AlaHis: 0.857 ± 0.526
4.287AlaIle: 4.287 ± 3.048
3.144AlaLys: 3.144 ± 0.977
2.858AlaLeu: 2.858 ± 1.023
2.286AlaMet: 2.286 ± 1.769
1.143AlaAsn: 1.143 ± 0.64
1.143AlaPro: 1.143 ± 0.415
1.715AlaGln: 1.715 ± 2.248
1.429AlaArg: 1.429 ± 0.791
2.572AlaSer: 2.572 ± 1.709
2.286AlaThr: 2.286 ± 1.293
1.429AlaVal: 1.429 ± 2.035
0.857AlaTrp: 0.857 ± 0.381
2.001AlaTyr: 2.001 ± 0.632
0.0AlaXaa: 0.0 ± 0.0
Cys
0.286CysAla: 0.286 ± 0.16
0.0CysCys: 0.0 ± 0.0
0.857CysAsp: 0.857 ± 0.526
0.286CysGlu: 0.286 ± 0.16
0.0CysPhe: 0.0 ± 0.0
0.286CysGly: 0.286 ± 0.16
0.286CysHis: 0.286 ± 0.16
0.857CysIle: 0.857 ± 0.526
1.143CysLys: 1.143 ± 0.415
1.715CysLeu: 1.715 ± 0.73
0.286CysMet: 0.286 ± 0.16
0.857CysAsn: 0.857 ± 1.134
0.0CysPro: 0.0 ± 0.0
0.857CysGln: 0.857 ± 0.398
0.0CysArg: 0.0 ± 0.0
2.001CysSer: 2.001 ± 1.12
0.572CysThr: 0.572 ± 0.32
0.286CysVal: 0.286 ± 0.484
0.0CysTrp: 0.0 ± 0.0
0.286CysTyr: 0.286 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
4.001AspAla: 4.001 ± 2.729
0.572AspCys: 0.572 ± 0.32
4.287AspAsp: 4.287 ± 0.932
4.573AspGlu: 4.573 ± 1.417
1.715AspPhe: 1.715 ± 0.669
3.715AspGly: 3.715 ± 0.703
0.857AspHis: 0.857 ± 0.381
4.859AspIle: 4.859 ± 0.344
5.144AspLys: 5.144 ± 1.333
6.573AspLeu: 6.573 ± 0.843
3.43AspMet: 3.43 ± 0.909
1.715AspAsn: 1.715 ± 0.593
1.715AspPro: 1.715 ± 0.573
1.143AspGln: 1.143 ± 0.397
2.572AspArg: 2.572 ± 1.178
3.144AspSer: 3.144 ± 0.987
2.858AspThr: 2.858 ± 1.581
3.715AspVal: 3.715 ± 0.535
0.0AspTrp: 0.0 ± 0.0
2.858AspTyr: 2.858 ± 1.202
0.0AspXaa: 0.0 ± 0.0
Glu
3.43GluAla: 3.43 ± 2.756
1.429GluCys: 1.429 ± 0.8
5.144GluAsp: 5.144 ± 1.759
12.003GluGlu: 12.003 ± 2.397
2.572GluPhe: 2.572 ± 0.51
2.286GluGly: 2.286 ± 0.359
0.572GluHis: 0.572 ± 0.542
10.003GluIle: 10.003 ± 2.216
11.432GluLys: 11.432 ± 2.384
10.86GluLeu: 10.86 ± 1.348
2.858GluMet: 2.858 ± 1.074
3.43GluAsn: 3.43 ± 1.722
0.857GluPro: 0.857 ± 0.48
2.858GluGln: 2.858 ± 0.496
4.001GluArg: 4.001 ± 1.524
4.287GluSer: 4.287 ± 0.932
3.43GluThr: 3.43 ± 1.486
5.144GluVal: 5.144 ± 1.02
0.286GluTrp: 0.286 ± 0.484
1.429GluTyr: 1.429 ± 0.8
0.0GluXaa: 0.0 ± 0.0
Phe
2.001PheAla: 2.001 ± 1.51
0.286PheCys: 0.286 ± 0.16
2.001PheAsp: 2.001 ± 0.547
3.144PheGlu: 3.144 ± 1.532
2.286PhePhe: 2.286 ± 1.83
2.286PheGly: 2.286 ± 0.732
1.429PheHis: 1.429 ± 0.274
3.715PheIle: 3.715 ± 1.61
4.287PheLys: 4.287 ± 1.375
3.43PheLeu: 3.43 ± 1.024
2.001PheMet: 2.001 ± 0.971
1.715PheAsn: 1.715 ± 0.209
1.715PhePro: 1.715 ± 0.797
1.429PheGln: 1.429 ± 0.511
2.001PheArg: 2.001 ± 0.769
6.002PheSer: 6.002 ± 1.701
2.286PheThr: 2.286 ± 0.904
2.286PheVal: 2.286 ± 1.769
0.0PheTrp: 0.0 ± 0.0
1.715PheTyr: 1.715 ± 0.96
0.0PheXaa: 0.0 ± 0.0
Gly
1.715GlyAla: 1.715 ± 0.738
0.0GlyCys: 0.0 ± 0.0
2.858GlyAsp: 2.858 ± 0.991
2.001GlyGlu: 2.001 ± 1.874
2.001GlyPhe: 2.001 ± 0.72
2.572GlyGly: 2.572 ± 1.155
0.286GlyHis: 0.286 ± 0.16
4.573GlyIle: 4.573 ± 2.272
5.43GlyLys: 5.43 ± 1.324
3.715GlyLeu: 3.715 ± 1.318
1.429GlyMet: 1.429 ± 0.274
3.144GlyAsn: 3.144 ± 1.457
0.572GlyPro: 0.572 ± 0.405
0.857GlyGln: 0.857 ± 0.381
3.43GlyArg: 3.43 ± 2.378
3.43GlySer: 3.43 ± 1.192
2.572GlyThr: 2.572 ± 1.231
3.43GlyVal: 3.43 ± 1.637
0.286GlyTrp: 0.286 ± 0.16
2.572GlyTyr: 2.572 ± 1.439
0.0GlyXaa: 0.0 ± 0.0
His
0.286HisAla: 0.286 ± 0.16
0.0HisCys: 0.0 ± 0.0
1.143HisAsp: 1.143 ± 2.007
0.572HisGlu: 0.572 ± 0.405
0.857HisPhe: 0.857 ± 0.381
0.286HisGly: 0.286 ± 0.602
0.286HisHis: 0.286 ± 0.16
0.857HisIle: 0.857 ± 0.969
2.001HisLys: 2.001 ± 1.12
1.143HisLeu: 1.143 ± 0.397
0.572HisMet: 0.572 ± 0.542
0.857HisAsn: 0.857 ± 0.526
0.857HisPro: 0.857 ± 0.54
0.572HisGln: 0.572 ± 0.32
1.429HisArg: 1.429 ± 0.511
0.0HisSer: 0.0 ± 0.0
0.572HisThr: 0.572 ± 0.32
0.572HisVal: 0.572 ± 0.32
0.0HisTrp: 0.0 ± 0.0
0.572HisTyr: 0.572 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
3.715IleAla: 3.715 ± 1.614
2.286IleCys: 2.286 ± 1.115
5.144IleAsp: 5.144 ± 1.779
10.86IleGlu: 10.86 ± 1.295
4.287IlePhe: 4.287 ± 1.375
3.43IleGly: 3.43 ± 1.192
1.143IleHis: 1.143 ± 0.557
5.716IleIle: 5.716 ± 1.543
6.859IleLys: 6.859 ± 1.505
3.43IleLeu: 3.43 ± 0.66
2.286IleMet: 2.286 ± 0.904
4.287IleAsn: 4.287 ± 0.992
2.858IlePro: 2.858 ± 1.541
2.858IleGln: 2.858 ± 0.496
2.858IleArg: 2.858 ± 1.038
6.573IleSer: 6.573 ± 1.965
3.144IleThr: 3.144 ± 1.331
3.715IleVal: 3.715 ± 0.888
0.572IleTrp: 0.572 ± 0.32
3.144IleTyr: 3.144 ± 1.072
0.0IleXaa: 0.0 ± 0.0
Lys
4.287LysAla: 4.287 ± 1.779
0.286LysCys: 0.286 ± 0.16
8.574LysAsp: 8.574 ± 1.481
8.86LysGlu: 8.86 ± 2.468
6.002LysPhe: 6.002 ± 1.527
4.573LysGly: 4.573 ± 1.875
1.143LysHis: 1.143 ± 0.397
6.288LysIle: 6.288 ± 0.21
6.573LysLys: 6.573 ± 2.146
9.717LysLeu: 9.717 ± 2.566
4.001LysMet: 4.001 ± 0.899
4.573LysAsn: 4.573 ± 1.217
2.858LysPro: 2.858 ± 0.517
1.715LysGln: 1.715 ± 0.797
6.002LysArg: 6.002 ± 1.785
7.145LysSer: 7.145 ± 1.007
4.001LysThr: 4.001 ± 1.131
4.573LysVal: 4.573 ± 1.59
0.286LysTrp: 0.286 ± 0.16
4.287LysTyr: 4.287 ± 1.41
0.0LysXaa: 0.0 ± 0.0
Leu
4.287LeuAla: 4.287 ± 1.458
0.572LeuCys: 0.572 ± 0.32
4.287LeuAsp: 4.287 ± 0.968
6.288LeuGlu: 6.288 ± 2.113
4.001LeuPhe: 4.001 ± 1.372
3.43LeuGly: 3.43 ± 0.828
0.572LeuHis: 0.572 ± 0.32
6.288LeuIle: 6.288 ± 2.218
7.431LeuLys: 7.431 ± 0.697
6.002LeuLeu: 6.002 ± 2.953
4.573LeuMet: 4.573 ± 0.634
6.859LeuAsn: 6.859 ± 1.551
3.43LeuPro: 3.43 ± 0.419
1.715LeuGln: 1.715 ± 0.762
2.858LeuArg: 2.858 ± 0.549
10.86LeuSer: 10.86 ± 2.27
2.572LeuThr: 2.572 ± 0.728
6.002LeuVal: 6.002 ± 0.582
0.857LeuTrp: 0.857 ± 0.526
3.43LeuTyr: 3.43 ± 0.849
0.0LeuXaa: 0.0 ± 0.0
Met
2.001MetAla: 2.001 ± 0.252
0.0MetCys: 0.0 ± 0.0
1.715MetAsp: 1.715 ± 0.209
4.287MetGlu: 4.287 ± 1.282
1.715MetPhe: 1.715 ± 0.573
1.143MetGly: 1.143 ± 0.925
0.572MetHis: 0.572 ± 1.07
2.858MetIle: 2.858 ± 0.882
3.715MetLys: 3.715 ± 0.535
4.001MetLeu: 4.001 ± 0.871
1.715MetMet: 1.715 ± 0.96
2.858MetAsn: 2.858 ± 1.541
0.572MetPro: 0.572 ± 0.405
0.286MetGln: 0.286 ± 0.602
2.286MetArg: 2.286 ± 1.279
4.287MetSer: 4.287 ± 1.07
2.858MetThr: 2.858 ± 1.554
1.429MetVal: 1.429 ± 0.77
0.572MetTrp: 0.572 ± 0.405
1.715MetTyr: 1.715 ± 0.669
0.0MetXaa: 0.0 ± 0.0
Asn
2.858AsnAla: 2.858 ± 0.978
0.857AsnCys: 0.857 ± 0.526
2.858AsnAsp: 2.858 ± 0.761
6.002AsnGlu: 6.002 ± 0.776
3.715AsnPhe: 3.715 ± 0.703
1.715AsnGly: 1.715 ± 0.669
2.001AsnHis: 2.001 ± 1.072
3.43AsnIle: 3.43 ± 1.127
5.144AsnLys: 5.144 ± 0.779
5.43AsnLeu: 5.43 ± 1.581
1.429AsnMet: 1.429 ± 0.277
4.859AsnAsn: 4.859 ± 0.816
1.715AsnPro: 1.715 ± 1.216
0.286AsnGln: 0.286 ± 0.16
1.429AsnArg: 1.429 ± 0.629
4.573AsnSer: 4.573 ± 0.402
2.286AsnThr: 2.286 ± 0.848
2.858AsnVal: 2.858 ± 1.023
0.286AsnTrp: 0.286 ± 0.16
4.287AsnTyr: 4.287 ± 2.399
0.0AsnXaa: 0.0 ± 0.0
Pro
0.857ProAla: 0.857 ± 0.969
0.286ProCys: 0.286 ± 0.16
2.001ProAsp: 2.001 ± 0.787
2.286ProGlu: 2.286 ± 1.279
1.429ProPhe: 1.429 ± 0.77
1.715ProGly: 1.715 ± 0.669
0.0ProHis: 0.0 ± 0.0
1.143ProIle: 1.143 ± 0.421
2.286ProLys: 2.286 ± 0.551
3.144ProLeu: 3.144 ± 0.901
0.572ProMet: 0.572 ± 0.444
2.286ProAsn: 2.286 ± 0.848
0.857ProPro: 0.857 ± 0.398
1.143ProGln: 1.143 ± 0.415
1.143ProArg: 1.143 ± 0.64
2.286ProSer: 2.286 ± 1.146
1.715ProThr: 1.715 ± 0.593
1.715ProVal: 1.715 ± 1.458
0.0ProTrp: 0.0 ± 0.0
0.286ProTyr: 0.286 ± 0.16
0.0ProXaa: 0.0 ± 0.0
Gln
0.857GlnAla: 0.857 ± 0.969
0.286GlnCys: 0.286 ± 0.16
0.857GlnAsp: 0.857 ± 0.398
2.858GlnGlu: 2.858 ± 0.496
0.572GlnPhe: 0.572 ± 0.444
1.143GlnGly: 1.143 ± 0.397
0.286GlnHis: 0.286 ± 0.16
0.857GlnIle: 0.857 ± 0.398
2.286GlnLys: 2.286 ± 1.85
1.715GlnLeu: 1.715 ± 0.797
0.572GlnMet: 0.572 ± 0.32
1.429GlnAsn: 1.429 ± 0.486
0.857GlnPro: 0.857 ± 0.48
0.0GlnGln: 0.0 ± 0.0
1.715GlnArg: 1.715 ± 0.669
2.286GlnSer: 2.286 ± 0.626
0.857GlnThr: 0.857 ± 0.48
1.715GlnVal: 1.715 ± 0.835
0.286GlnTrp: 0.286 ± 0.16
1.715GlnTyr: 1.715 ± 0.96
0.0GlnXaa: 0.0 ± 0.0
Arg
2.858ArgAla: 2.858 ± 1.023
1.143ArgCys: 1.143 ± 0.703
2.572ArgAsp: 2.572 ± 0.731
1.715ArgGlu: 1.715 ± 0.629
2.286ArgPhe: 2.286 ± 0.904
2.001ArgGly: 2.001 ± 1.171
0.572ArgHis: 0.572 ± 0.405
2.858ArgIle: 2.858 ± 1.021
5.716ArgLys: 5.716 ± 2.42
3.144ArgLeu: 3.144 ± 0.809
2.858ArgMet: 2.858 ± 0.655
2.858ArgAsn: 2.858 ± 0.761
0.857ArgPro: 0.857 ± 0.398
0.286ArgGln: 0.286 ± 0.484
2.286ArgArg: 2.286 ± 0.367
3.43ArgSer: 3.43 ± 1.018
3.144ArgThr: 3.144 ± 0.461
2.572ArgVal: 2.572 ± 0.922
0.0ArgTrp: 0.0 ± 0.0
2.858ArgTyr: 2.858 ± 0.882
0.0ArgXaa: 0.0 ± 0.0
Ser
2.572SerAla: 2.572 ± 1.991
1.429SerCys: 1.429 ± 0.486
4.859SerAsp: 4.859 ± 1.365
6.288SerGlu: 6.288 ± 1.974
4.287SerPhe: 4.287 ± 0.913
3.715SerGly: 3.715 ± 1.318
0.857SerHis: 0.857 ± 0.48
6.859SerIle: 6.859 ± 1.978
6.573SerLys: 6.573 ± 0.655
7.431SerLeu: 7.431 ± 1.849
3.144SerMet: 3.144 ± 0.876
4.287SerAsn: 4.287 ± 1.021
2.572SerPro: 2.572 ± 0.51
1.715SerGln: 1.715 ± 0.593
3.43SerArg: 3.43 ± 1.509
9.717SerSer: 9.717 ± 2.068
4.573SerThr: 4.573 ± 0.733
7.145SerVal: 7.145 ± 1.086
0.572SerTrp: 0.572 ± 0.32
3.144SerTyr: 3.144 ± 1.583
0.0SerXaa: 0.0 ± 0.0
Thr
1.715ThrAla: 1.715 ± 1.25
0.286ThrCys: 0.286 ± 0.16
2.286ThrAsp: 2.286 ± 1.221
3.144ThrGlu: 3.144 ± 0.954
2.858ThrPhe: 2.858 ± 1.021
4.001ThrGly: 4.001 ± 1.259
0.0ThrHis: 0.0 ± 0.0
4.287ThrIle: 4.287 ± 1.352
4.573ThrLys: 4.573 ± 0.927
4.287ThrLeu: 4.287 ± 0.723
2.858ThrMet: 2.858 ± 1.163
2.572ThrAsn: 2.572 ± 0.506
0.857ThrPro: 0.857 ± 0.48
1.429ThrGln: 1.429 ± 0.8
2.286ThrArg: 2.286 ± 1.789
4.859ThrSer: 4.859 ± 1.452
3.144ThrThr: 3.144 ± 1.207
1.429ThrVal: 1.429 ± 0.274
0.286ThrTrp: 0.286 ± 0.535
0.857ThrTyr: 0.857 ± 0.48
0.0ThrXaa: 0.0 ± 0.0
Val
2.572ValAla: 2.572 ± 1.231
0.286ValCys: 0.286 ± 0.602
4.859ValAsp: 4.859 ± 1.429
4.001ValGlu: 4.001 ± 2.146
1.715ValPhe: 1.715 ± 0.797
1.429ValGly: 1.429 ± 2.035
0.857ValHis: 0.857 ± 0.666
5.716ValIle: 5.716 ± 1.066
7.716ValLys: 7.716 ± 1.215
3.43ValLeu: 3.43 ± 0.964
1.715ValMet: 1.715 ± 0.534
4.287ValAsn: 4.287 ± 1.809
2.001ValPro: 2.001 ± 0.844
0.857ValGln: 0.857 ± 0.879
2.001ValArg: 2.001 ± 0.566
3.43ValSer: 3.43 ± 0.672
3.144ValThr: 3.144 ± 0.839
3.715ValVal: 3.715 ± 1.06
0.0ValTrp: 0.0 ± 0.0
2.286ValTyr: 2.286 ± 0.367
0.0ValXaa: 0.0 ± 0.0
Trp
0.286TrpAla: 0.286 ± 0.16
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.857TrpGly: 0.857 ± 0.48
0.286TrpHis: 0.286 ± 0.535
0.572TrpIle: 0.572 ± 0.32
0.286TrpLys: 0.286 ± 0.16
0.857TrpLeu: 0.857 ± 0.879
0.286TrpMet: 0.286 ± 0.602
0.286TrpAsn: 0.286 ± 0.16
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.572TrpArg: 0.572 ± 0.405
0.286TrpSer: 0.286 ± 0.16
0.572TrpThr: 0.572 ± 0.32
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.286TrpTyr: 0.286 ± 0.16
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.429TyrAla: 1.429 ± 0.643
0.286TyrCys: 0.286 ± 0.16
0.572TyrAsp: 0.572 ± 0.32
4.001TyrGlu: 4.001 ± 1.169
2.001TyrPhe: 2.001 ± 0.849
2.286TyrGly: 2.286 ± 0.367
0.572TyrHis: 0.572 ± 0.32
3.144TyrIle: 3.144 ± 0.367
4.001TyrLys: 4.001 ± 0.871
3.43TyrLeu: 3.43 ± 1.509
1.429TyrMet: 1.429 ± 0.511
3.715TyrAsn: 3.715 ± 1.575
0.857TyrPro: 0.857 ± 0.398
1.429TyrGln: 1.429 ± 0.486
2.286TyrArg: 2.286 ± 1.279
4.001TyrSer: 4.001 ± 2.239
1.429TyrThr: 1.429 ± 0.643
2.572TyrVal: 2.572 ± 1.051
0.286TyrTrp: 0.286 ± 0.16
0.857TyrTyr: 0.857 ± 0.48
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3500 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski