Amino acid dipepetide frequency for Hamiltosporidium magnivora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.039AlaAla: 1.039 ± 0.076
0.534AlaCys: 0.534 ± 0.017
1.229AlaAsp: 1.229 ± 0.034
1.626AlaGlu: 1.626 ± 0.039
1.559AlaPhe: 1.559 ± 0.033
0.93AlaGly: 0.93 ± 0.041
0.429AlaHis: 0.429 ± 0.018
2.436AlaIle: 2.436 ± 0.047
2.134AlaLys: 2.134 ± 0.041
2.637AlaLeu: 2.637 ± 0.049
0.539AlaMet: 0.539 ± 0.019
1.64AlaAsn: 1.64 ± 0.04
0.618AlaPro: 0.618 ± 0.021
0.668AlaGln: 0.668 ± 0.023
0.967AlaArg: 0.967 ± 0.032
1.871AlaSer: 1.871 ± 0.042
1.286AlaThr: 1.286 ± 0.027
1.364AlaVal: 1.364 ± 0.034
0.137AlaTrp: 0.137 ± 0.01
1.102AlaTyr: 1.102 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.47CysAla: 0.47 ± 0.019
0.505CysCys: 0.505 ± 0.019
1.101CysAsp: 1.101 ± 0.03
1.189CysGlu: 1.189 ± 0.025
1.417CysPhe: 1.417 ± 0.033
0.926CysGly: 0.926 ± 0.027
0.308CysHis: 0.308 ± 0.014
1.843CysIle: 1.843 ± 0.032
1.906CysLys: 1.906 ± 0.041
2.031CysLeu: 2.031 ± 0.039
0.404CysMet: 0.404 ± 0.018
1.418CysAsn: 1.418 ± 0.03
0.427CysPro: 0.427 ± 0.03
0.435CysGln: 0.435 ± 0.016
0.671CysArg: 0.671 ± 0.025
1.502CysSer: 1.502 ± 0.031
0.871CysThr: 0.871 ± 0.024
1.1CysVal: 1.1 ± 0.028
0.094CysTrp: 0.094 ± 0.008
0.976CysTyr: 0.976 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
1.219AspAla: 1.219 ± 0.032
0.998AspCys: 0.998 ± 0.028
2.344AspAsp: 2.344 ± 0.044
3.607AspGlu: 3.607 ± 0.067
4.002AspPhe: 4.002 ± 0.054
1.82AspGly: 1.82 ± 0.037
0.591AspHis: 0.591 ± 0.021
6.17AspIle: 6.17 ± 0.068
4.714AspLys: 4.714 ± 0.071
5.455AspLeu: 5.455 ± 0.068
1.043AspMet: 1.043 ± 0.028
3.781AspAsn: 3.781 ± 0.063
1.068AspPro: 1.068 ± 0.028
1.034AspGln: 1.034 ± 0.028
1.793AspArg: 1.793 ± 0.043
4.727AspSer: 4.727 ± 0.073
2.795AspThr: 2.795 ± 0.05
2.454AspVal: 2.454 ± 0.046
0.289AspTrp: 0.289 ± 0.014
2.167AspTyr: 2.167 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
1.846GluAla: 1.846 ± 0.034
1.445GluCys: 1.445 ± 0.033
3.708GluAsp: 3.708 ± 0.059
7.118GluGlu: 7.118 ± 0.132
3.937GluPhe: 3.937 ± 0.054
2.683GluGly: 2.683 ± 0.078
0.943GluHis: 0.943 ± 0.023
9.058GluIle: 9.058 ± 0.084
7.879GluLys: 7.879 ± 0.111
5.198GluLeu: 5.198 ± 0.062
1.876GluMet: 1.876 ± 0.035
8.004GluAsn: 8.004 ± 0.106
1.392GluPro: 1.392 ± 0.034
1.534GluGln: 1.534 ± 0.037
2.574GluArg: 2.574 ± 0.048
5.162GluSer: 5.162 ± 0.063
3.532GluThr: 3.532 ± 0.056
3.066GluVal: 3.066 ± 0.044
0.399GluTrp: 0.399 ± 0.014
3.573GluTyr: 3.573 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
1.343PheAla: 1.343 ± 0.031
1.523PheCys: 1.523 ± 0.032
3.605PheAsp: 3.605 ± 0.053
4.414PheGlu: 4.414 ± 0.064
4.209PhePhe: 4.209 ± 0.075
2.133PheGly: 2.133 ± 0.042
1.022PheHis: 1.022 ± 0.027
6.297PheIle: 6.297 ± 0.081
6.059PheLys: 6.059 ± 0.074
7.611PheLeu: 7.611 ± 0.091
1.225PheMet: 1.225 ± 0.031
4.175PheAsn: 4.175 ± 0.064
1.487PhePro: 1.487 ± 0.032
1.471PheGln: 1.471 ± 0.031
1.977PheArg: 1.977 ± 0.037
5.132PheSer: 5.132 ± 0.064
2.81PheThr: 2.81 ± 0.046
2.923PheVal: 2.923 ± 0.05
0.375PheTrp: 0.375 ± 0.017
3.813PheTyr: 3.813 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
1.035GlyAla: 1.035 ± 0.043
0.874GlyCys: 0.874 ± 0.029
1.746GlyAsp: 1.746 ± 0.044
1.914GlyGlu: 1.914 ± 0.038
2.188GlyPhe: 2.188 ± 0.043
2.051GlyGly: 2.051 ± 0.095
0.538GlyHis: 0.538 ± 0.02
3.633GlyIle: 3.633 ± 0.064
3.032GlyLys: 3.032 ± 0.052
3.037GlyLeu: 3.037 ± 0.043
0.788GlyMet: 0.788 ± 0.026
2.66GlyAsn: 2.66 ± 0.047
0.529GlyPro: 0.529 ± 0.019
0.598GlyGln: 0.598 ± 0.036
1.262GlyArg: 1.262 ± 0.044
2.565GlySer: 2.565 ± 0.059
1.593GlyThr: 1.593 ± 0.037
3.111GlyVal: 3.111 ± 0.125
0.244GlyTrp: 0.244 ± 0.016
1.644GlyTyr: 1.644 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
0.417HisAla: 0.417 ± 0.017
0.347HisCys: 0.347 ± 0.016
0.663HisAsp: 0.663 ± 0.019
1.05HisGlu: 1.05 ± 0.024
1.169HisPhe: 1.169 ± 0.032
0.533HisGly: 0.533 ± 0.02
0.33HisHis: 0.33 ± 0.015
1.645HisIle: 1.645 ± 0.033
1.479HisLys: 1.479 ± 0.031
1.828HisLeu: 1.828 ± 0.037
0.319HisMet: 0.319 ± 0.016
1.102HisAsn: 1.102 ± 0.03
0.958HisPro: 0.958 ± 0.044
0.463HisGln: 0.463 ± 0.018
0.593HisArg: 0.593 ± 0.02
1.342HisSer: 1.342 ± 0.029
0.926HisThr: 0.926 ± 0.029
0.712HisVal: 0.712 ± 0.021
0.067HisTrp: 0.067 ± 0.006
0.57HisTyr: 0.57 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
2.241IleAla: 2.241 ± 0.039
2.109IleCys: 2.109 ± 0.038
5.08IleAsp: 5.08 ± 0.057
7.3IleGlu: 7.3 ± 0.074
7.894IlePhe: 7.894 ± 0.094
3.139IleGly: 3.139 ± 0.053
1.694IleHis: 1.694 ± 0.028
8.146IleIle: 8.146 ± 0.088
9.823IleLys: 9.823 ± 0.112
11.092IleLeu: 11.092 ± 0.113
1.633IleMet: 1.633 ± 0.036
7.635IleAsn: 7.635 ± 0.083
2.952IlePro: 2.952 ± 0.048
2.792IleGln: 2.792 ± 0.049
3.321IleArg: 3.321 ± 0.051
9.2IleSer: 9.2 ± 0.095
4.285IleThr: 4.285 ± 0.056
3.941IleVal: 3.941 ± 0.052
0.465IleTrp: 0.465 ± 0.021
4.854IleTyr: 4.854 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
2.417LysAla: 2.417 ± 0.049
1.757LysCys: 1.757 ± 0.033
5.469LysAsp: 5.469 ± 0.083
8.768LysGlu: 8.768 ± 0.122
4.792LysPhe: 4.792 ± 0.071
3.395LysGly: 3.395 ± 0.084
1.516LysHis: 1.516 ± 0.028
11.126LysIle: 11.126 ± 0.106
10.385LysLys: 10.385 ± 0.117
7.275LysLeu: 7.275 ± 0.091
2.245LysMet: 2.245 ± 0.035
10.726LysAsn: 10.726 ± 0.114
2.023LysPro: 2.023 ± 0.039
2.469LysGln: 2.469 ± 0.05
3.884LysArg: 3.884 ± 0.057
6.667LysSer: 6.667 ± 0.085
4.722LysThr: 4.722 ± 0.058
3.905LysVal: 3.905 ± 0.056
0.406LysTrp: 0.406 ± 0.016
5.478LysTyr: 5.478 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
2.419LeuAla: 2.419 ± 0.048
1.851LeuCys: 1.851 ± 0.035
5.007LeuAsp: 5.007 ± 0.068
8.003LeuGlu: 8.003 ± 0.07
5.966LeuPhe: 5.966 ± 0.081
2.859LeuGly: 2.859 ± 0.044
1.84LeuHis: 1.84 ± 0.038
8.092LeuIle: 8.092 ± 0.084
11.498LeuLys: 11.498 ± 0.107
8.625LeuLeu: 8.625 ± 0.091
1.481LeuMet: 1.481 ± 0.031
8.475LeuAsn: 8.475 ± 0.096
2.609LeuPro: 2.609 ± 0.045
2.854LeuGln: 2.854 ± 0.043
3.677LeuArg: 3.677 ± 0.049
7.658LeuSer: 7.658 ± 0.08
4.013LeuThr: 4.013 ± 0.052
3.868LeuVal: 3.868 ± 0.052
0.427LeuTrp: 0.427 ± 0.018
4.598LeuTyr: 4.598 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
0.659MetAla: 0.659 ± 0.025
0.498MetCys: 0.498 ± 0.019
1.011MetAsp: 1.011 ± 0.026
1.366MetGlu: 1.366 ± 0.032
1.128MetPhe: 1.128 ± 0.029
0.822MetGly: 0.822 ± 0.027
0.436MetHis: 0.436 ± 0.016
1.673MetIle: 1.673 ± 0.032
2.126MetLys: 2.126 ± 0.038
1.675MetLeu: 1.675 ± 0.033
0.394MetMet: 0.394 ± 0.018
1.754MetAsn: 1.754 ± 0.038
0.507MetPro: 0.507 ± 0.018
0.524MetGln: 0.524 ± 0.021
0.737MetArg: 0.737 ± 0.021
1.279MetSer: 1.279 ± 0.033
0.854MetThr: 0.854 ± 0.027
1.01MetVal: 1.01 ± 0.026
0.114MetTrp: 0.114 ± 0.008
0.834MetTyr: 0.834 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
1.725AsnAla: 1.725 ± 0.033
1.362AsnCys: 1.362 ± 0.032
4.104AsnAsp: 4.104 ± 0.061
6.511AsnGlu: 6.511 ± 0.086
5.287AsnPhe: 5.287 ± 0.074
2.335AsnGly: 2.335 ± 0.043
1.382AsnHis: 1.382 ± 0.033
10.689AsnIle: 10.689 ± 0.107
7.938AsnLys: 7.938 ± 0.098
8.578AsnLeu: 8.578 ± 0.1
1.666AsnMet: 1.666 ± 0.039
8.772AsnAsn: 8.772 ± 0.187
2.164AsnPro: 2.164 ± 0.054
2.148AsnGln: 2.148 ± 0.044
2.767AsnArg: 2.767 ± 0.042
6.619AsnSer: 6.619 ± 0.096
6.546AsnThr: 6.546 ± 0.139
3.348AsnVal: 3.348 ± 0.047
0.341AsnTrp: 0.341 ± 0.016
3.569AsnTyr: 3.569 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
0.635ProAla: 0.635 ± 0.024
0.43ProCys: 0.43 ± 0.021
1.143ProAsp: 1.143 ± 0.031
1.773ProGlu: 1.773 ± 0.03
1.626ProPhe: 1.626 ± 0.035
0.843ProGly: 0.843 ± 0.024
0.467ProHis: 0.467 ± 0.019
2.12ProIle: 2.12 ± 0.037
2.08ProLys: 2.08 ± 0.041
2.674ProLeu: 2.674 ± 0.058
0.421ProMet: 0.421 ± 0.017
1.955ProAsn: 1.955 ± 0.039
1.169ProPro: 1.169 ± 0.052
0.668ProGln: 0.668 ± 0.028
0.905ProArg: 0.905 ± 0.027
2.242ProSer: 2.242 ± 0.049
1.602ProThr: 1.602 ± 0.039
1.353ProVal: 1.353 ± 0.044
0.106ProTrp: 0.106 ± 0.01
1.146ProTyr: 1.146 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
0.724GlnAla: 0.724 ± 0.027
0.38GlnCys: 0.38 ± 0.017
1.188GlnAsp: 1.188 ± 0.03
1.928GlnGlu: 1.928 ± 0.04
1.089GlnPhe: 1.089 ± 0.028
1.009GlnGly: 1.009 ± 0.049
0.625GlnHis: 0.625 ± 0.031
2.61GlnIle: 2.61 ± 0.044
2.711GlnLys: 2.711 ± 0.047
1.756GlnLeu: 1.756 ± 0.036
0.547GlnMet: 0.547 ± 0.021
2.623GlnAsn: 2.623 ± 0.045
0.811GlnPro: 0.811 ± 0.03
0.977GlnGln: 0.977 ± 0.038
0.995GlnArg: 0.995 ± 0.029
1.707GlnSer: 1.707 ± 0.037
1.284GlnThr: 1.284 ± 0.028
0.872GlnVal: 0.872 ± 0.024
0.1GlnTrp: 0.1 ± 0.006
0.936GlnTyr: 0.936 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
1.02ArgAla: 1.02 ± 0.027
0.736ArgCys: 0.736 ± 0.022
1.995ArgAsp: 1.995 ± 0.056
2.291ArgGlu: 2.291 ± 0.045
2.01ArgPhe: 2.01 ± 0.039
1.467ArgGly: 1.467 ± 0.041
0.523ArgHis: 0.523 ± 0.018
3.838ArgIle: 3.838 ± 0.054
3.832ArgLys: 3.832 ± 0.054
3.066ArgLeu: 3.066 ± 0.056
0.835ArgMet: 0.835 ± 0.025
3.421ArgAsn: 3.421 ± 0.048
0.788ArgPro: 0.788 ± 0.027
0.787ArgGln: 0.787 ± 0.028
1.638ArgArg: 1.638 ± 0.039
2.284ArgSer: 2.284 ± 0.043
1.434ArgThr: 1.434 ± 0.033
1.63ArgVal: 1.63 ± 0.035
0.196ArgTrp: 0.196 ± 0.011
1.551ArgTyr: 1.551 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
1.902SerAla: 1.902 ± 0.041
1.308SerCys: 1.308 ± 0.032
4.514SerAsp: 4.514 ± 0.06
5.577SerGlu: 5.577 ± 0.069
4.896SerPhe: 4.896 ± 0.065
2.793SerGly: 2.793 ± 0.062
1.27SerHis: 1.27 ± 0.03
7.247SerIle: 7.247 ± 0.081
7.906SerLys: 7.906 ± 0.089
7.873SerLeu: 7.873 ± 0.08
1.418SerMet: 1.418 ± 0.037
7.108SerAsn: 7.108 ± 0.105
1.643SerPro: 1.643 ± 0.041
1.969SerGln: 1.969 ± 0.041
2.569SerArg: 2.569 ± 0.05
6.705SerSer: 6.705 ± 0.113
3.919SerThr: 3.919 ± 0.062
4.182SerVal: 4.182 ± 0.06
0.333SerTrp: 0.333 ± 0.014
3.502SerTyr: 3.502 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
1.32ThrAla: 1.32 ± 0.033
0.852ThrCys: 0.852 ± 0.024
2.932ThrAsp: 2.932 ± 0.051
3.534ThrGlu: 3.534 ± 0.056
2.78ThrPhe: 2.78 ± 0.04
1.669ThrGly: 1.669 ± 0.036
1.045ThrHis: 1.045 ± 0.028
4.056ThrIle: 4.056 ± 0.058
4.386ThrLys: 4.386 ± 0.058
4.92ThrLeu: 4.92 ± 0.067
0.704ThrMet: 0.704 ± 0.021
5.148ThrAsn: 5.148 ± 0.1
2.054ThrPro: 2.054 ± 0.054
1.218ThrGln: 1.218 ± 0.032
1.619ThrArg: 1.619 ± 0.036
3.858ThrSer: 3.858 ± 0.076
3.082ThrThr: 3.082 ± 0.077
2.382ThrVal: 2.382 ± 0.048
0.252ThrTrp: 0.252 ± 0.013
2.068ThrTyr: 2.068 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
1.185ValAla: 1.185 ± 0.031
1.059ValCys: 1.059 ± 0.031
2.43ValAsp: 2.43 ± 0.042
3.509ValGlu: 3.509 ± 0.051
3.344ValPhe: 3.344 ± 0.053
1.921ValGly: 1.921 ± 0.049
0.656ValHis: 0.656 ± 0.02
3.863ValIle: 3.863 ± 0.055
4.118ValLys: 4.118 ± 0.053
4.91ValLeu: 4.91 ± 0.066
0.909ValMet: 0.909 ± 0.029
3.398ValAsn: 3.398 ± 0.081
1.104ValPro: 1.104 ± 0.029
1.087ValGln: 1.087 ± 0.029
1.551ValArg: 1.551 ± 0.034
4.138ValSer: 4.138 ± 0.073
1.963ValThr: 1.963 ± 0.044
2.586ValVal: 2.586 ± 0.048
0.251ValTrp: 0.251 ± 0.012
1.978ValTyr: 1.978 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.127TrpAla: 0.127 ± 0.008
0.134TrpCys: 0.134 ± 0.008
0.281TrpAsp: 0.281 ± 0.014
0.301TrpGlu: 0.301 ± 0.012
0.301TrpPhe: 0.301 ± 0.011
0.188TrpGly: 0.188 ± 0.012
0.076TrpHis: 0.076 ± 0.008
0.491TrpIle: 0.491 ± 0.018
0.488TrpLys: 0.488 ± 0.021
0.45TrpLeu: 0.45 ± 0.017
0.121TrpMet: 0.121 ± 0.009
0.437TrpAsn: 0.437 ± 0.018
0.142TrpPro: 0.142 ± 0.011
0.109TrpGln: 0.109 ± 0.009
0.192TrpArg: 0.192 ± 0.013
0.348TrpSer: 0.348 ± 0.015
0.191TrpThr: 0.191 ± 0.014
0.236TrpVal: 0.236 ± 0.013
0.052TrpTrp: 0.052 ± 0.005
0.227TrpTyr: 0.227 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.003TyrAla: 1.003 ± 0.022
0.894TyrCys: 0.894 ± 0.023
2.523TyrAsp: 2.523 ± 0.042
3.15TyrGlu: 3.15 ± 0.051
4.007TyrPhe: 4.007 ± 0.057
1.525TyrGly: 1.525 ± 0.034
0.821TyrHis: 0.821 ± 0.025
4.568TyrIle: 4.568 ± 0.067
4.928TyrLys: 4.928 ± 0.065
5.13TyrLeu: 5.13 ± 0.061
0.828TyrMet: 0.828 ± 0.025
3.62TyrAsn: 3.62 ± 0.057
0.913TyrPro: 0.913 ± 0.026
1.066TyrGln: 1.066 ± 0.025
1.652TyrArg: 1.652 ± 0.034
3.629TyrSer: 3.629 ± 0.057
2.171TyrThr: 2.171 ± 0.041
1.918TyrVal: 1.918 ± 0.043
0.24TyrTrp: 0.24 ± 0.011
1.892TyrTyr: 1.892 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4459 proteins (1572801 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski