Amino acid dipepetide frequency for Mycobacterium phage Imvubu

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.951AlaAla: 17.951 ± 1.84
0.957AlaCys: 0.957 ± 0.296
8.93AlaAsp: 8.93 ± 0.635
7.517AlaGlu: 7.517 ± 0.664
1.959AlaPhe: 1.959 ± 0.315
10.889AlaGly: 10.889 ± 1.25
2.278AlaHis: 2.278 ± 0.346
5.513AlaIle: 5.513 ± 0.612
3.554AlaLys: 3.554 ± 0.548
10.798AlaLeu: 10.798 ± 0.941
3.144AlaMet: 3.144 ± 0.385
3.736AlaAsn: 3.736 ± 0.465
8.11AlaPro: 8.11 ± 0.695
3.599AlaGln: 3.599 ± 0.453
9.294AlaArg: 9.294 ± 0.83
6.014AlaSer: 6.014 ± 0.541
8.338AlaThr: 8.338 ± 0.586
9.887AlaVal: 9.887 ± 0.769
2.141AlaTrp: 2.141 ± 0.39
2.05AlaTyr: 2.05 ± 0.305
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.256
0.182CysCys: 0.182 ± 0.089
0.911CysAsp: 0.911 ± 0.245
0.683CysGlu: 0.683 ± 0.215
0.228CysPhe: 0.228 ± 0.122
1.412CysGly: 1.412 ± 0.278
0.228CysHis: 0.228 ± 0.09
0.273CysIle: 0.273 ± 0.125
0.091CysLys: 0.091 ± 0.063
0.729CysLeu: 0.729 ± 0.207
0.182CysMet: 0.182 ± 0.083
0.273CysAsn: 0.273 ± 0.1
0.957CysPro: 0.957 ± 0.243
0.182CysGln: 0.182 ± 0.094
1.139CysArg: 1.139 ± 0.279
0.775CysSer: 0.775 ± 0.227
0.547CysThr: 0.547 ± 0.202
0.638CysVal: 0.638 ± 0.205
0.228CysTrp: 0.228 ± 0.131
0.182CysTyr: 0.182 ± 0.084
0.0CysXaa: 0.0 ± 0.0
Asp
8.474AspAla: 8.474 ± 0.742
0.547AspCys: 0.547 ± 0.197
4.146AspAsp: 4.146 ± 0.542
4.465AspGlu: 4.465 ± 0.508
1.002AspPhe: 1.002 ± 0.256
6.743AspGly: 6.743 ± 0.709
1.23AspHis: 1.23 ± 0.181
2.642AspIle: 2.642 ± 0.374
1.595AspLys: 1.595 ± 0.303
5.057AspLeu: 5.057 ± 0.42
1.595AspMet: 1.595 ± 0.274
1.822AspAsn: 1.822 ± 0.296
5.558AspPro: 5.558 ± 0.65
2.779AspGln: 2.779 ± 0.35
4.556AspArg: 4.556 ± 0.566
2.369AspSer: 2.369 ± 0.328
4.146AspThr: 4.146 ± 0.448
4.465AspVal: 4.465 ± 0.318
1.23AspTrp: 1.23 ± 0.207
1.276AspTyr: 1.276 ± 0.256
0.0AspXaa: 0.0 ± 0.0
Glu
7.335GluAla: 7.335 ± 0.642
0.456GluCys: 0.456 ± 0.147
3.599GluAsp: 3.599 ± 0.575
2.551GluGlu: 2.551 ± 0.395
1.503GluPhe: 1.503 ± 0.265
5.057GluGly: 5.057 ± 0.478
1.458GluHis: 1.458 ± 0.315
2.05GluIle: 2.05 ± 0.353
0.638GluLys: 0.638 ± 0.18
5.832GluLeu: 5.832 ± 0.561
1.185GluMet: 1.185 ± 0.224
1.093GluAsn: 1.093 ± 0.217
2.278GluPro: 2.278 ± 0.331
2.825GluGln: 2.825 ± 0.36
4.055GluArg: 4.055 ± 0.563
2.324GluSer: 2.324 ± 0.307
2.597GluThr: 2.597 ± 0.397
5.194GluVal: 5.194 ± 0.625
1.503GluTrp: 1.503 ± 0.286
1.23GluTyr: 1.23 ± 0.245
0.0GluXaa: 0.0 ± 0.0
Phe
2.688PheAla: 2.688 ± 0.32
0.228PheCys: 0.228 ± 0.114
2.05PheAsp: 2.05 ± 0.34
1.503PheGlu: 1.503 ± 0.298
0.501PhePhe: 0.501 ± 0.173
2.916PheGly: 2.916 ± 0.437
0.501PheHis: 0.501 ± 0.154
0.911PheIle: 0.911 ± 0.189
0.547PheLys: 0.547 ± 0.196
2.187PheLeu: 2.187 ± 0.332
0.319PheMet: 0.319 ± 0.142
0.775PheAsn: 0.775 ± 0.192
0.866PhePro: 0.866 ± 0.172
0.729PheGln: 0.729 ± 0.165
1.458PheArg: 1.458 ± 0.283
1.731PheSer: 1.731 ± 0.296
1.64PheThr: 1.64 ± 0.368
1.595PheVal: 1.595 ± 0.224
0.273PheTrp: 0.273 ± 0.118
0.364PheTyr: 0.364 ± 0.188
0.0PheXaa: 0.0 ± 0.0
Gly
9.568GlyAla: 9.568 ± 1.378
1.276GlyCys: 1.276 ± 0.284
6.515GlyAsp: 6.515 ± 0.558
5.558GlyGlu: 5.558 ± 0.603
2.369GlyPhe: 2.369 ± 0.429
11.299GlyGly: 11.299 ± 1.856
1.914GlyHis: 1.914 ± 0.317
4.328GlyIle: 4.328 ± 0.589
3.371GlyLys: 3.371 ± 0.451
7.381GlyLeu: 7.381 ± 0.672
2.187GlyMet: 2.187 ± 0.394
3.463GlyAsn: 3.463 ± 0.557
4.374GlyPro: 4.374 ± 0.518
3.69GlyGln: 3.69 ± 0.494
6.014GlyArg: 6.014 ± 0.525
5.057GlySer: 5.057 ± 0.622
6.834GlyThr: 6.834 ± 0.625
7.29GlyVal: 7.29 ± 0.74
2.232GlyTrp: 2.232 ± 0.374
2.415GlyTyr: 2.415 ± 0.325
0.0GlyXaa: 0.0 ± 0.0
His
2.232HisAla: 2.232 ± 0.377
0.182HisCys: 0.182 ± 0.111
1.914HisAsp: 1.914 ± 0.342
0.364HisGlu: 0.364 ± 0.131
0.456HisPhe: 0.456 ± 0.176
1.686HisGly: 1.686 ± 0.256
0.592HisHis: 0.592 ± 0.2
0.547HisIle: 0.547 ± 0.191
0.319HisLys: 0.319 ± 0.115
1.367HisLeu: 1.367 ± 0.235
0.638HisMet: 0.638 ± 0.161
0.592HisAsn: 0.592 ± 0.168
1.595HisPro: 1.595 ± 0.327
0.456HisGln: 0.456 ± 0.175
1.959HisArg: 1.959 ± 0.319
0.592HisSer: 0.592 ± 0.158
1.595HisThr: 1.595 ± 0.266
1.093HisVal: 1.093 ± 0.249
0.683HisTrp: 0.683 ± 0.189
0.547HisTyr: 0.547 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
5.513IleAla: 5.513 ± 0.445
0.364IleCys: 0.364 ± 0.137
3.508IleAsp: 3.508 ± 0.394
2.734IleGlu: 2.734 ± 0.391
0.592IlePhe: 0.592 ± 0.153
4.1IleGly: 4.1 ± 0.551
0.683IleHis: 0.683 ± 0.18
1.914IleIle: 1.914 ± 0.324
1.276IleLys: 1.276 ± 0.303
2.825IleLeu: 2.825 ± 0.359
0.683IleMet: 0.683 ± 0.266
1.185IleAsn: 1.185 ± 0.24
2.005IlePro: 2.005 ± 0.303
1.185IleGln: 1.185 ± 0.203
2.551IleArg: 2.551 ± 0.34
2.278IleSer: 2.278 ± 0.339
3.007IleThr: 3.007 ± 0.366
3.28IleVal: 3.28 ± 0.276
0.273IleTrp: 0.273 ± 0.138
0.592IleTyr: 0.592 ± 0.179
0.0IleXaa: 0.0 ± 0.0
Lys
3.554LysAla: 3.554 ± 0.47
0.0LysCys: 0.0 ± 0.0
1.321LysAsp: 1.321 ± 0.258
0.456LysGlu: 0.456 ± 0.165
0.456LysPhe: 0.456 ± 0.152
1.914LysGly: 1.914 ± 0.297
0.501LysHis: 0.501 ± 0.172
0.82LysIle: 0.82 ± 0.207
0.547LysLys: 0.547 ± 0.142
2.734LysLeu: 2.734 ± 0.356
0.456LysMet: 0.456 ± 0.143
0.683LysAsn: 0.683 ± 0.157
0.82LysPro: 0.82 ± 0.192
0.547LysGln: 0.547 ± 0.195
2.141LysArg: 2.141 ± 0.36
1.64LysSer: 1.64 ± 0.242
1.64LysThr: 1.64 ± 0.233
2.415LysVal: 2.415 ± 0.308
0.592LysTrp: 0.592 ± 0.194
0.501LysTyr: 0.501 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
12.028LeuAla: 12.028 ± 0.821
0.729LeuCys: 0.729 ± 0.213
4.829LeuAsp: 4.829 ± 0.574
4.237LeuGlu: 4.237 ± 0.433
2.369LeuPhe: 2.369 ± 0.35
8.019LeuGly: 8.019 ± 0.773
0.957LeuHis: 0.957 ± 0.259
2.916LeuIle: 2.916 ± 0.378
1.686LeuLys: 1.686 ± 0.33
5.239LeuLeu: 5.239 ± 0.492
2.005LeuMet: 2.005 ± 0.36
3.189LeuAsn: 3.189 ± 0.56
6.105LeuPro: 6.105 ± 0.476
1.959LeuGln: 1.959 ± 0.369
4.556LeuArg: 4.556 ± 0.479
3.599LeuSer: 3.599 ± 0.518
6.105LeuThr: 6.105 ± 0.636
5.513LeuVal: 5.513 ± 0.461
1.321LeuTrp: 1.321 ± 0.268
1.139LeuTyr: 1.139 ± 0.246
0.0LeuXaa: 0.0 ± 0.0
Met
3.326MetAla: 3.326 ± 0.372
0.273MetCys: 0.273 ± 0.122
1.321MetAsp: 1.321 ± 0.28
0.775MetGlu: 0.775 ± 0.198
0.638MetPhe: 0.638 ± 0.184
1.503MetGly: 1.503 ± 0.273
0.456MetHis: 0.456 ± 0.149
0.638MetIle: 0.638 ± 0.2
0.364MetLys: 0.364 ± 0.121
1.276MetLeu: 1.276 ± 0.227
0.41MetMet: 0.41 ± 0.146
0.729MetAsn: 0.729 ± 0.176
1.959MetPro: 1.959 ± 0.321
0.364MetGln: 0.364 ± 0.12
2.05MetArg: 2.05 ± 0.31
1.777MetSer: 1.777 ± 0.261
2.597MetThr: 2.597 ± 0.346
1.276MetVal: 1.276 ± 0.288
0.41MetTrp: 0.41 ± 0.156
0.547MetTyr: 0.547 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
3.964AsnAla: 3.964 ± 0.75
0.091AsnCys: 0.091 ± 0.064
1.686AsnAsp: 1.686 ± 0.286
1.412AsnGlu: 1.412 ± 0.267
0.364AsnPhe: 0.364 ± 0.136
2.961AsnGly: 2.961 ± 0.334
0.638AsnHis: 0.638 ± 0.186
1.503AsnIle: 1.503 ± 0.281
0.866AsnLys: 0.866 ± 0.224
1.822AsnLeu: 1.822 ± 0.295
0.547AsnMet: 0.547 ± 0.185
0.775AsnAsn: 0.775 ± 0.28
2.187AsnPro: 2.187 ± 0.317
0.638AsnGln: 0.638 ± 0.163
2.369AsnArg: 2.369 ± 0.452
1.64AsnSer: 1.64 ± 0.272
2.141AsnThr: 2.141 ± 0.291
1.686AsnVal: 1.686 ± 0.284
0.638AsnTrp: 0.638 ± 0.184
0.592AsnTyr: 0.592 ± 0.162
0.0AsnXaa: 0.0 ± 0.0
Pro
7.836ProAla: 7.836 ± 0.647
0.683ProCys: 0.683 ± 0.247
5.239ProAsp: 5.239 ± 0.676
4.966ProGlu: 4.966 ± 0.527
1.686ProPhe: 1.686 ± 0.303
7.745ProGly: 7.745 ± 0.755
1.549ProHis: 1.549 ± 0.269
2.551ProIle: 2.551 ± 0.338
0.82ProLys: 0.82 ± 0.216
3.964ProLeu: 3.964 ± 0.345
1.321ProMet: 1.321 ± 0.231
1.777ProAsn: 1.777 ± 0.28
5.194ProPro: 5.194 ± 0.624
1.822ProGln: 1.822 ± 0.294
3.645ProArg: 3.645 ± 0.401
3.28ProSer: 3.28 ± 0.463
5.331ProThr: 5.331 ± 0.669
5.331ProVal: 5.331 ± 0.466
1.002ProTrp: 1.002 ± 0.227
1.002ProTyr: 1.002 ± 0.226
0.0ProXaa: 0.0 ± 0.0
Gln
3.781GlnAla: 3.781 ± 0.52
0.41GlnCys: 0.41 ± 0.134
1.503GlnAsp: 1.503 ± 0.254
0.957GlnGlu: 0.957 ± 0.216
1.276GlnPhe: 1.276 ± 0.268
2.734GlnGly: 2.734 ± 0.369
0.638GlnHis: 0.638 ± 0.174
1.321GlnIle: 1.321 ± 0.355
0.501GlnLys: 0.501 ± 0.155
2.551GlnLeu: 2.551 ± 0.305
0.729GlnMet: 0.729 ± 0.166
0.729GlnAsn: 0.729 ± 0.266
2.87GlnPro: 2.87 ± 0.482
1.276GlnGln: 1.276 ± 0.223
2.916GlnArg: 2.916 ± 0.394
1.185GlnSer: 1.185 ± 0.222
2.415GlnThr: 2.415 ± 0.292
2.779GlnVal: 2.779 ± 0.383
0.592GlnTrp: 0.592 ± 0.149
0.547GlnTyr: 0.547 ± 0.156
0.0GlnXaa: 0.0 ± 0.0
Arg
8.429ArgAla: 8.429 ± 0.78
1.458ArgCys: 1.458 ± 0.322
3.964ArgAsp: 3.964 ± 0.616
4.192ArgGlu: 4.192 ± 0.419
2.141ArgPhe: 2.141 ± 0.296
5.467ArgGly: 5.467 ± 0.487
1.367ArgHis: 1.367 ± 0.317
2.779ArgIle: 2.779 ± 0.376
1.868ArgLys: 1.868 ± 0.316
5.877ArgLeu: 5.877 ± 0.588
2.324ArgMet: 2.324 ± 0.321
1.914ArgAsn: 1.914 ± 0.29
4.784ArgPro: 4.784 ± 0.627
2.278ArgGln: 2.278 ± 0.306
7.107ArgArg: 7.107 ± 0.86
3.463ArgSer: 3.463 ± 0.373
5.239ArgThr: 5.239 ± 0.552
5.331ArgVal: 5.331 ± 0.618
1.686ArgTrp: 1.686 ± 0.382
2.232ArgTyr: 2.232 ± 0.387
0.0ArgXaa: 0.0 ± 0.0
Ser
6.515SerAla: 6.515 ± 0.731
0.592SerCys: 0.592 ± 0.164
3.098SerAsp: 3.098 ± 0.347
2.141SerGlu: 2.141 ± 0.26
1.321SerPhe: 1.321 ± 0.238
5.649SerGly: 5.649 ± 0.664
0.82SerHis: 0.82 ± 0.204
1.822SerIle: 1.822 ± 0.219
1.321SerLys: 1.321 ± 0.287
3.69SerLeu: 3.69 ± 0.378
0.866SerMet: 0.866 ± 0.22
0.911SerAsn: 0.911 ± 0.219
3.326SerPro: 3.326 ± 0.414
1.64SerGln: 1.64 ± 0.264
4.465SerArg: 4.465 ± 0.484
2.415SerSer: 2.415 ± 0.434
2.87SerThr: 2.87 ± 0.364
3.463SerVal: 3.463 ± 0.391
0.82SerTrp: 0.82 ± 0.23
1.321SerTyr: 1.321 ± 0.295
0.0SerXaa: 0.0 ± 0.0
Thr
8.793ThrAla: 8.793 ± 0.708
0.82ThrCys: 0.82 ± 0.22
4.602ThrAsp: 4.602 ± 0.555
3.964ThrGlu: 3.964 ± 0.498
1.686ThrPhe: 1.686 ± 0.293
6.788ThrGly: 6.788 ± 0.557
1.23ThrHis: 1.23 ± 0.226
3.417ThrIle: 3.417 ± 0.511
1.868ThrLys: 1.868 ± 0.324
5.513ThrLeu: 5.513 ± 0.429
1.822ThrMet: 1.822 ± 0.252
1.595ThrAsn: 1.595 ± 0.244
6.151ThrPro: 6.151 ± 0.674
1.731ThrGln: 1.731 ± 0.241
4.966ThrArg: 4.966 ± 0.556
3.144ThrSer: 3.144 ± 0.353
5.239ThrThr: 5.239 ± 0.576
4.374ThrVal: 4.374 ± 0.467
1.549ThrTrp: 1.549 ± 0.25
1.276ThrTyr: 1.276 ± 0.256
0.0ThrXaa: 0.0 ± 0.0
Val
9.431ValAla: 9.431 ± 0.836
0.957ValCys: 0.957 ± 0.256
3.918ValAsp: 3.918 ± 0.43
4.192ValGlu: 4.192 ± 0.425
1.731ValPhe: 1.731 ± 0.289
7.062ValGly: 7.062 ± 0.567
1.093ValHis: 1.093 ± 0.239
3.371ValIle: 3.371 ± 0.385
1.868ValLys: 1.868 ± 0.261
6.697ValLeu: 6.697 ± 0.516
1.503ValMet: 1.503 ± 0.234
2.096ValAsn: 2.096 ± 0.358
5.331ValPro: 5.331 ± 0.443
2.141ValGln: 2.141 ± 0.333
4.875ValArg: 4.875 ± 0.574
4.009ValSer: 4.009 ± 0.383
5.422ValThr: 5.422 ± 0.615
6.014ValVal: 6.014 ± 0.668
1.367ValTrp: 1.367 ± 0.22
2.187ValTyr: 2.187 ± 0.366
0.0ValXaa: 0.0 ± 0.0
Trp
1.777TrpAla: 1.777 ± 0.299
0.501TrpCys: 0.501 ± 0.161
1.093TrpAsp: 1.093 ± 0.181
0.866TrpGlu: 0.866 ± 0.217
0.911TrpPhe: 0.911 ± 0.273
1.185TrpGly: 1.185 ± 0.202
0.957TrpHis: 0.957 ± 0.26
0.547TrpIle: 0.547 ± 0.124
0.091TrpLys: 0.091 ± 0.057
1.503TrpLeu: 1.503 ± 0.261
0.501TrpMet: 0.501 ± 0.168
0.364TrpAsn: 0.364 ± 0.12
1.23TrpPro: 1.23 ± 0.265
0.775TrpGln: 0.775 ± 0.181
1.822TrpArg: 1.822 ± 0.288
1.185TrpSer: 1.185 ± 0.264
1.367TrpThr: 1.367 ± 0.291
1.731TrpVal: 1.731 ± 0.408
0.41TrpTrp: 0.41 ± 0.146
0.456TrpTyr: 0.456 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.369TyrAla: 2.369 ± 0.373
0.228TyrCys: 0.228 ± 0.106
1.549TyrAsp: 1.549 ± 0.283
1.23TyrGlu: 1.23 ± 0.231
0.592TyrPhe: 0.592 ± 0.156
2.05TyrGly: 2.05 ± 0.421
0.319TyrHis: 0.319 ± 0.135
0.683TyrIle: 0.683 ± 0.275
0.547TyrLys: 0.547 ± 0.153
1.458TyrLeu: 1.458 ± 0.276
0.228TyrMet: 0.228 ± 0.111
0.82TyrAsn: 0.82 ± 0.237
1.048TyrPro: 1.048 ± 0.214
1.093TyrGln: 1.093 ± 0.258
1.959TyrArg: 1.959 ± 0.34
0.592TyrSer: 0.592 ± 0.185
1.458TyrThr: 1.458 ± 0.261
1.914TyrVal: 1.914 ± 0.372
0.319TyrTrp: 0.319 ± 0.117
0.683TyrTyr: 0.683 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 102 proteins (21950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski