Amino acid dipepetide frequency for Proteobacteria bacterium CAG:139

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.684AlaAla: 10.684 ± 0.166
1.318AlaCys: 1.318 ± 0.054
4.655AlaAsp: 4.655 ± 0.092
6.147AlaGlu: 6.147 ± 0.129
4.023AlaPhe: 4.023 ± 0.097
6.939AlaGly: 6.939 ± 0.13
1.467AlaHis: 1.467 ± 0.047
5.313AlaIle: 5.313 ± 0.107
5.801AlaLys: 5.801 ± 0.104
9.625AlaLeu: 9.625 ± 0.138
2.641AlaMet: 2.641 ± 0.071
2.861AlaAsn: 2.861 ± 0.068
3.822AlaPro: 3.822 ± 0.101
3.612AlaGln: 3.612 ± 0.087
4.454AlaArg: 4.454 ± 0.107
5.366AlaSer: 5.366 ± 0.107
3.825AlaThr: 3.825 ± 0.083
7.2AlaVal: 7.2 ± 0.126
0.987AlaTrp: 0.987 ± 0.048
2.334AlaTyr: 2.334 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.164CysAla: 1.164 ± 0.046
0.248CysCys: 0.248 ± 0.023
0.661CysAsp: 0.661 ± 0.039
0.696CysGlu: 0.696 ± 0.036
0.61CysPhe: 0.61 ± 0.033
1.3CysGly: 1.3 ± 0.055
0.338CysHis: 0.338 ± 0.038
0.672CysIle: 0.672 ± 0.038
0.577CysLys: 0.577 ± 0.035
1.273CysLeu: 1.273 ± 0.05
0.281CysMet: 0.281 ± 0.027
0.364CysAsn: 0.364 ± 0.033
0.682CysPro: 0.682 ± 0.039
0.322CysGln: 0.322 ± 0.023
0.677CysArg: 0.677 ± 0.036
0.85CysSer: 0.85 ± 0.04
0.649CysThr: 0.649 ± 0.034
0.883CysVal: 0.883 ± 0.041
0.151CysTrp: 0.151 ± 0.016
0.326CysTyr: 0.326 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.499AspAla: 4.499 ± 0.11
0.679AspCys: 0.679 ± 0.034
2.281AspAsp: 2.281 ± 0.062
3.708AspGlu: 3.708 ± 0.092
2.552AspPhe: 2.552 ± 0.076
3.754AspGly: 3.754 ± 0.089
0.907AspHis: 0.907 ± 0.046
3.276AspIle: 3.276 ± 0.074
3.382AspLys: 3.382 ± 0.084
5.211AspLeu: 5.211 ± 0.095
1.287AspMet: 1.287 ± 0.042
1.777AspAsn: 1.777 ± 0.058
2.916AspPro: 2.916 ± 0.083
1.706AspGln: 1.706 ± 0.056
2.767AspArg: 2.767 ± 0.077
2.61AspSer: 2.61 ± 0.066
2.22AspThr: 2.22 ± 0.053
3.683AspVal: 3.683 ± 0.09
0.793AspTrp: 0.793 ± 0.035
1.697AspTyr: 1.697 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.431GluAla: 6.431 ± 0.131
0.636GluCys: 0.636 ± 0.037
3.347GluAsp: 3.347 ± 0.069
5.212GluGlu: 5.212 ± 0.118
2.315GluPhe: 2.315 ± 0.061
4.504GluGly: 4.504 ± 0.095
1.313GluHis: 1.313 ± 0.057
4.551GluIle: 4.551 ± 0.092
5.256GluLys: 5.256 ± 0.12
6.386GluLeu: 6.386 ± 0.116
1.683GluMet: 1.683 ± 0.055
2.811GluAsn: 2.811 ± 0.069
2.372GluPro: 2.372 ± 0.072
2.282GluGln: 2.282 ± 0.067
3.385GluArg: 3.385 ± 0.094
3.037GluSer: 3.037 ± 0.072
3.155GluThr: 3.155 ± 0.077
4.688GluVal: 4.688 ± 0.097
0.656GluTrp: 0.656 ± 0.034
1.607GluTyr: 1.607 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.901PheAla: 3.901 ± 0.087
0.767PheCys: 0.767 ± 0.036
2.509PheAsp: 2.509 ± 0.063
2.72PheGlu: 2.72 ± 0.075
2.083PhePhe: 2.083 ± 0.078
3.702PheGly: 3.702 ± 0.083
0.752PheHis: 0.752 ± 0.038
2.698PheIle: 2.698 ± 0.073
2.327PheLys: 2.327 ± 0.06
4.274PheLeu: 4.274 ± 0.1
1.062PheMet: 1.062 ± 0.05
1.856PheAsn: 1.856 ± 0.062
1.718PhePro: 1.718 ± 0.054
1.139PheGln: 1.139 ± 0.042
1.797PheArg: 1.797 ± 0.06
3.114PheSer: 3.114 ± 0.071
2.132PheThr: 2.132 ± 0.058
3.176PheVal: 3.176 ± 0.072
0.59PheTrp: 0.59 ± 0.034
1.297PheTyr: 1.297 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
6.698GlyAla: 6.698 ± 0.114
1.139GlyCys: 1.139 ± 0.056
3.453GlyAsp: 3.453 ± 0.093
4.142GlyGlu: 4.142 ± 0.1
3.614GlyPhe: 3.614 ± 0.08
5.318GlyGly: 5.318 ± 0.124
1.429GlyHis: 1.429 ± 0.052
5.1GlyIle: 5.1 ± 0.094
5.259GlyLys: 5.259 ± 0.108
7.389GlyLeu: 7.389 ± 0.118
2.203GlyMet: 2.203 ± 0.057
2.611GlyAsn: 2.611 ± 0.071
2.251GlyPro: 2.251 ± 0.063
2.294GlyGln: 2.294 ± 0.054
3.682GlyArg: 3.682 ± 0.081
4.601GlySer: 4.601 ± 0.094
4.23GlyThr: 4.23 ± 0.089
5.706GlyVal: 5.706 ± 0.099
1.067GlyTrp: 1.067 ± 0.052
2.234GlyTyr: 2.234 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.543HisAla: 1.543 ± 0.046
0.282HisCys: 0.282 ± 0.022
0.894HisAsp: 0.894 ± 0.041
1.022HisGlu: 1.022 ± 0.039
0.849HisPhe: 0.849 ± 0.04
1.522HisGly: 1.522 ± 0.056
0.537HisHis: 0.537 ± 0.041
1.044HisIle: 1.044 ± 0.043
0.873HisLys: 0.873 ± 0.036
1.766HisLeu: 1.766 ± 0.056
0.438HisMet: 0.438 ± 0.028
0.738HisAsn: 0.738 ± 0.034
1.117HisPro: 1.117 ± 0.04
0.611HisGln: 0.611 ± 0.032
0.997HisArg: 0.997 ± 0.041
1.06HisSer: 1.06 ± 0.043
0.892HisThr: 0.892 ± 0.041
1.15HisVal: 1.15 ± 0.053
0.253HisTrp: 0.253 ± 0.02
0.639HisTyr: 0.639 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.981IleAla: 5.981 ± 0.114
0.89IleCys: 0.89 ± 0.04
3.545IleAsp: 3.545 ± 0.074
4.154IleGlu: 4.154 ± 0.09
2.598IlePhe: 2.598 ± 0.077
5.082IleGly: 5.082 ± 0.112
1.062IleHis: 1.062 ± 0.038
3.285IleIle: 3.285 ± 0.084
3.408IleLys: 3.408 ± 0.091
5.704IleLeu: 5.704 ± 0.121
1.257IleMet: 1.257 ± 0.051
2.487IleAsn: 2.487 ± 0.081
3.191IlePro: 3.191 ± 0.074
1.865IleGln: 1.865 ± 0.05
3.283IleArg: 3.283 ± 0.073
4.262IleSer: 4.262 ± 0.077
3.032IleThr: 3.032 ± 0.074
4.447IleVal: 4.447 ± 0.098
0.568IleTrp: 0.568 ± 0.031
1.55IleTyr: 1.55 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
6.31LysAla: 6.31 ± 0.118
0.468LysCys: 0.468 ± 0.029
3.841LysAsp: 3.841 ± 0.079
5.179LysGlu: 5.179 ± 0.103
2.054LysPhe: 2.054 ± 0.058
4.412LysGly: 4.412 ± 0.111
1.049LysHis: 1.049 ± 0.041
3.827LysIle: 3.827 ± 0.092
4.542LysLys: 4.542 ± 0.102
5.562LysLeu: 5.562 ± 0.101
1.759LysMet: 1.759 ± 0.057
2.94LysAsn: 2.94 ± 0.069
2.952LysPro: 2.952 ± 0.061
2.007LysGln: 2.007 ± 0.059
3.075LysArg: 3.075 ± 0.069
3.178LysSer: 3.178 ± 0.071
3.654LysThr: 3.654 ± 0.091
4.454LysVal: 4.454 ± 0.09
0.625LysTrp: 0.625 ± 0.033
1.553LysTyr: 1.553 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
9.036LeuAla: 9.036 ± 0.136
1.19LeuCys: 1.19 ± 0.047
4.987LeuAsp: 4.987 ± 0.089
5.971LeuGlu: 5.971 ± 0.12
4.116LeuPhe: 4.116 ± 0.102
7.27LeuGly: 7.27 ± 0.131
1.68LeuHis: 1.68 ± 0.05
6.038LeuIle: 6.038 ± 0.125
6.53LeuLys: 6.53 ± 0.114
9.386LeuLeu: 9.386 ± 0.161
2.501LeuMet: 2.501 ± 0.07
3.969LeuAsn: 3.969 ± 0.085
4.863LeuPro: 4.863 ± 0.092
3.122LeuGln: 3.122 ± 0.073
5.005LeuArg: 5.005 ± 0.094
7.251LeuSer: 7.251 ± 0.123
5.702LeuThr: 5.702 ± 0.1
6.447LeuVal: 6.447 ± 0.119
1.049LeuTrp: 1.049 ± 0.043
2.421LeuTyr: 2.421 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.513MetAla: 2.513 ± 0.063
0.272MetCys: 0.272 ± 0.02
1.318MetAsp: 1.318 ± 0.046
1.498MetGlu: 1.498 ± 0.054
0.859MetPhe: 0.859 ± 0.045
1.784MetGly: 1.784 ± 0.071
0.504MetHis: 0.504 ± 0.03
1.545MetIle: 1.545 ± 0.05
1.922MetLys: 1.922 ± 0.058
2.492MetLeu: 2.492 ± 0.057
0.672MetMet: 0.672 ± 0.036
1.134MetAsn: 1.134 ± 0.042
1.304MetPro: 1.304 ± 0.051
0.951MetGln: 0.951 ± 0.043
1.417MetArg: 1.417 ± 0.053
1.787MetSer: 1.787 ± 0.055
1.619MetThr: 1.619 ± 0.053
1.695MetVal: 1.695 ± 0.053
0.206MetTrp: 0.206 ± 0.017
0.545MetTyr: 0.545 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.375AsnAla: 3.375 ± 0.076
0.485AsnCys: 0.485 ± 0.027
1.744AsnAsp: 1.744 ± 0.059
2.243AsnGlu: 2.243 ± 0.066
1.699AsnPhe: 1.699 ± 0.062
2.984AsnGly: 2.984 ± 0.073
0.738AsnHis: 0.738 ± 0.038
2.203AsnIle: 2.203 ± 0.069
2.243AsnLys: 2.243 ± 0.057
3.794AsnLeu: 3.794 ± 0.085
0.985AsnMet: 0.985 ± 0.041
1.446AsnAsn: 1.446 ± 0.058
2.386AsnPro: 2.386 ± 0.066
1.283AsnGln: 1.283 ± 0.047
2.076AsnArg: 2.076 ± 0.068
2.177AsnSer: 2.177 ± 0.066
1.775AsnThr: 1.775 ± 0.066
2.649AsnVal: 2.649 ± 0.064
0.516AsnTrp: 0.516 ± 0.03
1.171AsnTyr: 1.171 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
4.054ProAla: 4.054 ± 0.091
0.44ProCys: 0.44 ± 0.029
2.532ProAsp: 2.532 ± 0.07
4.019ProGlu: 4.019 ± 0.095
2.042ProPhe: 2.042 ± 0.062
3.155ProGly: 3.155 ± 0.075
0.809ProHis: 0.809 ± 0.038
2.714ProIle: 2.714 ± 0.072
2.805ProLys: 2.805 ± 0.077
4.281ProLeu: 4.281 ± 0.079
1.127ProMet: 1.127 ± 0.049
1.747ProAsn: 1.747 ± 0.065
1.418ProPro: 1.418 ± 0.062
1.701ProGln: 1.701 ± 0.058
1.863ProArg: 1.863 ± 0.056
2.622ProSer: 2.622 ± 0.07
2.339ProThr: 2.339 ± 0.07
3.688ProVal: 3.688 ± 0.083
0.573ProTrp: 0.573 ± 0.034
1.335ProTyr: 1.335 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.254GlnAla: 3.254 ± 0.077
0.348GlnCys: 0.348 ± 0.028
1.467GlnAsp: 1.467 ± 0.049
2.194GlnGlu: 2.194 ± 0.065
1.294GlnPhe: 1.294 ± 0.041
2.111GlnGly: 2.111 ± 0.071
0.601GlnHis: 0.601 ± 0.03
2.166GlnIle: 2.166 ± 0.059
2.617GlnLys: 2.617 ± 0.075
3.093GlnLeu: 3.093 ± 0.073
0.984GlnMet: 0.984 ± 0.045
1.418GlnAsn: 1.418 ± 0.055
1.423GlnPro: 1.423 ± 0.057
1.209GlnGln: 1.209 ± 0.048
1.818GlnArg: 1.818 ± 0.064
1.739GlnSer: 1.739 ± 0.057
1.818GlnThr: 1.818 ± 0.059
2.314GlnVal: 2.314 ± 0.062
0.383GlnTrp: 0.383 ± 0.029
0.951GlnTyr: 0.951 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.992ArgAla: 3.992 ± 0.091
0.584ArgCys: 0.584 ± 0.033
2.481ArgAsp: 2.481 ± 0.076
3.375ArgGlu: 3.375 ± 0.085
2.407ArgPhe: 2.407 ± 0.06
3.233ArgGly: 3.233 ± 0.068
1.058ArgHis: 1.058 ± 0.044
3.408ArgIle: 3.408 ± 0.092
3.269ArgLys: 3.269 ± 0.073
5.375ArgLeu: 5.375 ± 0.108
1.458ArgMet: 1.458 ± 0.049
1.924ArgAsn: 1.924 ± 0.063
2.225ArgPro: 2.225 ± 0.067
1.81ArgGln: 1.81 ± 0.056
3.14ArgArg: 3.14 ± 0.091
3.044ArgSer: 3.044 ± 0.081
2.611ArgThr: 2.611 ± 0.07
3.273ArgVal: 3.273 ± 0.071
0.629ArgTrp: 0.629 ± 0.035
1.704ArgTyr: 1.704 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.439SerAla: 5.439 ± 0.091
0.682SerCys: 0.682 ± 0.041
3.228SerAsp: 3.228 ± 0.076
3.87SerGlu: 3.87 ± 0.076
3.018SerPhe: 3.018 ± 0.071
4.932SerGly: 4.932 ± 0.097
1.158SerHis: 1.158 ± 0.043
3.503SerIle: 3.503 ± 0.08
3.375SerLys: 3.375 ± 0.084
6.135SerLeu: 6.135 ± 0.112
1.631SerMet: 1.631 ± 0.049
1.969SerAsn: 1.969 ± 0.056
2.649SerPro: 2.649 ± 0.072
1.99SerGln: 1.99 ± 0.056
3.209SerArg: 3.209 ± 0.073
3.972SerSer: 3.972 ± 0.094
2.854SerThr: 2.854 ± 0.072
4.537SerVal: 4.537 ± 0.092
0.741SerTrp: 0.741 ± 0.036
1.655SerTyr: 1.655 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.736ThrAla: 4.736 ± 0.101
0.578ThrCys: 0.578 ± 0.03
2.873ThrAsp: 2.873 ± 0.073
3.11ThrGlu: 3.11 ± 0.077
2.324ThrPhe: 2.324 ± 0.068
4.133ThrGly: 4.133 ± 0.088
0.992ThrHis: 0.992 ± 0.039
3.169ThrIle: 3.169 ± 0.067
2.672ThrLys: 2.672 ± 0.077
5.031ThrLeu: 5.031 ± 0.097
1.195ThrMet: 1.195 ± 0.048
1.785ThrAsn: 1.785 ± 0.059
2.828ThrPro: 2.828 ± 0.067
1.692ThrGln: 1.692 ± 0.057
2.388ThrArg: 2.388 ± 0.067
2.887ThrSer: 2.887 ± 0.073
2.62ThrThr: 2.62 ± 0.074
4.305ThrVal: 4.305 ± 0.081
0.504ThrTrp: 0.504 ± 0.034
1.346ThrTyr: 1.346 ± 0.051
0.002ThrXaa: 0.002 ± 0.002
Val
6.324ValAla: 6.324 ± 0.103
1.124ValCys: 1.124 ± 0.045
3.875ValAsp: 3.875 ± 0.082
4.243ValGlu: 4.243 ± 0.099
3.259ValPhe: 3.259 ± 0.085
5.216ValGly: 5.216 ± 0.096
1.141ValHis: 1.141 ± 0.043
4.807ValIle: 4.807 ± 0.116
4.392ValLys: 4.392 ± 0.099
7.33ValLeu: 7.33 ± 0.133
1.912ValMet: 1.912 ± 0.061
2.691ValAsn: 2.691 ± 0.072
3.439ValPro: 3.439 ± 0.072
2.208ValGln: 2.208 ± 0.055
3.763ValArg: 3.763 ± 0.078
4.601ValSer: 4.601 ± 0.086
3.993ValThr: 3.993 ± 0.083
5.612ValVal: 5.612 ± 0.106
0.829ValTrp: 0.829 ± 0.041
1.917ValTyr: 1.917 ± 0.052
0.002ValXaa: 0.002 ± 0.002
Trp
0.862TrpAla: 0.862 ± 0.038
0.187TrpCys: 0.187 ± 0.019
0.53TrpAsp: 0.53 ± 0.029
0.571TrpGlu: 0.571 ± 0.035
0.545TrpPhe: 0.545 ± 0.034
0.765TrpGly: 0.765 ± 0.045
0.225TrpHis: 0.225 ± 0.023
0.842TrpIle: 0.842 ± 0.041
0.738TrpLys: 0.738 ± 0.041
1.484TrpLeu: 1.484 ± 0.062
0.362TrpMet: 0.362 ± 0.025
0.521TrpAsn: 0.521 ± 0.032
0.41TrpPro: 0.41 ± 0.027
0.457TrpGln: 0.457 ± 0.026
0.623TrpArg: 0.623 ± 0.037
0.636TrpSer: 0.636 ± 0.033
0.679TrpThr: 0.679 ± 0.033
0.826TrpVal: 0.826 ± 0.036
0.158TrpTrp: 0.158 ± 0.018
0.291TrpTyr: 0.291 ± 0.023
0.002TrpXaa: 0.002 ± 0.002
Tyr
2.277TyrAla: 2.277 ± 0.071
0.407TyrCys: 0.407 ± 0.026
1.484TyrAsp: 1.484 ± 0.049
1.553TyrGlu: 1.553 ± 0.054
1.356TyrPhe: 1.356 ± 0.05
2.303TyrGly: 2.303 ± 0.06
0.468TyrHis: 0.468 ± 0.029
1.491TyrIle: 1.491 ± 0.052
1.456TyrLys: 1.456 ± 0.054
2.94TyrLeu: 2.94 ± 0.06
0.597TyrMet: 0.597 ± 0.031
0.923TyrAsn: 0.923 ± 0.046
1.295TyrPro: 1.295 ± 0.047
0.939TyrGln: 0.939 ± 0.04
1.579TyrArg: 1.579 ± 0.048
1.758TyrSer: 1.758 ± 0.056
1.366TyrThr: 1.366 ± 0.047
1.945TyrVal: 1.945 ± 0.054
0.435TyrTrp: 0.435 ± 0.033
0.821TyrTyr: 0.821 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.002XaaTrp: 0.002 ± 0.002
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 1880 proteins (577478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski