Amino acid dipepetide frequency for Enterococcus phage LY0323

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.807AlaAla: 0.807 ± 0.296
0.242AlaCys: 0.242 ± 0.152
3.226AlaAsp: 3.226 ± 0.589
3.549AlaGlu: 3.549 ± 0.488
2.662AlaPhe: 2.662 ± 0.484
3.226AlaGly: 3.226 ± 0.591
1.049AlaHis: 1.049 ± 0.314
4.759AlaIle: 4.759 ± 0.862
5.807AlaLys: 5.807 ± 0.815
5.565AlaLeu: 5.565 ± 0.604
2.742AlaMet: 2.742 ± 0.589
3.952AlaAsn: 3.952 ± 0.575
2.178AlaPro: 2.178 ± 0.381
1.291AlaGln: 1.291 ± 0.301
1.855AlaArg: 1.855 ± 0.4
3.226AlaSer: 3.226 ± 0.526
4.598AlaThr: 4.598 ± 0.69
4.356AlaVal: 4.356 ± 0.653
0.403AlaTrp: 0.403 ± 0.19
2.258AlaTyr: 2.258 ± 0.417
0.0AlaXaa: 0.0 ± 0.0
Cys
0.403CysAla: 0.403 ± 0.189
0.0CysCys: 0.0 ± 0.0
0.242CysAsp: 0.242 ± 0.149
0.807CysGlu: 0.807 ± 0.254
0.081CysPhe: 0.081 ± 0.098
0.484CysGly: 0.484 ± 0.216
0.161CysHis: 0.161 ± 0.121
0.323CysIle: 0.323 ± 0.141
0.726CysLys: 0.726 ± 0.232
0.565CysLeu: 0.565 ± 0.225
0.081CysMet: 0.081 ± 0.081
0.807CysAsn: 0.807 ± 0.289
0.081CysPro: 0.081 ± 0.073
0.161CysGln: 0.161 ± 0.118
0.242CysArg: 0.242 ± 0.14
0.484CysSer: 0.484 ± 0.218
0.484CysThr: 0.484 ± 0.179
0.403CysVal: 0.403 ± 0.166
0.081CysTrp: 0.081 ± 0.081
0.081CysTyr: 0.081 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
3.226AspAla: 3.226 ± 0.501
0.403AspCys: 0.403 ± 0.158
2.258AspAsp: 2.258 ± 0.548
4.678AspGlu: 4.678 ± 0.515
2.742AspPhe: 2.742 ± 0.526
4.356AspGly: 4.356 ± 0.514
0.645AspHis: 0.645 ± 0.23
4.194AspIle: 4.194 ± 0.779
6.372AspLys: 6.372 ± 0.758
4.92AspLeu: 4.92 ± 0.63
1.694AspMet: 1.694 ± 0.376
4.598AspAsn: 4.598 ± 0.595
2.178AspPro: 2.178 ± 0.412
0.887AspGln: 0.887 ± 0.185
2.339AspArg: 2.339 ± 0.476
3.146AspSer: 3.146 ± 0.369
3.872AspThr: 3.872 ± 0.681
3.952AspVal: 3.952 ± 0.494
0.807AspTrp: 0.807 ± 0.256
2.904AspTyr: 2.904 ± 0.521
0.0AspXaa: 0.0 ± 0.0
Glu
4.517GluAla: 4.517 ± 0.631
0.726GluCys: 0.726 ± 0.255
4.356GluAsp: 4.356 ± 0.692
7.905GluGlu: 7.905 ± 1.503
2.984GluPhe: 2.984 ± 0.473
4.92GluGly: 4.92 ± 0.573
1.371GluHis: 1.371 ± 0.37
3.872GluIle: 3.872 ± 0.476
6.049GluLys: 6.049 ± 0.72
8.872GluLeu: 8.872 ± 0.956
2.339GluMet: 2.339 ± 0.44
3.872GluAsn: 3.872 ± 0.606
2.5GluPro: 2.5 ± 0.55
3.791GluGln: 3.791 ± 0.54
3.065GluArg: 3.065 ± 0.481
4.275GluSer: 4.275 ± 0.553
4.275GluThr: 4.275 ± 0.406
6.533GluVal: 6.533 ± 0.599
1.694GluTrp: 1.694 ± 0.307
3.468GluTyr: 3.468 ± 0.597
0.0GluXaa: 0.0 ± 0.0
Phe
1.533PheAla: 1.533 ± 0.295
0.323PheCys: 0.323 ± 0.195
3.146PheAsp: 3.146 ± 0.459
2.823PheGlu: 2.823 ± 0.638
0.968PhePhe: 0.968 ± 0.317
2.5PheGly: 2.5 ± 0.448
0.081PheHis: 0.081 ± 0.087
3.872PheIle: 3.872 ± 0.626
4.356PheLys: 4.356 ± 0.565
2.258PheLeu: 2.258 ± 0.464
1.049PheMet: 1.049 ± 0.28
3.226PheAsn: 3.226 ± 0.428
0.807PhePro: 0.807 ± 0.214
1.855PheGln: 1.855 ± 0.395
1.452PheArg: 1.452 ± 0.287
2.581PheSer: 2.581 ± 0.401
4.194PheThr: 4.194 ± 0.727
2.5PheVal: 2.5 ± 0.371
0.484PheTrp: 0.484 ± 0.186
1.049PheTyr: 1.049 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
4.517GlyAla: 4.517 ± 1.204
0.161GlyCys: 0.161 ± 0.123
3.226GlyAsp: 3.226 ± 0.509
3.549GlyGlu: 3.549 ± 0.515
3.307GlyPhe: 3.307 ± 0.402
4.275GlyGly: 4.275 ± 0.954
0.968GlyHis: 0.968 ± 0.277
5.081GlyIle: 5.081 ± 0.89
5.807GlyLys: 5.807 ± 0.585
5.727GlyLeu: 5.727 ± 0.688
1.533GlyMet: 1.533 ± 0.337
3.71GlyAsn: 3.71 ± 0.469
0.726GlyPro: 0.726 ± 0.249
1.936GlyGln: 1.936 ± 0.401
2.42GlyArg: 2.42 ± 0.352
3.468GlySer: 3.468 ± 0.522
4.275GlyThr: 4.275 ± 0.837
3.952GlyVal: 3.952 ± 0.572
1.371GlyTrp: 1.371 ± 0.303
3.146GlyTyr: 3.146 ± 0.483
0.0GlyXaa: 0.0 ± 0.0
His
0.484HisAla: 0.484 ± 0.195
0.242HisCys: 0.242 ± 0.152
1.049HisAsp: 1.049 ± 0.287
0.887HisGlu: 0.887 ± 0.309
0.887HisPhe: 0.887 ± 0.272
1.129HisGly: 1.129 ± 0.376
0.323HisHis: 0.323 ± 0.162
1.049HisIle: 1.049 ± 0.218
2.016HisLys: 2.016 ± 0.448
0.726HisLeu: 0.726 ± 0.268
0.323HisMet: 0.323 ± 0.174
1.291HisAsn: 1.291 ± 0.352
0.242HisPro: 0.242 ± 0.108
0.484HisGln: 0.484 ± 0.166
1.21HisArg: 1.21 ± 0.353
0.403HisSer: 0.403 ± 0.203
0.726HisThr: 0.726 ± 0.305
0.968HisVal: 0.968 ± 0.274
0.161HisTrp: 0.161 ± 0.104
0.807HisTyr: 0.807 ± 0.246
0.0HisXaa: 0.0 ± 0.0
Ile
4.114IleAla: 4.114 ± 0.534
0.565IleCys: 0.565 ± 0.227
5.081IleAsp: 5.081 ± 0.487
7.421IleGlu: 7.421 ± 0.989
2.097IlePhe: 2.097 ± 0.385
4.598IleGly: 4.598 ± 0.754
0.887IleHis: 0.887 ± 0.276
4.033IleIle: 4.033 ± 0.453
6.695IleLys: 6.695 ± 0.68
4.598IleLeu: 4.598 ± 0.64
1.936IleMet: 1.936 ± 0.336
4.436IleAsn: 4.436 ± 0.603
2.581IlePro: 2.581 ± 0.362
3.146IleGln: 3.146 ± 0.47
2.258IleArg: 2.258 ± 0.356
3.63IleSer: 3.63 ± 0.552
4.598IleThr: 4.598 ± 0.549
3.549IleVal: 3.549 ± 0.459
0.565IleTrp: 0.565 ± 0.205
1.533IleTyr: 1.533 ± 0.346
0.0IleXaa: 0.0 ± 0.0
Lys
6.453LysAla: 6.453 ± 0.955
0.565LysCys: 0.565 ± 0.21
4.759LysAsp: 4.759 ± 0.581
8.711LysGlu: 8.711 ± 1.033
3.872LysPhe: 3.872 ± 0.533
4.517LysGly: 4.517 ± 0.773
1.21LysHis: 1.21 ± 0.32
4.759LysIle: 4.759 ± 0.688
6.291LysLys: 6.291 ± 0.881
7.098LysLeu: 7.098 ± 0.993
3.226LysMet: 3.226 ± 0.484
5.727LysAsn: 5.727 ± 0.638
3.226LysPro: 3.226 ± 0.583
4.678LysGln: 4.678 ± 0.58
4.275LysArg: 4.275 ± 0.627
3.791LysSer: 3.791 ± 0.759
5.162LysThr: 5.162 ± 0.55
6.291LysVal: 6.291 ± 0.681
1.291LysTrp: 1.291 ± 0.303
3.226LysTyr: 3.226 ± 0.375
0.0LysXaa: 0.0 ± 0.0
Leu
4.194LeuAla: 4.194 ± 0.505
0.645LeuCys: 0.645 ± 0.248
6.211LeuAsp: 6.211 ± 0.617
8.63LeuGlu: 8.63 ± 0.924
3.71LeuPhe: 3.71 ± 0.534
4.436LeuGly: 4.436 ± 0.573
1.21LeuHis: 1.21 ± 0.279
4.839LeuIle: 4.839 ± 0.59
6.614LeuLys: 6.614 ± 0.851
6.372LeuLeu: 6.372 ± 0.905
1.694LeuMet: 1.694 ± 0.291
5.888LeuAsn: 5.888 ± 0.66
2.581LeuPro: 2.581 ± 0.531
3.791LeuGln: 3.791 ± 0.481
2.742LeuArg: 2.742 ± 0.441
4.759LeuSer: 4.759 ± 0.549
3.549LeuThr: 3.549 ± 0.388
5.888LeuVal: 5.888 ± 0.717
0.968LeuTrp: 0.968 ± 0.283
2.904LeuTyr: 2.904 ± 0.584
0.0LeuXaa: 0.0 ± 0.0
Met
1.694MetAla: 1.694 ± 0.463
0.242MetCys: 0.242 ± 0.146
1.452MetAsp: 1.452 ± 0.382
2.581MetGlu: 2.581 ± 0.482
1.371MetPhe: 1.371 ± 0.45
1.452MetGly: 1.452 ± 0.315
0.242MetHis: 0.242 ± 0.145
1.936MetIle: 1.936 ± 0.391
2.42MetLys: 2.42 ± 0.409
2.016MetLeu: 2.016 ± 0.402
0.323MetMet: 0.323 ± 0.161
1.774MetAsn: 1.774 ± 0.37
0.807MetPro: 0.807 ± 0.256
1.21MetGln: 1.21 ± 0.26
1.452MetArg: 1.452 ± 0.294
1.855MetSer: 1.855 ± 0.421
1.533MetThr: 1.533 ± 0.391
2.178MetVal: 2.178 ± 0.46
0.403MetTrp: 0.403 ± 0.235
1.129MetTyr: 1.129 ± 0.321
0.0MetXaa: 0.0 ± 0.0
Asn
5.162AsnAla: 5.162 ± 1.016
0.484AsnCys: 0.484 ± 0.184
2.984AsnAsp: 2.984 ± 0.508
5.646AsnGlu: 5.646 ± 0.567
1.613AsnPhe: 1.613 ± 0.345
6.614AsnGly: 6.614 ± 0.75
1.452AsnHis: 1.452 ± 0.345
4.759AsnIle: 4.759 ± 0.54
6.291AsnLys: 6.291 ± 0.819
4.759AsnLeu: 4.759 ± 0.68
1.694AsnMet: 1.694 ± 0.341
3.468AsnAsn: 3.468 ± 0.451
1.694AsnPro: 1.694 ± 0.327
1.774AsnGln: 1.774 ± 0.291
1.774AsnArg: 1.774 ± 0.381
3.468AsnSer: 3.468 ± 0.553
5.001AsnThr: 5.001 ± 0.585
3.63AsnVal: 3.63 ± 0.517
0.968AsnTrp: 0.968 ± 0.257
2.984AsnTyr: 2.984 ± 0.556
0.0AsnXaa: 0.0 ± 0.0
Pro
1.533ProAla: 1.533 ± 0.366
0.081ProCys: 0.081 ± 0.085
2.258ProAsp: 2.258 ± 0.453
2.984ProGlu: 2.984 ± 0.477
0.968ProPhe: 0.968 ± 0.239
0.0ProGly: 0.0 ± 0.0
0.242ProHis: 0.242 ± 0.14
1.613ProIle: 1.613 ± 0.335
2.5ProLys: 2.5 ± 0.625
3.065ProLeu: 3.065 ± 0.488
1.129ProMet: 1.129 ± 0.23
1.936ProAsn: 1.936 ± 0.402
0.323ProPro: 0.323 ± 0.154
1.613ProGln: 1.613 ± 0.388
0.565ProArg: 0.565 ± 0.181
1.855ProSer: 1.855 ± 0.365
2.178ProThr: 2.178 ± 0.451
2.097ProVal: 2.097 ± 0.445
0.161ProTrp: 0.161 ± 0.107
1.613ProTyr: 1.613 ± 0.483
0.0ProXaa: 0.0 ± 0.0
Gln
2.016GlnAla: 2.016 ± 0.405
0.323GlnCys: 0.323 ± 0.192
1.855GlnAsp: 1.855 ± 0.299
2.339GlnGlu: 2.339 ± 0.43
1.774GlnPhe: 1.774 ± 0.379
1.694GlnGly: 1.694 ± 0.425
0.645GlnHis: 0.645 ± 0.21
2.904GlnIle: 2.904 ± 0.531
2.339GlnLys: 2.339 ± 0.476
3.71GlnLeu: 3.71 ± 0.463
1.371GlnMet: 1.371 ± 0.36
1.533GlnAsn: 1.533 ± 0.355
1.129GlnPro: 1.129 ± 0.275
2.178GlnGln: 2.178 ± 0.381
2.016GlnArg: 2.016 ± 0.434
2.097GlnSer: 2.097 ± 0.419
1.371GlnThr: 1.371 ± 0.261
2.823GlnVal: 2.823 ± 0.389
0.484GlnTrp: 0.484 ± 0.309
2.5GlnTyr: 2.5 ± 0.371
0.0GlnXaa: 0.0 ± 0.0
Arg
1.694ArgAla: 1.694 ± 0.312
0.484ArgCys: 0.484 ± 0.172
2.823ArgAsp: 2.823 ± 0.49
1.694ArgGlu: 1.694 ± 0.457
1.774ArgPhe: 1.774 ± 0.414
2.016ArgGly: 2.016 ± 0.39
0.645ArgHis: 0.645 ± 0.312
2.581ArgIle: 2.581 ± 0.413
3.388ArgLys: 3.388 ± 0.588
2.984ArgLeu: 2.984 ± 0.542
1.21ArgMet: 1.21 ± 0.273
2.904ArgAsn: 2.904 ± 0.475
0.968ArgPro: 0.968 ± 0.296
1.21ArgGln: 1.21 ± 0.368
1.291ArgArg: 1.291 ± 0.316
1.936ArgSer: 1.936 ± 0.389
1.694ArgThr: 1.694 ± 0.442
2.904ArgVal: 2.904 ± 0.431
0.484ArgTrp: 0.484 ± 0.202
1.371ArgTyr: 1.371 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
2.904SerAla: 2.904 ± 0.644
0.161SerCys: 0.161 ± 0.117
3.468SerAsp: 3.468 ± 0.481
3.388SerGlu: 3.388 ± 0.445
2.662SerPhe: 2.662 ± 0.328
5.081SerGly: 5.081 ± 0.77
1.291SerHis: 1.291 ± 0.32
4.275SerIle: 4.275 ± 0.526
5.243SerLys: 5.243 ± 0.847
4.114SerLeu: 4.114 ± 0.5
1.533SerMet: 1.533 ± 0.325
3.71SerAsn: 3.71 ± 0.469
1.049SerPro: 1.049 ± 0.236
2.178SerGln: 2.178 ± 0.478
1.291SerArg: 1.291 ± 0.346
2.742SerSer: 2.742 ± 0.486
3.952SerThr: 3.952 ± 0.755
2.984SerVal: 2.984 ± 0.437
0.726SerTrp: 0.726 ± 0.257
2.42SerTyr: 2.42 ± 0.5
0.0SerXaa: 0.0 ± 0.0
Thr
3.791ThrAla: 3.791 ± 0.458
0.161ThrCys: 0.161 ± 0.12
3.388ThrAsp: 3.388 ± 0.519
3.952ThrGlu: 3.952 ± 0.481
1.936ThrPhe: 1.936 ± 0.416
4.759ThrGly: 4.759 ± 0.646
1.533ThrHis: 1.533 ± 0.358
4.598ThrIle: 4.598 ± 0.621
5.969ThrLys: 5.969 ± 0.613
5.485ThrLeu: 5.485 ± 0.809
1.533ThrMet: 1.533 ± 0.313
4.114ThrAsn: 4.114 ± 0.544
2.178ThrPro: 2.178 ± 0.339
2.097ThrGln: 2.097 ± 0.451
1.452ThrArg: 1.452 ± 0.368
2.823ThrSer: 2.823 ± 0.555
4.759ThrThr: 4.759 ± 1.031
4.517ThrVal: 4.517 ± 0.463
0.645ThrTrp: 0.645 ± 0.236
2.823ThrTyr: 2.823 ± 0.567
0.0ThrXaa: 0.0 ± 0.0
Val
5.485ValAla: 5.485 ± 0.589
0.242ValCys: 0.242 ± 0.146
4.517ValAsp: 4.517 ± 0.562
5.081ValGlu: 5.081 ± 0.623
2.984ValPhe: 2.984 ± 0.385
4.356ValGly: 4.356 ± 0.657
0.726ValHis: 0.726 ± 0.192
4.436ValIle: 4.436 ± 0.534
5.565ValLys: 5.565 ± 0.81
4.194ValLeu: 4.194 ± 0.496
1.613ValMet: 1.613 ± 0.274
4.92ValAsn: 4.92 ± 0.702
2.5ValPro: 2.5 ± 0.375
1.533ValGln: 1.533 ± 0.37
2.581ValArg: 2.581 ± 0.518
5.565ValSer: 5.565 ± 0.669
3.468ValThr: 3.468 ± 0.62
4.598ValVal: 4.598 ± 0.742
0.726ValTrp: 0.726 ± 0.306
2.823ValTyr: 2.823 ± 0.503
0.0ValXaa: 0.0 ± 0.0
Trp
0.645TrpAla: 0.645 ± 0.225
0.161TrpCys: 0.161 ± 0.113
0.726TrpAsp: 0.726 ± 0.234
1.613TrpGlu: 1.613 ± 0.331
0.807TrpPhe: 0.807 ± 0.213
0.968TrpGly: 0.968 ± 0.287
0.081TrpHis: 0.081 ± 0.069
0.968TrpIle: 0.968 ± 0.351
0.645TrpLys: 0.645 ± 0.243
1.129TrpLeu: 1.129 ± 0.276
0.081TrpMet: 0.081 ± 0.087
0.645TrpAsn: 0.645 ± 0.257
0.0TrpPro: 0.0 ± 0.0
0.323TrpGln: 0.323 ± 0.129
0.645TrpArg: 0.645 ± 0.22
0.726TrpSer: 0.726 ± 0.227
0.645TrpThr: 0.645 ± 0.226
1.291TrpVal: 1.291 ± 0.234
0.161TrpTrp: 0.161 ± 0.094
0.403TrpTyr: 0.403 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.581TyrAla: 2.581 ± 0.492
0.484TyrCys: 0.484 ± 0.172
3.146TyrAsp: 3.146 ± 0.463
3.146TyrGlu: 3.146 ± 0.541
1.855TyrPhe: 1.855 ± 0.335
1.774TyrGly: 1.774 ± 0.4
0.645TyrHis: 0.645 ± 0.181
3.468TyrIle: 3.468 ± 0.59
4.114TyrLys: 4.114 ± 0.616
3.468TyrLeu: 3.468 ± 0.538
0.887TyrMet: 0.887 ± 0.207
3.71TyrAsn: 3.71 ± 0.641
0.968TyrPro: 0.968 ± 0.313
0.968TyrGln: 0.968 ± 0.278
1.129TyrArg: 1.129 ± 0.331
2.339TyrSer: 2.339 ± 0.389
2.178TyrThr: 2.178 ± 0.366
2.5TyrVal: 2.5 ± 0.4
0.081TyrTrp: 0.081 ± 0.069
1.452TyrTyr: 1.452 ± 0.46
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (12399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski