Amino acid dipepetide frequency for Bacteroides sp. CAG:189

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.392AlaAla: 5.392 ± 0.089	0.967AlaCys: 0.967 ± 0.03	4.235AlaAsp: 4.235 ± 0.054	4.456AlaGlu: 4.456 ± 0.065	3.205AlaPhe: 3.205 ± 0.05	5.197AlaGly: 5.197 ± 0.072	1.16AlaHis: 1.16 ± 0.03	4.783AlaIle: 4.783 ± 0.064	3.828AlaLys: 3.828 ± 0.06	6.32AlaLeu: 6.32 ± 0.08	1.896AlaMet: 1.896 ± 0.04	3.209AlaAsn: 3.209 ± 0.041	2.222AlaPro: 2.222 ± 0.043	2.542AlaGln: 2.542 ± 0.046	2.961AlaArg: 2.961 ± 0.05	4.143AlaSer: 4.143 ± 0.057	3.935AlaThr: 3.935 ± 0.055	4.72AlaVal: 4.72 ± 0.059	0.821AlaTrp: 0.821 ± 0.024	2.977AlaTyr: 2.977 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.727CysAla: 0.727 ± 0.023	0.225CysCys: 0.225 ± 0.016	0.665CysAsp: 0.665 ± 0.023	0.685CysGlu: 0.685 ± 0.02	0.657CysPhe: 0.657 ± 0.022	0.982CysGly: 0.982 ± 0.029	0.282CysHis: 0.282 ± 0.015	0.957CysIle: 0.957 ± 0.028	0.666CysLys: 0.666 ± 0.024	1.091CysLeu: 1.091 ± 0.028	0.325CysMet: 0.325 ± 0.016	0.564CysAsn: 0.564 ± 0.016	0.51CysPro: 0.51 ± 0.021	0.343CysGln: 0.343 ± 0.015	0.634CysArg: 0.634 ± 0.024	0.778CysSer: 0.778 ± 0.025	0.723CysThr: 0.723 ± 0.025	0.705CysVal: 0.705 ± 0.02	0.16CysTrp: 0.16 ± 0.012	0.601CysTyr: 0.601 ± 0.02	0.001CysXaa: 0.001 ± 0.001
Asp	3.905AspAla: 3.905 ± 0.052	0.613AspCys: 0.613 ± 0.019	2.691AspAsp: 2.691 ± 0.043	3.811AspGlu: 3.811 ± 0.062	2.895AspPhe: 2.895 ± 0.048	4.494AspGly: 4.494 ± 0.08	0.864AspHis: 0.864 ± 0.025	4.271AspIle: 4.271 ± 0.059	3.975AspLys: 3.975 ± 0.058	4.497AspLeu: 4.497 ± 0.053	1.573AspMet: 1.573 ± 0.035	2.873AspAsn: 2.873 ± 0.048	1.933AspPro: 1.933 ± 0.039	1.31AspGln: 1.31 ± 0.027	2.519AspArg: 2.519 ± 0.042	3.073AspSer: 3.073 ± 0.053	2.797AspThr: 2.797 ± 0.05	3.478AspVal: 3.478 ± 0.056	0.878AspTrp: 0.878 ± 0.027	2.95AspTyr: 2.95 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.572GluAla: 4.572 ± 0.077	0.627GluCys: 0.627 ± 0.023	3.188GluAsp: 3.188 ± 0.042	5.113GluGlu: 5.113 ± 0.075	2.465GluPhe: 2.465 ± 0.04	4.191GluGly: 4.191 ± 0.06	1.205GluHis: 1.205 ± 0.03	4.747GluIle: 4.747 ± 0.06	5.212GluLys: 5.212 ± 0.068	6.118GluLeu: 6.118 ± 0.066	2.012GluMet: 2.012 ± 0.038	3.713GluAsn: 3.713 ± 0.052	1.771GluPro: 1.771 ± 0.042	2.519GluGln: 2.519 ± 0.042	3.079GluArg: 3.079 ± 0.054	3.283GluSer: 3.283 ± 0.049	3.456GluThr: 3.456 ± 0.044	4.315GluVal: 4.315 ± 0.059	0.867GluTrp: 0.867 ± 0.025	2.914GluTyr: 2.914 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.998PheAla: 2.998 ± 0.045	0.66PheCys: 0.66 ± 0.021	2.822PheAsp: 2.822 ± 0.041	2.481PheGlu: 2.481 ± 0.04	2.27PhePhe: 2.27 ± 0.045	3.179PheGly: 3.179 ± 0.051	0.87PheHis: 0.87 ± 0.025	3.339PheIle: 3.339 ± 0.059	2.383PheLys: 2.383 ± 0.048	3.985PheLeu: 3.985 ± 0.059	1.219PheMet: 1.219 ± 0.032	2.383PheAsn: 2.383 ± 0.046	1.783PhePro: 1.783 ± 0.041	1.287PheGln: 1.287 ± 0.032	2.191PheArg: 2.191 ± 0.041	3.583PheSer: 3.583 ± 0.051	2.915PheThr: 2.915 ± 0.05	2.893PheVal: 2.893 ± 0.048	0.597PheTrp: 0.597 ± 0.019	2.099PheTyr: 2.099 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.346GlyAla: 4.346 ± 0.067	0.883GlyCys: 0.883 ± 0.027	3.685GlyAsp: 3.685 ± 0.064	4.313GlyGlu: 4.313 ± 0.058	3.183GlyPhe: 3.183 ± 0.049	4.887GlyGly: 4.887 ± 0.078	1.248GlyHis: 1.248 ± 0.032	5.608GlyIle: 5.608 ± 0.068	5.227GlyLys: 5.227 ± 0.066	5.785GlyLeu: 5.785 ± 0.073	2.169GlyMet: 2.169 ± 0.045	3.788GlyAsn: 3.788 ± 0.063	1.284GlyPro: 1.284 ± 0.034	2.104GlyGln: 2.104 ± 0.039	2.88GlyArg: 2.88 ± 0.051	4.055GlySer: 4.055 ± 0.062	4.628GlyThr: 4.628 ± 0.074	4.776GlyVal: 4.776 ± 0.063	1.042GlyTrp: 1.042 ± 0.032	3.516GlyTyr: 3.516 ± 0.059	0.001GlyXaa: 0.001 ± 0.001
His	1.134HisAla: 1.134 ± 0.031	0.285HisCys: 0.285 ± 0.014	0.87HisAsp: 0.87 ± 0.027	0.995HisGlu: 0.995 ± 0.026	0.993HisPhe: 0.993 ± 0.029	1.167HisGly: 1.167 ± 0.03	0.469HisHis: 0.469 ± 0.02	1.385HisIle: 1.385 ± 0.032	1.003HisLys: 1.003 ± 0.028	1.698HisLeu: 1.698 ± 0.037	0.376HisMet: 0.376 ± 0.014	0.917HisAsn: 0.917 ± 0.023	1.071HisPro: 1.071 ± 0.031	0.604HisGln: 0.604 ± 0.021	0.866HisArg: 0.866 ± 0.025	1.125HisSer: 1.125 ± 0.028	1.053HisThr: 1.053 ± 0.027	0.986HisVal: 0.986 ± 0.025	0.262HisTrp: 0.262 ± 0.013	0.897HisTyr: 0.897 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.254IleAla: 5.254 ± 0.077	1.018IleCys: 1.018 ± 0.026	4.389IleAsp: 4.389 ± 0.051	4.472IleGlu: 4.472 ± 0.061	2.892IlePhe: 2.892 ± 0.054	4.716IleGly: 4.716 ± 0.066	1.353IleHis: 1.353 ± 0.031	4.713IleIle: 4.713 ± 0.07	4.293IleLys: 4.293 ± 0.055	6.17IleLeu: 6.17 ± 0.074	1.521IleMet: 1.521 ± 0.035	3.608IleAsn: 3.608 ± 0.055	3.18IlePro: 3.18 ± 0.047	2.269IleGln: 2.269 ± 0.04	3.524IleArg: 3.524 ± 0.046	4.832IleSer: 4.832 ± 0.062	4.308IleThr: 4.308 ± 0.05	4.474IleVal: 4.474 ± 0.062	0.772IleTrp: 0.772 ± 0.027	3.037IleTyr: 3.037 ± 0.052	0.001IleXaa: 0.001 ± 0.001
Lys	4.708LysAla: 4.708 ± 0.064	0.537LysCys: 0.537 ± 0.02	3.851LysAsp: 3.851 ± 0.056	5.774LysGlu: 5.774 ± 0.07	2.132LysPhe: 2.132 ± 0.041	4.549LysGly: 4.549 ± 0.055	1.174LysHis: 1.174 ± 0.028	4.379LysIle: 4.379 ± 0.066	4.963LysLys: 4.963 ± 0.08	5.359LysLeu: 5.359 ± 0.069	2.073LysMet: 2.073 ± 0.039	3.625LysAsn: 3.625 ± 0.051	2.024LysPro: 2.024 ± 0.042	2.51LysGln: 2.51 ± 0.044	2.979LysArg: 2.979 ± 0.046	3.351LysSer: 3.351 ± 0.048	3.53LysThr: 3.53 ± 0.051	4.302LysVal: 4.302 ± 0.061	0.797LysTrp: 0.797 ± 0.024	2.927LysTyr: 2.927 ± 0.052	0.001LysXaa: 0.001 ± 0.001
Leu	6.013LeuAla: 6.013 ± 0.073	1.301LeuCys: 1.301 ± 0.035	4.484LeuAsp: 4.484 ± 0.056	5.012LeuGlu: 5.012 ± 0.068	4.565LeuPhe: 4.565 ± 0.07	5.458LeuGly: 5.458 ± 0.075	1.669LeuHis: 1.669 ± 0.033	5.773LeuIle: 5.773 ± 0.076	6.139LeuLys: 6.139 ± 0.071	8.9LeuLeu: 8.9 ± 0.107	2.358LeuMet: 2.358 ± 0.043	4.782LeuAsn: 4.782 ± 0.062	4.184LeuPro: 4.184 ± 0.062	3.189LeuGln: 3.189 ± 0.054	3.988LeuArg: 3.988 ± 0.053	6.782LeuSer: 6.782 ± 0.074	5.313LeuThr: 5.313 ± 0.079	4.977LeuVal: 4.977 ± 0.07	1.039LeuTrp: 1.039 ± 0.034	3.784LeuTyr: 3.784 ± 0.047	0.001LeuXaa: 0.001 ± 0.001
Met	1.963MetAla: 1.963 ± 0.039	0.258MetCys: 0.258 ± 0.014	1.468MetAsp: 1.468 ± 0.033	1.79MetGlu: 1.79 ± 0.036	0.991MetPhe: 0.991 ± 0.024	1.864MetGly: 1.864 ± 0.043	0.462MetHis: 0.462 ± 0.018	1.659MetIle: 1.659 ± 0.038	2.584MetLys: 2.584 ± 0.038	2.314MetLeu: 2.314 ± 0.041	0.781MetMet: 0.781 ± 0.022	1.719MetAsn: 1.719 ± 0.036	1.13MetPro: 1.13 ± 0.03	1.001MetGln: 1.001 ± 0.025	1.296MetArg: 1.296 ± 0.028	1.518MetSer: 1.518 ± 0.031	1.452MetThr: 1.452 ± 0.032	1.555MetVal: 1.555 ± 0.035	0.269MetTrp: 0.269 ± 0.014	0.936MetTyr: 0.936 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.509AsnAla: 3.509 ± 0.047	0.573AsnCys: 0.573 ± 0.023	2.753AsnAsp: 2.753 ± 0.046	3.251AsnGlu: 3.251 ± 0.051	2.298AsnPhe: 2.298 ± 0.039	4.222AsnGly: 4.222 ± 0.069	0.927AsnHis: 0.927 ± 0.028	3.996AsnIle: 3.996 ± 0.054	3.332AsnLys: 3.332 ± 0.058	4.43AsnLeu: 4.43 ± 0.064	1.395AsnMet: 1.395 ± 0.029	2.886AsnAsn: 2.886 ± 0.053	2.501AsnPro: 2.501 ± 0.043	1.619AsnGln: 1.619 ± 0.037	2.468AsnArg: 2.468 ± 0.039	2.997AsnSer: 2.997 ± 0.044	2.896AsnThr: 2.896 ± 0.05	3.258AsnVal: 3.258 ± 0.055	0.705AsnTrp: 0.705 ± 0.024	2.503AsnTyr: 2.503 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.899ProAla: 2.899 ± 0.052	0.357ProCys: 0.357 ± 0.017	2.62ProAsp: 2.62 ± 0.048	3.341ProGlu: 3.341 ± 0.058	1.879ProPhe: 1.879 ± 0.036	2.538ProGly: 2.538 ± 0.044	0.656ProHis: 0.656 ± 0.022	2.278ProIle: 2.278 ± 0.039	1.884ProLys: 1.884 ± 0.036	3.232ProLeu: 3.232 ± 0.049	0.925ProMet: 0.925 ± 0.024	1.723ProAsn: 1.723 ± 0.035	0.812ProPro: 0.812 ± 0.029	1.402ProGln: 1.402 ± 0.034	1.272ProArg: 1.272 ± 0.032	2.266ProSer: 2.266 ± 0.04	1.848ProThr: 1.848 ± 0.039	3.223ProVal: 3.223 ± 0.049	0.466ProTrp: 0.466 ± 0.018	1.799ProTyr: 1.799 ± 0.037	0.001ProXaa: 0.001 ± 0.001
Gln	2.443GlnAla: 2.443 ± 0.042	0.322GlnCys: 0.322 ± 0.015	1.509GlnAsp: 1.509 ± 0.028	2.301GlnGlu: 2.301 ± 0.044	1.313GlnPhe: 1.313 ± 0.032	2.018GlnGly: 2.018 ± 0.043	0.568GlnHis: 0.568 ± 0.022	2.349GlnIle: 2.349 ± 0.036	2.401GlnLys: 2.401 ± 0.052	3.16GlnLeu: 3.16 ± 0.054	0.97GlnMet: 0.97 ± 0.027	1.818GlnAsn: 1.818 ± 0.033	1.233GlnPro: 1.233 ± 0.031	1.44GlnGln: 1.44 ± 0.037	1.499GlnArg: 1.499 ± 0.035	1.936GlnSer: 1.936 ± 0.04	2.043GlnThr: 2.043 ± 0.039	2.081GlnVal: 2.081 ± 0.043	0.479GlnTrp: 0.479 ± 0.017	1.482GlnTyr: 1.482 ± 0.036	0.001GlnXaa: 0.001 ± 0.001
Arg	2.637ArgAla: 2.637 ± 0.05	0.466ArgCys: 0.466 ± 0.02	2.066ArgAsp: 2.066 ± 0.04	2.974ArgGlu: 2.974 ± 0.051	2.314ArgPhe: 2.314 ± 0.045	2.417ArgGly: 2.417 ± 0.044	0.868ArgHis: 0.868 ± 0.027	3.641ArgIle: 3.641 ± 0.054	3.283ArgLys: 3.283 ± 0.054	4.358ArgLeu: 4.358 ± 0.06	1.513ArgMet: 1.513 ± 0.032	2.477ArgAsn: 2.477 ± 0.043	1.651ArgPro: 1.651 ± 0.034	1.67ArgGln: 1.67 ± 0.034	2.121ArgArg: 2.121 ± 0.045	2.361ArgSer: 2.361 ± 0.044	2.52ArgThr: 2.52 ± 0.041	2.582ArgVal: 2.582 ± 0.045	0.658ArgTrp: 0.658 ± 0.022	2.218ArgTyr: 2.218 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	4.129SerAla: 4.129 ± 0.06	0.885SerCys: 0.885 ± 0.028	3.45SerAsp: 3.45 ± 0.048	3.575SerGlu: 3.575 ± 0.05	3.259SerPhe: 3.259 ± 0.049	4.794SerGly: 4.794 ± 0.061	1.112SerHis: 1.112 ± 0.029	4.457SerIle: 4.457 ± 0.062	3.447SerLys: 3.447 ± 0.051	5.931SerLeu: 5.931 ± 0.07	1.469SerMet: 1.469 ± 0.034	2.892SerAsn: 2.892 ± 0.051	2.359SerPro: 2.359 ± 0.039	1.87SerGln: 1.87 ± 0.036	2.586SerArg: 2.586 ± 0.046	4.089SerSer: 4.089 ± 0.069	3.404SerThr: 3.404 ± 0.053	4.438SerVal: 4.438 ± 0.065	0.862SerTrp: 0.862 ± 0.026	2.937SerTyr: 2.937 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.127ThrAla: 4.127 ± 0.058	0.605ThrCys: 0.605 ± 0.023	3.634ThrAsp: 3.634 ± 0.051	3.562ThrGlu: 3.562 ± 0.051	2.837ThrPhe: 2.837 ± 0.04	4.73ThrGly: 4.73 ± 0.066	1.018ThrHis: 1.018 ± 0.027	4.053ThrIle: 4.053 ± 0.061	2.925ThrLys: 2.925 ± 0.047	5.419ThrLeu: 5.419 ± 0.063	1.221ThrMet: 1.221 ± 0.029	2.633ThrAsn: 2.633 ± 0.053	2.854ThrPro: 2.854 ± 0.045	1.71ThrGln: 1.71 ± 0.035	2.17ThrArg: 2.17 ± 0.038	3.433ThrSer: 3.433 ± 0.052	3.289ThrThr: 3.289 ± 0.054	4.228ThrVal: 4.228 ± 0.062	0.709ThrTrp: 0.709 ± 0.027	2.566ThrTyr: 2.566 ± 0.046	0.001ThrXaa: 0.001 ± 0.001
Val	4.405ValAla: 4.405 ± 0.057	0.914ValCys: 0.914 ± 0.024	3.591ValAsp: 3.591 ± 0.052	4.054ValGlu: 4.054 ± 0.062	2.98ValPhe: 2.98 ± 0.047	4.041ValGly: 4.041 ± 0.06	1.067ValHis: 1.067 ± 0.031	4.471ValIle: 4.471 ± 0.062	4.246ValLys: 4.246 ± 0.06	5.703ValLeu: 5.703 ± 0.076	1.642ValMet: 1.642 ± 0.037	3.443ValAsn: 3.443 ± 0.051	2.564ValPro: 2.564 ± 0.045	1.927ValGln: 1.927 ± 0.041	2.882ValArg: 2.882 ± 0.043	4.66ValSer: 4.66 ± 0.066	4.03ValThr: 4.03 ± 0.064	4.428ValVal: 4.428 ± 0.061	0.778ValTrp: 0.778 ± 0.025	2.91ValTyr: 2.91 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.761TrpAla: 0.761 ± 0.026	0.188TrpCys: 0.188 ± 0.013	0.724TrpAsp: 0.724 ± 0.025	0.868TrpGlu: 0.868 ± 0.023	0.571TrpPhe: 0.571 ± 0.022	0.992TrpGly: 0.992 ± 0.029	0.255TrpHis: 0.255 ± 0.015	0.907TrpIle: 0.907 ± 0.027	0.948TrpLys: 0.948 ± 0.026	1.16TrpLeu: 1.16 ± 0.032	0.45TrpMet: 0.45 ± 0.019	0.828TrpAsn: 0.828 ± 0.027	0.314TrpPro: 0.314 ± 0.014	0.511TrpGln: 0.511 ± 0.018	0.584TrpArg: 0.584 ± 0.022	0.729TrpSer: 0.729 ± 0.023	0.704TrpThr: 0.704 ± 0.023	0.725TrpVal: 0.725 ± 0.023	0.195TrpTrp: 0.195 ± 0.012	0.558TrpTyr: 0.558 ± 0.023	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.049TyrAla: 3.049 ± 0.048	0.597TyrCys: 0.597 ± 0.019	2.704TyrAsp: 2.704 ± 0.057	2.537TyrGlu: 2.537 ± 0.044	2.236TyrPhe: 2.236 ± 0.042	2.967TyrGly: 2.967 ± 0.042	0.931TyrHis: 0.931 ± 0.027	3.031TyrIle: 3.031 ± 0.042	2.807TyrLys: 2.807 ± 0.047	4.084TyrLeu: 4.084 ± 0.054	1.12TyrMet: 1.12 ± 0.027	2.637TyrAsn: 2.637 ± 0.052	2.041TyrPro: 2.041 ± 0.043	1.537TyrGln: 1.537 ± 0.033	2.299TyrArg: 2.299 ± 0.044	2.948TyrSer: 2.948 ± 0.053	2.881TyrThr: 2.881 ± 0.044	2.591TyrVal: 2.591 ± 0.047	0.616TyrTrp: 0.616 ± 0.022	2.296TyrTyr: 2.296 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.005

Statistics based on 3866 proteins (1447579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---