Amino acid dipepetide frequency for Mycobacterium conspicuum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.669AlaAla: 20.669 ± 0.182	1.039AlaCys: 1.039 ± 0.028	8.249AlaAsp: 8.249 ± 0.082	7.671AlaGlu: 7.671 ± 0.08	3.551AlaPhe: 3.551 ± 0.05	12.884AlaGly: 12.884 ± 0.241	2.689AlaHis: 2.689 ± 0.047	5.325AlaIle: 5.325 ± 0.064	3.07AlaLys: 3.07 ± 0.059	12.8AlaLeu: 12.8 ± 0.115	2.878AlaMet: 2.878 ± 0.045	2.9AlaAsn: 2.9 ± 0.046	6.344AlaPro: 6.344 ± 0.086	4.158AlaGln: 4.158 ± 0.054	8.693AlaArg: 8.693 ± 0.079	6.215AlaSer: 6.215 ± 0.064	7.057AlaThr: 7.057 ± 0.074	11.201AlaVal: 11.201 ± 0.1	1.646AlaTrp: 1.646 ± 0.028	2.329AlaTyr: 2.329 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.103CysAla: 1.103 ± 0.026	0.09CysCys: 0.09 ± 0.008	0.558CysAsp: 0.558 ± 0.018	0.441CysGlu: 0.441 ± 0.015	0.23CysPhe: 0.23 ± 0.012	0.936CysGly: 0.936 ± 0.027	0.198CysHis: 0.198 ± 0.01	0.267CysIle: 0.267 ± 0.012	0.136CysLys: 0.136 ± 0.008	0.671CysLeu: 0.671 ± 0.02	0.132CysMet: 0.132 ± 0.008	0.183CysAsn: 0.183 ± 0.01	0.54CysPro: 0.54 ± 0.021	0.238CysGln: 0.238 ± 0.01	0.605CysArg: 0.605 ± 0.018	0.489CysSer: 0.489 ± 0.016	0.479CysThr: 0.479 ± 0.017	0.696CysVal: 0.696 ± 0.022	0.148CysTrp: 0.148 ± 0.009	0.199CysTyr: 0.199 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.769AspAla: 7.769 ± 0.083	0.459AspCys: 0.459 ± 0.016	4.193AspAsp: 4.193 ± 0.051	3.973AspGlu: 3.973 ± 0.061	1.852AspPhe: 1.852 ± 0.035	6.169AspGly: 6.169 ± 0.101	1.384AspHis: 1.384 ± 0.036	2.625AspIle: 2.625 ± 0.046	1.333AspLys: 1.333 ± 0.033	5.938AspLeu: 5.938 ± 0.062	1.013AspMet: 1.013 ± 0.026	1.252AspAsn: 1.252 ± 0.025	4.352AspPro: 4.352 ± 0.046	1.747AspGln: 1.747 ± 0.035	4.388AspArg: 4.388 ± 0.059	2.751AspSer: 2.751 ± 0.037	3.069AspThr: 3.069 ± 0.047	5.146AspVal: 5.146 ± 0.056	0.998AspTrp: 0.998 ± 0.026	1.483AspTyr: 1.483 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.066GluAla: 6.066 ± 0.064	0.385GluCys: 0.385 ± 0.015	2.318GluAsp: 2.318 ± 0.039	2.447GluGlu: 2.447 ± 0.046	1.842GluPhe: 1.842 ± 0.034	3.163GluGly: 3.163 ± 0.045	1.558GluHis: 1.558 ± 0.028	2.63GluIle: 2.63 ± 0.041	1.241GluLys: 1.241 ± 0.031	6.597GluLeu: 6.597 ± 0.065	1.068GluMet: 1.068 ± 0.025	1.049GluAsn: 1.049 ± 0.026	2.96GluPro: 2.96 ± 0.047	2.192GluGln: 2.192 ± 0.035	4.36GluArg: 4.36 ± 0.058	2.56GluSer: 2.56 ± 0.037	2.503GluThr: 2.503 ± 0.04	4.216GluVal: 4.216 ± 0.049	0.73GluTrp: 0.73 ± 0.022	1.119GluTyr: 1.119 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.03PheAla: 4.03 ± 0.052	0.351PheCys: 0.351 ± 0.015	2.516PheAsp: 2.516 ± 0.042	1.611PheGlu: 1.611 ± 0.031	1.042PhePhe: 1.042 ± 0.028	3.538PheGly: 3.538 ± 0.051	0.719PheHis: 0.719 ± 0.02	1.128PheIle: 1.128 ± 0.026	0.571PheLys: 0.571 ± 0.019	2.495PheLeu: 2.495 ± 0.046	0.541PheMet: 0.541 ± 0.019	0.828PheAsn: 0.828 ± 0.022	1.489PhePro: 1.489 ± 0.029	0.752PheGln: 0.752 ± 0.02	1.677PheArg: 1.677 ± 0.039	1.769PheSer: 1.769 ± 0.031	1.986PheThr: 1.986 ± 0.032	2.588PheVal: 2.588 ± 0.043	0.451PheTrp: 0.451 ± 0.019	0.729PheTyr: 0.729 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.147GlyAla: 11.147 ± 0.222	0.826GlyCys: 0.826 ± 0.022	5.218GlyAsp: 5.218 ± 0.104	4.13GlyGlu: 4.13 ± 0.047	3.13GlyPhe: 3.13 ± 0.05	10.83GlyGly: 10.83 ± 0.56	2.137GlyHis: 2.137 ± 0.042	4.126GlyIle: 4.126 ± 0.054	2.372GlyLys: 2.372 ± 0.036	8.578GlyLeu: 8.578 ± 0.088	2.152GlyMet: 2.152 ± 0.037	3.035GlyAsn: 3.035 ± 0.225	4.807GlyPro: 4.807 ± 0.063	3.079GlyGln: 3.079 ± 0.053	6.123GlyArg: 6.123 ± 0.067	5.585GlySer: 5.585 ± 0.105	5.56GlyThr: 5.56 ± 0.143	7.525GlyVal: 7.525 ± 0.066	1.645GlyTrp: 1.645 ± 0.033	2.415GlyTyr: 2.415 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.595HisAla: 2.595 ± 0.04	0.245HisCys: 0.245 ± 0.013	1.396HisAsp: 1.396 ± 0.027	1.053HisGlu: 1.053 ± 0.025	0.725HisPhe: 0.725 ± 0.022	2.231HisGly: 2.231 ± 0.04	0.666HisHis: 0.666 ± 0.024	0.886HisIle: 0.886 ± 0.022	0.387HisLys: 0.387 ± 0.014	2.163HisLeu: 2.163 ± 0.041	0.344HisMet: 0.344 ± 0.014	0.521HisAsn: 0.521 ± 0.017	1.68HisPro: 1.68 ± 0.034	0.771HisGln: 0.771 ± 0.023	1.833HisArg: 1.833 ± 0.032	1.13HisSer: 1.13 ± 0.025	1.203HisThr: 1.203 ± 0.025	1.735HisVal: 1.735 ± 0.029	0.413HisTrp: 0.413 ± 0.015	0.588HisTyr: 0.588 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.223IleAla: 6.223 ± 0.073	0.436IleCys: 0.436 ± 0.015	3.439IleAsp: 3.439 ± 0.043	2.6IleGlu: 2.6 ± 0.05	1.108IlePhe: 1.108 ± 0.028	4.475IleGly: 4.475 ± 0.057	0.831IleHis: 0.831 ± 0.023	1.444IleIle: 1.444 ± 0.034	0.959IleLys: 0.959 ± 0.024	2.977IleLeu: 2.977 ± 0.045	0.633IleMet: 0.633 ± 0.017	1.276IleAsn: 1.276 ± 0.031	2.415IlePro: 2.415 ± 0.04	0.995IleGln: 0.995 ± 0.026	2.638IleArg: 2.638 ± 0.036	2.263IleSer: 2.263 ± 0.04	2.774IleThr: 2.774 ± 0.042	3.558IleVal: 3.558 ± 0.049	0.489IleTrp: 0.489 ± 0.016	0.873IleTyr: 0.873 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.64LysAla: 2.64 ± 0.053	0.131LysCys: 0.131 ± 0.009	1.142LysAsp: 1.142 ± 0.03	0.985LysGlu: 0.985 ± 0.029	0.664LysPhe: 0.664 ± 0.023	1.588LysGly: 1.588 ± 0.031	0.544LysHis: 0.544 ± 0.016	1.029LysIle: 1.029 ± 0.026	0.634LysLys: 0.634 ± 0.026	2.285LysLeu: 2.285 ± 0.035	0.479LysMet: 0.479 ± 0.018	0.532LysAsn: 0.532 ± 0.02	1.53LysPro: 1.53 ± 0.032	0.743LysGln: 0.743 ± 0.021	1.659LysArg: 1.659 ± 0.032	1.207LysSer: 1.207 ± 0.031	1.385LysThr: 1.385 ± 0.029	1.948LysVal: 1.948 ± 0.039	0.323LysTrp: 0.323 ± 0.013	0.498LysTyr: 0.498 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.98LeuAla: 13.98 ± 0.124	0.869LeuCys: 0.869 ± 0.022	6.455LeuAsp: 6.455 ± 0.073	4.289LeuGlu: 4.289 ± 0.054	2.775LeuPhe: 2.775 ± 0.044	8.495LeuGly: 8.495 ± 0.078	2.097LeuHis: 2.097 ± 0.032	4.157LeuIle: 4.157 ± 0.049	1.91LeuLys: 1.91 ± 0.035	9.579LeuLeu: 9.579 ± 0.09	1.717LeuMet: 1.717 ± 0.035	2.226LeuAsn: 2.226 ± 0.035	5.852LeuPro: 5.852 ± 0.06	2.652LeuGln: 2.652 ± 0.042	7.648LeuArg: 7.648 ± 0.085	5.658LeuSer: 5.658 ± 0.061	6.125LeuThr: 6.125 ± 0.062	7.995LeuVal: 7.995 ± 0.08	1.196LeuTrp: 1.196 ± 0.03	1.7LeuTyr: 1.7 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.64MetAla: 2.64 ± 0.038	0.19MetCys: 0.19 ± 0.01	0.905MetAsp: 0.905 ± 0.024	0.682MetGlu: 0.682 ± 0.019	0.648MetPhe: 0.648 ± 0.018	1.53MetGly: 1.53 ± 0.031	0.43MetHis: 0.43 ± 0.017	0.894MetIle: 0.894 ± 0.026	0.493MetLys: 0.493 ± 0.019	2.097MetLeu: 2.097 ± 0.033	0.423MetMet: 0.423 ± 0.019	0.529MetAsn: 0.529 ± 0.016	1.264MetPro: 1.264 ± 0.029	0.573MetGln: 0.573 ± 0.016	1.578MetArg: 1.578 ± 0.029	1.488MetSer: 1.488 ± 0.028	1.706MetThr: 1.706 ± 0.029	1.606MetVal: 1.606 ± 0.033	0.259MetTrp: 0.259 ± 0.012	0.362MetTyr: 0.362 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.964AsnAla: 2.964 ± 0.044	0.192AsnCys: 0.192 ± 0.011	1.332AsnAsp: 1.332 ± 0.032	1.021AsnGlu: 1.021 ± 0.023	0.76AsnPhe: 0.76 ± 0.023	3.083AsnGly: 3.083 ± 0.238	0.523AsnHis: 0.523 ± 0.019	0.992AsnIle: 0.992 ± 0.028	0.495AsnLys: 0.495 ± 0.017	2.179AsnLeu: 2.179 ± 0.042	0.431AsnMet: 0.431 ± 0.015	0.66AsnAsn: 0.66 ± 0.022	1.868AsnPro: 1.868 ± 0.038	0.752AsnGln: 0.752 ± 0.021	1.605AsnArg: 1.605 ± 0.028	1.307AsnSer: 1.307 ± 0.032	1.359AsnThr: 1.359 ± 0.034	1.857AsnVal: 1.857 ± 0.03	0.406AsnTrp: 0.406 ± 0.016	0.591AsnTyr: 0.591 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.369ProAla: 7.369 ± 0.091	0.31ProCys: 0.31 ± 0.013	4.338ProAsp: 4.338 ± 0.052	3.617ProGlu: 3.617 ± 0.048	1.686ProPhe: 1.686 ± 0.033	5.82ProGly: 5.82 ± 0.069	1.27ProHis: 1.27 ± 0.025	2.26ProIle: 2.26 ± 0.038	1.358ProLys: 1.358 ± 0.027	4.959ProLeu: 4.959 ± 0.058	1.208ProMet: 1.208 ± 0.026	1.412ProAsn: 1.412 ± 0.032	3.921ProPro: 3.921 ± 0.084	1.867ProGln: 1.867 ± 0.032	3.405ProArg: 3.405 ± 0.051	3.123ProSer: 3.123 ± 0.041	3.451ProThr: 3.451 ± 0.048	4.892ProVal: 4.892 ± 0.056	0.851ProTrp: 0.851 ± 0.021	1.191ProTyr: 1.191 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.867GlnAla: 3.867 ± 0.046	0.229GlnCys: 0.229 ± 0.01	1.272GlnAsp: 1.272 ± 0.027	1.122GlnGlu: 1.122 ± 0.028	1.033GlnPhe: 1.033 ± 0.023	2.154GlnGly: 2.154 ± 0.049	0.824GlnHis: 0.824 ± 0.023	1.517GlnIle: 1.517 ± 0.03	0.588GlnLys: 0.588 ± 0.019	3.706GlnLeu: 3.706 ± 0.057	0.713GlnMet: 0.713 ± 0.019	0.68GlnAsn: 0.68 ± 0.02	1.921GlnPro: 1.921 ± 0.035	1.35GlnGln: 1.35 ± 0.029	2.936GlnArg: 2.936 ± 0.039	1.536GlnSer: 1.536 ± 0.036	1.601GlnThr: 1.601 ± 0.03	2.553GlnVal: 2.553 ± 0.045	0.546GlnTrp: 0.546 ± 0.018	0.671GlnTyr: 0.671 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.559ArgAla: 8.559 ± 0.09	0.606ArgCys: 0.606 ± 0.02	4.216ArgAsp: 4.216 ± 0.05	3.725ArgGlu: 3.725 ± 0.052	2.412ArgPhe: 2.412 ± 0.036	5.208ArgGly: 5.208 ± 0.06	1.752ArgHis: 1.752 ± 0.032	3.3ArgIle: 3.3 ± 0.049	1.583ArgLys: 1.583 ± 0.037	7.652ArgLeu: 7.652 ± 0.092	1.769ArgMet: 1.769 ± 0.032	1.61ArgAsn: 1.61 ± 0.035	3.951ArgPro: 3.951 ± 0.056	2.316ArgGln: 2.316 ± 0.038	6.477ArgArg: 6.477 ± 0.089	3.799ArgSer: 3.799 ± 0.052	3.845ArgThr: 3.845 ± 0.044	5.568ArgVal: 5.568 ± 0.056	1.385ArgTrp: 1.385 ± 0.027	1.926ArgTyr: 1.926 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.036SerAla: 7.036 ± 0.069	0.418SerCys: 0.418 ± 0.015	3.113SerAsp: 3.113 ± 0.045	2.497SerGlu: 2.497 ± 0.04	1.736SerPhe: 1.736 ± 0.03	5.978SerGly: 5.978 ± 0.106	1.094SerHis: 1.094 ± 0.023	2.189SerIle: 2.189 ± 0.036	1.185SerLys: 1.185 ± 0.03	4.785SerLeu: 4.785 ± 0.052	1.334SerMet: 1.334 ± 0.027	1.191SerAsn: 1.191 ± 0.029	3.058SerPro: 3.058 ± 0.042	1.483SerGln: 1.483 ± 0.032	3.625SerArg: 3.625 ± 0.039	3.067SerSer: 3.067 ± 0.043	3.307SerThr: 3.307 ± 0.043	4.364SerVal: 4.364 ± 0.048	0.917SerTrp: 0.917 ± 0.024	1.319SerTyr: 1.319 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	7.581ThrAla: 7.581 ± 0.06	0.401ThrCys: 0.401 ± 0.016	3.491ThrAsp: 3.491 ± 0.043	2.962ThrGlu: 2.962 ± 0.04	1.805ThrPhe: 1.805 ± 0.034	6.096ThrGly: 6.096 ± 0.128	1.175ThrHis: 1.175 ± 0.027	2.443ThrIle: 2.443 ± 0.039	1.268ThrLys: 1.268 ± 0.03	5.455ThrLeu: 5.455 ± 0.058	1.229ThrMet: 1.229 ± 0.028	1.394ThrAsn: 1.394 ± 0.035	3.681ThrPro: 3.681 ± 0.053	1.53ThrGln: 1.53 ± 0.032	3.505ThrArg: 3.505 ± 0.045	3.048ThrSer: 3.048 ± 0.046	3.648ThrThr: 3.648 ± 0.052	5.466ThrVal: 5.466 ± 0.06	0.822ThrTrp: 0.822 ± 0.023	1.282ThrTyr: 1.282 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.121ValAla: 11.121 ± 0.097	0.75ValCys: 0.75 ± 0.02	5.533ValAsp: 5.533 ± 0.06	4.425ValGlu: 4.425 ± 0.051	2.499ValPhe: 2.499 ± 0.044	7.056ValGly: 7.056 ± 0.072	1.794ValHis: 1.794 ± 0.032	3.862ValIle: 3.862 ± 0.05	1.688ValLys: 1.688 ± 0.034	8.435ValLeu: 8.435 ± 0.086	1.59ValMet: 1.59 ± 0.03	2.17ValAsn: 2.17 ± 0.035	4.513ValPro: 4.513 ± 0.06	2.165ValGln: 2.165 ± 0.032	5.717ValArg: 5.717 ± 0.073	4.625ValSer: 4.625 ± 0.054	5.174ValThr: 5.174 ± 0.056	8.119ValVal: 8.119 ± 0.088	1.032ValTrp: 1.032 ± 0.03	1.547ValTyr: 1.547 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.534TrpAla: 1.534 ± 0.031	0.166TrpCys: 0.166 ± 0.01	0.818TrpAsp: 0.818 ± 0.026	0.697TrpGlu: 0.697 ± 0.017	0.505TrpPhe: 0.505 ± 0.017	1.055TrpGly: 1.055 ± 0.028	0.379TrpHis: 0.379 ± 0.016	0.657TrpIle: 0.657 ± 0.019	0.311TrpLys: 0.311 ± 0.014	1.715TrpLeu: 1.715 ± 0.035	0.331TrpMet: 0.331 ± 0.013	0.42TrpAsn: 0.42 ± 0.017	0.851TrpPro: 0.851 ± 0.021	0.663TrpGln: 0.663 ± 0.019	1.311TrpArg: 1.311 ± 0.029	0.947TrpSer: 0.947 ± 0.027	0.853TrpThr: 0.853 ± 0.023	1.101TrpVal: 1.101 ± 0.025	0.319TrpTrp: 0.319 ± 0.014	0.325TrpTyr: 0.325 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.475TyrAla: 2.475 ± 0.035	0.246TyrCys: 0.246 ± 0.012	1.395TyrAsp: 1.395 ± 0.03	1.054TyrGlu: 1.054 ± 0.027	0.803TyrPhe: 0.803 ± 0.023	2.131TyrGly: 2.131 ± 0.033	0.501TyrHis: 0.501 ± 0.017	0.677TyrIle: 0.677 ± 0.022	0.366TyrLys: 0.366 ± 0.015	2.31TyrLeu: 2.31 ± 0.036	0.31TyrMet: 0.31 ± 0.013	0.512TyrAsn: 0.512 ± 0.017	1.31TyrPro: 1.31 ± 0.03	0.795TyrGln: 0.795 ± 0.021	1.876TyrArg: 1.876 ± 0.038	1.126TyrSer: 1.126 ± 0.028	1.2TyrThr: 1.2 ± 0.026	1.679TyrVal: 1.679 ± 0.033	0.379TyrTrp: 0.379 ± 0.014	0.524TyrTyr: 0.524 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5457 proteins (1826921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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